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Journal Articles

The Sequential Flamsa-Bu Conditioning Regimen Does Not Improve Outcome in Patients Allografted for High Risk Acute Myeloid and Myelodysplasia Irrespective of Pre-Transplant MRD Status: Results of the UK NCRI Figaro Trial

Charles Craddock, FRCP, FRCPath, Aimee E Jackson, MSc, Ram K Malladi, FRCPath, Maria H Gilleece, MD FRCPath, MB, BSc, FRCP, Andy Peniket, MD, Rahuman Salim, MRCP, FRCPath, Eleni Tholouli, MD PhD, Victoria Potter, MD PhD, Charles R Crawley, Rachel Elizabeth Protheroe, FRCPath,PhDMBBS,FRCP, Anne Parker, MD FRCP, BSc, FRCPath, Keith Wilson, FRCPath, MRCP, MBBS, Jiri Pavlu, MDMRCP,FRCPath, Sandeep Nagra, MBChB, Shamyla Siddique, BSc.(Hons.), MPhil, Andrea Hodgkinson, BSc(Hons),PhD, John Mason, Keith Wheatley, DPhil, Nigel H. Russell, MD, Sylvie D. Freeman, MBChB, DPhil
Journal: Blood
Blood (2019) 134 (Supplement_1): 2031.
https://doi.org/10.1182/blood-2019-125646
Published: 2019
Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Comprehensive DNA 5-Hydroxymethylation Landscapes in Myelodysplastic Syndromes (MDS)

Jia Li, PhD, Yue Wei, PhD, Minjung Lee, MS, Caleb Class, PhD, Hui Yang, PhDMD, Deqiang Sun, PhD, Guillermo Garcia-Manero, MD, Yun Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2996.
https://doi.org/10.1182/blood-2019-128599
Published: 2019
Journal Articles

DNA Cytosine-Demethylating Agent 5-Aza-2'-Deoxycytidine Targets Leukemia Cells through Reducing DNA N 6 -Methyladenine

Xiaochang Liu, PhD, Jiuxia Pang, Christopher Seiler, Ryan Kempen, Hao Liu, Aref Al-Kali, MD, Y. Natalia Tretyakova, Mark Litzow, MD, Shujun Liu
Journal: Blood
Blood (2019) 134 (Supplement_1): 2513.
https://doi.org/10.1182/blood-2019-130490
Published: 2019
Journal Articles

Active DNA Demethylation Mediated By GADD45β Is Essential during G-CSF Triggered Granulocytic Differentiation

Perihan Mir, Maksim Klimiankou, Narges Aghaallaei, Betuel Findik, Frederic Thalheimer, Susanne Wingert, Michael A. Rieger, Thomas Thumberger, Cornelia Zeidler, Baubak Bajoghli, Karl Welte, Julia Skokowa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 211.
https://doi.org/10.1182/blood-2019-128508
Published: 2019
Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Sakshi Jasra, MD, Orsi Giricz, PhD, Rachel Zeig-Owens, M.P.H, David Goldfarb, M.P.H, Angelica Barreto-Galvez, Kith Pradhan, PhD, Jiahao Chen, PhD, Gaurav S Choudhary, PhD, Srinivas Aluri, Tushar D Bhagat, PhD, Aditi Shastri, MD, Victor Thiruthuvanathan, M.S, Hiroki Goto, MD PhD, Jeannine Gerhardt, PhD, Shanisha Gordon, Arul Veerappan, PhD, Syed Hissam Haider, MD, Matthias Bartenstein, MD, George Nwankwo, Ola Landgren, MD PhD, Michael Weiden, MD, Frederick Fletcher, Lee Greenberger, PhD, Benjamin L. Ebert, MD PhD, Ulrich G. Steidl, MD PhD, Britta Will, PhD, Anna Nolan, MD MS, David Prezant, MD, Advaitha Madireddy, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3720.
https://doi.org/10.1182/blood-2019-129276
Published: 2019
Journal Articles

APOBEC3B Induction Following DNA Damage Response Modulates the Survival and Treatment Response in Human Multiple Myeloma

