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Journal Articles

Synthetic Lethal Interaction between Apto-253 and IDH1/2 Mutations

Cheng-Yu Tsai, PhD, Hongying Zhang, MD PhD, William G Rice, PhD, Stephen B Howell, MD

Blood (2019) 134 (Supplement_1): 5755.

https://doi.org/10.1182/blood-2019-123571

Published: 2019

Journal Articles

Updated Report on Identification of Molecular Predictors of Tazemetostat Response in an Ongoing NHL Phase 2 Study

Blood (2018) 132 (Supplement 1): 4097.

https://doi.org/10.1182/blood-2018-99-115132

Published: 2018

Journal Articles

Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH)

Wenyi Shen, MD, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Hideki Makishima, MD PhD, Louis Williams, MD MBA, Sudipto Mukherjee, MD PhD MPH, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 2583.

https://doi.org/10.1182/blood-2018-99-115228

Published: 2018

Journal Articles

BRCA1 & BRCA2 Germline Variants Are Enriched in MDS/AML and Portend Higher Average Mutational Burden

Louis Williams, MD MBA, Teodora Kuzmanovic, BA, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Yogenthiran Saunthararajah, MD, Hassan Awada, MD, Vera Adema, PhD, Amy C Graham, BS, MS, Tomas Radivoyevitch, PhD, Hetty E. Carraway, MD MBA, Aziz Nazha, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 4352.

https://doi.org/10.1182/blood-2018-99-116802

Published: 2018

Journal Articles

Analysis of BRCA1 and BRCA2 Mutations and Gene Expression in Hematological Malignancies - Implications for Differential Involvement in Pathogenesis of Lymphoid Neoplasms

Anna Stengel, PhD, Wencke Walter, PhD, Stephan Hutter, PhD, Wolfgang Kern, MD, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2018) 132 (Supplement 1): 1348.

https://doi.org/10.1182/blood-2018-99-111826

Published: 2018

Journal Articles

Mutational Burden before and after Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Acute Myeloid Leukemia (AML)

Aziz Nazha, MD, Betty K. Hamilton, MD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MD PhD MPH, Aaron T. Gerds, MDMS, Rabi Hanna, MD, Cassandra M. Hirsch, BS, Teodora Kuzmanovic, BA, Karam Al-Issa, MD, Bartlomiej P. Przychodzen, MSc, Ronald Sobecks, MD, Matt Kalaycio, MD, Navneet S. Majhail, MD MS, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 3272.

https://doi.org/10.1182/blood.V130.Suppl_1.3272.3272

Published: 2017

Journal Articles

PRMT5 Regulates DNA Repair By Controlling the Alternative Splicing of Epigenetic Factors

Pierre-Jacques Hamard, PhD, Gabriel Emmanuel Santiago, Fan Liu, PhD, Sarah Greenblatt, PhD, Daniel Karl, PhD, Concepcion Martinez, B.S., Ramiro E Verdun, PhD, Stephen D. Nimer, MD

Blood (2017) 130 (Supplement 1): 1148.

https://doi.org/10.1182/blood.V130.Suppl_1.1148.1148

Published: 2017

Journal Articles

IGH/MYC Translocation in Burkitt Lymphoma Is Associated with BRCA2 Deficiency and Synthetic Lethality By PARP1 Inhibitors

Silvia Maifrede, Kayla Martin, Paulina Podszywalow-Bartnicka, PhD, Sullivan Katherine, Samantha Langer, Reza Nejati, Yashodhara Dasgupta, Daniel Gritsyuk, Margaret Nieborowska-Skorska, Lena Lupey, Katarzyna Piwocka, Mariusz A Wasik, MD, Italo Tempera, Tomasz Skorski

Blood (2016) 128 (22): 4111.

https://doi.org/10.1182/blood.V128.22.4111.4111

Published: 2016

Journal Articles

FANCA Fine-Tunes Chromosome Segregation By Controlling BUBR1 K250 Acetylation at the Kinetochores

Zahi Abdul Sater, Richa Sharma, MD, Elizabeth Sierra Potchanant, PhD, Ying He, Grzegorz Nalepa, MDPhD

Blood (2016) 128 (22): 1040.

https://doi.org/10.1182/blood.V128.22.1040.1040

Published: 2016

Journal Articles

First-in-Human Phase 1a Study of the Safety, Pharmacokinetics, and Pharmacodynamics of the Noncovalent Bruton Tyrosine Kinase (BTK) Inhibitor SNS-062 in Healthy Subjects

Linda L. Neuman, MD MBA, Renee Ward, MD PhD, David Arnold, Daniel L. Combs, BS, Deena Gruver, MS, Wendy Hill, MBA, Josué Mfopou Kunjom, MD PhD, Langdon L. Miller, MD, Judith A. Fox, PhD

Blood (2016) 128 (22): 2032.

https://doi.org/10.1182/blood.V128.22.2032.2032

Published: 2016

Journal Articles

A Novel Role of PALB2 in Lymphoid Tumour Development

Tatjana Stankovic, MD PhD, Philip J Byrd, PhD, Grant S Stewart, PhD, Alexander J Taylor, Anna Smith, Peggy Fooks, Robert Horsley, James I Last, PhD, Dragana Janic, MD PhD, Lidija Dokmanovic, MD PhD, Antony W Oliver, PhD, A.Malcolm R Taylor, PhD

Blood (2016) 128 (22): 5113.

https://doi.org/10.1182/blood.V128.22.5113.5113

Published: 2016

Journal Articles

Fanconi Anemia Pathway Suppression of R Loops Is a Mechanism of Maintenance of Genomic Stability

Gary Kupfer, MD

Blood (2015) 126 (23): 1216.

