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Journal Articles

Dasmahapatra G, Rahmani M, Dent P, Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)–dependent mechanism. Blood . 2006;107(1):232-240.

Blood (2019) 134 (1): 95.

https://doi.org/10.1182/blood-2019-05-901215

Published: 2019

Journal Articles

C-Myc- Dependent Stabilization of Hif-1alpha in MM: Therapeutic Implications

Klaus Podar, MD, MSc, PhD, Jing Zhang, MS, Giovanni Tonon, MD, PHD, Clemens Grabher, MSc, PHD, Samir Lababidi, PHD, Marc S Raab, MD, Sonia Vallet, MD, Yiming Zhou, PHD, Marie-Astrid Cartron, MS, Martin Sattler, PhD, Dharminder Chauhan, JD, PHD, Kenneth C Anderson, MD

Blood (2008) 112 (11): 2750.

https://doi.org/10.1182/blood.V112.11.2750.2750

Published: 2008

Journal Articles

The Tyrophostin Adaphostin (NSC680410) Inhibits Multiple Myeloma Bone Marrow Angiogenesis In Vitro and In Vivo.

Klaus Podar, MD, PhD, Jing Zhang, MSc, Marc S. Raab, MD, Sonia Vallet, MD, Mariateresa Fulciniti, MSc, Martin Sattler, PhD, Yutaka Ikeda, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2007) 110 (11): 2507.

https://doi.org/10.1182/blood.V110.11.2507.2507

Published: 2007

Journal Articles

Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma.

Klaus Podar, MD, MSc, PhD, Marc S. Raab, MD, Giovanni Tonon, MD, PhD, Martin Sattler, PhD, Daniela Barila, PhD, Yu-Tzu Tai, PhD, Hiroshi Yasui, MD, PhD, Noopur Raje, MD, Ronald A. Depinho, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, JD, PhD, Kenneth C. Anderson, MD

Blood (2006) 108 (11): 3415.

https://doi.org/10.1182/blood.V108.11.3415.3415

Published: 2006

Journal Articles

Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

Joya Chandra, Jeannette Tracy, David Loegering, Karen Flatten, Srdan Verstovsek, Miloslav Beran, Mercedes Gorre, Zeev Estrov, Nicholas Donato, Moshe Talpaz, Charles Sawyers, Kapil Bhalla, Judith Karp, Edward Sausville, Scott H. Kaufmann

Blood (2006) 107 (6): 2501–2506.

https://doi.org/10.1182/blood-2005-07-2966

Published: 2006

Journal Articles

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism

Girija Dasmahapatra, Mohamed Rahmani, Paul Dent, Steven Grant

Blood (2006) 107 (1): 232–240.

https://doi.org/10.1182/blood-2005-06-2302

Published: 2006

Journal Articles

ROS 'n' roll: a bunch of JNK?

Steven D. Gore

Blood (2006) 107 (1): 9–10.

https://doi.org/10.1182/blood-2005-10-4115

Published: 2006

Journal Articles

Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells.

Klaus Podar, MD, PhD, Giovanni Tonon, MD, PhD, Marc S. Raab, MD, Martin Sattler, PhD, Dean Abtahi, BS, Yu-Tzu Tai, PhD, Steven LeGouill, MD, PhD, Kenji Ishitsuka, MD, PhD, Hiroshi Yasui, MD, PhD, Ron A. Depinho, MD, Teru Hideshima, MD, PhD, Dharminder Chauhan, JD, PhD, Kenneth C. Anderson, MD

Blood (2005) 106 (11): 1585.

https://doi.org/10.1182/blood.V106.11.1585.1585

Published: 2005

Journal Articles

Evaluation of the In Vitro Activity of the Multikinase Inhibitor BAY 43-9006 (Sorafenib) in Primary Cells from Patients with Myelofibrosis with Myeloid Metaplasia (MMM).

Joseph W. Smith, BS, Heather Powell, MS, Ayalew Tefferi, MD, Scott H. Kaufmann, MD, PhD, Terra Lasho, BS, David Loegerling, Marina Galvez, Ruben Mesa, MD

Blood (2005) 106 (11): 4943.

https://doi.org/10.1182/blood.V106.11.4943.4943

Published: 2005

Journal Articles

Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine

Tait D. Shanafelt, Yean K. Lee, Nancy D. Bone, Ann K. Strege, Ven L. Narayanan, Edward A. Sausville, Susan M. Geyer, Scott H. Kaufmann, Neil E. Kay

Blood (2005) 105 (5): 2099–2106.

https://doi.org/10.1182/blood-2004-06-2205

Published: 2005

Journal Articles

The Tyrosine Kinase Inhibitor Adaphostin (NSC 680410), but Not Imatinib Mesylate, Inhibits Survival and Src Tyrosine Kinase Family- Triggered Signaling Pathways of MM Cells.

