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Journal Articles

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Eric R. Henry, Belhu Metaferia, Quan Li, Julia Harper, Robert B. Best, Kristen E. Glass, Troy Cellmer, Emily B. Dunkelberger, Anna Conrey, Swee Lay Thein, H. Franklin Bunn, William A. Eaton

Blood (2021) 138 (13): 1172–1181.

https://doi.org/10.1182/blood.2021012070

Published: 2021

Includes: Supplemental data

Journal Articles

HIF2α is a direct regulator of neutrophil motility

Sundary Sormendi, Mathieu Deygas, Anupam Sinha, Mathilde Bernard, Anja Krüger, Ioannis Kourtzelis, Gregoire Le Lay, Pablo J. Sáez, Michael Gerlach, Kristin Franke, Ana Meneses, Martin Kräter, Alessandra Palladini, Jochen Guck, Ünal Coskun, Triantafyllos Chavakis, Pablo Vargas, Ben Wielockx

Blood (2021) 137 (24): 3416–3427.

https://doi.org/10.1182/blood.2020007505

Published: 2021

Includes: Supplemental data

Journal Articles

Red cell membrane disorders: structure meets function

Mary Risinger, Theodosia A. Kalfa

Blood (2020) 136 (11): 1250–1261.

https://doi.org/10.1182/blood.2019000946

Published: 2020

Journal Articles

Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing

Erica B. Esrick, MD, Maureen Achebe, MD MPH, Myriam Armant, PhD, Pablo Bartolucci, MD PhD, Marioara Felicia Ciuculescu, MD, Heather Daley, Colleen Dansereau, MSN, RN, CPN, Giuseppe Di Caprio, PhD, Bronner Goncalves, MD PhD, Nicolas Hebert, Matthew M Heeney, MD, John M. Higgins, MD PhD, Leslie E. Lehmann, MD, John P Manis, MD, Olivier Negre, PhD, Sarah Nikiforow, MD PhD, Ethan Schonbrun, PhD, David K. Wood, PhD, David A. Williams, MD

Blood (2019) 134 (Supplement_2): LBA-5.

https://doi.org/10.1182/blood-2019-132745

Published: 2019

Journal Articles

Cerebral Oxygen Delivery and Metabolic Rate in Chronically Anemic Subjects

Chau Vu, BS, Adam Bush, PhD, Thomas Coates, MD, John C Wood, MD PhD

Blood (2019) 134 (Supplement_1): 2273.

https://doi.org/10.1182/blood-2019-125897

Published: 2019

Journal Articles

The Oxygenscan Provides Clinically Relevant Biomarkers for Treatment Efficacy That Are Associated with Frequency of Vaso-Occlusive Crisis in Sickle Cell Disease

Minke A.E. Rab, MD, Richard van Wijk, PhD, Celeste K. Kanne, BA, Brigitte A. van Oirschot, Jennifer Bos, Camille Boisson, Maite E. Houwing, MD, Jorn J. Gerritsma, MD, Karin Fijnvandraat, MD PhD, Celine Renoux, PhD, Marije Bartels, MD PhD, Erfan Nur, MD PhD, Marjon H. Cnossen, MD PhD, Philippe Joly, PhD, Romain Fort, MD, Philippe Connes, PhD, Eduard J. van Beers, MD PhD, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 2275.

https://doi.org/10.1182/blood-2019-128870

Published: 2019

Journal Articles

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Susana Brito Dos Santos, MSc PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD

Blood (2019) 134 (Supplement_1): 2219.

https://doi.org/10.1182/blood-2019-131085

Published: 2019

Journal Articles

Treatment of Delayed Hemolytic Transfusion Reactions in Sickle Cell Disease Patients By an Anti-C5 Antibody

Blood (2019) 134 (Supplement_1): 2458.

https://doi.org/10.1182/blood-2019-127176

Published: 2019

Journal Articles

A Novel Approach to Assess Capacities of Red Cells in Dissolving Oxygen and Carrying Oxygen Based on a Portable Near-Infrared Spectroscopy Device

