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Issue Archive

Volume 8, Issue 3
February 13 2024
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

CARs for Hodgkin: engine fine-tuning is in order
Clinical Trials & Observations
Natalie S. Grover,Carlos A. Ramos
View Articletitled, CARs for Hodgkin: engine fine-tuning is in order
A leap in recognizing drug-induced immune hemolytic anemia
Clinical Trials & Observations
Dennis Lund Hansen,Henrik Frederiksen
View Articletitled, A leap in recognizing drug-induced immune hemolytic anemia
Under AI’s lens: spotting mutations visually
Joshua A. Fein,Sanjay S. Patel
View Articletitled, Under AI’s lens: spotting mutations visually

REVIEW ARTICLE

Utility or futility? A contemporary approach to allogeneic hematopoietic cell transplantation for TP53-mutated MDS/AML
Mariam T. Nawas,Satyajit Kosuri
View Articletitled, Utility or futility? A contemporary approach to allogeneic hematopoietic cell transplantation for <em>TP53-</em>mutated MDS/AML

SYSTEMATIC REVIEW

Pregnancy outcomes and iron status in β-thalassemia major and intermedia: a systematic review and meta-analysis
Evangelia Vlachodimitropoulou,Hussain Mogharbel,Kevin H. M. Kuo,Michelle Hwang,Richard Ward,Nadine Shehata,Ann Kinga Malinowski
View Articletitled, Pregnancy outcomes and iron status in β-thalassemia major and intermedia: a systematic review and meta-analysis
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Blinatumomab consolidation post–autologous stem cell transplantation in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations
Armin Ghobadi,Nicole C. Foley,Jared Cohen,Michael P. Rettig,Amanda F. Cashen,Leah Gehrs,Stephanie Christ,Emily Street,Nicholas Wallace,Julie Ritchey,Neha Mehta-Shah,Peter Westervelt,Todd A. Fehniger,Brad Kahl,Nancy L. Bartlett,John F. DiPersio
View Articletitled, Blinatumomab consolidation post–autologous stem cell transplantation in patients with diffuse large B-cell lymphoma
Supplemental data
Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population
Clinical Trials & Observations
Janine M. Joseph,Jens Hillengass,Li Tang,Alexander M. Lesokhin,Ola Landgren,Saad Z. Usmani,Kirsten B. Moysich,Susan E. McCann,Urvi A. Shah
View Articletitled, Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population
Supplemental data
Phase 1b trial of tagraxofusp in combination with azacitidine with or without venetoclax in acute myeloid leukemia
Clinical Trials & Observations
Andrew A. Lane,Jacqueline S. Garcia,Evangeline G. Raulston,Jada L. Garzon,Ilene Galinsky,Emilie W. Baxter,Rebecca Leonard,Daniel J. DeAngelo,Marlise R. Luskin,Christopher R. Reilly,Maximilian Stahl,Richard M. Stone,Rahul S. Vedula,Martha M. Wadleigh,Eric S. Winer,Tariq Mughal,Christopher Brooks,Ira V. Gupta,Kristen E. Stevenson,Donna S. Neuberg,Siyang Ren,Julia Keating,Marina Konopleva,Anthony Stein,Naveen Pemmaraju
View Articletitled, Phase 1b trial of tagraxofusp in combination with azacitidine with or without venetoclax in acute myeloid leukemia
Supplemental data
Three years of maintenance with VRD in multiple myeloma: results of total therapy IIIB with a 15-year follow-up
Clinical Trials & Observations
Samer Al Hadidi,Obada Ehab Ababneh,Carolina D. Schinke,Sharmilan Thanendrarajan,Clyde Bailey,Robert Smith,Susan Panozzo,Daisy Alapat,Michele Cottler-Fox,Guido Tricot,John D. Shaughnessy, Jr.,Fenghuang Zhan,Jeffrey Sawyer,Bart Barlogie,Maurizio Zangari,Frits van Rhee
View Articletitled, Three years of maintenance with VRD in multiple myeloma: results of total therapy IIIB with a 15-year follow-up
Supplemental data
Transient responses and significant toxicities of anti-CD30 CAR T cells for CD30+ lymphomas: results of a phase 1 trial
Clinical Trials & Observations
Jennifer N. Brudno,Danielle A. Natrakul,Jeremiah Karrs,Nisha Patel,Roberto Maass-Moreno,Mark A. Ahlman,Lekha Mikkilineni,Jennifer Mann,David F. Stroncek,Steven L. Highfill,Genevieve C. Fromm,Rashmika Patel,Stefania Pittaluga,James N. Kochenderfer
View Articletitled, Transient responses and significant toxicities of anti-CD30 CAR T cells for CD30<sup>+</sup> lymphomas: results of a phase 1 trial
Supplemental data
CARs for Hodgkin: engine fine-tuning is in order
Clinical Trials & Observations
Natalie S. Grover,Carlos A. Ramos
View Articletitled, CARs for Hodgkin: engine fine-tuning is in order

