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Julia Z. Xu
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Journal Articles

Inhibition of Purine Nucleoside Phosphorylase Is a Promising Anti-Sickling Approach for Sickle Cell Disease

Adekunle Emmanuel Alagbe, Lynda Little-Ihrig, Brian J Philips, Stephanie M Mutchler, Julia Z Xu, Edwin K Jackson, Stevan Tofovic, Enrico M Novelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 3861.
https://doi.org/10.1182/blood-2024-199595
Published: 2024
Journal Articles

A Phase 1b/2 Study of the Efficacy and Safety of Combination Hydroxyurea and Dose-Escalated Erythropoietin for Treatment of Anemia in Sickle Cell Disease (ACHiEvE-SCD)

Titilope A Adeyemo, Nelly Kiriza, Feyisayo T. Oluwole, Mark Jelinek, Jude Jonassaint, Olubusola Oluwole, Christine Saber, Brian J Philips, Olusegun-Joseph D Akinsanya, Vincent O Osunkalu, Laura M. DeCastro, Enrico M Novelli, Julia Z Xu
Journal: Blood
Blood (2024) 144 (Supplement 1): 178.
https://doi.org/10.1182/blood-2024-205261
Published: 2024
Journal Articles

Results from a Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Tebapivat (AG-946) in Patients with Sickle Cell Disease

Julia Z Xu, Enrico M Novelli, Jean-Antoine Ribeil, Andreas Glenthøj, Srila Gopal, Hanny Al-Samkari, Modupe Idowu, Jenny Despotovic, Spurthi Patil, Xiaoshu Dai, Abdullah Al Masud, Michael Callaghan, Fuad El Rassi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2496.
https://doi.org/10.1182/blood-2024-203509
Published: 2024
Journal Articles

Feasibility of Near-Infrared Spectroscopy for Monitoring Hemodynamic Changes in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, Julia Z Xu, Ingrid Frey, Kathryn Jaroszynski, Elise M. Berning, Anna Conrey, Ruth Pierre Charles, Brian Y Hill, Neal Jeffries, Swee Lay Thein, Bruce J. Tromberg
Journal: Blood
Blood (2022) 140 (Supplement 1): 2526–2527.
https://doi.org/10.1182/blood-2022-159559
Published: 2022
Journal Articles

The Pyruvate Kinase Activator Mitapivat Improves Red Blood Cell Deformability and Sickling Kinetics in Adult Patients with Sickle Cell Disease

Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (Supplement 1): 2508–2509.
https://doi.org/10.1182/blood-2022-170010
Published: 2022
Journal Articles

Inhibition of Hypoxia Inducible Factor Prolyl Hydroxylase By FG-4592 (Roxadustat) Increases Erythropoietic Stimulation in a Mouse Model of Sickle Cell Disease

Malini Sharma, Timothy Lequang, Brian J Philips, Fabliha A Chowdhury, Katherine C Wood, Adam C Straub, Julia Z Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 5391–5392.
https://doi.org/10.1182/blood-2022-164803
Published: 2022
Journal Articles

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Clinical Trials & Observations
Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A. Menapace, Laxminath Tumburu, Maureen Lundt, Timothy Lequang, Quan Li, Kristen Glass, Emily B. Dunkelberger, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William A. Eaton, Swee Lay Thein
Journal: Blood
Blood (2022) 140 (19): 2053–2062.
https://doi.org/10.1182/blood.2022015403
Published: 2022
Includes: Supplemental data
Journal Articles

Mitapivat (AG-348) Demonstrates Safety, Tolerability, and Improvements in Anemia, Hemolysis, Oxygen Affinity, and Hemoglobin S Polymerization Kinetics in Adults with Sickle Cell Disease: A Phase 1 Dose Escalation Study

Julia Z. Xu, Anna Conrey, Ingrid Frey, Eveline Gwaabe, Laurel A Menapace, Laxminath Tumburu, Maureen Lundt, Quan Li, Kristen Glass, Varsha Iyer, Heidi Mangus, Charles Kung, Lenny Dang, Penelope A. Kosinski, Peter Hawkins, Neal Jeffries, William Eaton, Swee Lay Thein
Journal: Blood
Blood (2021) 138 (Supplement 1): 10.
https://doi.org/10.1182/blood-2021-145398
Published: 2021
Journal Articles

