Nona Shayegi,on behalf of the Study Alliance Leukemia (SAL),Michael Kramer,on behalf of the Study Alliance Leukemia (SAL),Martin Bornhäuser,on behalf of the Study Alliance Leukemia (SAL),Markus Schaich,on behalf of the Study Alliance Leukemia (SAL),Johannes Schetelig,on behalf of the Study Alliance Leukemia (SAL),Uwe Platzbecker,on behalf of the Study Alliance Leukemia (SAL),Christoph Röllig,on behalf of the Study Alliance Leukemia (SAL),Caroline Heiderich,on behalf of the Study Alliance Leukemia (SAL),Olfert Landt,on behalf of the Study Alliance Leukemia (SAL),Gerhard Ehninger,on behalf of the Study Alliance Leukemia (SAL),Christian Thiede,on behalf of the Study Alliance Leukemia (SAL)

View Articletitled, The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML

Supplemental data

Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia

Konrad Aumann,Anna-Verena Frey,Annette M. May,Dieter Hauschke,Clemens Kreutz,Jan P. Marx,Jens Timmer,Martin Werner,Heike L. Pahl

View Articletitled, Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia

Supplemental data

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

Jan Krönke,Lars Bullinger,Veronica Teleanu,Florian Tschürtz,Verena I. Gaidzik,Michael W. M. Kühn,Frank G. Rücker,Karlheinz Holzmann,Peter Paschka,Silke Kapp-Schwörer,Daniela Späth,Thomas Kindler,Marcus Schittenhelm,Jürgen Krauter,Arnold Ganser,Gudrun Göhring,Brigitte Schlegelberger,Richard F. Schlenk,Hartmut Döhner,Konstanze Döhner

View Articletitled, Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

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PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations
Brief Report

Xi Wen Zhao,Roel P. Gazendam,Agata Drewniak,Michel van Houdt,Anton T. J. Tool,John L. van Hamme,Iwan Kustiawan,Alexander B. Meijer,Hans Janssen,David G. Russell,Lisette van de Corput,Kiki Tesselaar,Jaap J. Boelens,Ingrid Kuhnle,Jutte Van Der Werff Ten Bosch,Taco W. Kuijpers,Timo K. van den Berg

View Articletitled, Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD)

Daniel H. Wiseman,Alison May,Stephen Jolles,Philip Connor,Colin Powell,Matthew M. Heeney,Patricia J. Giardina,Robert J. Klaassen,Pranesh Chakraborty,Michael T. Geraghty,Nathalie Major-Cook,Caroline Kannengiesser,Isabelle Thuret,Alexis A. Thompson,Laura Marques,Stephen Hughes,Denise K. Bonney,Sylvia S. Bottomley,Mark D. Fleming,Robert F. Wynn

View Articletitled, A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD)

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Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: a longitudinal study

Sant-Rayn Pasricha,David M. Frazer,Donald K. Bowden,Gregory J. Anderson

View Articletitled, Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: a longitudinal study

THROMBOSIS AND HEMOSTASIS

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

Ramzi A. Ajjan,Toby Gamlen,Kristina F. Standeven,Salihah Mughal,Katharina Hess,Kerrie A. Smith,Emma J. Dunn,M. Maqsud Anwar,Naila Rabbani,Paul J. Thornalley,Helen Philippou,Peter J. Grant

View Articletitled, Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

VASCULAR BIOLOGY

Notch1 regulates angio-supportive bone marrow–derived cells in mice: relevance to chemoresistance

Jeanine M. L. Roodhart,Huanhuan He,Laura G. M. Daenen,Arnaud Monvoisin,Chad L. Barber,Miranda van Amersfoort,Jennifer J. Hofmann,Freddy Radtke,Timothy F. Lane,Emile E. Voest,M. Luisa Iruela-Arispe

View Articletitled, Notch1 regulates angio-supportive bone marrow–derived cells in mice: relevance to chemoresistance

Supplemental data

Cover Image

Cover Image

Perls stained bone marrow aspirate particle from a child with sideroblastic anemia, B-cell immunodeficiency, fevers, and developmental delay (SIFD): a newly-described syndromic form of congenital sideroblastic anemia. Particle shows gross iron overload, with higher power magnification revealing >50% of erythroid precursors as ring sideroblasts. The child also displayed hypogammaglobulinemia, B-lymphopenia, periodic inflammatory episodes, and developmental delay. See the article by Wiseman et al on page 112.
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