HEMATOPOIESIS AND STEM CELLS

R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation
Eiko Hayase,Takahide Ara,Yumika Saito,Shuichiro Takahashi,Kosuke Yoshioka,Hiroyuki Ohigashi,Reiki Ogasawara,Emi Yokoyama,Tomohiro Yamakawa,Ko Ebata,Yuta Hasegawa,Kazuma Tomizuka,Takanori Teshima
View Articletitled, R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation
Supplemental data
Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation
Stijn N. R. Fuchs,Ursula S. A. Stalmann,Inge A. M. Snoeren,Eric Bindels,Stephani Schmitz,Bella Banjanin,Remco M. Hoogenboezem,Stanley van Herk,Mohamed Saad,Wencke Walter,Torsten Haferlach,Lancelot Seillier,Julio Saez-Rodriguez,Aurélien J. F. Dugourd,Kjong-Van Lehmann,Yinon Ben-Neriah,Hélène F. E. Gleitz,Rebekka K. Schneider
View Articletitled, Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Bendamustine lymphodepletion before axicabtagene ciloleucel is safe and associates with reduced inflammatory cytokines
Clinical Trials & Observations
Guido Ghilardi,Luca Paruzzo,Jakub Svoboda,Elise A. Chong,Alexander A. Shestov,Linhui Chen,Ivan J. Cohen,Giulia Gabrielli,Sunita D. Nasta,Patrizia Porazzi,Daniel J. Landsburg,James N. Gerson,Jordan Carter,Stefan K. Barta,Rebecca Yelton,Raymone Pajarillo,Vrutti Patel,Griffin White,Hatcher J. Ballard,Elizabeth Weber,Ellen Napier,Emeline R. Chong,Joseph A. Fraietta,Alfred L. Garfall,David L. Porter,Michael C. Milone,Roderick O’Connor,Stephen J. Schuster,Marco Ruella
View Articletitled, Bendamustine lymphodepletion before axicabtagene ciloleucel is safe and associates with reduced inflammatory cytokines
Supplemental data
Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A∗03 and HLA-B∗15 via peptide-PRISM
Alice Felicitas Rein,Chris David Lauruschkat,Ihsan Muchsin,Carolin Köchel,Sabine Tischer-Zimmermann,Liane Bauersfeld,Annika Nelde,Maren Lübke,Bhupesh Kumar Prusty,Andreas Schlosser,Anne Halenius,Britta Eiz-Vesper,Lars Dölken,Götz Ulrich Grigoleit,Hermann Einsele,Florian Erhard,Sabrina Kraus
View Articletitled, Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A∗03 and HLA-B∗15 via peptide-PRISM
Supplemental data

LYMPHOID NEOPLASIA

Utility of FDG-PET in predicting the histology of relapsed or refractory lymphoma
Shin Hnin Wai,Sze Ting Lee,Edward R. Scheffer Cliff,Michael Bei,Jiwoo Lee,Eliza A. Hawkes,Geoffrey Chong
View Articletitled, Utility of FDG-PET in predicting the histology of relapsed or refractory lymphoma
Supplemental data

