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Journal Articles

Iron Deficiency in HbSC Disease Is Associated with Less Sickle Cell Disease-Related Complications - a Rationale for Repetitive Phlebotomy As Disease Modifying Therapy

Marissa J.M. Traets, Aida Kidane, Jennifer Bos, Brigitte A. van Oirschot, Sigrid van der Veen, Mandy N. Lauw, Erfan Nur, Bart J. Biemond, Marjon H. Cnossen, Eduard J. Van Beers, Richard van Wijk, Minke A.E. Rab
Journal: Blood
Blood (2024) 144 (Supplement 1): 1112.
https://doi.org/10.1182/blood-2024-204666
Published: 2024
Journal Articles

Analysis of Red Blood Cells Oxidative Stress Susceptibility in Sickle Cell Disease Variants Using the Roxyscan

Carolina Andrea Hernandez, Richard van Wijk, Marissa J.M. Traets, Wouter W. van Solinge, Eduard J. Van Beers, Minke A.E. Rab, Anita W. Rijneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 5273.
https://doi.org/10.1182/blood-2024-204720
Published: 2024
Journal Articles

Ex Vivo G lucose Tracing in Red Blood Cells from Patients with Hereditary Xerocytosis Reveals Enhanced Glycolytic Flux

Titine J.J. Ruiter, Jonathan R.A. De Wilde, Brigitte A. van Oirschot, Wouter W. van Solinge, Minke A.E. Rab, Richard van Wijk, Judith J.M. Jans
Journal: Blood
Blood (2024) 144 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2024-199653
Published: 2024
Journal Articles

Satisfy: A Eurobloodnet Multicenter, Single-Arm Phase 2 Trial of Mitapivat in Adult Patients with Erythrocyte Membranopathies and Congenital Dyserythropoietic Anemia Type II - Results from the 8-Week Dose-Escalation Period

Thomas Doeven, Eduard J. Van Beers, Richard van Wijk, Evelyn Groot, Joline L Saes, Jennifer Bos, Jonathan R.A. De Wilde, Minke A.E. Rab, Selma K Bendtsen, Jesper Petersen, Niels G Vejlstrup, Jens Helby, Adeline Gladieux, Fatiha Chermat, Pierre Fenaux, Kevin H.M. Kuo, Andreas Glenthøj
Journal: Blood
Blood (2024) 144 (Supplement 1): 3831.
https://doi.org/10.1182/blood-2024-198359
Published: 2024
Journal Articles

Oxygen Gradient Ektacytometry Is Associated with Markers of Hemolysis and Inflammation in a Large Sickle Cell Disease Cohort within the GenoMed4ALL Project

Amira Idrizovic, Marissa J.M. Traets, Anna Collado Gimbert, Sara Reidel, Sigrid van der Veen, Anne-Laure Pham Hung D'Alexandry D'Orengiani, Mirco D'Agnolo, Emmanuel Adu, Mickael MARIN, Emmanuelle Bourdelier, Elisabetta Mezzalira, Betzabel Cajiao Garcia, Santiago Zazo, Tiziana Sanavia, Cesare Rollo, David Beneitez, Bart J. Biemond, Erfan Nur, Karin Fijnvandraat, Saskia EM Schols, Anita W. Rijneveld, Marjon H. Cnossen, Aida Kidane, Nicolas Hebert, Maria Paola Boaro, Slimane Allali, Caroline Le van kim, Anna Ruiz Llobet, Béatrice Gulbis, Federico Alvarez, Piero Fariselli, Petros Kountouris, Raffaella Colombatti, Pablo Bartolucci, Mariane De Montalembert, Richard van Wijk, Eduard J. Van Beers, Maria del Mar Mañú-Pereira, Minke A.E. Rab
Journal: Blood
Blood (2024) 144 (Supplement 1): 290.
https://doi.org/10.1182/blood-2024-200639
Published: 2024
Journal Articles

uRADAR: European Patients Referral Frame to Improve Access to New Drugs and Therapies in Ultra-Rare Anemia Disorders and Severe Hereditary Spherocytosis

Maria A. Rodríguez Sánchez, Anna Collado Gimbert, Sara Reidel, Patricia Aguilar-Martinez, Celeste Bento, Elena Cela, Laurence Dedeken, Emma Drasar, Frederic Galacteros, Andreas Glenthoej, Monika Horvathova, Pavla Koralkova, Andreas E. Kulozik, Joachim B. Kunz, Marta Morado-Arias, Ana Ortuno Cabrero, Dagmar Pospíšilová, Minke A.E. Rab, Noemi Roy, Eduard J. Van Beers, Richard van Wijk, Sarah Wambacq, Claire Diot, Victoria Gutiérrez Valle, Raquel Mosull del Campo, Stella Tamana, Raffaella Colombatti, Petros Kountouris, Béatrice Gulbis, Paola Bianchi, Maria del Mar Mañú-Pereira
Journal: Blood
Blood (2024) 144 (Supplement 1): 794.
https://doi.org/10.1182/blood-2024-201501
Published: 2024
Journal Articles

