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Journal Articles

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

Zhihong Zeng, Yue Xi Shi, Twee Tsao, YiHua Qiu, Steven M. Kornblau, Keith A. Baggerly, Wenbin Liu, Katti Jessen, Yi Liu, Hagop Kantarjian, Christian Rommel, David A. Fruman, Michael Andreeff, Marina Konopleva

Blood (2012) 120 (13): 2679–2689.

https://doi.org/10.1182/blood-2011-11-393934

Published: 2012

Includes: Supplemental data

Journal Articles

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

Ye Chen, Rodrigo Jacamo, Yue-xi Shi, Rui-yu Wang, Venkata Lokesh Battula, Sergej Konoplev, Dirk Strunk, Nicole A. Hofmann, Andreas Reinisch, Marina Konopleva, Michael Andreeff

Blood (2012) 119 (21): 4971–4980.

https://doi.org/10.1182/blood-2011-11-389957

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Human Extramedullary Bone and Bone Marrow in Mice: First In Vivo Model of a Genetically Controlled Hematopoietic Environment

Ye Chen, Ph.D., Rodrigo O Jacamo, Ph.D., Nicole A. Hofmann, Yue-xi Shi, PhD, Rui-yu Wang, PhD, Sergej Konoplev, MD, PhD, Dirk Strunk, MD, Marina Konopleva, M.D., Ph.D., Michael Andreeff, M.D., Ph.D.

Blood (2011) 118 (21): 1323.

https://doi.org/10.1182/blood.V118.21.1323.1323

Published: 2011

Journal Articles

Mesenchymal Stem Cells From Patients with Acute Myeloid Leukemia (AML) Can Differentiate Into B-Cells in NOD/SCID/IL-2Rγ -/- Mice .

Rui-Yu Wang, MD, PhD, Yue-Xi Shi, Zhihong Zeng, MD, Wendy D. Schober, Teresa J. McQueen, BS, Vicki L. Hopwood, MS, BS, Borys Korchin, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD

Blood (2009) 114 (22): 4573.

https://doi.org/10.1182/blood.V114.22.4573.4573

Published: 2009

Journal Articles

Therapeutic Targeting of the Hypoxic Microenvironment in Acute Lymphocytic Leukemia.

Marina Konopleva, MD, PhD, Juliana Benito, PhD, Yue-Xi Shi, Sergej Konoplev, MD, PhD, Steven M. Kornblau, MD, Olga Frolova, MD, PhD, Patrick A. Zweidler-McKay, MD, PhD, YiHua Qiu, MD, MS, William R. Wilson, PhD, Dario Campana, MD, PhD, Rodrigo Jacamo, PhD, Hongbo Lu, MMSC, Wendy Fang, MD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, MD, Hagop M. Kantarjian, MD, Deborah A. Thomas, MD, Michael Andreeff, MD, PhD

Blood (2009) 114 (22): 2040.

https://doi.org/10.1182/blood.V114.22.2040.2040

Published: 2009

Journal Articles

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

Zhihong Zeng, Yue Xi Shi, Ismael J. Samudio, Rui-Yu Wang, Xiaoyang Ling, Olga Frolova, Mark Levis, Joshua B. Rubin, Robert R. Negrin, Elihu H. Estey, Sergej Konoplev, Michael Andreeff, Marina Konopleva

Blood (2009) 113 (24): 6215–6224.

https://doi.org/10.1182/blood-2008-05-158311

Published: 2009

Includes: Supplemental data

Journal Articles

Massive Mobilization of AML Cells into Circulation by Disruption of Leukemia/Stroma Cell Interactions Using CXCR4 Antagonist AMD3100: First Evidence in Patients and Potential for Abolishing Bone Marrow Microenvironment-Mediated Resistance.

Michael Andreeff, MD, PhD, Sergej Konoplev, M.D., Ph.D., Rui-Yu Wang, M.D., Ph.D., Zhihong Zeng, Ph.D., Teresa McQueen, Yue-Xi Shi, L. Jeffrey Medeiros, M.D., Elihu Estey, M.D., John M. McCarty, M.D., Stephanie Elkins, M.D., Richard Champlin, M.D., Gary Calandra, M.D., Ph.D., Gary Bridger, Ph.D., Marina Konopleva, M.D., Ph.D.

Blood (2006) 108 (11): 568.

https://doi.org/10.1182/blood.V108.11.568.568

Published: 2006

Journal Articles

Sorafenib (BAY 43-9006) Directly Targets FLT3-ITD in Acute Myelogenous Leukemia.

