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Issue Archive

Volume 2, Issue 21
November 13 2018
Issue Cover

Table of Contents

POINT-COUNTERPOINT

Timing of treatment of smoldering myeloma: early treatment
Clinical Trials & Observations
María-Victoria Mateos,Verónica González-Calle

This article has a companion Counterpoint by Kumar.

View Articletitled, Timing of treatment of smoldering myeloma: early treatment
Timing of treatment of smoldering myeloma: delay until progression
Clinical Trials & Observations
Shaji K. Kumar

This article has a companion Point by Mateos and González-Calle.

View Articletitled, Timing of treatment of smoldering myeloma: delay until progression

EXCEPTIONAL CASE REPORTS

A novel FAS mutation with variable expressivity in a family with unicentric and idiopathic multicentric Castleman disease
Clinical Trials & Observations
Turner S. Baker,Kristyne J. Gambino,Lawrence Schriefer,Jung-Yeon Lim,Karyn Meltz Steinberg,David C. Fajgenbaum,Alejandro Martín García-Sancho,Minji Byun
View Articletitled, A novel <em>FAS</em> mutation with variable expressivity in a family with unicentric and idiopathic multicentric Castleman disease
Supplemental data
Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate
Clinical Trials & Observations
Pavan K. Bendapudi,Alissa Robbins,Nicole LeBoeuf,Olga Pozdnyakova,Ami Bhatt,Fujiko Duke,Ryan Sells,John McQuiston,Ben Humrighouse,Betty Rouaisnel,Meaghan Colling,Kathryn E. Stephenson,Arturo Saavedra,Julie-Aurore Losman
View Articletitled, Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate
Supplemental data

STIMULUS REPORT

Myeloma MRD by deep sequencing from circulating tumor DNA does not correlate with results obtained in the bone marrow
Clinical Trials & Observations
Céline Mazzotti,Laure Buisson,Sabrina Maheo,Aurore Perrot,Marie-Lorraine Chretien,Xavier Leleu,Cyrille Hulin,Salomon Manier,Benjamin Hébraud,Murielle Roussel,Laura Do Souto,Michel Attal,Hervé Avet-Loiseau,Jill Corre
View Articletitled, Myeloma MRD by deep sequencing from circulating tumor DNA does not correlate with results obtained in the bone marrow
Supplemental data

REVIEW ARTICLES

Activity of eltrombopag in severe aplastic anemia
Clinical Trials & Observations
Phillip Scheinberg
View Articletitled, Activity of eltrombopag in severe aplastic anemia
Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish
Samuel J. Wattrus,Leonard I. Zon
View Articletitled, Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish
When to obtain genomic data in acute myeloid leukemia (AML) and which mutations matter
Gregory W. Roloff,Elizabeth A. Griffiths
View Articletitled, When to obtain genomic data in acute myeloid leukemia (AML) and which mutations matter
Who should get long-term anticoagulant therapy for venous thromboembolism and with what?
Clinical Trials & Observations
Marc Alan Rodger,Gregoire Le Gal
View Articletitled, Who should get long-term anticoagulant therapy for venous thromboembolism and with what?

HEMATOPOIESIS AND STEM CELLS

Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1
Hairui Su,Chiao-Wang Sun,Szu-Mam Liu,Xin He,Hao Hu,Kevin M. Pawlik,Tim M. Townes,Xiaosi Han,Christopher A. Klug,Maged Henary,Yabing Chen,Ling Li,Y. George Zheng,Xinyang Zhao
View Articletitled, Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

CD16+ monocytes give rise to CD103+RALDH2+TCF4+ dendritic cells with unique transcriptional and immunological features
Vanessa Sue Wacleche,Amélie Cattin,Jean-Philippe Goulet,Dominique Gauchat,Annie Gosselin,Aurélie Cleret-Buhot,Yuwei Zhang,Cécile L. Tremblay,Jean-Pierre Routy,Petronela Ancuta
View Articletitled, CD16<sup>+</sup> monocytes give rise to CD103<sup>+</sup>RALDH2<sup>+</sup>TCF4<sup>+</sup> dendritic cells with unique transcriptional and immunological features
Supplemental data
Recombinant factor VIII Fc fusion protein drives regulatory macrophage polarization
Katalin Kis-Toth,Gaurav Manohar Rajani,Allison Simpson,Kate L. Henry,Jennifer Dumont,Robert T. Peters,Joe Salas,Christine Loh
View Articletitled, Recombinant factor VIII Fc fusion protein drives regulatory macrophage polarization
Supplemental data
Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia
Kamira Maharaj,John J. Powers,Alex Achille,Susan Deng,Renee Fonseca,Mibel Pabon-Saldana,Steven N. Quayle,Simon S. Jones,Alejandro Villagra,Eduardo M. Sotomayor,Eva Sahakian,Javier Pinilla-Ibarz
View Articletitled, Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia
Supplemental data