Safety and Efficacy of Mitapivat in Adult Patients with Erythrocyte Membranopathies (SATISFY)

Andreas Glenthoej, Eduard J. Van Beers, Richard van Wijk, Minke A.E. Rab, Evelyn Groot, Niels G Vejlstrup, Selma K Bendtsen, Nina Toft, Jesper Petersen, Jens Helby, Fatiha Chermat, Pierre Fenaux, Kevin H.M. Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 1085.
https://doi.org/10.1182/blood-2023-173147
Published: 2023
Journal Articles

Roxyscan: A Novel Method to Assess Red Blood Cell Resilience to Oxidative Stress in Sickle Cell Disease

Carolina A. Hernandez, Marissa J.M. Traets, Myrthe J. van Dijk, Wouter W. van Solinge, Frans A. Kuypers, Minke A.E. Rab, Eduard J. Van Beers, Richard van Wijk
Journal: Blood
Blood (2023) 142 (Supplement 1): 2497.
https://doi.org/10.1182/blood-2023-188676
Published: 2023
Journal Articles

Pyruvate Kinase Thermostability Is Associated with Red Blood Cell Adhesion, Deformability and Oxygen Affinity in Patients with Sickle Cell Disease

Marissa J.M. Traets, Sigrid van der Veen, Jennifer Bos, Laura van Pelt, Aida Kidane, Brigitte A. van Oirschot, Wouter W. van Solinge, Saskia Schols, Mandy N. Lauw, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Eduard J. Van Beers, Anita W. Rijneveld, Richard van Wijk, Minke A.E. Rab
Journal: Blood
Blood (2023) 142 (Supplement 1): 561.
https://doi.org/10.1182/blood-2023-180755
Published: 2023
Journal Articles

Red Blood Cell Pyruvate Kinase Properties in Sickle Cell Disease - of Mice and Men

Marissa J.M. Traets, Brigitte A. van Oirschot, Titine J.J. Ruiter, Charles Levine, Anita W. Rijneveld, Judith J.M. Jans, Minke A.E. Rab, Yu-Wei Chen, Richard van Wijk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1115.
https://doi.org/10.1182/blood-2023-173572
Published: 2023
Journal Articles

Novel Biomarkers for Assessing Clinical Severity in Hereditary Spherocytosis - Application of Routine and Advanced Diagnostic Tests

Jonathan R.A. De Wilde, Maryse E. Boesveld, Annelies J. van Vuren, Wouter W. van Solinge, Eduard J. Van Beers, Marije Bartels, Esmé Waanders, Minke A.E. Rab, Richard van Wijk
Journal: Blood
Blood (2023) 142 (Supplement 1): 2453.
https://doi.org/10.1182/blood-2023-189034
Published: 2023
Journal Articles

The Pyruvate Kinase (PK) Activator AG-946 Improves PK Properties and Red Blood Cell (RBC) Characteristics upon Ex Vivo treatment of RBCs from Patients with Myelodysplastic Syndromes

Jonathan R.A. De Wilde, Titine J.J. Ruiter, Brigitte A. van Oirschot, Judith J.M. Jans, Lenny Dang, Megan Wind-Rotolo, Noortje Thielen, Wouter W. van Solinge, Anna van Rhenen, Richard van Wijk, Minke A.E. Rab
Journal: Blood
Blood (2023) 142 (Supplement 1): 3222.
https://doi.org/10.1182/blood-2023-185772
Published: 2023
Journal Articles

One-Year Safety and Efficacy of Mitapivat in Sickle Cell Disease: Follow-up Results of a Phase 2, Open-Label Study

Myrthe J. van Dijk, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Judith J.M. Jans, Wouter W. van Solinge, Roger E.G. Schutgens, Richard van Wijk, Eduard J. Van Beers
Journal: Blood
Blood (2023) 142 (Supplement 1): 2515.
https://doi.org/10.1182/blood-2023-172829
Published: 2023
Journal Articles

In silico and Functional Studies for Classification of EPAS1/HIF2A Genetic Variants Identified in Patients with Erythrocytosis

