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Journal Articles

The Protein Kinase C Inhibitor MS-553 for the Treatment of Chronic Lymphocytic Leukemia

Elizabeth M. Muhowski, Amy M. Lehman, M.A.S, Sean D. Reiff, PhD, Janani Ravikrishnan, Rose Mantel, Shrilekha Misra, Michael Niesman, PhD, Kai Zhang, MD, James S. Blachly, MD, Deepa Sampath, PhD, John C. Byrd, MD, Jennifer Woyach, MD

Blood (2019) 134 (Supplement_1): 2077.

https://doi.org/10.1182/blood-2019-128871

Published: 2019

Journal Articles

Regulation of Drug Resistance Via the Overexpression of Phopho-RKIP (P-RKIP) in Multiple Myeloma: Dephosphorylation of P-RKIP Reverses Drug Resistance

Devasis Chatterjee, Ph. D, Stavroula Baritaki, PhD, Benjamin Bonavida, PhD

Blood (2017) 130 (Supplement 1): 4971.

https://doi.org/10.1182/blood.V130.Suppl_1.4971.4971

Published: 2017

Journal Articles

Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22 lo B-Lineage Leukemia and Lymphoma

Sneha Ramakrishna, MD, Sang M Nguyen, BS, Haiying Qin, MS, Steven L Highfill, PhD, Ira Kraft, John Shern, MD, Zachary Walsh, Dimiter Dimitrov, PhD, Terry J Fry, MD

Blood (2017) 130 (Supplement 1): 3894.

https://doi.org/10.1182/blood.V130.Suppl_1.3894.3894

Published: 2017

Journal Articles

Protein Kinase C-Dependent Von Willebrand Factor Secretion Is a Dual-Phased Process That Originates from 2 Distinct Intracellular Compartments

Laura Knipe, Nicola Hellen, PhD, Ianina Conte, PhD, Marjon Mourik, PhD, Aina Masgrau-Fortuny, PhD, Bijal Patel, PhD, Sayibrinthan Vickneswaran, Matthew Hannah, PhD, Tom Carter, PhD, Ruben Bierings, PhD

Blood (2017) 130 (Supplement 1): 1020.

https://doi.org/10.1182/blood.V130.Suppl_1.1020.1020

Published: 2017

Journal Articles

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM,PhD, Xiaokui Mo, PhD MAS, Pearlly S. Yan, PhD, Michael B Broe, PhD, Ralf Bundschuh, PhD, Larry State Beaver, Kevan Zapolnik, BS, Zhiliang Xie, Donna Bucci, David M. Lucas, PhD, Allison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B. Klisovic, MD, Ching-Shih Chen, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MDMBBS, Natarajan Muthusamy, DVM,PhD

Blood (2017) 130 (Supplement 1): 1247.

https://doi.org/10.1182/blood.V130.Suppl_1.1247.1247

Published: 2017

Journal Articles

DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors

Muntasir M Majumder, MSc, MPharm, David Tamborero, PhD, Pekka Anttila, MD, Raija Silvennoinen, MD, Samuli Eldfors, MSc, Ashwini Kumar, MSc, Juha Lievonen, MD, Alun Parsons, MSc, Minna Suvela, Esa Jantunen, MD PhD, Kimmo Porkka, MD PhD, Caroline A Heckman, PhD

Blood (2016) 128 (22): 198.

https://doi.org/10.1182/blood.V128.22.198.198

Published: 2016

Journal Articles

Downregulation of Tissue Factor in Pericytes By a Protein Kinase C-Dependent Mechanism

Laura Sommerville, PhD, Kristen Gorman, Angela Crabtree, Maureane Hoffman, MD PhD

Blood (2015) 126 (23): 4637.

https://doi.org/10.1182/blood.V126.23.4637.4637

Published: 2015

Journal Articles

Anamorsin Overexpression Leads to Dysregulation of Lipopolysaccharide-Stimulated B Cell Proliferation through Ras Signaling

Yuri Hamanaka, Hirohiko Shibayama, Akira Tanimura, Takafumi Yokota, Sachiko Ezoe, Michiko Ichii, Norimitsu Saito, Keiko Matsui, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Yasuhiro Nagate, Masako Takemoto, Kenji Oritani, Yuzuru Kanakura