Weiguo Zhang, MD, PhD, Marina Konopleva, M.D., Ph.D., Yue-Xi Shi, David Harris, Donald Small, M.D., Ph.D., Xiaoyang Ling, Ph.D., Zeev Estrov, M.D., Jorge Cortes, M.D., Michael Andreeff, M.D., Ph.D.

Blood (2006) 108 (11): 255.

https://doi.org/10.1182/blood.V108.11.255.255

Published: 2006

Journal Articles

Mechanisms of Apoptosis Induction by BH3 Inhibitor ABT-737 in AML.

Michael Andreeff, MD, PhD, Rooha Contractor, Peter P. Ruvolo, PhD, Xingming Deng, MD, PhD, Ismael Samudio, PhD, Yue-Xi Shi, Teresa McQueen, BS, Rui-Yu Wang, MD, PhD, Wendy Schober, Xiaoyang Ling, PhD, Frank C. Marini, PhD, David Harris, Zeev Estrov, MD, James McCubrey, PhD, W. Stratford May, MD, PhD, Marina Konopleva, MD, PhD

Blood (2005) 106 (11): 244.

https://doi.org/10.1182/blood.V106.11.244.244

Published: 2005

Journal Articles

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

Marina Konopleva, MD, PhD, Ismael Samudio, PhD, Twee Tsao, Steven M. Kornblau, MD, Yue-Xi Shi, Teresa McQueen, BS, Rooha Contractor, Michael B. Sporn, MD, Colin J. Meyer, MD, Warren Huff, Stephen H. Safe, PhD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 2460.

https://doi.org/10.1182/blood.V106.11.2460.2460

Published: 2005

Journal Articles

Regulation and Targeting of Eg5 in Blast Crisis CML: Overcoming Imatinib Resistance.

Bing Z. Carter, PhD, Duncan Mak, Yue-Xi Shi, Wendy D. Schober, Rui-Yu Wang, MD, PhD, Teresa McQueen, BS, Marina Konopleva, MD, PhD, Erich Koller, PhD, Nicholas M. Dean, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 2877.

https://doi.org/10.1182/blood.V106.11.2877.2877

Published: 2005

Journal Articles

Distribution and Differentiation of Donor-Derived Bone Marrow Stem Cells in Various Areas of the Human Brain.

Rui-Yu Wang, MD, PhD, Gregory N. Fuller, MD, PhD, Teresa McQueen, BS, Yue-Xi Shi, Richard E. Champlin, MD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 1685.

https://doi.org/10.1182/blood.V106.11.1685.1685

Published: 2005

Journal Articles

Triterpenoid Methyl-CDDO Is a Potent Inducer of Apoptosis in CD34 + AML Progenitor Cells Via Activation of SAPK Pathways and Inhibition of MAPK Cascades.

Marina Konopleva, M.D., Ph.D., Peter Ruvolo, Ph.D., Rooha Contractor, Svitlana Kurinna, Yue-Xi Shi, Teresa McQueen, Michele Milella, M.D., Michael Andreeff, M.D., Ph.D.

Blood (2004) 104 (11): 2533.

https://doi.org/10.1182/blood.V104.11.2533.2533

Published: 2004

NARROW

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

Human Extramedullary Bone and Bone Marrow in Mice: First In Vivo Model of a Genetically Controlled Hematopoietic Environment

Mesenchymal Stem Cells From Patients with Acute Myeloid Leukemia (AML) Can Differentiate Into B-Cells in NOD/SCID/IL-2Rγ -/- Mice .

Therapeutic Targeting of the Hypoxic Microenvironment in Acute Lymphocytic Leukemia.

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

Massive Mobilization of AML Cells into Circulation by Disruption of Leukemia/Stroma Cell Interactions Using CXCR4 Antagonist AMD3100: First Evidence in Patients and Potential for Abolishing Bone Marrow Microenvironment-Mediated Resistance.

Sorafenib (BAY 43-9006) Directly Targets FLT3-ITD in Acute Myelogenous Leukemia.

Mechanisms of Apoptosis Induction by BH3 Inhibitor ABT-737 in AML.

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

Regulation and Targeting of Eg5 in Blast Crisis CML: Overcoming Imatinib Resistance.

Distribution and Differentiation of Donor-Derived Bone Marrow Stem Cells in Various Areas of the Human Brain.

Triterpenoid Methyl-CDDO Is a Potent Inducer of Apoptosis in CD34 + AML Progenitor Cells Via Activation of SAPK Pathways and Inhibition of MAPK Cascades.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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