MYELOID NEOPLASIA

A Markov analysis of azacitidine and venetoclax vs induction chemotherapy for medically fit patients with AML
Mithunan Ravindran,Lee Mozessohn,Matthew Cheung,Rena Buckstein,Jennifer Teichman
View Articletitled, A Markov analysis of azacitidine and venetoclax vs induction chemotherapy for medically fit patients with AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Ongoing production of tissue-resident macrophages from hematopoietic stem cells in healthy adult macaques
Andrew R. Rahmberg,Chuanfeng Wu,Taehoon Shin,So Gun Hong,Luxin Pei,Tovah E. Markowitz,Heather D. Hickman,Cynthia E. Dunbar,Jason M. Brenchley
View Articletitled, Ongoing production of tissue-resident macrophages from hematopoietic stem cells in healthy adult macaques
Supplemental data
Clinical and immunological features in ACKR1/DARC-associated neutropenia
Jan Palmblad,Ebba Sohlberg,Christer C. Nilsson,Henric Lindqvist,Stefan Deneberg,Paul Ratcliffe,Stephan Meinke,Anette Mörtberg,Monika Klimkowska,Petter Höglund
View Articletitled, Clinical and immunological features in ACKR1/DARC-associated neutropenia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Drug-induced immune hemolytic anemia: detection of new signals and risk assessment in a nationwide cohort study
Clinical Trials & Observations
Julien Maquet,Margaux Lafaurie,Marc Michel,Maryse Lapeyre-Mestre,Guillaume Moulis
View Articletitled, Drug-induced immune hemolytic anemia: detection of new signals and risk assessment in a nationwide cohort study
Supplemental data
A leap in recognizing drug-induced immune hemolytic anemia
Clinical Trials & Observations
Dennis Lund Hansen,Henrik Frederiksen
View Articletitled, A leap in recognizing drug-induced immune hemolytic anemia

THROMBOSIS AND HEMOSTASIS

Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism
Kiwamu Hatakeyama,Yoshikane Kikushige,Daisuke Ishihara,Shunsuke Yamamoto,Gentaro Kawano,Taro Tochigi,Toshihiro Miyamoto,Teppei Sakoda,Andy Christoforou,Yuya Kunisaki,Mitsuhiro Fukata,Koji Kato,Takumi Ito,Hiroshi Handa,Koichi Akashi
View Articletitled, Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism
Supplemental data

TRANSPLANTATION

Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML
Joshua A. Fein,Roni Shouval,Elizabeth Krieger,Stephen R. Spellman,Tao Wang,Henning Baldauf,Katharina Fleischhauer,Nicolaus Kröger,Mary Horowitz,Martin Maiers,Jeffrey S Miller,Mohamad Mohty,Arnon Nagler,Daniel Weisdorf,Karl-Johan Malmberg,Amir A. Toor,Johannes Schetelig,Rizwan Romee,John Koreth
View Articletitled, Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML
Supplemental data
Cerebral hemodynamic changes after haploidentical hematopoietic stem cell transplant in adults with sickle cell disease
Megan A. Aumann,Wesley Richerson,Alexander K. Song,L. Taylor Davis,Sumit Pruthi,Samantha Davis,Niral J. Patel,Chelsea Custer,Adetola A. Kassim,Michael R. DeBaun,Manus J. Donahue,Lori C. Jordan
View Articletitled, Cerebral hemodynamic changes after haploidentical hematopoietic stem cell transplant in adults with sickle cell disease
Supplemental data
Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan
Mizuki Watanabe,Junya Kanda,Fernanda Volt,Annalisa Ruggeri,Ritsuro Suzuki,Hanadi Rafii,Fumihiko Kimura,Barbara Cappelli,Eisei Kondo,Graziana Maria Scigliuolo,Satoshi Takahashi,Chantal Kenzey,Monica M. Rivera-Franco,Shinichiro Okamoto,Vanderson Rocha,Patrice Chevallier,Jaime Sanz,Sabine Fürst,Jan Cornelissen,Noel Milpied,Naoyuki Uchida,Yasuhiro Sugio,Takafumi Kimura,Tatsuo Ichinohe,Takahiro Fukuda,Mohamad Mohty,Régis Peffault de Latour,Yoshiko Atsuta,Eliane Gluckman
View Articletitled, Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan
Supplemental data
Heightened TLR7 signaling primes BCR-activated B cells in chronic graft-versus-host disease for effector functions
Sonali J. Bracken,Amy N. Suthers,Rachel A. DiCioccio,Hsuan Su,Sarah Anand,Jonathan C. Poe,Wei Jia,Jonathan Visentin,Fahmin Basher,Collin Z. Jordan,William C. McManigle,Zhiguo Li,Frances T. Hakim,Steven Z. Pavletic,Nazmim S. Bhuiya,Vincent T. Ho,Mitchell E. Horwitz,Nelson J. Chao,Stefanie Sarantopoulos
View Articletitled, Heightened TLR7 signaling primes BCR-activated B cells in chronic graft-versus-host disease for effector functions
Supplemental data
Longitudinal clinical data improve survival prediction after hematopoietic cell transplantation using machine learning
Yiwang Zhou,Jesse Smith,Dinesh Keerthi,Cai Li,Yilun Sun,Suraj Sarvode Mothi,David C. Shyr,Barbara Spitzer,Andrew Harris,Avijit Chatterjee,Subrata Chatterjee,Roni Shouval,Swati Naik,Alice Bertaina,Jaap Jan Boelens,Brandon M. Triplett,Li Tang,Akshay Sharma
View Articletitled, Longitudinal clinical data improve survival prediction after hematopoietic cell transplantation using machine learning
Supplemental data
Expanding donor options: haploidentical transplant recipients are also highly likely to have a 7/8-matched unrelated donor
Stephanie Fingerson,Martin Maiers,Yung-Tsi Bolon,Steven M. Devine,Stephen R. Spellman
View Articletitled, Expanding donor options: haploidentical transplant recipients are also highly likely to have a 7/8-matched unrelated donor
Supplemental data

