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Laxminath Tumburu
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Journal Articles

8-Oxoguanine DNA Glycosylase 1 Inhibition Suppresses Inflammatory Responses in Sickle Cell Disease

Kang Le, Zenaide Quezado, Sayuri Kamimura, Meghann L. Smith, Yuki Tahara, Yujeong Lee, Laxminath Tumburu, Anna Conrey, Eric T Kool, Swee Lay Thein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2482.
https://doi.org/10.1182/blood-2023-182157
Published: 2023
Journal Articles

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Clinical Trials & Observations
Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A. Menapace, Laxminath Tumburu, Maureen Lundt, Timothy Lequang, Quan Li, Kristen Glass, Emily B. Dunkelberger, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William A. Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (19): 2053–2062.
https://doi.org/10.1182/blood.2022015403
Published: 2022
Includes: Supplemental data
Journal Articles

Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study

Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A Menapace, Laxminath Tumburu, Maureen Lundt, Quan Li, Kristen Glass, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2021) 138 (Supplement 1): 10.
https://doi.org/10.1182/blood-2021-145398
Published: 2021
Journal Articles

Individuals with Sickle Cell Disease Have a Higher Burden of Mitochondrial DNA Heteroplasmy

Laxminath Tumburu, Maliha Maryam Ahmad, Chunyu Liu, Clifton L. Dalgard, Mehdi Pirooznia, Swee Lay Thein
Journal: Blood
Blood (2021) 138 (Supplement 1): 954.
https://doi.org/10.1182/blood-2021-153000
Published: 2021
Journal Articles

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

Laxminath Tumburu, Shohini Ghosh-Choudhary, Fayaz T. Seifuddin, Emilia A. Barbu, Simon Yang, Maliha M. Ahmad, Lauren H. W. Wilkins, Ilker Tunc, Ishwarya Sivakumar, James S. Nichols, Pradeep K. Dagur, Shutong Yang, Luis E. F. Almeida, Zenaide M. N. Quezado, Christian A. Combs, Eric Lindberg, Christopher K. E. Bleck, Jun Zhu, Arun S. Shet, Jay H. Chung, Mehdi Pirooznia, Swee Lay Thein
Journal: Blood
Blood (2021) 137 (22): 3116–3126.
https://doi.org/10.1182/blood.2020009063
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Mitochondrial DNA Variation in Individuals with Sickle Cell Disease

Maliha Maryam Ahmad, BS, Laxminath Tumburu, PhD, Chunyu Liu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-138518
Published: 2020
Journal Articles

RNA Seq Profiles and Bioinformatics Validation in a Large Sample of Sickle Cell Disease Patients

Jen Judy, PhDMS, Xunde Wang, PhD, Fayaz Seifuddin, PhD, Laxminath Tumburu, PhD, Mehdi Pirooznia, MD PhD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-139382
Published: 2020
Journal Articles

Phase 1 Multiple Ascending Dose Study of Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Mitapivat (AG-348) in Subjects with Sickle Cell Disease

Julia Z. Xu, MDMS, Anna Conrey, NP, Ingrid Frey, RN, BSN, MS, James Nichols, RN, Laurel A Menapace, MD, Laxminath Tumburu, PhD, Timothy Lequang, MSc, Quan Li, PhD, Emily Dunkelberger, PhD, Eric Henry, PhD, Troy Cellmer, PhD, Varsha Iyer, Heidi Mangus, BS, Charles Kung, PhD, Lenny Dang, PhD, Penelope A. Kosinski, MS, Peter Hawkins, PhD, Neal Jeffries, PhD, William Eaton, MD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137716
Published: 2020
Journal Articles

Cell-Free Mitochondrial DNA Is Elevated in Sickle Cell Disease Patients, and Serve As a Potential Proinflammatory DAMP

Laxminath Tumburu, PhD, Shohini Ghosh-Choudhary, Emilia Alina Barbu, Simon Yang, Lauren D Harrison Ware, Ilker Tunc, PhD, Fayaz Tasaduck Seifuddin, Mehdi Pirooznia, MD PhD, Jun Zhu, PhD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 1068.
https://doi.org/10.1182/blood-2018-99-118440
Published: 2018
Journal Articles

Erythroid-Expression of HMGA2 Increases Fetal Hemoglobin in Human Adult Erythroblasts

Jaira F. de Vasconcellos, Y. Terry Lee, Colleen Byrnes, MS, Laxminath Tumburu, Antoinette Rabel, Jeffery L. Miller, MD
Journal: Blood
Blood (2015) 126 (23): 2161.
https://doi.org/10.1182/blood.V126.23.2161.2161
Published: 2015
Journal Articles

Early Pathogenesis of Sickle Cell Anemia: Absolute Reticulocyte Counts Are Correlated with Increased Detection of CD36+ Reticulocytes during the First Two Years of Postnatal Life

Emily Riehm Meier, MD, Colleen Byrnes, MS, Brenda Martin, MSN, CPNP, Laxminath Tumburu, PhD, Y. Terry Lee, MS, Naomi L.C. Luban, MD, Jeffery L. Miller, MD
Journal: Blood
Blood (2015) 126 (23): 2181.
https://doi.org/10.1182/blood.V126.23.2181.2181
Published: 2015
Journal Articles

IGF2BP1 Reverses Hemoglobin Switching in Adult Erythroblasts

Laxminath Tumburu, Colleen Byrnes, MS, Y. Terry Lee, Jaira F. de Vasconcellos, Antoinette Rabel, Jeffery L. Miller, MD
Journal: Blood
Blood (2015) 126 (23): 639.
https://doi.org/10.1182/blood.V126.23.639.639
Published: 2015
Journal Articles

Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

Y. Terry Lee, Colleen Byrnes, Jaira F. de Vasconcellos, Megha Kaushal, Antoinette Rabel, Laxminath Tumburu, Joshua M. Allwardt, Jeffery L. Miller
Journal: Blood
Blood (2014) 124 (21): 50.
https://doi.org/10.1182/blood.V124.21.50.50
Published: 2014