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Journal Articles

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function

Jahnavi Aluri, Alicia Bach, Saara Kaviany, Luana Chiquetto Paracatu, Maleewan Kitcharoensakkul, Magdalena A. Walkiewicz, Christopher D. Putnam, Marwan Shinawi, Nermina Saucier, Elise M. Rizzi, Michael T. Harmon, Molly P. Keppel, Michelle Ritter, Morgan Similuk, Elaine Kulm, Michael Joyce, Adriana A. de Jesus, Raphaela Goldbach-Mansky, Yi-Shan Lee, Marina Cella, Peggy L. Kendall, Mary C. Dinauer, Jeffrey J. Bednarski, Christina Bemrich-Stolz, Scott W. Canna, Shirley M. Abraham, Matthew M. Demczko, Jonathan Powell, Stacie M. Jones, Amy M. Scurlock, Suk See De Ravin, Jack J. Bleesing, James A. Connelly, V. Koneti Rao, Laura G. Schuettpelz, Megan A. Cooper
Journal: Blood
Blood (2021) 137 (18): 2450–2462.
https://doi.org/10.1182/blood.2020009620
Published: 2021
Includes: Supplemental data
Journal Articles

A master erythroid regulator gets its own GPS

Lily Jun-shen Huang, James J. Bieker
Journal: Blood
Blood (2020) 135 (25): 2209–2210.
https://doi.org/10.1182/blood.2020005882
Published: 2020
Journal Articles

Effects of Rifaximin on Intestinal Pathophysiologic Changes Associated with Sickle Cell Disease (SCD)

Dibyendu Dutta, PhD, Seah H Lim, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2282.
https://doi.org/10.1182/blood-2019-127043
Published: 2019
Journal Articles

Phase 1 Dose-Finding Study Investigating CA-4948, an IRAK4 Kinase Inhibitor, in Patients with R/R NHL: Report of Initial Efficacy and Updated Safety Information

Anas Younes, MD, Grzegorz Nowakowski, MD, Allison C. Rosenthal, DO, Lori A. Leslie, MD, Han W. Tun, MD, Matthew A. Lunning, DO, FACP, Iris Isufi, MD, Robert Martell, MD PhD, Krish Patel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5327.
https://doi.org/10.1182/blood-2019-131851
Published: 2019
Journal Articles

Alterations of Gut Microbiome in Untreated Chronic Lymphocytic Leukemia (CLL); Future Therapeutic Potentials

Mohammed Kawari, Mahmood Akhtar, Mohamed Sager, Zakaria Basbous, Ibrahim Baydoun, Juma Kabanja, Mohammed Darweesh, MD, Nihad Mokhtar, MD, Solaf Kanfar, MD, Enas Mutahar, MD, John Apostolidis, MD, Khalid Ahmed Al-Anazi, MD, Hani Al Hashmi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5455.
https://doi.org/10.1182/blood-2019-121643
Published: 2019
Journal Articles

Combined Ibrutinib and Venetoclax Changes Myeloid Phenotype and Improves Immune Function in CLL Patients

Rebecka Svanberg, MD, Sisse Rye Ostrowski, MD PhD DMSc, Ass Prof, Jakob Thaning Bay, MD PhD, Lars Peter Ryder, MSc, PhD, Hanne Vibeke Vibeke Marquart, Arnon P Kater, MD PhD, Carsten Utoft Niemann, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4289.
https://doi.org/10.1182/blood-2019-123410
Published: 2019
Journal Articles

JAK2V617F Hematopoietic Stem and Progenitors Are More Resistant to Chronic Blockage of IL-10 Signaling in a Murine Model of Myeloproliferative Neoplasms

Hew Yeng Lai, PhD, Tiffany Trieu, Tiffany Han, Stefan Brooks, Brianna Craver, MS, Gajalakshmi Ramanathan, PhD, Angela G. Fleischman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4206.
https://doi.org/10.1182/blood-2019-131166
Published: 2019
Journal Articles