Valéna Karaghiannis, Darko Maric, Céline Garrec, Nada Maaziz, Alexandre Buffet, Vincent Antunes, Amandine le Roy, Fabrice Airaud, Bernard Aral, Loic Schmitt, Sébastien Corbineau, Lamisse Mansour-Hendili, Valentine Lesieur, Antoine Rimbert, Fabien Laporte, Marine Delamare, Stephane Bezieau, Bruno Cassinat, Frédéric Galactéros, Anne-Paule Gimenez-Roqueplo, Nelly Burnichon, Holger Cario, Richard van Wijk, Celeste Bento, Anaise Blouet, Juliette Bouteloup, Françoise Boyer perrard, Aisha Aiko Bruce, Emilie Cayssials, Nicole Casadevall, Brieuc Cherel, Marielaure Couec, Louis Drevon, Cecile Dumesnil, Thierry Lamy De La Chapelle, Marion Gambart, Loic Garcon, Brigitte Granel, Pierre Hirsch, Agnès Lahary, Amira Mejri, Sandrine Meunier, Franck E. Nicolini, Emmanuel Raffoux, Dana Ranta, Nicolas Schleinitz, Jean Baptiste Valentin, Mathieu Wemeau, Francois Girodon, David Hoogewijs, Betty Gardie, Olivier Hermine
Journal: Blood
Blood (2022) 140 (Supplement 1): 8157–8158.
https://doi.org/10.1182/blood-2022-163123
Published: 2022
Journal Articles

Untargeted Metabolomics on Dried Blood Spots of Patients with Sickle Cell Disease Treated with the Pyruvate Kinase Activator Mitapivat

Myrthe J. van Dijk, Sigrid van der Veen, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Judith J.M. Jans, Richard van Wijk, Eduard J. van Beers
Journal: Blood
Blood (2022) 140 (Supplement 1): 21–23.
https://doi.org/10.1182/blood-2022-155997
Published: 2022
Journal Articles

An Endogenous Metabolic Modulator Composition Improves Hydration Status and Decreases Adhesion Properties of Red Blood Cells from Patients with Sickle Cell Disease

Myrthe J. van Dijk, Marissa J.M. Traets, Brigitte A. van Oirschot, Jonathan R.A. de Wilde, Jennifer Bos, Wouter W. van Solinge, Margaret J. Koziel, Revati Wani, Eduard J. van Beers, Richard van Wijk, Minke A.E. Rab
Journal: Blood
Blood (2022) 140 (Supplement 1): 8235–8237.
https://doi.org/10.1182/blood-2022-166177
Published: 2022
Journal Articles

Safety and Efficacy of Mitapivat (AG-348), an Oral Activator of Pyruvate Kinase R, in Subjects with Sickle Cell Disease: A Phase 2, Open-Label Study (ESTIMATE)

Myrthe J. van Dijk, Minke A.E. Rab, Anita W. Rijneveld, Erfan Nur, Marije Bartels, Judith J.M. Jans, Wouter W. van Solinge, Roger E.G. Schutgens, Richard van Wijk, Eduard J. Van Beers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2047.
https://doi.org/10.1182/blood-2021-150234
Published: 2021
Journal Articles

Use of Red Blood Cell Phenotypes for Second Line Therapy Selection in Sickle Cell Disease

Celeste K. Kanne, Ashwin P Patel, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Evelyn Kendall Williams, Meredith E. Fay, Kirby S. Fibben, Wilbur A. Lam, Richard van Wijk, Vivien A. Sheehan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2053.
https://doi.org/10.1182/blood-2021-153919
Published: 2021
Journal Articles

Pharmacodynamic Effects of AG-946, a Highly Potent Next-Generation Activator of Pyruvate Kinase, in Ex Vivo Treatment of Red Blood Cells from Sickle Cell Disease Patients

Minke A.E. Rab, Myrthe J. Van Dijk, Jennifer Bos, Brigitte A. van Oirschot, Johan Gerrits, Penelope A. Kosinski, Charles Kung, Judith J.M. Jans, Eduard J. Van Beers, Lenny Dang, Richard van Wijk
Journal: Blood
Blood (2021) 138 (Supplement 1): 2029.
https://doi.org/10.1182/blood-2021-145374
Published: 2021
Journal Articles

Ferritin Levels Do Not Reflect the Severity of Iron Overload in Diamond Blackfan Anemia

Jonathan de Wilde, Birgit van Dooijeweert, Elise Huisman, Frans Smiers, Eduard J. Van Beers, Wouter Van Solinge, Edward E.S. Nieuwenhuis, Richard van Wijk, Marije Bartels
Journal: Blood
Blood (2021) 138 (Supplement 1): 3078.
https://doi.org/10.1182/blood-2021-152730
Published: 2021