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Journal Articles

AT1412, a Patient-Derived Antibody in Development for the Treatment of CD9 Positive Precursor B-Acute Lymphoblastic Leukemia

Greta De Jong, Sophie E Levie, Remko Schotte, PhD, Wouter Pos, PhD, Daniel Go, Etsuko Yasuda, Madalina Cercel, Susan E van Hal-van Veen, Esmay Frankin, Anikó Szabó, MD, Julien Villaudy, PhD, Pauline M van Helden, PhD, Hans van Eenennaam, PhD, Hergen Spits, PhD, Anita W Rijneveld, MD PhD, Mette D Hazenberg, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4461.
https://doi.org/10.1182/blood-2019-127894
Published: 2019
Journal Articles

The Molecular Basis of Long First Remissions in Normal Karyotype AML Patients

Francesca Ferraro, MD PhD, Christopher A Miller, PhD, Amy Abdalla, Nichole Helton, Nathan Salomonis, PhD, Robert S Fulton, Catrina Fronick, BS, Sharon E Heath, Peter Westervelt, MD PhD, Timothy J Ley, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3827.
https://doi.org/10.1182/blood-2019-122967
Published: 2019
Journal Articles

Effect of Avelumab to Immune Response in AML: A Phase I Study of Avelumab in Combination with Decitabine As First Line Treatment of Unfit Patients

Hong Zheng, MD PhD, Shin Mineishi, David F. Claxton, MD, Junjia Zhu, Chenchen Zhao, MD, Bei Jia, MD PhD, W. Christopher Ehmann, MD, Seema Naik, MD, Natthapol Songdej, Raymond J. Hohl
Journal: Blood
Blood (2019) 134 (Supplement_1): 3939.
https://doi.org/10.1182/blood-2019-125153
Published: 2019
Journal Articles

Interrogating the Spatial Architecture of Human Bone Marrow Via Imaging Mass Cytometry

Karolyn A. Oetjen, MD, Diane E. Bender, PhD, Marianna B. Ruzinova, MD PhD, Stephen T. Oh, MD, Daniel C. Link, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3728.
https://doi.org/10.1182/blood-2019-127460
Published: 2019
Journal Articles

Inhibition of BMP-Smad Pathway Reduces Leukemic Stemness in Pediatric AML

Xin Long, PhD, Chris Man, PhD, Padmini Narayanan, PhD, Elizabeth Seashore, MD, Michele Redell, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3731.
https://doi.org/10.1182/blood-2019-129074
Published: 2019
Journal Articles

Transcriptome Sequencing Demonstrates Unique Signature Associated with Durable Clinical Response to DC/AML Fusion Vaccine

Jessica Liegel, MD, Manoj Bhasin, PhD, German A. Pihan, MD, Dina Stroopinsky, PhD, Beena Thomas, PhD, Shreya Sindhu, Haider Ghiasuddin, Emma Logan, Adam Morin, Marzia Capelletti, PhD MMSc, Shira Orr, PhD, Myrna Nahas, MD, Matthew Weinstock, MD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Richard M. Stone, MD, Donald Kufe, MD, David E. Avigan, MD, Jacalyn Rosenblatt, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3832.
https://doi.org/10.1182/blood-2019-129451
Published: 2019
Journal Articles

PTPN11 Mutated Acute Myeloid Leukemia (AML) Features an Abundant Epichaperome Network and Is Sensitive to the Epichaperome Inhibitor PU-H71

Justin D. Kaner, MD, Montreh Tavakkoli, MA,MD, Lisa Toudic, Brett M. Stevens, PhD, Craig T Jordan, PhD, Tony Taldone, PhD, Gabriela Chiosis, PhD, Ellen K. Ritchie, MD, Pinkal Desai, MDMPH, Michael B. Samuel, MD, Sangmin Lee, MD, Gail J. Roboz, MD, Monica L. Guzman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3935.
https://doi.org/10.1182/blood-2019-128276
Published: 2019
Journal Articles

A Multisite Phase Ib Study of Pevonedistat, Azacitidine and Venetoclax (PAVE) for the Treatment of Subjects with Acute Myelogenous Leukemia (AML)

Guru Subramanian Guru Guru Murthy, MBBS, Scott H. Kaufmann, MD PhD, Aniko Szabo, PhD, Arielle Baim, Ashish Anshu, Alexander Hinman, Laura C. Michaelis, MD, Sameem Abedin, MD, Karen-Sue B. Carlson, MD PhD, Lyndsey Runaas, MD, Ehab L. Atallah, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3837.
https://doi.org/10.1182/blood-2019-131728
Published: 2019
Journal Articles

The PRIME Trial: PARP Inhibition in IDH Mutant Effectiveness Trial. a Phase II Study of Olaparib in Isocitrate Dehydrogenase (IDH) Mutant Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

Namrata S Chandhok, MD, Wei Wei, MD PhD, Ranjit Bindra, MD PhD, Stephanie Halene, MD, Yu Shyr, Jing Li, PhD, Michael Berens, PhD, Chris Karlovich, PhD, S. Percy Ivy, MD, Thomas Prebet, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3909.
https://doi.org/10.1182/blood-2019-129168
Published: 2019
Journal Articles

Genetic Ancestry and Skeletal Toxicities Among Childhood Acute Lymphoblastic Leukemia Patients in the DFCI 05-001 Cohort

