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Severe chronic primary neutropenia in adults: report on a series of 108 patients
A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children
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INSIDE BLOOD COMMENTARIES
CLINICAL TRIALS AND OBSERVATIONS
Severe chronic primary neutropenia in adults: report on a series of 108 patients
Clinical Trials & Observations
Flore Sicre de Fontbrune,Aline Moignet,Blandine Beaupain,Felipe Suarez,Lionel Galicier,Gérard Socié,Bruno Varet,Paul Coppo,Marc Michel,Cécile Pautas,Eric Oksenhendler,Etienne Lengline,Louis Terriou,Philippe Moreau,Sylvain Chantepie,Nicole Casadevall,Jean Marie Michot,Martine Gardembas,Mauricette Michallet,Laure Croisille,Marie Audrain,Christine Bellanné-Chantelot,Jean Donadieu,Thierry Lamy,for the French Severe Chronic Neutropenia Registry
A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children
Clinical Trials & Observations
David C. Brousseau,J. Paul Scott,Oluwakemi Badaki-Makun,Deepika S. Darbari,Corrie E. Chumpitazi,Gladstone E. Airewele,Angela M. Ellison,Kim Smith-Whitley,Prashant Mahajan,Sharada A. Sarnaik,T. Charles Casper,Lawrence J. Cook,J. Michael Dean,Julie Leonard,Monica L. Hulbert,Elizabeth C. Powell,Robert I. Liem,Robert Hickey,Lakshmanan Krishnamurti,Cheryl A. Hillery,Mark Nimmer,Julie A. Panepinto,for the Pediatric Emergency Care Applied Research Network (PECARN)
IMMUNOBIOLOGY
Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency
Sebastian Fuchs,Anne Rensing-Ehl,Ulrich Pannicke,Myriam R. Lorenz,Paul Fisch,Yogesh Jeelall,Jan Rohr,Carsten Speckmann,Thomas Vraetz,Susan Farmand,Annette Schmitt-Graeff,Marcus Krüger,Brigitte Strahm,Philipp Henneke,Anselm Enders,Keisuke Horikawa,Christopher Goodnow,Klaus Schwarz,Stephan Ehl
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice
Sebastien Verhenne,Frederik Denorme,Sarah Libbrecht,Aline Vandenbulcke,Inge Pareyn,Hans Deckmyn,Antoon Lambrecht,Bernhard Nieswandt,Christoph Kleinschnitz,Karen Vanhoorelbeke,Simon F. De Meyer
TRANSPLANTATION
Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome
Daniela Weber,Peter J. Oefner,Andreas Hiergeist,Josef Koestler,André Gessner,Markus Weber,Joachim Hahn,Daniel Wolff,Frank Stämmler,Rainer Spang,Wolfgang Herr,Katja Dettmer,Ernst Holler
BLOOD WORK
CORRESPONDENCE
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Cover Image
Cover Image
Representative image of megakaryocytes deficient in the anaphase-promoting complex/cyclosome (APC/C) subunit Cdc20. In the absence of Cdc20, these giant cells arrest in mitosis with condensed chromosomes (as shown by phosphorylation of histone H3; magenta) and multipolar spindles (bright green within the magenta areas). DNA is shown in blue and tubulin is shown in green. The authors describe how megakaryocytes display a functional mitotic checkpoint that senses spindle aberrations leading to mitotic arrest. See the article by Trakala et al on page 1707.
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