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Judith J.M. Jans
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Journal Articles

Ex Vivo G lucose Tracing in Red Blood Cells from Patients with Hereditary Xerocytosis Reveals Enhanced Glycolytic Flux

Titine J.J. Ruiter, Jonathan R.A. De Wilde, Brigitte A. van Oirschot, Wouter W. van Solinge, Minke A.E. Rab, Richard van Wijk, Judith J.M. Jans
Journal: Blood
Blood (2024) 144 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2024-199653
Published: 2024
Journal Articles

Red Blood Cell Pyruvate Kinase Properties in Sickle Cell Disease - of Mice and Men

Marissa J.M. Traets, Brigitte A. van Oirschot, Titine J.J. Ruiter, Charles Levine, Anita W. Rijneveld, Judith J.M. Jans, Minke A.E. Rab, Yu-Wei Chen, Richard van Wijk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1115.
https://doi.org/10.1182/blood-2023-173572
Published: 2023
Journal Articles

One-Year Safety and Efficacy of Mitapivat in Sickle Cell Disease: Follow-up Results of a Phase 2, Open-Label Study

Myrthe J. van Dijk, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Judith J.M. Jans, Wouter W. van Solinge, Roger E.G. Schutgens, Richard van Wijk, Eduard J. Van Beers
Journal: Blood
Blood (2023) 142 (Supplement 1): 2515.
https://doi.org/10.1182/blood-2023-172829
Published: 2023
Journal Articles

The Pyruvate Kinase (PK) Activator AG-946 Improves PK Properties and Red Blood Cell (RBC) Characteristics upon Ex Vivo treatment of RBCs from Patients with Myelodysplastic Syndromes

Jonathan R.A. De Wilde, Titine J.J. Ruiter, Brigitte A. van Oirschot, Judith J.M. Jans, Lenny Dang, Megan Wind-Rotolo, Noortje Thielen, Wouter W. van Solinge, Anna van Rhenen, Richard van Wijk, Minke A.E. Rab
Journal: Blood
Blood (2023) 142 (Supplement 1): 3222.
https://doi.org/10.1182/blood-2023-185772
Published: 2023
Journal Articles

Untargeted Metabolomics on Dried Blood Spots of Patients with Sickle Cell Disease Treated with the Pyruvate Kinase Activator Mitapivat

Myrthe J. van Dijk, Sigrid van der Veen, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Judith J.M. Jans, Richard van Wijk, Eduard J. van Beers
Journal: Blood
Blood (2022) 140 (Supplement 1): 21–23.
https://doi.org/10.1182/blood-2022-155997
Published: 2022
Journal Articles

Pharmacodynamic Effects of AG-946, a Highly Potent Next-Generation Activator of Pyruvate Kinase, in Ex Vivo Treatment of Red Blood Cells from Sickle Cell Disease Patients

Minke A.E. Rab, Myrthe J. Van Dijk, Jennifer Bos, Brigitte A. van Oirschot, Johan Gerrits, Penelope A. Kosinski, Charles Kung, Judith J.M. Jans, Eduard J. Van Beers, Lenny Dang, Richard van Wijk
Journal: Blood
Blood (2021) 138 (Supplement 1): 2029.
https://doi.org/10.1182/blood-2021-145374
Published: 2021
Journal Articles

Safety and Efficacy of Mitapivat (AG-348), an Oral Activator of Pyruvate Kinase R, in Subjects with Sickle Cell Disease: A Phase 2, Open-Label Study (ESTIMATE)

Myrthe J. van Dijk, Minke A.E. Rab, Anita W. Rijneveld, Erfan Nur, Marije Bartels, Judith J.M. Jans, Wouter W. van Solinge, Roger E.G. Schutgens, Richard van Wijk, Eduard J. Van Beers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2047.
https://doi.org/10.1182/blood-2021-150234
Published: 2021