LYMPHOID NEOPLASIA

Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B
Carolina R. Batista,Michelle Lim,Anne-Sophie Laramée,Faisal Abu-Sardanah,Li S. Xu,Rajon Hossain,Gillian I. Bell,David A. Hess,Rodney P. DeKoter
View Articletitled, Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B
Supplemental data
Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia
Clinical Trials & Observations
Zachary R. Hunter,Lian Xu,Nickolas Tsakmaklis,Maria G. Demos,Amanda Kofides,Cristina Jimenez,Gloria G. Chan,Jiaji Chen,Xia Liu,Manit Munshi,Joshua Gustine,Kirsten Meid,Christopher J. Patterson,Guang Yang,Toni Dubeau,Mehmet K. Samur,Jorge J. Castillo,Kenneth C. Anderson,Nikhil C. Munshi,Steven P. Treon
View Articletitled, Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia
Supplemental data

MYELOID NEOPLASIA

Impact of somatic and germline mutations on the outcome of systemic mastocytosis
Clinical Trials & Observations
Javier I. Muñoz-González,María Jara-Acevedo,Iván Alvarez-Twose,Jason D. Merker,Cristina Teodosio,Yanli Hou,Ana Henriques,Krishna M. Roskin,Laura Sanchez-Muñoz,Albert G. Tsai,Carolina Caldas,Almudena Matito,J. Ignacio Sánchez-Gallego,Andrea Mayado,Noelia Dasilva-Freire,Jason R. Gotlib,Luis Escribano,Alberto Orfao,Andrés C. García-Montero
View Articletitled, Impact of somatic and germline mutations on the outcome of systemic mastocytosis
Supplemental data
Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia
Clinical Trials & Observations
Hidemasa Matsuo,Kenichi Yoshida,Kazutaka Fukumura,Kana Nakatani,Yuki Noguchi,Saho Takasaki,Mina Noura,Yusuke Shiozawa,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Ai Okada,Yasuhito Nannya,June Takeda,Hiroo Ueno,Norio Shiba,Genki Yamato,Hiroshi Handa,Yuichiro Ono,Nobuhiro Hiramoto,Takayuki Ishikawa,Kensuke Usuki,Ken Ishiyama,Shuichi Miyawaki,Hidehiro Itonaga,Yasushi Miyazaki,Machiko Kawamura,Hiroki Yamaguchi,Nobutaka Kiyokawa,Daisuke Tomizawa,Takashi Taga,Akio Tawa,Yasuhide Hayashi,Hiroyuki Mano,Satoru Miyano,Yasuhiko Kamikubo,Seishi Ogawa,Souichi Adachi
View Articletitled, Recurrent <em>CCND3</em> mutations in <em>MLL</em>-rearranged acute myeloid leukemia
Supplemental data
Aberrant GSK3β nuclear localization promotes AML growth and drug resistance
James J. Ignatz-Hoover,Victoria Wang,Nathan M. Mackowski,Anne J. Roe,Isaac K. Ghansah,Masumi Ueda,Hillard M. Lazarus,Marcos de Lima,Elisabeth Paietta,Hugo Fernandez,Larry Cripe,Martin Tallman,David N. Wald
View Articletitled, Aberrant GSK3β nuclear localization promotes AML growth and drug resistance
Supplemental data
Mayo alliance prognostic system for mastocytosis: clinical and hybrid clinical-molecular models
Animesh Pardanani,Sahrish Shah,Francesco Mannelli,Yoseph C. Elala,Paola Guglielmelli,Terra L. Lasho,Mrinal M. Patnaik,Naseema Gangat,Rhett P. Ketterling,Kaaren K. Reichard,Curtis A. Hanson,Alessandro M. Vannucchi,Ayalew Tefferi
View Articletitled, Mayo alliance prognostic system for mastocytosis: clinical and hybrid clinical-molecular models

PLATELETS AND THROMBOPOIESIS

SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
Irina D. Pokrovskaya,Smita Joshi,Michael Tobin,Rohan Desai,Maria A. Aronova,Jeffrey A. Kamykowski,Guofeng Zhang,Sidney W. Whiteheart,Richard D. Leapman,Brian Storrie
View Articletitled, SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Denosumab in transfusion-dependent thalassemia osteoporosis: a randomized, placebo-controlled, double-blind phase 2b clinical trial
Clinical Trials & Observations
Ersi Voskaridou,Ioannis Ntanasis-Stathopoulos,Athanasios Papaefstathiou,Dimitrios Christoulas,Maria Dimopoulou,Konstantina Repa,Athanasios Papatheodorou,Melpomeni Peppa,Evangelos Terpos
View Articletitled, Denosumab in transfusion-dependent thalassemia osteoporosis: a randomized, placebo-controlled, double-blind phase 2b clinical trial
Supplemental data