Lijie Xing, MD, Jiye Liu, PhD, Yuyin Li, PhD, Liang Lin, PhD, Kenneth Wen, Shih-Feng Cho, MD PhD, Tengteng Yu, MD PhD, Gang An, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4381.
https://doi.org/10.1182/blood-2019-130297
Published: 2019
Journal Articles

Highly Efficient Multiplexed Base Editing with Minimized Off-Targets for the Development of Universal CAR-T Cells to Treat Pediatric T-ALL

Jason M Gehrke, PhD, Aaron Edwards, MS, Ryan C. Murray, MS, Amy Shaw, MS, Yeh-Chuin Poh, PhD, Sarah Smith, Yi Yu, PhD, Nicole M. Gaudelli, PhD, Waseem Qasim, MBBS, PhD, Giuseppe Ciaramella, PhD, B.Sc.
Journal: Blood
Blood (2019) 134 (Supplement_1): 5127.
https://doi.org/10.1182/blood-2019-130562
Published: 2019
Journal Articles

Azacytidine Inhibits Megakaryopoiesis Via the Induction of Immunogenic RNA Species and Activation of Type-I Interferon Signaling

Ujunwa Cynthia Okoye-Okafor, MS,PhD, Komal Kumar Javarappa, PhD, Dimitrios Tsallos, BSc(Hons),MSc, Joseph J Saad, MSc, BSc, Lumie Benard, Victor Thiruthuvanathan, M.S, Sally Cole, Madhuri Tatiparthy, M.S., Stephen Ruiz, B.Sc, Stefanie DeFronzo, Celine Pallaud, PhD, Pedro Marques Ramos, PhD, Amit Verma, MBBS, Aditi Shastri, MD, Caroline A Heckman, PhD, Britta Will, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1280.
https://doi.org/10.1182/blood-2019-131461
Published: 2019
Journal Articles

Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects in an Immune Competent Lymphoma Model

Adam Yuh Lin, MD PhD, Jonathan Rink, PhD, Reem Karmali, MD, Colby Shad Thaxton, MD PhD, Leo I. Gordon, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1577.
https://doi.org/10.1182/blood-2019-125308
Published: 2019
Journal Articles

Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia

Huafeng Wang, MD, Jie Sun, PhD, Dandan Zhao, MD, Hongyan Tong, Herman Wu, BS, Xia Li, PhD, Yingwan Luo, MD, Dan Dong, PhD, Tinisha McDonald, MS, Anthony Stein, MD, Monzr M. Al Malki, MD, Flavia Pichiorri, PhD, Nadia Carlesso, MD, Ya-Huei Kuo, PhD, Bin Zhang, PhD, Guido Marcucci, MD, Ling Li, PhD, Jie Jin, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1707.
https://doi.org/10.1182/blood-2019-130375
Published: 2019
Journal Articles

Complementary Base Editing Approaches for the Treatment of Sickle Cell Disease and Beta Thalassemia

Ling Lin, PhD, Adrian P. Rybak, PhD, Conrad Rinaldi, M.S., Jonathan Yen, PhD, Yanfang Fu, PhD, Elsie Akrawi, Sarah Smith, Scott J. Haskett, M.S., Minerva E. Sanchez, Yeh-Chuin Poh, PhD, Michael S. Packer, PhD, Nicole M. Gaudelli, PhD, Manmohan Singh, PhD, Giuseppe Ciaramella, PhD, B.Sc., Dana N. Levasseur, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3352.
https://doi.org/10.1182/blood-2019-126710
Published: 2019
Journal Articles

Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia

Brian Giacopelli, Qiuhong Zhao, Amy S. Ruppert, Akwasi Agyeman, Christoph Weigel, Yue-Zhong Wu, Madelyn M. Gerber, Kari G. Rabe, Melissa C. Larson, Junyan Lu, James S. Blachly, Kerry A. Rogers, William G. Wierda, Jennifer R. Brown, Kanti R. Rai, Michael Keating, Laura Z. Rassenti, Thomas J. Kipps, Thorsten Zenz, Tait D. Shanafelt, Neil E. Kay, Lynne V. Abruzzo, Kevin R. Coombes, Jennifer A. Woyach, John C. Byrd, Christopher C. Oakes
Journal: Blood
Blood (2019) 134 (8): 688–698.
https://doi.org/10.1182/blood.2019000490
Published: 2019
Includes: Supplemental data
Journal Articles