RESEARCH LETTERS

Outcomes of marginal zone lymphoma treated with ibrutinib in the first-line setting in the United States: a real-world analysis
Clinical Trials & Observations
Narendranath Epperla,Qiuhong Zhao,Tamara Moyo,Marcus P. Watkins,Montreh Tavakkoli,Celeste Bello,Pallawi Torka,Nishitha Reddy,Colin Thomas,Kaitlin Annunzio,Beth Christian,Stefan K. Barta,Geoffrey Shouse,Adam J. Olszewski,Nancy L. Bartlett
View Articletitled, Outcomes of marginal zone lymphoma treated with ibrutinib in the first-line setting in the United States: a real-world analysis
Supplemental data
Genetic features and outcomes of allogeneic transplantation in patients with WT1-mutated myeloid neoplasms
Clinical Trials & Observations
Anmol Baranwal,Rami Basmaci,Rong He,David Viswanatha,Patricia Greipp,Hemant S. Murthy,James Foran,Jeanne Palmer,William J. Hogan,Mark R. Litzow,Mehrdad Hefazi,Abhishek Mangaonkar,Mithun Vinod Shah,Aref Al-Kali,Hassan B. Alkhateeb
View Articletitled, Genetic features and outcomes of allogeneic transplantation in patients with <em>WT1</em>-mutated myeloid neoplasms
Supplemental data
Clinical, immunological features, treatments, and outcomes of autoimmune hemolytic anemia in patients with RAG deficiency
Chen Wang,Bijun Sun,Kevin Wu,Jocelyn R. Farmer,Boglarka Ujhazi,Christoph B. Geier,Sumai Gordon,Emma Westermann-Clark,Sinisa Savic,Elizabeth Secord,Ravishankar Sargur,Karin Chen,Jay J. Jin,Cullen M. Dutmer,Maria G. Kanariou,Mehdi Adeli,Paolo Palma,Carmem Bonfim,Evangelia Lycopoulou,Beata Wolska-Kusnierz,Ghassan Dbaibo,Jack Bleesing,Despina Moshous,Benedicte Neven,Catharina Schuetz,Raif S. Geha,Luigi D. Notarangelo,Maurizio Miano,David K. Buchbinder,Krisztian Csomos,Wenjie Wang,Ji-Yang Wang,Xiaochuan Wang,Jolan E. Walter
View Articletitled, Clinical, immunological features, treatments, and outcomes of autoimmune hemolytic anemia in patients with RAG deficiency
Supplemental data
A descriptive analysis of fatal outcomes in immune thrombotic thrombocytopenic purpura in the USTMA TTP Registry
Mouhamed Yazan Abou-Ismail,Chong Zhang,Angela P. Presson,Shruti Chaturvedi,Ana G. Antun,Andrew M. Farland,Ryan Woods,Ara Metjian,Yara A. Park,Gustaaf de Ridder,Briana Gibson,Raj S. Kasthuri,Darla K. Liles,Frank Akwaa,Todd Clover,Lisa Baumann Kreuziger,Meera Sridharan,Ronald S. Go,Keith R. McCrae,Harsh Vardhan Upreti,Radhika Gangaraju,Nicole K. Kocher,X. Long Zheng,Jay S. Raval,Camila Masias,Spero R. Cataland,Andrew D. Johnson,Elizabeth Davis,Michael D. Evans,Marshall Mazepa,Ming Y. Lim,for the United States Thrombotic Microangiopathies Consortium
View Articletitled, A descriptive analysis of fatal outcomes in immune thrombotic thrombocytopenic purpura in the USTMA TTP Registry
Supplemental data
In utero hematopoietic cell transplantation leads to sustained engraftment in a mouse model of Fanconi anemia
Apeksha Dave,Suying Liu,John S. Riley,Sourav Bose,Valerie Luks,Cara Berkowitz,Pallavi Menon,Seul Jung,Haiying Li,Peter Kurre,William H. Peranteau
View Articletitled, In utero hematopoietic cell transplantation leads to sustained engraftment in a mouse model of Fanconi anemia
Supplemental data
Evaluating self- vs interviewer-administered screening for depression in sickle cell disease
Maria Lysandrou,Nives Quaye,Kristina Landes,Regina D. Crawford,Payal Desai,Susan Creary,Patrick M. Schnell,Robert M. Cronin
View Articletitled, Evaluating self- vs interviewer-administered screening for depression in sickle cell disease
Frontline chemoimmunotherapy with nivolumab and dose-adjusted EPOCH in peripheral T-cell lymphoma: a phase 1 trial
Clinical Trials & Observations
Bradley Haverkos,Jasmine Zain,Manali Kamdar,Alexander Neuwelt,Eduardo Davila,Xander Bradeen,Ajay Major,Steven Bair,Jagar Jasem,Clayton Smith,Diana Abbott,Pierluigi Porcu
View Articletitled, Frontline chemoimmunotherapy with nivolumab and dose-adjusted EPOCH in peripheral T-cell lymphoma: a phase 1 trial
Perioperative management of apixaban in patients with advanced CKD undergoing a planned invasive procedure
Gabriella Hrubesz,Kevin Dwyer,Daniel I. McIsaac,Manish M. Sood,Edward Clark,James Douketis,Marc Carrier,Joseph R. Shaw
View Articletitled, Perioperative management of apixaban in patients with advanced CKD undergoing a planned invasive procedure
Supplemental data
Specificity of immunoglobulin high-throughput sequencing minimal residual disease monitoring in non-Hodgkin lymphomas
Navika D. Shukla,Joseph G. Schroers-Martin,Brian J. Sworder,Karan Raj Kathuria,Stefan K. Alig,Matthew J. Frank,David B. Miklos,Steven Coutre,Maximilian Diehn,Michael S. Khodadoust,Mark Roschewski,David M. Kurtz,Ash A. Alizadeh
View Articletitled, Specificity of immunoglobulin high-throughput sequencing minimal residual disease monitoring in non-Hodgkin lymphomas