THROMBOSIS AND HEMOSTASIS

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo
Moua Yang,Andaleb Kholmukhamedov,Marie L. Schulte,Brian C. Cooley,Na’il O. Scoggins,Jeremy P. Wood,Scott J. Cameron,Craig N. Morrell,Shawn M. Jobe,Roy L. Silverstein
View Articletitled, Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo
Supplemental data
The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation
Maryam F. Salamah,Divyashree Ravishankar,Xenia Kodji,Leonardo A. Moraes,Harry F. Williams,Thomas M. Vallance,Dina A. Albadawi,Rajendran Vaiyapuri,Kim Watson,Jonathan M. Gibbins,Susan D. Brain,Mauro Perretti,Sakthivel Vaiyapuri
View Articletitled, The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation
Supplemental data
Venous thromboembolism in chronic lymphocytic leukemia: a Danish nationwide cohort study
Clinical Trials & Observations
Inger Lise Gade,Signe Juul Riddersholm,Ilse Christiansen,Annika Rewes,Mikael Frederiksen,Lisbeth Enggaard,Christian Bjørn Poulsen,Olav Jonas Bergmann,Dorte Balle Gillström,Robert Schou Pedersen,Linda Nielsen,Helle Højmark Eriksen,Christian Torp-Pedersen,Søren Risom Kristensen,Marianne Tang Severinsen
View Articletitled, Venous thromboembolism in chronic lymphocytic leukemia: a Danish nationwide cohort study
Supplemental data

TRANSFUSION MEDICINE

Antibody-mediated immune suppression by antigen modulation is antigen-specific
Cheryl L. Maier,Amanda Mener,Seema R. Patel,Ryan P. Jajosky,Ashley L. Bennett,Connie M. Arthur,Jeanne E. Hendrickson,Sean R. Stowell
View Articletitled, Antibody-mediated immune suppression by antigen modulation is antigen-specific
Supplemental data
High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1)
Huiying Zhi,Maria Therese Ahlen,Aye Myat Myat Thinn,Hartmut Weiler,Brian R. Curtis,Bjørn Skogen,Jieqing Zhu,Peter J. Newman
View Articletitled, High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (Pl<sup>A1</sup>)
Supplemental data

TRANSPLANTATION

Myeloablative vs reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chronic myeloid leukemia
Saurabh Chhabra,Kwang Woo Ahn,Zhen-Huan Hu,Sandeep Jain,Amer Assal,Jan Cerny,Edward A. Copelan,Andrew Daly,Zachariah DeFilipp,Shahinaz M. Gadalla,Robert Peter Gale,Siddhartha Ganguly,Betty K. Hamilton,Gerhard Carl Hildebrandt,Jack W. Hsu,Yoshihiro Inamoto,Abraham S. Kanate,H. Jean Khoury,Hillard M. Lazarus,Mark R. Litzow,Sunita Nathan,Richard F. Olsson,Attaphol Pawarode,Olle Ringden,Jacob M. Rowe,Ayman Saad,Bipin N. Savani,Harry C. Schouten,Sachiko Seo,Nirav N. Shah,Melhem Solh,Robert K. Stuart,Celalettin Ustun,Ann E. Woolfrey,Jean A. Yared,Edwin P. Alyea,Matt E. Kalaycio,Uday Popat,Ronald M. Sobecks,Wael Saber
View Articletitled, Myeloablative vs reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chronic myeloid leukemia
Supplemental data

GLOBAL ADVANCES

Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children
Global Advances
Patrick T. McGann,Anne M. Williams,Graham Ellis,Kathryn E. McElhinney,Laurel Romano,Julia Woodall,Thad A. Howard,Gerald Tegha,Robert Krysiak,R. Murray Lark,E. Louise Ander,Carine Mapango,Kenneth I. Ataga,Satish Gopal,Nigel S. Key,Russell E. Ware,Parminder S. Suchdev
View Articletitled, Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Principal component analysis of the top 500 high-variance genes revealed a clustering of Waldenström macroglobulinemia (WM) samples, regardless of MYD88 and CXCR4 mutation status. The finding may explain the overlapping disease characteristics observed among WM patients. See the article by Hunter et al.

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