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Volume 6, Issue 23

December 13 2022

In this Issue

STIMULUS REPORT
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
TRANSFUSION MEDICINE
RESEARCH LETTERS
COMMENTARY
RESPONSE
ERRATA

STIMULUS REPORT

PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin

Reem Elagooz,Anita R. Dhara,Rose M. Gott,Sarah E. Adams,Rachael A. White,Arnab Ghosh,Shinjini Ganguly,Yuncheng Man,Amma Owusu-Ansah,Omar Y. Mian,Umut A. Gurkan,Anton A. Komar,Mahesh Ramamoorthy,Merlin Nithya Gnanapragasam

View Articletitled, PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL
Clinical Trials & Observations

Jeremy S. Abramson,Patrick B. Johnston,Manali Kamdar,Sami Ibrahimi,Koji Izutsu,Jon Arnason,Bertram Glass,Pim Mutsaers,Matthew Lunning,Julia Braverman,Fei Fei Liu,Alessandro Crotta,Sandrine Montheard,Alessandro Previtali,Shien Guo,Ling Shi,Scott R. Solomon

View Articletitled, Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL

Supplemental data

D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study
Clinical Trials & Observations

Gualtiero Palareti,Daniela Poli,Walter Ageno,Cristina Legnani,Emilia Antonucci,Eugenio Bucherini,Sophie Testa,Oriana Paoletti,Antonio Chistolini,Alessandra Serrao,Ida Martinelli,Paolo Bucciarelli,Anna Falanga,Alberto Tosetto,Luca Sarti,Daniela Mastroiacovo,Benilde Cosmi,Adriana Visonà,Rita Carlotta Santoro,Nello Zanatta,Elvira Grandone,Lorenza Bertù,Vittorio Pengo,Lucia Caiano,Paolo Prandoni,for the Apidulcis study group

View Articletitled, D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study

Supplemental data

The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes
Clinical Trials & Observations

Aiman J. Faruqi,John A. Ligon,Paul Borgman,Seth M. Steinberg,Toni Foley,Lauren Little,Crystal L. Mackall,Daniel W. Lee,Terry J. Fry,Haneen Shalabi,Jennifer Brudno,Bonnie Yates,Lekha Mikkilineni,James Kochenderfer,Nirali N. Shah

View Articletitled, The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation

Daniel Hwang,Larissa Lumi Watanabe Ishikawa,Maryam S. Seyedsadr,Elisabeth Mari,Ezgi Kasimoglu,Ziver Sahin,Alexandra Boehm,Soohwa Jang,Javad Rasouli,Courtney Vaccaro,Michael Gonzalez,Hakon Hakonarson,Abdolmohamad Rostami,Guang-Xian Zhang,Bogoljub Ciric

View Articletitled, GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation

Supplemental data

A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions
Clinical Trials & Observations

Sojeong Kim,Sang Won Lee,June-Young Koh,Donghoon Choi,Minkyu Heo,Jae-Yong Chung,Byung Ha Lee,Se Hwan Yang,Young Chul Sung,Howard Lee,Eui-Cheol Shin,Su-Hyung Park

View Articletitled, A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions

Supplemental data

LYMPHOID NEOPLASIA

A tumor volume and performance status model to predict outcome before treatment in diffuse large B-cell lymphoma

Catherine Thieblemont,Loic Chartier,Ulrich Dührsen,Umberto Vitolo,Sally F. Barrington,Jan M. Zaucha,Laetitia Vercellino,Maria Gomes Silva,Ines Patrocinio-Carvalho,Pierre Decazes,Pierre-Julien Viailly,Herve Tilly,Alina Berriolo-Riedinger,Oliver Casasnovas,Andreas Hüttmann,Hajira Ilyas,N. George Mikhaeel,Joel Dunn,Anne-Ségolène Cottereau,Christine Schmitz,Lale Kostakoglu,Joseph N. Paulson,Tina Nielsen,Michael Meignan

View Articletitled, A tumor volume and performance status model to predict outcome before treatment in diffuse large B-cell lymphoma

Supplemental data

MYELOID NEOPLASIA

RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS

Yi-Jou Huang,Jia-Yu Chen,Ming Yan,Amanda G. Davis,Sayuri Miyauchi,Liang Chen,Yajing Hao,Sigrid Katz,Rafael Bejar,Omar Abdel-Wahab,Xiang-Dong Fu,Dong-Er Zhang