COMMENTARY

Chimeric antigen receptor T-cell therapy and fludarabine: precision dosing imperatives
Clinical Trials & Observations
Sebastian G. Wicha,Eva M. A. Wansing,Adrin Dadkhah,Francis A. Ayuk,Nicolaus M. Kröger,Claudia Langebrake
View Articletitled, Chimeric antigen receptor T-cell therapy and fludarabine: precision dosing imperatives

RESPONSE

CHIP-JAK2V617F, chronic inflammation, abnormal megakaryocyte morphology, organ failure, and multimorbidities
Hans Carl Hasselbalch,Marie Hvelplund Kristiansen,Lasse Kjær,Vibe Skov,Morten Kranker Larsen,Christina Ellervik,Troels Wienecke
View Articletitled, CHIP-<em>JAK2V617F</em>, chronic inflammation, abnormal megakaryocyte morphology, organ failure, and multimorbidities

ERRATUM

Dave H, Terpilowski M, Mai M, et al. Tumor-associated antigen–specific T cells with nivolumab are safe and persist in vivo in relapsed/refractory Hodgkin lymphoma. Blood Adv. 2022;6(2):473-485.
View Articletitled, Dave H, Terpilowski M, Mai M, et al. Tumor-associated antigen–specific T cells with nivolumab are safe and persist in vivo in relapsed/refractory Hodgkin lymphoma. <em>Blood Adv.</em> 2022;6(2):473-485.
  • Cover Image

    Cover Image

    issue cover

    Confocal micrograph of nonhuman primate tissue–resident macrophages derived from transduced hematopoietic stem cells demonstrating different intracellular locations of green fluorescent protein (green). See the article by Rahmberg et al.

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