Klaus Podar, MD, PhD, Melissa Simoncini, BS, Yu-Tzu Tai, PhD, Martin Sattler, PhD, Kenji Ishitsuka, MD, PhD, Steven Le Gouill, MD, Makoto Hamasaki, MD, PhD, Renate Burger, PhD, Noopur Raje, MD, Teru C. Hideshima, MD, PhD, Dharminder Chauhan, JD, PhD, Kenneth Anderson, MD

Blood (2004) 104 (11): 3352.

https://doi.org/10.1182/blood.V104.11.3352.3352

Published: 2004

Journal Articles

Adaphostin-Induced Apoptosis in CLL B-Cells Is Associated with Induction of Oxidative Stress and Exhibits Synergy with Fludarabine.

Tait D. Shanafelt, M.D., Y. Kit Lee, Nancy D. Bone, Ann K. Strege, Scott H. Kaufmann, M.D., Ph.D., Neil E. Kay, M.D.

Blood (2004) 104 (11): 3482.

https://doi.org/10.1182/blood.V104.11.3482.3482

Published: 2004

Journal Articles

Effects of Adaphostin, a Novel Tyrphostin Inhibitor, in Diverse Models of Imatinib Mesylate Resistance.

Joya Chandra, Ph.D., Jeannette Tracy, Mercedes Gorre, Ph.D., Moshe Talpaz, M.D., James Griffin, M.D., Srdan Verstovsek, M.D., Ph.D., Miloslav Beran, M.D., Charles Sawyers, M.D., Edward Sausville, M.D., Scott Kaufmann, M.D., Ph.D.

Blood (2004) 104 (11): 2097.

https://doi.org/10.1182/blood.V104.11.2097.2097

Published: 2004

Journal Articles

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

Joya Chandra, Jennifer Hackbarth, Son Le, David Loegering, Nancy Bone, Laura M. Bruzek, Ven L. Narayanan, Alex A. Adjei, Neil E. Kay, Ayalew Tefferi, Judith E. Karp, Edward A. Sausville, Scott H. Kaufmann

Blood (2003) 102 (13): 4512–4519.

https://doi.org/10.1182/blood-2003-02-0562

Published: 2003

Journal Articles

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

Benjamin M. F. Mow, Joya Chandra, Phyllis A. Svingen, Christopher G. Hallgren, Ellen Weisberg, Timothy J. Kottke, Ven L. Narayanan, Mark R. Litzow, James D. Griffin, Edward A. Sausville, Ayalew Tefferi, Scott H. Kaufmann

Blood (2002) 99 (2): 664–671.

https://doi.org/10.1182/blood.V99.2.664

Published: 2002

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Dasmahapatra G, Rahmani M, Dent P, Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)–dependent mechanism. Blood . 2006;107(1):232-240.

C-Myc- Dependent Stabilization of Hif-1alpha in MM: Therapeutic Implications

The Tyrophostin Adaphostin (NSC680410) Inhibits Multiple Myeloma Bone Marrow Angiogenesis In Vitro and In Vivo.

Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma.

Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism

ROS 'n' roll: a bunch of JNK?

Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells.

Evaluation of the In Vitro Activity of the Multikinase Inhibitor BAY 43-9006 (Sorafenib) in Primary Cells from Patients with Myelofibrosis with Myeloid Metaplasia (MMM).

Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine

The Tyrosine Kinase Inhibitor Adaphostin (NSC 680410), but Not Imatinib Mesylate, Inhibits Survival and Src Tyrosine Kinase Family- Triggered Signaling Pathways of MM Cells.

Adaphostin-Induced Apoptosis in CLL B-Cells Is Associated with Induction of Oxidative Stress and Exhibits Synergy with Fludarabine.

Effects of Adaphostin, a Novel Tyrphostin Inhibitor, in Diverse Models of Imatinib Mesylate Resistance.

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

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