Human and Pathogen Derived Ndpks Act As Novel Damps and PAMPs to Drive Leukemia Cell Survival and Progression through Signaling Via the TLR4-Mediated Alternative NLRP3 Inflammasome Pathway

Sandro Trova, PhD, Matthew Fenton, MBChB, Bhavini Chauhan, BSc, Avani Puri, Santosh Lomada, BSc, PhD, Alexandra Adams, Thomas Wieland, BSc, PhD, Mark T Drayson, MB ChB, PhD FRCPath, Farhat Latif Khanim, PhD, Chistopher M Bunce, BSc, Fei Lin, MBChB
Journal: Blood
Blood (2019) 134 (Supplement_1): 2684.
https://doi.org/10.1182/blood-2019-131236
Published: 2019
Journal Articles

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells

Cesarina Giallongo, PhD, Daniele Tibullo, PhD, Giuseppina Camiolo, Fabrizio Puglisi, Daniela Cambria, Alessandro Barbato, Nunziatina Laura Parrinello, PhD, Alessandra Romano, MD PhD, Concetta Conticello, MD, Angela Amorini, PhD, Giovanni Li Volti, MD PhD, Giuseppe Lazzarino, Giuseppe A. Palumbo, MD PhD, Francesco Di Raimondo, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3073.
https://doi.org/10.1182/blood-2019-129812
Published: 2019
Journal Articles

Functional Calcitriol/Vitamin D Receptor Signaling in Chronic Lymphocytic Leukemia

Marina Gerousi, Fotis Psomopoulos, Kostantia Kotta, Niki Stavroyianni, Achilles Anagnostopoulos, Ioannis Kotsianidis, Stavroula Ntoufa, Kostas Stamatopoulos
Journal: Blood
Blood (2019) 134 (Supplement_1): 3019.
https://doi.org/10.1182/blood-2019-127910
Published: 2019
Journal Articles

TNFR1 Blockade Rather then TNFR2 Blockade Reduces Chronic Inflammation in JAK2 +/V617F Mice

Peter Müller, PhD, Bärbel Edelmann-Stephan, PhD, Fabian Richter, PhD, Klaus Pfizenmaier, PhD, Thomas Fischer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2966.
https://doi.org/10.1182/blood-2019-127997
Published: 2019
Journal Articles

MLL1 Modulates IgM and Inflammatory Cytokines in Waldenstrom's Macroglobulinemia

Mona Karbalivand, MSc, BSc, Weiguo Han, PhD, Luciana L Almada, PhD, Stephen M Ansell, MD PhD, Martin Fernandez-Zapico, MD, Sherine F Elsawa, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3966.
https://doi.org/10.1182/blood-2019-125833
Published: 2019
Journal Articles

A Phase II Trial of Nivolumab and Ibrutinib for Patients with Relapsed or Refractory Central Nervous System Lymphoma

Jason R. Westin, MD, Nathan H. Fowler, MD, Loretta J. Nastoupil, MD MSc, Sattva S Neelapu, MD, Hun Ju Lee, Fredrick B. Hagemeister, MD, Maria Alma Rodriguez, MD, Raphael E Steiner, MD, Sairah Ahmed, MD, Simrit Parmar, MBBS, Ranjit Nair, MBBS,MD, Rebecca Harrison, MD, Luis Fayad, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4086.
https://doi.org/10.1182/blood-2019-131463
Published: 2019
Journal Articles

Elotuzumab Enhances the Th2-Mediated Immune Response of Dendritic Cell Induced By Immunomodulatory Drugs (IMiDs)

Yoshiko Azuma, MD, Tomoki Ito, MD PhD, Muneo Inaba, PhD, Kai Imai, MD, Masaaki Hotta, MD, Atsushi Satake, MD PhD, Shosaku Nomura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4342.
https://doi.org/10.1182/blood-2019-129680
Published: 2019
Journal Articles

Systematic Investigation of Microenvironmental Drug Resistance Mechanisms in Chronic Lymphocytic Leukemia