View Articletitled, RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS

Supplemental data

PLATELETS AND THROMBOPOIESIS

Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

Paul C. Armstrong,Harriet E. Allan,Nicholas S. Kirkby,Clemens Gutmann,Abhishek Joshi,Marilena Crescente,Jane A. Mitchell,Manuel Mayr,Timothy D. Warner

View Articletitled, Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

Aoi Wakabayashi,Maryanne Kihiu,Malini Sharma,A. Josephine Thrasher,Megan S. Saari,Mathieu Quesnel-Vallières,Osheiza Abdulmalik,Scott A. Peslak,Eugene Khandros,Cheryl A. Keller,Belinda M. Giardine,Yoseph Barash,Ross C. Hardison,Junwei Shi,Gerd A. Blobel

View Articletitled, Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

Supplemental data

TRANSFUSION MEDICINE

Production and nonclinical evaluation of an autologous iPSC–derived platelet product for the iPLAT1 clinical trial

Naoshi Sugimoto,Sou Nakamura,Shin Shimizu,Akiko Shigemasa,Junya Kanda,Nobuki Matsuyama,Mitsunobu Tanaka,Tomoya Hayashi,Akihiro Fuchizaki,Masayuki Nogawa,Naohide Watanabe,Shinichiro Okamoto,Makoto Handa,Akira Sawaguchi,Dai Momose,Ki-Ryang Koh,Yoshihiko Tani,Akifumi Takaori-Kondo,Koji Eto

View Articletitled, Production and nonclinical evaluation of an autologous iPSC–derived platelet product for the iPLAT1 clinical trial

Supplemental data

RESEARCH LETTERS

Vaccine-boosted convalescent plasma therapy for patients with immunosuppression and COVID-19
Clinical Trials & Observations

Juan G. Ripoll,Ellen K. Gorman,Justin E. Juskewitch,Raymund R. Razonable,Ravindra Ganesh,Ryan T. Hurt,Elitza S. Theel,James R. Stubbs,Jeffrey L. Winters,Sameer A. Parikh,Neil E. Kay,Michael J. Joyner,Jonathon W. Senefeld

View Articletitled, Vaccine-boosted convalescent plasma therapy for patients with immunosuppression and COVID-19

Hematopoietic stem cell transplant for Hurler syndrome: does using bone marrow or umbilical cord blood make a difference?
Clinical Trials & Observations

Paul J. Orchard,Ashish O. Gupta,Julie B. Eisengart,Lynda E. Polgreen,Laura M. Pollard,Elizabeth Braunlin,Marzia Pasquali,Troy C. Lund

View Articletitled, Hematopoietic stem cell transplant for Hurler syndrome: does using bone marrow or umbilical cord blood make a difference?

Supplemental data

Recurrent switch 2 domain RAC2 mutations in intravascular large B-cell lymphoma

Rohan Kodgule,Jie Chen,Pooja Khonde,Joshua Robinson,Amy D’Albora,Lisa Cook,Catrina C. Fronick,Robert Fulton,Sridhar Nonavinkere Srivatsan,Patrick J. Cimino,Eric J. Duncavage

View Articletitled, Recurrent switch 2 domain RAC2 mutations in intravascular large B-cell lymphoma

Supplemental data

C5 inhibition allows continued antineoplastic therapy in cancer- and chemotherapy-associated thrombotic microangiopathy
Clinical Trials & Observations

Hridaya Shah,Hang Chen,Xiang-Zuo Pan,Ara Metjian,Robert A. Brodsky,Evan M. Braunstein,Shruti Chaturvedi

View Articletitled, C5 inhibition allows continued antineoplastic therapy in cancer- and chemotherapy-associated thrombotic microangiopathy

Supplemental data

COMMENTARY

Is donor-recipient sex associated with transfusion-related outcomes in critically ill patients?

Henry Wood,Suzy Morton

View Articletitled, Is donor-recipient sex associated with transfusion-related outcomes in critically ill patients?

RESPONSE

Yes, donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

Abdulrahman Alshalani,Nicole P. Juffermans

View Articletitled, Yes, donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

ERRATA

Narkhede M, Goyal G, Shea L, et al. Evaluating real-world treatment patterns and outcomes of mantle cell lymphoma. Blood Adv. 2022; 6(14):4122-4131.

