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William A Eaton
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Journal Articles

A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects with Stable Sickle Cell Disease: Trial in Progress

Anna Conrey, Dianna Lovins, Rivers Kimberly, Yuan Yee Lee, Kang Le, Britney Kruah, Xunde Wang, Belhu Metaferia, Philip S. Low, Neal Jeffries, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2024) 144 (Supplement 1): 1143.1.
https://doi.org/10.1182/blood-2024-193267
Published: 2024
Journal Articles

Recent developments in the use of pyruvate kinase activators as a new approach for treating sickle cell disease

Dina S. Parekh, William A. Eaton, Swee Lay Thein
Journal: Blood
Blood (2024) 143 (10): 866–871.
https://doi.org/10.1182/blood.2023021167
Published: 2024
Journal Articles

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 273.
https://doi.org/10.1182/blood-2023-180165
Published: 2023
Journal Articles

Functional and Multi-Omics Signatures of Mitapivat Efficacy upon Activation of Pyruvate Kinase in Red Blood Cells from Patients with Sickle Cell Disease

Angelo D'Alessandro, Kang Le, Maureen Lundt, Quan Li, Emily Dunkelberger, Troy Cellmer, Andrew J Worth, Spurthi Patil, Chris Huston, Abby Grier, Monika monikA.dzieciatkow, Daniel Stephenson, William A Eaton, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2485.
https://doi.org/10.1182/blood-2023-181213
Published: 2023
Journal Articles

Phenotypic Screening of the Reframe Drug Repurposing Library to Discover New Drugs for Treating Sickle Cell Disease

William A. Eaton, Belhu Metaferia, Troy Cellmer, Emily B. Dunkelberger, Quan Li, Eric R. Henry, James Hofrichter, Dwayne Staton, Matthew M. Hsieh, Anna Conrey, John Tisdale, Arnab K. Chatterjee, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 11089–11090.
https://doi.org/10.1182/blood-2022-159634
Published: 2022
Journal Articles

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Clinical Trials & Observations
Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A. Menapace, Laxminath Tumburu, Maureen Lundt, Timothy Lequang, Quan Li, Kristen Glass, Emily B. Dunkelberger, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William A. Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (19): 2053–2062.
https://doi.org/10.1182/blood.2022015403
Published: 2022
Includes: Supplemental data
Journal Articles

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Clinical Trials & Observations
Eric R. Henry, Belhu Metaferia, Quan Li, Julia Harper, Robert B. Best, Kristen E. Glass, Troy Cellmer, Emily B. Dunkelberger, Anna Conrey, Swee Lay Thein, H. Franklin Bunn, William A. Eaton
Journal: Blood
Blood (2021) 138 (13): 1172–1181.
https://doi.org/10.1182/blood.2021012070
Published: 2021
Includes: Supplemental data
Journal Articles

Treating sickle cell disease by targeting HbS polymerization

William A. Eaton, H. Franklin Bunn
Journal: Blood
Blood (2017) 129 (20): 2719–2726.
https://doi.org/10.1182/blood-2017-02-765891
Published: 2017