Peter-Martin Bruch, Holly Giles, BA, Carolin Kolb, Sophie Rabe, MSc, Tobias Roider, MD, Mareike Knoll, Mark Kriegsmann, MD, Katharina Kriegsmann, MD, Christiane Zgorzelski, Sebastian Scheinost, Lena Wagner, Carsten Müller-Tidow, MD, Thorsten Zenz, MD, Wolfgang Huber, PhD, Sascha Dietrich, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3363.
https://doi.org/10.1182/blood-2019-128392
Published: 2019
Journal Articles

CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib

Shih-Shih Chen, PhD, Constantine S. Tam, MBBS (Hons), MD, Alan G. Ramsay, BSc,MSc,PhD, Priyadarshini Ravichandran, Natalia C. Couto-Francisco, Michael Ibrahim, Gerardo Ferrer, PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, He Zhou, Jacqueline C Barrientos, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 477.
https://doi.org/10.1182/blood-2019-127255
Published: 2019
Journal Articles

Linking Microenvironmental Signals to Metabolic Switches and Drug Responses in Chronic Lymphocytic Leukemia

Zhenghao Chen, Gaspard Cretenet, Hanneke ter Burg, Gabriela Andrejeva, Jeffrey C Rathmell, Francesco Forconi, MD DM, PhD FRCPath, Gerritje J. W. van der Windt, Arnon P. Kater, Eric Eldering
Journal: Blood
Blood (2019) 134 (Supplement_1): 479.
https://doi.org/10.1182/blood-2019-123005
Published: 2019
Journal Articles

Polymorphisms in Inflammatory Genes Modulate the Occurrence of Clinical Complications in Patients with Sickle Cell Disease

Karina Tozatto-Maio, MD, Robert Girot, MD PhD, Indou Deme Ly, MD, Vanderson Rocha, MD PhD, Ana Cristina Silva Pinto, MD PhD, Ibrahima Diagne, Prof, Yahia Benzerara, Francisco Fernandes, Carla Luana Dinardo, MD PhD, Simone Kashima, PhD, Itaua Leston Araujo, MSc, PhD, Chantal Kenzey, Guilherme Henrique Hencklain Fonseca, MD, Evandra Strazza Rodrigues, PhD, Fernanda Volt, MSc, Luciana Ribeiro Jarduli, PhD, Annalisa Ruggeri, MD, Christina Mary Mariaselvam, PhD, Sandra Fatima Menosi Gualandro, MD PhD, Hanadi Elayoubi, MD, Renato Cunha, MD PhD, Barbara Cappelli, MD, Julia Pavan, PhD, Belinda Pinto Simões, MD PhD, Eliane Gluckman, MD PhD, Ryad Tamouza, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4825.
https://doi.org/10.1182/blood-2019-124218
Published: 2019
Journal Articles

Innate Immune Signaling Suppresses Acute Leukemia By Modifying MYC Oncogenic Activity

Tomoya Muto, MD PhD, Maria Guillamot, PhD, Jing Fang, MD PhD, Luna Zea Redondo, MS, Kwangmin Choi, PhD, Yixiao Gong, MSc, Callum S Walker, MSc, Kathleen Hueneman, Lyndsey C Bolanos, BSc, Laura Barreyro, PhD, Lynn Lee, MD, Kenneth D Greis, PhD, Alireza Khodadadi-Jamayran, M.Sc., Amaia Lujambio, PhD, Scott W. Lowe, PhD, Iannis Aifantis, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 727.
https://doi.org/10.1182/blood-2019-121423
Published: 2019
Journal Articles

Targeted Next Generation Sequencing Reveals Molecular Heterogeneity in Non-CLL Clonal B-Cell Lymphocytosis

Irene Defrancesco, Silvia Zibellini, Emanuela Boveri, Marco Frigeni, Virginia Valeria Ferretti, Ettore Rizzo, Francesca Capuano, Arturo Bonometti, Chiara Candido, Sara Rattotti, Elena Flospergher, Fabio Bergamini, Caterina Zerbi, Marco Paulli, Marzia Varettoni, Luca Arcaini
Journal: Blood
Blood (2019) 134 (Supplement_1): 1502.
https://doi.org/10.1182/blood-2019-130233
Published: 2019