A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript

Xinjun Ji, Jesse Humenik, Stephen A. Liebhaber
Journal: Blood
Blood (2019) 133 (21): 2338–2347.
https://doi.org/10.1182/blood-2018-12-891408
Published: 2019
Includes: Supplemental data
Journal Articles

Hematological Cancer Consortium: Multi-Center Acute Myeloid Leukemia Registry Data from India

Rajan Kapoor, MD DM, Hasmukh Jain, MD DM, Anu Korula, MD DM, Dinesh Bhurani, MD DM, FRCPA, Venkatraman Radhakrishnan, MD DM, Chepsy C Philip, MD, Jina Bhattacharyya, MD, Maitreyee Bhattacharyya, DM, Smita Kayal, MD, Pankaj Malhotra, MD, Govind Babu, MD DM, Lalit Kumar, MD DM, Om Prakash, MSc, Ambily Nadaraj, MSc, Jeyaseelan Lakshmanan, PhD, Biju George, DM, Poonkuzhali Balasubramanian, MSc, Bhausaheb Bagal, MD DM, Satyaranjan Das, MD, Rayaz Ahmed, MD DM, Prasanth Ganesan, MD DM, Gaurav Prakash, MD DM, Nikita Mehra, MD DM, Manju Sengar, MD DM, Vikram Mathews, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4006.
https://doi.org/10.1182/blood-2018-99-116853
Published: 2018
Journal Articles

Inhibitory Effect of a Novel DNA Aptamer with Artificial Nucleic Bases for Von Willebrand Factor A1 Domain on Platelet Thrombosis Formation

Kazuya Sakai, MD, Hideo Yagi, MD, Masaki Hayakawa, MD, Tatsuhiko Someya, PhD, Kaori Harada, PhD, Masanori Matsumoto, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2522.
https://doi.org/10.1182/blood-2018-99-113948
Published: 2018
Journal Articles

Multiplex Human T Cell Engineering without Double-Strand Break Induction Using the Cas9 Base Editor System

Beau Webber, PhD, Cara-lin Lonetree, MS, Miechaleen Diers, Walker S Lahr, Kluesner Mitchell, Matthew J Johnson, PhD, Branden S Moriarity, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3495.
https://doi.org/10.1182/blood-2018-99-120372
Published: 2018
Journal Articles

Disulfiram May Contribute to Apoptosis of Myeloma Cells By Reactivating of Cell Cycle Regulating Gene CDKN2A

Denisa Hrckova Drozdkova, Jan Gursky, PhD, Petra Luzna, Sabina Sevcikova, PhD, Jiri Minarik, MD PhD, Katerina Smesny Trtkova, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5125.
https://doi.org/10.1182/blood-2018-99-114743
Published: 2018
Journal Articles

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Rumen Kostadinov, PhD, Byunggil Yoo, MS, Midhat S. Farooqi, MD PhD, Shannon Kelley, MS, Erin Guest, MD, Michael J. Burke, MD, Sarah Wheelan, MD PhD, Patrick Brown, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 918.
https://doi.org/10.1182/blood-2018-99-119206
Published: 2018
Journal Articles

Genomic Analysis of Myelodysplastic Syndromes Among Nagasaki Atomic Bomb Survivors

Masataka Taguchi, Hiroyuki Mishima, DDS, PhD, Yusuke Shiozawa, MD, PhD, Chisa Hayashida, Akira Kinoshita, PhD, Shinya Sato, MD, PhD, Makiko Horai, MD, PhD, Masatoshi Matsuo, MD, PhD, Hidehiro Itonaga, MD, PhD, Takeharu Kato, MD, PhD, Hiroaki Taniguchi, MD, PhD, Daisuke Imanishi, MD, PhD, Yoshitaka Imaizumi, MD, PhD, Tomoko Hata, MD, PhD, Motoi Takenaka, MD, PhD, Hideki Makishima, MD PhD, Yasuhito Nannya, MD PhD, Yukiyoshi Moriuchi, MD, Seishi Ogawa, MD PhD, Koh-ichiro Yoshiura, MD, PhD, Yasushi Miyazaki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4341.
https://doi.org/10.1182/blood-2018-99-113735
Published: 2018