Qianqian Zhu, PhD, Song Yao, PhD, Peter D Cole, MD, Justine M. Kahn, MD MS, Marian H. Harris, MD PhD, Emily Schiller, MS, Uma Athale, MDMBBS,MSc, Luis A. Clavell, MD, Caroline Laverdiere, MD FRCPC, Jean-Marie Leclerc, MDFRCPC, Bruno Michon, MD FRCPC, Marshall A. Schorin, MD, Jennifer J.G. Welch, MD, Stephen E. Sallan, MD, Lewis B. Silverman, MD, Kara M. Kelly, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3811.
https://doi.org/10.1182/blood-2019-126814
Published: 2019
Journal Articles

Role of IGF2BP1 and Target Genes in ETV6-RUNX1 Positive B-Acute Lymphoblastic Leukemia

Jayanth Kumar Palanichamy, MD, Gunjan Sharma, MSc, Thakur Nidhi, MBBS, Anita Chopra, MD DM, Sameer Bakhshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3818.
https://doi.org/10.1182/blood-2019-128019
Published: 2019
Journal Articles

Blinatumomab in Combination with Pembrolizumab Is Safe for Adults with Relapsed or Refractory B-Lineage Acute Lymphoblastic Leukemia: University of California Hematologic Malignancies Consortium Study 1504

Marc Schwartz, MD, Lloyd E. Damon, MD, Deepa Jeyakumar, MD, Caitlin L. Costello, MD, Dimitrios Tzachanis, MD PhD, Gary J. Schiller, MD, Jesika Reiner, MPH, Matthew J. Wieduwilt, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3880.
https://doi.org/10.1182/blood-2019-131061
Published: 2019
Journal Articles

Frequency and Prognostic Impact of IKZF1 and Co-Existed Gene Alterations in Childhood B-ALL in Taiwan

Hsi-Che Liu, MD, Ying-Jung Huang, PhD, Ting-Chi Yeh, MD, Tang-Her Jaing, MD, Chao-Ping Yang, MD, Shih-Hsiang Chen, MD, Jen-Yin Hou, MD, Tung-Huei Lin, MS, Iou-Jih Hung, MD, Lee-Yung Shih, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2750.
https://doi.org/10.1182/blood-2019-128863
Published: 2019
Journal Articles

Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia

Gretchen Johnston, Haley E. Ramsey, PhDMSc, Kristy Stengel, PhD, Shilpa Sampathi, PhD, Pankaj Acharya, PhD, Maria Arrate, MSc, Matthew C. Stubbs, PhD, Timothy Burn, PhD, Scott Hiebert, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2509.
https://doi.org/10.1182/blood-2019-130458
Published: 2019
Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
https://doi.org/10.1182/blood-2019-125713
Published: 2019
Journal Articles

NPM1 Quantitative Monitoring of Minimal Residual Disease in Acute Myeloid Leukemia Allows More Precise Selection of Patients for Allogeneic Stem Cell Transplantation without Affecting Their Survival

Yishai Ofran, MD, Ronit Leiba, Dina Rosenberg, Israel Henig, MD, Dana Yehudai-Ofir, MD, Nuhad Haddad, MD, Riva Fineman, MD, Avraham Frisch, MD, Doaa Okasha, MD, Yariv Carasso, MD, Tsila Zuckerman, MD, Nurit Horesh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2603.
https://doi.org/10.1182/blood-2019-126553
Published: 2019
Journal Articles

Single Cell Sequencing Reveals Heterogeneity of Gene Expression in KMT2A Rearranged Infant ALL at Relapse Compared to Diagnosis

Erin Guest, MD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Midhat S. Farooqi, MD PhD, Emily Farrow, PhD CGC, Margaret Gibson, Neil Miller, Karina Shah, Tomi Pastinen, MD PhD, Patrick A. Brown, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2756.
https://doi.org/10.1182/blood-2019-131999
Published: 2019
Journal Articles

Minimal Residual Disease Monitoring By Next-Generation Sequencing in Patients with Acute Myeloid Leukemia: MRD Positivity after First Consolidation Chemotherapy Can Better Predict Clinical Outcomes Than That after Induction Chemotherapy

Cheng-Hong Tsai, MD MSc, Jih-Luh Tang, MD, PhD, Feng-Ming Tien, MD, M.Sc, Yuan-Yeh Kuo, PhD, Chien-Chin Lin, MD, Mei-Hsuan Tseng, M.Sc., Yen-Ling Peng, M.Sc., Ming-Chih Liu, Chia-Wen Liu, Ming Yao, Liang-In Lin, PhD, Wen-Chien Chou, MD, PhD, Chien-Yu Chen, PhD, Hsin-An Hou, Hwei-Fang Tien, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2698.
https://doi.org/10.1182/blood-2019-126870
Published: 2019
Journal Articles

Prognostic Significance of IKZF1 , PAX5 , and CDKN2A Deletions in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated with Hyper-CVAD/MA with Dasatinib or Ponatinib

Yuya Sasaki, MD PhD, Nicholas J. Short, MD, Hagop M. Kantarjian, MD, Rebecca Garris, MSc, Nitin Jain, MD, Koji Sasaki, MD, Farhad Ravandi, MD, Marina Y Konopleva, MD PhD, Michael E. Rytting, MD, Guillermo Garcia-Manero, MD, Latasha Little, BS, Curtis Gumbs, Li Zhao, PhD, P. Andrew Futreal, PhD, Feng Wang, PhD, Koichi Takahashi, MD, Elias Jabbour, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2753.
https://doi.org/10.1182/blood-2019-122017
Published: 2019
Journal Articles

Improved Anti-Leukemic Pre-Clinical Efficacy of a Protac Based MDM2 Degrader in a Large AML Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Megha Ramappan, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2670.
https://doi.org/10.1182/blood-2019-131949
Published: 2019