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Synthetic Lethal Interaction between Apto-253 and IDH1/2 Mutations

Cheng-Yu Tsai, PhD, Hongying Zhang, MD PhD, William G Rice, PhD, Stephen B Howell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5755.
https://doi.org/10.1182/blood-2019-123571
Published: 2019
Journal Articles

Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells

Zhaowei Tu, PhD, Chen Wang, MSc, Chuntao Zhao, PhD, Lei Huang, PhD, Nathan Salomonis, PhD, Richard Q Lu, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1191.
https://doi.org/10.1182/blood-2019-127313
Published: 2019
Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Ellie Wilson, BS, Nichole Helton, Catrina Fronick, BS, Robert Fulton, MS, John S. Welch, MD PhD, Timothy J Ley, MD, David H Spencer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3755.
https://doi.org/10.1182/blood-2019-122340
Published: 2019
Journal Articles

Significant Features of DNA Methylation at Bivalent Promotor and Repressed Polycomb Regions in Pediatric AML-the Jccg Study, JPLSG AML-05-

Genki Yamato, Tomoko Kawai, PhD, Norio Shiba, Yusuke Hara, Kentaro Ohki, MD PhD, Taeko Kaburagi, MD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Akira Shimada, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Souichi Adachi, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Kenichiro Hata, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2739.
https://doi.org/10.1182/blood-2019-125025
Published: 2019
Journal Articles

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Gregory Lazarian, PharmD, Shanye Yin, PhD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, MSc,PhD, Alba Font-tello, PhD, Heather Joyal, Elizabeth Witten, Mei Zheng, Christopher J. Ott, PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 848.
https://doi.org/10.1182/blood-2019-123963
Published: 2019
Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 983.
https://doi.org/10.1182/blood-2019-127300
Published: 2019
Journal Articles

Comprehensive Genomic Analysis of IDH Inhibitor-Treated AML Samples Delineates Molecular Mechanisms of Differentiation and Heterogeneous Patterns of Acquired Resistance

Feng Wang, PhD, Kiyomi Morita, MD, Courtney D. DiNardo, MDMSc, Keyur Patel, MD PhD, Kyle MacBeth, PhD, Alessandra Tosolini, BS, Mark G. Frattini, MD, Jairo Matthews, BA, Latasha Little, Curtis Gumbs, Samantha Tippen, Xingzhi Song, PhD, Jianhua Zhang, PhD, Erika Thompson, MS, Tapan M. Kadia, MD, Guillermo Garcia-Manero, MD, Elias J. Jabbour, MD, Farhad Ravandi, MD, Marina Y. Konopleva, MD PhD, Hagop M. Kantarjian, MD, Andrew Futreal, PhD, Koichi Takahashi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 441.
https://doi.org/10.1182/blood-2018-99-116383
Published: 2018
Journal Articles

RAB31-Mediated Endosomal Trafficking Is Defective in RUNX1 Haplodeficiency

Gauthami S. Jalagadugula, PhD, Guangfen Mao, MD, Lawrence E. Goldfinger, PhD, Jeremy Wurtzel, MS, Michele P. Lambert, MD, Angara Koneti Rao, MBBS
Journal: Blood
Blood (2018) 132 (Supplement 1): 519.
https://doi.org/10.1182/blood-2018-99-118312
Published: 2018
Journal Articles

Long Intergenic Non-Coding RNAs Unambiguously Classify AML Subgroups

Wencke Walter, PhD, Jesús María Hernández, Claudia Haferlach, MD, Wolfgang Kern, MD, Torsten Haferlach, MD, Manja Meggendorfer, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5112.
https://doi.org/10.1182/blood-2018-99-118276
Published: 2018
Journal Articles

Downstream Pathway of AML1-ETO Targeted ARHGEF12 Might be Targetable for Rock Inhibitor to Improve Therapy Outcome

Yangyang Xie, Ruichi Wu, Xiaoxiao Chen, Xiao-Jian Sun, PhD, Shuhong Shen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3914.
https://doi.org/10.1182/blood-2018-99-117845
Published: 2018
Journal Articles

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3197.
https://doi.org/10.1182/blood-2018-99-118712
Published: 2018
Journal Articles

The Critical Role of HDAC1-IRF4-Pim-2 Axis in Myeloma Cell Growth and Survival: Therapeutic Impacts of Targeting the HDAC1-IRF4-Pim-2 Axis

Takeshi Harada, MD PhD, Asuka Oda, PhD, Yohann Grondin, PhD, Jumpei Teramachi, DDS, PhD, Ariunzaya Bat-Erdene, MD PhD, Masami Iwasa, MD, Masahiro Oura, MD, Shingen Nakamura, MD PhD, Kumiko Kagawa, MD PhD, Yasunobu Okamoto, MD, Kimiko Sogabe, MD, Shiro Fujii, MD, Hirokazu Miki, MD PhD, Shuji Ozaki, MD PhD, Teru Hideshima, MD PhD, Kenneth C. Anderson, MD, Masahiro Abe, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1939.
https://doi.org/10.1182/blood-2018-99-114086
Published: 2018
Journal Articles

