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Journal Articles

Dual Activation of PKR and PKM2 Reduced the Development of Fibrosis and Iron Deposition in a Sickle Cell Disease Nephropathy Mouse Model

Trang Nguyen, Christy Ingersoll, Katie Lizotte, Chi-Chao Chen, Erin Tsai, Megan Wind-Rotolo, Hui Gao

Blood (2024) 144 (Supplement 1): 1107.

https://doi.org/10.1182/blood-2024-200634

Published: 2024

Journal Articles

Mitapivat-Induced Improvements in RBC Deformability and Membrane Integrity in Patients with Sickle Cell Disease Are Sustained during Extended Therapy

Xunde Wang, Yechan Cho, Nancy Asomaning, Maureen Lundt, Anna Conrey, Britney Kruah, Amber M Yates, Megan Wind-Rotolo, Haiou Li, Kang Le, Swee Lay Thein

Blood (2024) 144 (Supplement 1): 2491.

https://doi.org/10.1182/blood-2024-206051

Published: 2024

Journal Articles

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

Anna Conrey, Ingrid Frey, Nancy Asomaning, Ruth Pierre Charles, Dina Parekh, Julia Xu, Kang Le, Britney Kruah, Quan Li, Emily Dunkelberger, Troy Cellmer, Amber M Yates, Megan Wind-Rotolo, Neal Jeffries, William A Eaton, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 273.

https://doi.org/10.1182/blood-2023-180165

Published: 2023

Journal Articles

AG-946, an Activator of Pyruvate Kinase, Improves Ineffective Erythropoiesis in the Bone Marrow of Mouse Models of Myelodysplastic Syndromes

Alexandra Bunda, Hui Gao, Cecelia Burgwardt, Christy Ingersoll, Rohitash Jamwal, Lenny Dang, Megan Wind-Rotolo

Blood (2023) 142 (Supplement 1): 1854.

https://doi.org/10.1182/blood-2023-186197

Published: 2023

Journal Articles

Biochemical and Metabolomic Analysis of Glycolytic Activity in Red Blood Cells from Low-Risk Myelodysplastic Syndromes (LR-MDS) Patients and in-Vitro Effect of the Pyruvate Kinase Activator AG-946

Bruno Fattizzo, Cristina Vercellati, Anna Marcello, Parija Patel, Megan Wind-Rotolo, Loredana Pettine, Marcella Bonanomi, Daniela Gaglio, Claudia Leoni, Elisa Fermo, Paola Bianchi, Anna Zaninoni, Wilma Barcellini

Blood (2023) 142 (Supplement 1): 6456.

https://doi.org/10.1182/blood-2023-188316

Published: 2023

Journal Articles

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

Nancy Asomaning, Xunde Wang, Maureen Lundt, Britney Kruah, Mai Hill, Anna Conrey, Ruth Pierre Charles, Ingrid Frey, Megan Wind-Rotolo, Chris Huston, Neal Jeffries, Swee Lay Thein

Blood (2023) 142 (Supplement 1): 5262.

https://doi.org/10.1182/blood-2023-184834

Published: 2023

Journal Articles

The Pyruvate Kinase (PK) Activator AG-946 Improves PK Properties and Red Blood Cell (RBC) Characteristics upon Ex Vivo treatment of RBCs from Patients with Myelodysplastic Syndromes

Jonathan R.A. De Wilde, Titine J.J. Ruiter, Brigitte A. van Oirschot, Judith J.M. Jans, Lenny Dang, Megan Wind-Rotolo, Noortje Thielen, Wouter W. van Solinge, Anna van Rhenen, Richard van Wijk, Minke A.E. Rab

Blood (2023) 142 (Supplement 1): 3222.

https://doi.org/10.1182/blood-2023-185772

Published: 2023

Journal Articles

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model

Rohitash Jamwal, Lily C. Wain, Christopher Copeland, Penelope A. Kosinski, Megan Wind-Rotolo, Ilya Gertsman, William Eaton, David M Bodine, Lenny Dang, Swee Lay Thein

Blood (2022) 140 (Supplement 1): 950–951.

https://doi.org/10.1182/blood-2022-156591

Published: 2022

Journal Articles

A Phase 2a/2b Multicenter Study of AG-946 in Patients with Anemia Due to Lower-Risk Myelodysplastic Syndromes

Hanny Al-Samkari, Pierre Fenaux, Mikkael A. Sekeres, Eytan Stein, David A. Sallman, Andrew M. Brunner, Xiaoshu D. Gurov, Ophelia Yin, Meghan Frisbie, James Xiao, Joy Bhatia, Vanessa Beynon, Megan Wind-Rotolo, Melissa Dibacco, Uwe Platzbecker

Blood (2022) 140 (Supplement 1): 4076–4078.

https://doi.org/10.1182/blood-2022-168907

Published: 2022

NARROW

Dual Activation of PKR and PKM2 Reduced the Development of Fibrosis and Iron Deposition in a Sickle Cell Disease Nephropathy Mouse Model

Mitapivat-Induced Improvements in RBC Deformability and Membrane Integrity in Patients with Sickle Cell Disease Are Sustained during Extended Therapy

Long-Term Safety and Efficacy of Mitapivat, an Oral Pyruvate Kinase Activator, in Adults with Sickle Cell Disease: Extension of a Phase 1 Dose Escalation Study

AG-946, an Activator of Pyruvate Kinase, Improves Ineffective Erythropoiesis in the Bone Marrow of Mouse Models of Myelodysplastic Syndromes

Biochemical and Metabolomic Analysis of Glycolytic Activity in Red Blood Cells from Low-Risk Myelodysplastic Syndromes (LR-MDS) Patients and in-Vitro Effect of the Pyruvate Kinase Activator AG-946

Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters

The Pyruvate Kinase (PK) Activator AG-946 Improves PK Properties and Red Blood Cell (RBC) Characteristics upon Ex Vivo treatment of RBCs from Patients with Myelodysplastic Syndromes

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model

A Phase 2a/2b Multicenter Study of AG-946 in Patients with Anemia Due to Lower-Risk Myelodysplastic Syndromes

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American Society of Hematology

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American Society of Hematology

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