Blood (2014) 124 (21): 4130.

https://doi.org/10.1182/blood.V124.21.4130.4130

Published: 2014

Journal Articles

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL

Dalia El-Gamal, Katie Williams, Taylor D. LaFollette, Matthew Cannon, James S. Blachly, Yiming Zhong, Jennifer A. Woyach, Erich Williams, Farrukh T. Awan, Jeffrey Jones, Leslie Andritsos, Kami Maddocks, Chia-Hsien Wu, Ching-Shih Chen, Amy Lehman, Xiaoli Zhang, Rosa Lapalombella, John C. Byrd

Blood (2014) 124 (9): 1481–1491.

https://doi.org/10.1182/blood-2014-05-574830

Published: 2014

Includes: Supplemental data

Journal Articles

Progenitor Cell Differentiation Into Dendritic Cells Requires Cytokine Mediated PKC-IRF Relationships

Haley Spangler, Matthew R Farren, Louise M Carlson, BS, Scott Abrams, Kelvin P Lee, MD

Blood (2013) 122 (21): 2449.

https://doi.org/10.1182/blood.V122.21.2449.2449

Published: 2013

Journal Articles

PKC Inhibitor AEB071 Demonstrates Pre-Clinical Activity In Chronic Lymphocytic Leukemia

Dalia ElGamal, PhD, Yiming Zhong, PhD, Katie Williams, MS, Chia-Hsien Wu, Ching-Shih Chen, PhD, Rosa Lapalombella, PhD, John C. Byrd, MD

Blood (2013) 122 (21): 4187.

https://doi.org/10.1182/blood.V122.21.4187.4187

Published: 2013

Journal Articles

Protein Synthesis and Degradation in the Late Stages of Megakaryocyte Maturation Trigger Proplatelet Formation

Kellie R Machlus, PhD, Dallas Shi, PhD, Andrew S Weyrich, PhD, Joseph E Italiano, Jr., PhD

Blood (2012) 120 (21): 1218.

https://doi.org/10.1182/blood.V120.21.1218.1218

Published: 2012

Journal Articles

Src Family Kinases Contribute to G I and G q -Mediated Platelet Activation

Binggang Xiang, PhD, Guoying Zhang, Zhenyu Li, MD, PhD

Blood (2011) 118 (21): 5263.

https://doi.org/10.1182/blood.V118.21.5263.5263

Published: 2011

Journal Articles

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Rajeswaran Mani, DVM, Frank W Frissora, M.S., Ching-Shih Chen, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2011) 118 (21): 2499.

https://doi.org/10.1182/blood.V118.21.2499.2499

Published: 2011

Journal Articles

Similarities and Differences in Signal Transduction and Crosstalk of the G Protein-Coupled Receptors CXCR4 and CysLT1 in CD34+ Hematopoietic Stem/Progenitor Cells,

Adriana C Drost, Ute Krauß, Lothar Kanz, MD, Robert Möhle

Blood (2011) 118 (21): 3392.

https://doi.org/10.1182/blood.V118.21.3392.3392

Published: 2011

Journal Articles

DISTINCT ROLES for Rap1b In PLATELET SECRETION and INTEGRIN a IIB b 3 OUTSIDE-In SIGNALING

Guoying Zhang, Binggang Xiang, PhD, Ye Shaojing, Magdalena Chrzanowska-Wodnicka, Andrew J. Morris, PhD, T. Kent Gartner, PhD, Sidney W. Whiteheart, PhD, Gilbert C. White, II II, MD, Susan S. Smyth, MD, PhD, Zhenyu Li, MD, PhD

Blood (2011) 118 (21): 2200.

https://doi.org/10.1182/blood.V118.21.2200.2200

Published: 2011

Journal Articles

Lack of Protein Kinase C Alpha Is Associated with Poor Prognosis in Pediatric T-Lineage Acute Lymphoblastic Leukemia

Gloria Milani, Benedetta Accordi, PhD, Marco Giordan, PhD, Silvia Bresolin, Luisa Galla, Manuela Sciro, Elena Vendramini, Giovanni Cazzaniga, Geertruy Kronnie, Giuseppe Basso

Blood (2011) 118 (21): 744.