Defining the Transcriptional Code That Specifies Sinusoidal Endothelial Cells in the HSPC Niche

Elliott J. Hagedorn, PhD, Julie R. Perlin, PhD, Clara Mao, Shelby E. Redfield, B.S., Madeleine L. Daily, B.S., Samantha H. Collins, B.S., Christopher R. D'Amato, B.S., Raquel Riquelme, Brian Li, B.S., Samuel J. Wattrus, B.S., Karoline Holler, B.S., Alexander van Oudenaarden, PhD, Jan Philipp Junker, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 136.
https://doi.org/10.1182/blood.V130.Suppl_1.136.136
Published: 2017
Journal Articles

AML Differentially Alters Fate and Function of Mesenchymal Stem- and Osteolineage Cells in the Leukemic Niche

Ben Doron, BS, Sherif Abdelhamed, PhD, Ryan M Mulqueen, B.S., Julja Burchard, M.S., Andrew Adey, PhD, Peter Kurre, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1197.
https://doi.org/10.1182/blood.V130.Suppl_1.1197.1197
Published: 2017
Journal Articles

The Phosphorylation State of Ezh2 Determines Its Capacity to Maintain CD8 + Memory T Cells for Antitumor Immunity

Shan He, PhD, Yongnian Liu, Lijun Meng, Hongxing SUN, Ying Wang, Yun Ji, Janaki Purushe, BS, Pan Chen, Changhong Li, Jozef Madzo, Jean-Pierre Issa, MD, Jonathan Soboloff, Ran Reshef, MD, Bethany Moore, Luca Gattinoni, Yi Zhang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4455.
https://doi.org/10.1182/blood.V130.Suppl_1.4455.4455
Published: 2017
Journal Articles

Identification of SETBP1 As an Epigenetic Hub Protein That Induces the Transcription of a Network of Development-Related Genes

Rocco Piazza, MD PhD, VERA Magistroni, PhD, Sara Redaelli, PhD, Mario Mauri, PhD, Luca Massimino, PhD, Alessandro Sessa, PhD, Marco Peronaci, PhD, Maciej Lalowski, PhD, Rabah Soliymani, PhD, Caterina Mezzatesta, M.Sc., Alessandra Pirola, M.Sc., Federica Banfi, M.Sc., Alicia Rubio, PhD, Delphine Rea, MD, Fabio Stagno, MD PhD, Emilio Usala, MD, Bruno Martino, Leonardo Campiotti, MD, Michele Merli, Francesco Passamonti, MD, Francesco Onida, MD, Alessandro Morotti, MD PhD, Francesca Pavesi, MD, Marco Bregni, MD, Vania Broccoli, PhD, Marc Baumann, MBA, MB, PhD, Carlo Gambacorti-Passerini, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4980.
https://doi.org/10.1182/blood.V130.Suppl_1.4980.4980
Published: 2017
Journal Articles

Fetal Inactivation of the Nuclear Interacting SET Domain Protein 1 Impairs Terminal Erythroid Maturation and Results in Acute Erythroleukemia in Mice

Katharina Leonards, PhD, Marwa Almosailleakh, MSc, Samantha Tauchmann, Msc, Helene Mereau, PhD, Sabine Juge, Matheus Filgueira Bezerra, MSc, Susanne Kasper, PhD, Robert Ivanek, PhD, Alexandar Tzankov, Antoine HFM Peters, PhD, Juerg Schwaller, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 713.
https://doi.org/10.1182/blood.V130.Suppl_1.713.713
Published: 2017
Journal Articles

LSD1 Inhibition Exerts Its Anti-Leukemic Effect By Recommissioning PU.1- and C/Ebpα-Dependent Enhancers in AML

Monica Cusan, MD, Sheng Cai, MD PhD, Helai P Mohammad, PhD, Andrei V. Krivtsov, PhD, Alan Chramiec, Evangelia Loizou, Daniel G. Tenen, MD, Min Ye, PhD, Britta Will, PhD, Ulrich G. Steidl, MDPhD, Ryan G. Kruger, PhD, Richard Koche, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 242.
https://doi.org/10.1182/blood.V130.Suppl_1.242.242
Published: 2017
Journal Articles

Defective Rab1b Related Megakaryocytic ER-to-Golgi Transport in RUNX1 Haplodeficiency

Gauthami S. Jalagadugula, PhD, Lawrence E. Goldfinger, PhD, Guangfen Mao, MD, Angara Koneti Rao, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2333.
https://doi.org/10.1182/blood.V130.Suppl_1.2333.2333
Published: 2017