https://doi.org/10.1182/blood.V126.23.1216.1216

Published: 2015

Journal Articles

XRCC5 Plays an Important Role in Homologous Recombination, Genome Stability and Survival of Myeloma Cells

Edward Laane, MD PhD, Purushothama Nanjappa, Subodh Kumar, PhD, Florence Magrangeas, Stephane Minvielle, Hele Everaus, MD PhD, Kenneth C Anderson, MD, Herve Avet-Loiseau, Masood A Shammas, PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 1218.

https://doi.org/10.1182/blood.V126.23.1218.1218

Published: 2015

Journal Articles

Acute Myeloid Leukemia in the Elderly Is Characterized By a Distinct Genetic Landscape

Patricia Silva, Martin Neumann, MD, Sebastian Vosberg, Cornelia Schlee, Konstandina Isaakidis, Michael P Schroeder, Jutta Ortiz-Tánchez, Lars R. Fransecky, Teresa Hartung, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Gerhard Ehninger, Hubert Serve, MD, Wolfgang E Berdel, MD, Philipp A. Greif, Christoph Röllig, MD, Claudia D Baldus, MD

Blood (2015) 126 (23): 804.

https://doi.org/10.1182/blood.V126.23.804.804

Published: 2015

Journal Articles

The Impact of Nuclear Organization and Homolgous Recombination in Repair of DNA Damage Introduced By Aid during Class Switch Recombination

Pedro P Rocha, PhD, Yi Fu, JungHyun Kim, Jane Skok, PhD

Blood (2014) 124 (21): 2738.

https://doi.org/10.1182/blood.V124.21.2738.2738

Published: 2014

Journal Articles

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Kimberly Cramer-Morales, Margaret Nieborowska-Skorska, Kara Scheibner, Michelle Padget, David A. Irvine, Tomasz Sliwinski, Kimberly Haas, Jaewoong Lee, Huimin Geng, Darshan Roy, Artur Slupianek, Feyruz V. Rassool, Mariusz A. Wasik, Wayne Childers, Mhairi Copland, Markus Müschen, Curt I. Civin, Tomasz Skorski

Blood (2013) 122 (7): 1293–1304.

https://doi.org/10.1182/blood-2013-05-501072

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Multifunctionality of the FA pathway

Laura E. Hays

Blood (2013) 121 (1): 3–4.

https://doi.org/10.1182/blood-2012-11-464636

Published: 2013

Journal Articles

A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay

Kajal Biswas, Ranabir Das, Blanche P. Alter, Sergey G. Kuznetsov, Stacey Stauffer, Susan L. North, Sandra Burkett, Lawrence C. Brody, Stefan Meyer, R. Andrew Byrd, Shyam K. Sharan

Blood (2011) 118 (9): 2430–2442.

https://doi.org/10.1182/blood-2010-12-324541

Published: 2011

Includes: Supplemental data

Journal Articles

Dysfunctional Double-Strand DNA Break Repair In Primary t-AML/t-MDS Myeloblasts.

Meagan A Jacoby, MD/PhD, Rigoberto de Jesus, Matthew J. Walter, MD

Blood (2010) 116 (21): 3366.

https://doi.org/10.1182/blood.V116.21.3366.3366

Published: 2010

Journal Articles

Homologous Recombination Repair of DNA Strand Breaks Induced by the Nucleoside Analogue CNDAG.

Xiaojun Liu, Ph.D., Yingjun Jiang, Ph.D., Akira Matsuda, Ph.D., William Plunkett, PhD

Blood (2010) 116 (21): 1189.

https://doi.org/10.1182/blood.V116.21.1189.1189

Published: 2010

NARROW

Synthetic Lethal Interaction between Apto-253 and IDH1/2 Mutations

Updated Report on Identification of Molecular Predictors of Tazemetostat Response in an Ongoing NHL Phase 2 Study

Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH)

BRCA1 & BRCA2 Germline Variants Are Enriched in MDS/AML and Portend Higher Average Mutational Burden

Analysis of BRCA1 and BRCA2 Mutations and Gene Expression in Hematological Malignancies - Implications for Differential Involvement in Pathogenesis of Lymphoid Neoplasms

Mutational Burden before and after Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Acute Myeloid Leukemia (AML)

PRMT5 Regulates DNA Repair By Controlling the Alternative Splicing of Epigenetic Factors

IGH/MYC Translocation in Burkitt Lymphoma Is Associated with BRCA2 Deficiency and Synthetic Lethality By PARP1 Inhibitors

FANCA Fine-Tunes Chromosome Segregation By Controlling BUBR1 K250 Acetylation at the Kinetochores

First-in-Human Phase 1a Study of the Safety, Pharmacokinetics, and Pharmacodynamics of the Noncovalent Bruton Tyrosine Kinase (BTK) Inhibitor SNS-062 in Healthy Subjects

A Novel Role of PALB2 in Lymphoid Tumour Development

Fanconi Anemia Pathway Suppression of R Loops Is a Mechanism of Maintenance of Genomic Stability

XRCC5 Plays an Important Role in Homologous Recombination, Genome Stability and Survival of Myeloma Cells

Acute Myeloid Leukemia in the Elderly Is Characterized By a Distinct Genetic Landscape

The Impact of Nuclear Organization and Homolgous Recombination in Repair of DNA Damage Introduced By Aid during Class Switch Recombination

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Multifunctionality of the FA pathway

A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay

Dysfunctional Double-Strand DNA Break Repair In Primary t-AML/t-MDS Myeloblasts.

Homologous Recombination Repair of DNA Strand Breaks Induced by the Nucleoside Analogue CNDAG.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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