https://doi.org/10.1182/blood.V118.21.744.744

Published: 2011

Journal Articles

The Overexpression of Inactive Phosphorylated Raf-1 Kinase Inhibitory Protein (RKIP) in Multiple Myeloma (MM) Regulates the Resistance to Bortezomib-Induced Cytotoxicity: Reversal of Resistance by the PKC Inhibitor Bisindolylmalemide

Sara Huerta-Yepez, PhD, Stavroula Baritaki, PhD, Hong Liu, Karla MC Mendez-Maldonado, B.S., Manuel L Penichet, M.D., Ph.D., Mario I Vega, PhD, Otoniel Martinez-Maza, PhD, Haiming Chen, James R. Berenson, MD, Devasis Chatterjee, PhD, Benjamin Bonavida, Ph.D

Blood (2011) 118 (21): 2892.

https://doi.org/10.1182/blood.V118.21.2892.2892

Published: 2011

Journal Articles

Erythropoietin Regulates GATA-1 Function and Erythroid Differentiation by a PKD-HDAC5 Signal Transduction Pathway

Lorrie L. Delehanty, Adam N. Goldfarb

Blood (2010) 116 (21): 85.

https://doi.org/10.1182/blood.V116.21.85.85

Published: 2010

Journal Articles

A Cell-Death-Defying Factor, Anamorsin, Contributes Cell Growth through Binding with PICOT and Inactivation of PKCs and p38MAPK.

Hirohiko Shibayama, MD, PhD, Yuri Saito, Akira Tanimura, MD, PhD, Hirokazu Tanaka, MD, PhD, Itaru Matsumura, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2010) 116 (21): 1552.

https://doi.org/10.1182/blood.V116.21.1552.1552

Published: 2010

NARROW

The Protein Kinase C Inhibitor MS-553 for the Treatment of Chronic Lymphocytic Leukemia

Regulation of Drug Resistance Via the Overexpression of Phopho-RKIP (P-RKIP) in Multiple Myeloma: Dephosphorylation of P-RKIP Reverses Drug Resistance

Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22 lo B-Lineage Leukemia and Lymphoma

Protein Kinase C-Dependent Von Willebrand Factor Secretion Is a Dual-Phased Process That Originates from 2 Distinct Intracellular Compartments

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

DNA Damage Repair Pathway Alterations in Multiple Myeloma Predict Poor Prognosis, but Correlate with Sensitivity to IGF1R-PI3K-mTOR and HDAC Inhibitors

Downregulation of Tissue Factor in Pericytes By a Protein Kinase C-Dependent Mechanism

Anamorsin Overexpression Leads to Dysregulation of Lipopolysaccharide-Stimulated B Cell Proliferation through Ras Signaling

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL

Progenitor Cell Differentiation Into Dendritic Cells Requires Cytokine Mediated PKC-IRF Relationships

PKC Inhibitor AEB071 Demonstrates Pre-Clinical Activity In Chronic Lymphocytic Leukemia

Protein Synthesis and Degradation in the Late Stages of Megakaryocyte Maturation Trigger Proplatelet Formation

Src Family Kinases Contribute to G I and G q -Mediated Platelet Activation

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Similarities and Differences in Signal Transduction and Crosstalk of the G Protein-Coupled Receptors CXCR4 and CysLT1 in CD34+ Hematopoietic Stem/Progenitor Cells,

DISTINCT ROLES for Rap1b In PLATELET SECRETION and INTEGRIN a IIB b 3 OUTSIDE-In SIGNALING

Lack of Protein Kinase C Alpha Is Associated with Poor Prognosis in Pediatric T-Lineage Acute Lymphoblastic Leukemia

The Overexpression of Inactive Phosphorylated Raf-1 Kinase Inhibitory Protein (RKIP) in Multiple Myeloma (MM) Regulates the Resistance to Bortezomib-Induced Cytotoxicity: Reversal of Resistance by the PKC Inhibitor Bisindolylmalemide

Erythropoietin Regulates GATA-1 Function and Erythroid Differentiation by a PKD-HDAC5 Signal Transduction Pathway

A Cell-Death-Defying Factor, Anamorsin, Contributes Cell Growth through Binding with PICOT and Inactivation of PKCs and p38MAPK.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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