Phase 1 Multiple Ascending Dose Study of Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Mitapivat (AG-348) in Subjects with Sickle Cell Disease

Julia Z. Xu, MDMS, Anna Conrey, NP, Ingrid Frey, RN, BSN, MS, James Nichols, RN, Laurel A Menapace, MD, Laxminath Tumburu, PhD, Timothy Lequang, MSc, Quan Li, PhD, Emily Dunkelberger, PhD, Eric Henry, PhD, Troy Cellmer, PhD, Varsha Iyer, Heidi Mangus, BS, Charles Kung, PhD, Lenny Dang, PhD, Penelope A. Kosinski, MS, Peter Hawkins, PhD, Neal Jeffries, PhD, William Eaton, MD, Swee Lay Thein, DSc, FRCP, MBBS, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137716
Published: 2020
Journal Articles

Quality Improvement Initiative: Improving Time to First Dose in a Sickle Cell Infusion Center

Foluso Joy Ogunsile, MD, Julia Z. Xu, MD MSc, Elizabeth Brown, Elizabeth Williams, BA, Sophie M. Lanzkron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3404.
https://doi.org/10.1182/blood-2019-131970
Published: 2019
Journal Articles

Identification of Optimal Thalassemia Screening Strategies for Migrant Populations in Thailand: A Mixed-Methods Approach

Julia Z. Xu, MD MSc, Meghan Foe, Wilaslak Tanongsaksakul, MD, Thidarat Suksangpleng, PhD, Supachai Ekwattanakit, PhDMD, Suchada Riolueang, MSc, Marilyn J. Telen, MD, Bonnie N. Kaiser, PhD, Vip Viprakasit, MD DPhil
Journal: Blood
Blood (2019) 134 (Supplement_1): 2112.
https://doi.org/10.1182/blood-2019-131805
Published: 2019
Journal Articles

International Multi-Site Clinical Validation of Point-of-Care Microchip Electrophoresis Test for Hemoglobin Variant Identification

Arwa Fraiwan, PhD, Muhammad Noman Hasan, MS, Ran An, PhD, Julia Z. Xu, MD MSc, Amy J. Rezac, Nicholas J. Kocmich, Tolulope Oginni, BS, Grace Mfon Olanipekun, Fatimah Hassan-Hanga, MD, Binta W. Jibir, MBBS MPH, Safiya Gambo, MBBS, Anil K. Verma, Praveen K. Bharti, Suchada Riolueang, MSc, Takdanai Ngimhung, Thidarat Suksangpleng, PhD, Priyaleela Thota, MD, Rajasubramaniam Shanmugam, PhD, Aparup Das, PhD, Vip Viprakasit, MD DPhil, Connie M. Piccone, MD, Jane A. Little, MD, Stephen K. Obaro, MD PhD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3373.
https://doi.org/10.1182/blood-2019-129336
Published: 2019
Journal Articles

Knowledge, Cultural, and Structural Barriers to Thalassemia Screening in Migrant Populations in Thailand

Julia Z. Xu, MD MScGH, Wilaslak Tanongsaksakul, MD, Thidarat Suksangpleng, PhD, Supachai Ekwattanakit, PhD MD, Suchada Riolueang, MSc, Bonnie N. Kaiser, PhD, Nathan M. Thielman, MD, Marilyn J. Telen, MD, Vip Viprakasit, MD DPhil
Journal: Blood
Blood (2018) 132 (Supplement 1): 2228.
https://doi.org/10.1182/blood-2018-99-114117
Published: 2018
Journal Articles

Factors Related to the Progression of Sickle Cell Disease Nephropathy

Julia Z. Xu, MD, Melanie E. Garrett, MS, Karen L. Soldano, BS, Sean T. Chen, Allison E. Ashley-Koch, PhD, Marilyn J. Telen, MD
Journal: Blood
Blood (2016) 128 (22): 9.
https://doi.org/10.1182/blood.V128.22.9.9
Published: 2016