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Journal Articles

FXII inhibition: multipronged benefits

Helen Philippou
Journal: Blood
Blood (2021) 138 (2): 107–109.
https://doi.org/10.1182/blood.2021011032
Published: 2021
Journal Articles

Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity

Qingxiao Song, Xiaoning Wang, Xiwei Wu, Hanjun Qin, Yingfei Li, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Journal: Blood
Blood (2021) 137 (16): 2243–2255.
https://doi.org/10.1182/blood.2020006345
Published: 2021
Includes: Supplemental data
Journal Articles

Phase 1 study of lenzilumab, a recombinant anti–human GM-CSF antibody, for chronic myelomonocytic leukemia

Clinical Trials & Observations
Mrinal M. Patnaik, David A. Sallman, Abhishek A. Mangaonkar, Rachel Heuer, Jeffery Hirvela, Darci Zblewski, Aref Al-Kali, Moritz Binder, Maria E. Balasis, Hannah Newman, Christopher Letson, Traci L. Kruer, Naseema Gangat, Rami S. Komrokji, Ayalew Tefferi, Adrian Lo, Ted Shih, Cameron Durrant, Alan F. List, Eric Padron
Journal: Blood
Blood (2020) 136 (7): 909–913.
https://doi.org/10.1182/blood.2019004352
Published: 2020
Includes: Supplemental data
Journal Articles

A new role for an old cytokine: GM-CSF amplifies GVHD

Edmund K. Waller
Journal: Blood
Blood (2020) 135 (8): 520–521.
https://doi.org/10.1182/blood.2019004681
Published: 2020
Journal Articles

Pathogenic Bhlhe40 + GM-CSF + CD4 + T cells promote indirect alloantigen presentation in the GI tract during GVHD

Clint Piper, Vivian Zhou, Richard Komorowski, Aniko Szabo, Benjamin Vincent, Jonathan Serody, Maria-Luisa Alegre, Brian T. Edelson, Reshma Taneja, William R. Drobyski
Journal: Blood
Blood (2020) 135 (8): 568–581.
https://doi.org/10.1182/blood.2019001696
Published: 2020
Includes: Supplemental data
Journal Articles

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

Ami B. Patel, Anca Franzini, Emilie Leroy, Soo Jin Kim, Anthony D. Pomicter, Lidvine Genet, Michael Xiao, Dongqing Yan, Jonathan M. Ahmann, Archana M. Agarwal, Phillip Clair, Juanah Addada, Jonathan Lambert, Matthew Salmon, Gerald J. Gleich, Nicholas C. P. Cross, Stefan N. Constantinescu, Thomas O’Hare, Josef T. Prchal, Michael W. Deininger
Journal: Blood
Blood (2019) 134 (26): 2388–2398.
https://doi.org/10.1182/blood.2019001385
Published: 2019
Includes: Supplemental data
Journal Articles

Global Gene Expression and Mutation Signatures Are Preserved in PDX Models of Pediatric AML and Aid Discovery of Targeted Therapy for Cases with CBFA2T3/GLIS2 Rearrangement

Mark Wunderlich, MS, Jing Chen, Eric O'Brien, BSc, Nicole Manning, Christina Sexton, Luke Byerly, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Journal: Blood
Blood (2019) 134 (Supplement_1): 3766.
https://doi.org/10.1182/blood-2019-129225
Published: 2019
Journal Articles

NUP98-KDM5A Fusion Induces Hematopoietic Cell Proliferation and Alters Myelo-Erythropoietic Differentiation

Jonathan Miller, MD PhD, Ryan Hiltenbrand, MS, Tamara Lamprecht, BS, Aman Seth, MS, Sherif Abdelhamed, PhD, Ilaria Iacobucci, PhD, Charles G. Mullighan, MBBS, MD, Jeffery M. Klco, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3775.
https://doi.org/10.1182/blood-2019-130768
Published: 2019
Journal Articles

Nicotinamide (NAM) Modulates Transcriptional Signature of Ex Vivo Cultured UCB CD34+ Cells (Omidubicel) and Preserves Their Stemness and Engraftment Potential

Tracey Lodie, PhD, Julian Adams, PhD, Dima Yackoubov, Msc, Yair Steinhardt, MSc, Dorit Ashengrau, Adi Bitansky, Alina Maliutina, Sherry Cohen, Boaz Buhenvald, PhD, Moshe Shahor, PhD, Nathan Dinowitz, PhD, Vered Caspi, PhD, Amnon Peled, PhD, Tony Peled, MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3718.
https://doi.org/10.1182/blood-2019-131124
Published: 2019
Journal Articles

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)

Liana E Gynn, BSc, Elizabeth Anderson, PhD, Gareth M Robinson, PhD, Sarah Anne Wexler, MBBS, MRCP, FRCPath, Gillian Upstill-Goddard, Christine Cox, Rhys Gareth Morgan, PhD, Jennifer E May, PhD BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2492.
https://doi.org/10.1182/blood-2019-122891
Published: 2019
Journal Articles

