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Vanessa Beynon
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Journal Articles

A Phase 2B, Open-Label Multicenter Study of Tebapivat (AG-946), a Potent Pyruvate Kinase Activator, in Patients with Anemia Due to Lower-Risk Myelodysplastic Syndromes

Amer M. Zeidan, Mikkael A. Sekeres, Hanny Al-Samkari, Hetty E. Carraway, Amy E. DeZern, Moshe Mittelman, Meredith Little, Vanessa Beynon, Xiaoshu Dai, Sal Sommakia, Jenny M. Despotovic, Parija Patel, Melissa Dibacco, Bruno Fattizzo, Eytan M. Stein, David Sallman, Austin G. Kulasekararaj, Uwe Platzbecker, Pierre Fenaux
Journal: Blood
Blood (2024) 144 (Supplement 1): 6708.
https://doi.org/10.1182/blood-2024-203073
Published: 2024
Journal Articles

Mitapivat Improves Iron Overload in Patients with Pyruvate Kinase Deficiency

Eduard J. van Beers, Hanny Al-Samkari, Rachael F. Grace, Wilma Barcellini, Andreas Glenthøj, Melissa Dibacco, Penelope A. Kosinski, Emily Xu, Vanessa Beynon, Parija Patel, John B. Porter, Kevin H.M. Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 2460–2462.
https://doi.org/10.1182/blood-2022-169098
Published: 2022
Journal Articles

Long-Term Improvements in Patient-Reported Outcomes in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat

Kevin H.M. Kuo, Rachael F. Grace, Eduard J. van Beers, Wilma Barcellini, Andreas Glenthøj, Susanne Holzhauer, Parija Patel, Vanessa Beynon, Junlong Li, Erin Zagadailov, Hanny Al-Samkari
Journal: Blood
Blood (2022) 140 (Supplement 1): 1223–1225.
https://doi.org/10.1182/blood-2022-168954
Published: 2022
Journal Articles

A Phase 2a/2b Multicenter Study of AG-946 in Patients with Anemia Due to Lower-Risk Myelodysplastic Syndromes

Hanny Al-Samkari, Pierre Fenaux, Mikkael A. Sekeres, Eytan Stein, David A. Sallman, Andrew M. Brunner, Xiaoshu D. Gurov, Ophelia Yin, Meghan Frisbie, James Xiao, Joy Bhatia, Vanessa Beynon, Megan Wind-Rotolo, Melissa Dibacco, Uwe Platzbecker
Journal: Blood
Blood (2022) 140 (Supplement 1): 4076–4078.
https://doi.org/10.1182/blood-2022-168907
Published: 2022
Journal Articles

Mitapivat Improves Markers of Hemolysis and Erythropoiesis in Patients with Pyruvate Kinase Deficiency Irrespective of Hemoglobin Response

Hanny Al-Samkari, Rachael F. Grace, Eduard J. van Beers, Feng Tai, Jaime Morales-Arias, Vanessa Beynon, Andreas Glenthøj
Journal: Blood
Blood (2022) 140 (Supplement 1): 8159–8160.
https://doi.org/10.1182/blood-2022-167147
Published: 2022
Journal Articles

ACTIVATE-Kids: Mitapivat in Children with Pyruvate Kinase Deficiency Who Are Not Regularly Transfused

Rachael F. Grace, Patrick D. Tyler, Erin Larcom, Penelope A. Kosinski, Vanessa Beynon
Journal: Blood
Blood (2022) 140 (Supplement 1): 5331–5332.
https://doi.org/10.1182/blood-2022-168652
Published: 2022
Journal Articles

ACTIVATE-KidsT: Mitapivat in Children with Pyruvate Kinase Deficiency Who Are Regularly Transfused

Rachael F. Grace, Patrick D. Tyler, Meredith Little, Penelope A. Kosinski, Vanessa Beynon
Journal: Blood
Blood (2022) 140 (Supplement 1): 5319–5320.
https://doi.org/10.1182/blood-2022-167452
Published: 2022
Journal Articles

Long-Term Hemoglobin Response and Reduction in Transfusion Burden Are Maintained in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat

Rachael F. Grace, Andreas Glenthøj, Wilma Barcellini, Madeleine Verhovsek, Jennifer A. Rothman, Marta Morado, D. Mark Layton, Oliver Andres, Frédéric Galactéros, Eduard J. van Beers, Koichi Onodera, Vip Viprakasit, Satheesh Chonat, Malia P. Judge, Penelope A. Kosinski, Peter Hawkins, Sarah Gheuens, Emily Xu, Bryan McGee, Vanessa Beynon, Hanny Al-Samkari
Journal: Blood
Blood (2022) 140 (Supplement 1): 5313–5315.
https://doi.org/10.1182/blood-2022-169125
Published: 2022
Journal Articles

Mitapivat Improves Ineffective Erythropoiesis and Reduces Iron Overload in Patients with Pyruvate Kinase Deficiency

Eduard J. Van Beers, Hanny Al-Samkari, Rachael F. Grace, Wilma Barcellini, Andreas Glenthoej, Malia P. Judge, Penelope A. Kosinski, Emily Xu, Vanessa Beynon, Bryan McGee, John B. Porter, Kevin H.M. Kuo
Journal: Blood
Blood (2021) 138 (Supplement 1): 2005.
https://doi.org/10.1182/blood-2021-147317
Published: 2021
Journal Articles

Durability of Hemoglobin Response and Reduction in Transfusion Burden Is Maintained over Time in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat in a Long-Term Extension Study

Rachael F. Grace, Andreas Glenthoej, Wilma Barcellini, Madeleine Verhovsek, Jennifer A. Rothman, Marta Morado, D. Mark Layton, Oliver Andres, Frédéric Galactéros, Eduard J. Van Beers, Koichi Onodera, Vip Viprakasit, Satheesh Chonat, John B. Porter, Malia P. Judge, Penelope A. Kosinski, Peter Hawkins, Sarah Gheuens, Emily Xu, Bryan McGee, Vanessa Beynon, Hanny Al-Samkari
Journal: Blood
Blood (2021) 138 (Supplement 1): 848.
https://doi.org/10.1182/blood-2021-147711
Published: 2021