Ting Li, PhD, Yue Zhao, Master, Yunlong Sun, Master, Kai Li, Master, Wenjie Li, Meixue Duan, PhD, Chenyang Gao, PhD

Blood (2019) 134 (Supplement_1): 4792.

https://doi.org/10.1182/blood-2019-124003

Published: 2019

Journal Articles

Red Blood Cell Deformability Demonstrated with the Oxygenscan: Exploring the Association with Hydroxyurea Treatment, Co-Inherited α-Thalassemia, and Frequency of Pain in Children with Sickle Cell Anemia

Amina Nardo-Marino, Jesper Petersen, Andreas Glenthoej, MD PhD, John N. Brewin, Joergen Kurtzhals, Thomas N. Williams, David C. Rees, Henrik Birgens

Blood (2019) 134 (Supplement_1): 4834.

https://doi.org/10.1182/blood-2019-129836

Published: 2019

Journal Articles

Carbon Dots As a Potential Therapeutic Agent for Anemia Treatment in Malignancies

Yuanlin Xu, Boyang Wang, Huan Zhang, Xiaoli Qu, Mingming Zhang, Xiuli An, Siyu Lu, Shijie Zhang

Blood (2019) 134 (Supplement_1): 941.

https://doi.org/10.1182/blood-2019-130971

Published: 2019

Journal Articles

Comprehensive Molecular Profiling of Idiopathic Erythrocytosis By Genetic Ancestry

Caitlin O'Neill, MD, Zarko Manojlovic, PhD BS, Ah-Reum Jeong, MD, Yili Xu, MS, Yuxin Jin, MS, Sharon Chang, BS, Eric Kwok, BS, Michelle Webb, MS, Casey O'Connell, MD

Blood (2019) 134 (Supplement_1): 945.

https://doi.org/10.1182/blood-2019-122619

Published: 2019

Journal Articles

Hemoglobin S Polymerization Can be Inhibited By Alterations in Erythrocyte Glycolysis

William R. Simmons, Quan Li, PhD, John A. Hausman, Suilan Zheng, PhD, William Eaton, MD, Philip S. Low, PhD, David M. Bodine, PhD

Blood (2019) 134 (Supplement_1): 977.

https://doi.org/10.1182/blood-2019-121709

Published: 2019

Journal Articles

Lower Oxygen Saturation in the Internal Cerebral Vein of Patients with Sickle Cell Disease Revealed By Qsm-MRI

Jian Shen, MSc, Thomas Coates, MD, John C Wood, MD PhD

Blood (2019) 134 (Supplement_1): 984.

https://doi.org/10.1182/blood-2019-131968

Published: 2019

Journal Articles

Outcomes Related to Intravenous Fluid Administration in Sickle Cell Patients during Vaso-Occlusive Crisis

Daria Gaut, MD, Jennifer Jones, MD, Caroline Chen, MD, Sanaz Ghafouri, MD, Mei Ling, MD, Roswell Quinn, MD PhD

Blood (2019) 134 (Supplement_1): 992.

https://doi.org/10.1182/blood-2019-121945

Published: 2019

Journal Articles

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Theodosia A. Kalfa, MD PhD, Frans A Kuypers, PhD, Marilyn J. Telen, MD, Punam Malik, MD, Diamantis G. Konstantinidis, PhD BSc, Jeremy H. Estepp, MD, Hyon J. Kim, MD PhD, Santosh L. Saraf, MD, Lindsey Wilson, Maria D Ribadeneira, PhD, Sanjeev Forsyth, Patricia Schroeder, Adam Drake, Olga Polyanskaya, Patrick Kelly, MD, Lukasz Biernat, MD

Blood (2019) 134 (Supplement_1): 616.