Relative Depletion of Soluble Interleukin 6 Receptors Abolished the Development of Cytokine Release Syndrome after CART19/22 and Lenalidomide Treatment for Lymphoma

Caixia Li, Changfeng Zhang, PhD, Xiaochen Chen, Ying Zhang, Jia Chen, MD, Liqing Kang, Xiaoyan Lou, Jin Zhou, Xiangping Zong, Zhen Yang, Jiaqi Li, Wei Qi, Lei Yu, Depei Wu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5313.
https://doi.org/10.1182/blood-2019-126821
Published: 2019
Journal Articles

Dynamic Analysis of Cytokine Profile for Cytokine Release Syndrome in Multiple Myeloma Patients after CAR-T Cell Therapy

Shuangshuang Yang, MD, Lijuan Chen, MD PhD, Jie Xu, MD PhD, Frank Xiao-Hu Fan, MD PhD, Sun Yan, PhD, Wen Wu, MD PhD, Yan Wang, MD, Jin Wang, MD PhD, Shiwei Jin, MD, Yuebo Zhou, Yuanfang Liu, MD PhD, Yan Zhuang, PhD, Wu Zhang, PhD, Jun-Min Li, Jian Hou, PhD MD, Jian-Yong Li, MD PhD, Zhu Chen, PhD, Jian-Qing Mi, MD PhD, Sai-Juan Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5617.
https://doi.org/10.1182/blood-2019-131799
Published: 2019
Journal Articles

High-Throughput RNA Sequencing Analysis Reveals Distinct Molecular Signature in NRAS and PTPN11 JMML Patients

Pier Paolo Leoncini, PhD, Alessandro Domenico Silvestris, PhD, Patrizia Vitullo, PhD, Marco Zecca, MD, Christian Flotho, MD PhD, Charlotte M. Niemeyer, MD, Angela Gallo, PhD, Alice Bertaina, MD PhD, Franco Locatelli, MD PhD, Pietro Merli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4229.
https://doi.org/10.1182/blood-2019-129965
Published: 2019
Journal Articles

A Phase 1 Study of Lenzilumab, a humaneered recombinant Anti-Human Granulocyte-Macrophage Colony- Stimulating Factor (anti-hGM-CSF) Antibody, for Chronic Myelomonocytic Leukemia (CMML)

Mrinal M Patnaik, MDMBBS, David A Sallman, MD, Abhishek A Mangaonkar, MBBS, Rachel Heuer, Jeffery Hirvela, Darci Zblewski, APRN, C-NP, Aref Al-Kali, MD, Deanna Kanne, Rahil Ismail, Rami S. Komrokji, MD, Adrian Lo, Maria E Balasis, Cameron Durrant, Dale Chappell, Omar Ahmed, Alan F. List, MD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4234.
https://doi.org/10.1182/blood-2019-131181
Published: 2019
Journal Articles

Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia (CMML)

Gregor Eisenwort, MD PhD, Alexandra Keller, Michael Willmann, Irina Sadovnik, Greiner Georg, MD PhD, Karoline V. Gleixner, MD, Daniel Ivanov, MSc, Daniela Berger, Gabriele Stefanzl, Christiana Winding, DVM, Gregor Hoermann, Wolfgang R. Sperr, MD, Heinz Sill, MD, Peter Bettelheim, MD, Klaus Geissler, MD, Michael W. Deininger, Thomas Rülicke, Peter Valent, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4223.
https://doi.org/10.1182/blood-2019-122530
Published: 2019
Journal Articles

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Elizabeth Bulaeva, Davide Pellacani, PhD, Naoto Nakamichi, MD PhD, Philip Beer, MD PhD, Colin Hammond, Alireza Lorzadeh, Michelle Moksa, Annaick Carles, Misha Bilenky, Sylvain Lefort, PhD, Jeremy Shu, Brian T. Wilhelm, PhDBSc, Andrew P. Weng, MD PhD, Martin Hirst, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2533.
https://doi.org/10.1182/blood-2019-122768
Published: 2019
Journal Articles

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

Kathryn I Sunthankar, MD, Benjamin J Reisman, BS, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2680.
https://doi.org/10.1182/blood-2019-129602
Published: 2019
Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3027.
https://doi.org/10.1182/blood-2019-122038
Published: 2019
Journal Articles

Loss of Asxl1 Cooperates with Oncogenic Nras to Drive CMML Progression

Xiaona You, PhD, Zhi Wen, PhD, Guangyao Kong, Adhithi Rajagopalan, BS, Erik A. Ranheim, MD PhD, Yun Zhou, MS, Mrinal M Patnaik, MDMBBS, Jing Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3790.
https://doi.org/10.1182/blood-2019-131347
Published: 2019
Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3868.
https://doi.org/10.1182/blood-2019-129349
Published: 2019