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Journal Articles

A Pipeline for Comparison and Selection of Clinically Applicable Gene Therapy Approaches for ELANE -Associated Severe Congenital Neutropenia

Malte Ulrich Ritter, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Benjamin Secker, Cornelia Zeidler, Maksim Klimiankou, Karl Welte, Julia Skokowa
Journal: Blood
Blood (2023) 142 (Supplement 1): 934.
https://doi.org/10.1182/blood-2023-188707
Published: 2023
Journal Articles

A Universal CRISPR/Cas9n-Mediated Genome Editing Approach for ELANE -Related Severe Congenital Neutropenia

Masoud Nasri, Malte Ulrich Ritter, Perihan Mir, Benjamin Dannenmann, Masako Monika Kaufmann, Yun Xu, Natalia Borbaran-Bravo, Maksim Klimiankou, Claudia Lengerke, Cornelia Zeidler, Toni Cathomen, Karl Welte, Julia Skokowa
Journal: Blood
Blood (2023) 142 (Supplement 1): 932.
https://doi.org/10.1182/blood-2023-181678
Published: 2023
Journal Articles

Efficient Correction of HAX1 Mutations in Primary HSPCs of Severe Congenital Neutropenia Patients Using CRISPR/CAS9 GENE-Editing

Malte U Ritter, Benjamin Secker, Masoud Nasri, MSc, Maksim Klimiankou, Benjamin Dannenmann, MSc, Diana Amend, Jeremy Haaf, Msc, Perihan Mir, Regine Bernhard, Ingeborg Steiert, Cornelia Zeidler, Karl Welte, Julia Skokowa, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22.
https://doi.org/10.1182/blood-2020-140260
Published: 2020
Journal Articles

Disease Modeling of Severe Congenital Neutropenia Using CRISPR/Cas9 Gene Correction or Knockout of ELANE in Patients Derived Induced Pluripotent Stem Cells

Masoud Nasri, MSc, Benjamin Dannenmann, Perihan Mir, Malte U Ritter, Diana Amend, Yun Xu, Maksim Klimiankou, Cornelia Zeidler, Karl Welte, Julia Skokowa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 434.
https://doi.org/10.1182/blood-2019-129991
Published: 2019
Journal Articles

Active DNA Demethylation Mediated By GADD45β Is Essential during G-CSF Triggered Granulocytic Differentiation

Perihan Mir, Maksim Klimiankou, Narges Aghaallaei, Betuel Findik, Frederic Thalheimer, Susanne Wingert, Michael A. Rieger, Thomas Thumberger, Cornelia Zeidler, Baubak Bajoghli, Karl Welte, Julia Skokowa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 211.
https://doi.org/10.1182/blood-2019-128508
Published: 2019
Journal Articles

GADD45b Plays an Essential Role in the G-CSF Triggered Granulocytic Differentiation of Human Hematopoietic Cells

Perihan Mir, Masoud Nasri, Benjamin Dannenmann, Maksim Klimiankou, Betuel Findik, Regine Bernhard, Michael A. Rieger, Cornelia Zeidler, Lothar Kanz, Karl Welte, Julia Skokowa, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 17.
https://doi.org/10.1182/blood-2018-99-114875
Published: 2018
Journal Articles

A Method to Fluorescently Label the CRISPR/Cas9-gRNA RNP Complexes Enables Enrichment of Clinical-Grade Gene-Edited Primary Hematopoietic Stem Cells and iPSCs

Masoud Nasri, Perihan Mir, Benjamin Dannenmann, Diana Amend, Yun Xu, Anna Solovyeva, Sylwia Stefanczyk, Maksim Klimiankou, Cornelia Zeidler, Lothar Kanz, Karl Welte, Julia Skokowa, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1108.
https://doi.org/10.1182/blood-2018-99-114844
Published: 2018
Journal Articles

Establishment of the Safe and Efficient CRISPR/Cas9-RNP Based Gene-Correction Platform of ELANE Mutations in iPSCs of Severe Congenital Neutropenia (CN) Patients with No Response to G-CSF and High Risk to Develop Leukemia

Masoud Nasri, MSc, Benjamin Dannenmann, Perihan Mir, Tessa Skroblyn, Anna Solovjeva, Maksim Klimiankou, Cornelia Zeidler, Lothar Kanz, Karl Welte, Julia Skokowa
Journal: Blood
Blood (2017) 130 (Supplement 1): 542.
https://doi.org/10.1182/blood.V130.Suppl_1.542.542
Published: 2017
Journal Articles

BAALC Is a Key Mediator of Leukemia Development in Congenital Neutropenia

Benjamin Dannenmann, Maksim Klimiankou, Anna Solovyeva, Azadeh Zahabi, MSc, Perihan Mir, Masoud Nasri, MSc, Regine Bernhard, Christian Lindner, Tatsuya Morishima, MD PhD, Doris Steinemann, PhD, Cornelia Zeidler, Lothar Kanz, Karl Welte, MD PhD, Julia Skokowa
Journal: Blood
Blood (2017) 130 (Supplement 1): 541.
https://doi.org/10.1182/blood.V130.Suppl_1.541.541
Published: 2017
Journal Articles

Abrogated GADD45b-Mediated Integrity Control of Hematopoietic Stem Cells upon ER Stress and DNA Damage Triggers Lymphopoiesis over Granulopoiesis in Congenital Neutropenia

Perihan Mir, Masoud Nasri, MSc, Benjamin Dannenmann, Karin Haehnel, Maksim Klimiankou, Cornelia Zeidler, Lothar Kanz, Karl Welte, Julia Skokowa
Journal: Blood
Blood (2017) 130 (Supplement 1): 450.
https://doi.org/10.1182/blood.V130.Suppl_1.450.450
Published: 2017
Journal Articles

Impaired DNA Damage Repair in Severe Congenital Neutropenia Patients

Perihan Mir, Maksim Klimiankou, PhD, Benjamin Dannenmann, Cornelia Zeidler, MD, Klaus Schulze-Osthoff, PhD, Lothar Kanz, MD, Karl Welte, MD, Julia Skokowa, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1334.
https://doi.org/10.1182/blood.V128.22.1334.1334
Published: 2016