https://doi.org/10.1182/blood-2019-121889

Published: 2019

Journal Articles

SLC20A1 at the Interface between Macrophages and Red Blood Cells

Federica Quattrone, MSc, Riem Gawish, PhD, Rui Martins, PhD, Anna-Dorothea Gorki, PhD, Martin Watzenboeck, MD, Anastasiya Hladik, Karin Lakovits, Manuele Rebsamen, PhD, Enrico Girardi, PhD, Giulio Superti-Furga, PhD, Sylvia Knapp, MD PhD

Blood (2019) 134 (Supplement_1): 428.

https://doi.org/10.1182/blood-2019-123758

Published: 2019

Journal Articles

Ibrutinib in Combination with Venetoclax Decreases Mitochondrial Bioenergetics through the Impaired BTK, AKT and AMPK/SIRT/PGC-1α Signaling Pathway in CLL

Subir Roy Chowdhury, MD PhD, Amandeep Singh, MSc, Edwin Nguyen, Aaron Marshall, PhD, James B. Johnston, MD, Spencer Bruce Gibson, PhD, Versha Banerji, MD

Blood (2019) 134 (Supplement_1): 1282.

https://doi.org/10.1182/blood-2019-127562

Published: 2019

Journal Articles

Collection and Processing of Bone Marrow at 3% Oxygen Significantly Alters the Manifestation of Aged Mouse Hematopoietic Stem Cell Phenotype

Maegan L. Capitano, PhD, Scott Cooper, M.S., Bin Guo, PhD, Xinxin Huang, PhD, Carol Sampson, MS, Safa Mohamad, Edward F. Srour, PhD, Christie M. Orschell, PhD, Hal E. Broxmeyer, PhD

Blood (2019) 134 (Supplement_1): 1202.

https://doi.org/10.1182/blood-2019-128642

Published: 2019

Journal Articles

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Manasa K Nayak, PhD, Madankumar Ghatge, PhD, Nirav Dhanesha, PhD, Gagan D Flora, PhD, Manish Jain, PhD, Omar Rodriguez, MD BS, Kathleen Markan, PhD, Mathhhew Potthoff, PhD, Steven R. Lentz, MD PhD, Anil K Chauhan, PhD

Blood (2019) 134 (Supplement_1): 1056.

https://doi.org/10.1182/blood-2019-129027

Published: 2019

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Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

HIF2α is a direct regulator of neutrophil motility

Red cell membrane disorders: structure meets function

Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing

Cerebral Oxygen Delivery and Metabolic Rate in Chronically Anemic Subjects

The Oxygenscan Provides Clinically Relevant Biomarkers for Treatment Efficacy That Are Associated with Frequency of Vaso-Occlusive Crisis in Sickle Cell Disease

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Treatment of Delayed Hemolytic Transfusion Reactions in Sickle Cell Disease Patients By an Anti-C5 Antibody

A Novel Approach to Assess Capacities of Red Cells in Dissolving Oxygen and Carrying Oxygen Based on a Portable Near-Infrared Spectroscopy Device

Red Blood Cell Deformability Demonstrated with the Oxygenscan: Exploring the Association with Hydroxyurea Treatment, Co-Inherited α-Thalassemia, and Frequency of Pain in Children with Sickle Cell Anemia

Carbon Dots As a Potential Therapeutic Agent for Anemia Treatment in Malignancies

Comprehensive Molecular Profiling of Idiopathic Erythrocytosis By Genetic Ancestry

Hemoglobin S Polymerization Can be Inhibited By Alterations in Erythrocyte Glycolysis

Lower Oxygen Saturation in the Internal Cerebral Vein of Patients with Sickle Cell Disease Revealed By Qsm-MRI

Outcomes Related to Intravenous Fluid Administration in Sickle Cell Patients during Vaso-Occlusive Crisis

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

SLC20A1 at the Interface between Macrophages and Red Blood Cells

Ibrutinib in Combination with Venetoclax Decreases Mitochondrial Bioenergetics through the Impaired BTK, AKT and AMPK/SIRT/PGC-1α Signaling Pathway in CLL

Collection and Processing of Bone Marrow at 3% Oxygen Significantly Alters the Manifestation of Aged Mouse Hematopoietic Stem Cell Phenotype

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

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