View Articletitled, Narkhede M, Goyal G, Shea L, et al. Evaluating real-world treatment patterns and outcomes of mantle cell lymphoma. Blood Adv. 2022; 6(14):4122-4131.

Ayuk FA, Berger C, Badbaran A, et al. Axicabtagene ciloleucel in vivo expansion and treatment outcome in aggressive B-cell lymphoma in a real-world setting. Blood Adv. 2021;5(11):2523-2527.

View Articletitled, Ayuk FA, Berger C, Badbaran A, et al. Axicabtagene ciloleucel in vivo expansion and treatment outcome in aggressive B-cell lymphoma in a real-world setting. Blood Adv. 2021;5(11):2523-2527.

Cover Image

Cover Image

Image shows t-SNE plots of CD45+ cells including monocyte-derived dendritic cells (moDCs), undifferentiated monocytes, microglia, neutrophils, and other APCs (CD45HiCD11b+Ly6G-MHCII-Ly6C). Other CD45+ cells are CD45+CD11b-CD4-CD11c-.
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Predictive model for the risk of cytokine release syndrome with glofitamab treatment for diffuse large B-cell lymphoma

Table of Contents

STIMULUS REPORT

PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin

CLINICAL TRIALS AND OBSERVATIONS

Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL
Clinical Trials & Observations

D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study
Clinical Trials & Observations

The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes
Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation

A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions
Clinical Trials & Observations

LYMPHOID NEOPLASIA

A tumor volume and performance status model to predict outcome before treatment in diffuse large B-cell lymphoma

MYELOID NEOPLASIA

RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS

PLATELETS AND THROMBOPOIESIS

Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

RED CELLS, IRON, AND ERYTHROPOIESIS

Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

TRANSFUSION MEDICINE

Production and nonclinical evaluation of an autologous iPSC–derived platelet product for the iPLAT1 clinical trial

RESEARCH LETTERS

Vaccine-boosted convalescent plasma therapy for patients with immunosuppression and COVID-19
Clinical Trials & Observations

Hematopoietic stem cell transplant for Hurler syndrome: does using bone marrow or umbilical cord blood make a difference?
Clinical Trials & Observations

Recurrent switch 2 domain RAC2 mutations in intravascular large B-cell lymphoma

C5 inhibition allows continued antineoplastic therapy in cancer- and chemotherapy-associated thrombotic microangiopathy
Clinical Trials & Observations

COMMENTARY

Is donor-recipient sex associated with transfusion-related outcomes in critically ill patients?

RESPONSE

Yes, donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

ERRATA

Narkhede M, Goyal G, Shea L, et al. Evaluating real-world treatment patterns and outcomes of mantle cell lymphoma. Blood Adv. 2022; 6(14):4122-4131.

Ayuk FA, Berger C, Badbaran A, et al. Axicabtagene ciloleucel in vivo expansion and treatment outcome in aggressive B-cell lymphoma in a real-world setting. Blood Adv. 2021;5(11):2523-2527.

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ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

STIMULUS REPORT

CLINICAL TRIALS AND OBSERVATIONS

Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL Clinical Trials & Observations

D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study Clinical Trials & Observations

The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions Clinical Trials & Observations

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

TRANSFUSION MEDICINE

RESEARCH LETTERS

Vaccine-boosted convalescent plasma therapy for patients with immunosuppression and COVID-19 Clinical Trials & Observations

Hematopoietic stem cell transplant for Hurler syndrome: does using bone marrow or umbilical cord blood make a difference? Clinical Trials & Observations

C5 inhibition allows continued antineoplastic therapy in cancer- and chemotherapy-associated thrombotic microangiopathy Clinical Trials & Observations

COMMENTARY

RESPONSE

ERRATA

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL
Clinical Trials & Observations

D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study
Clinical Trials & Observations

The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes
Clinical Trials & Observations

A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions
Clinical Trials & Observations

Vaccine-boosted convalescent plasma therapy for patients with immunosuppression and COVID-19
Clinical Trials & Observations

Hematopoietic stem cell transplant for Hurler syndrome: does using bone marrow or umbilical cord blood make a difference?
Clinical Trials & Observations

C5 inhibition allows continued antineoplastic therapy in cancer- and chemotherapy-associated thrombotic microangiopathy
Clinical Trials & Observations