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Journal Articles

RUX-AZA Response in AP/BP-MPN Is Driven By Release of the Differentiation Block in Mutant HSPCs: A Single-Cell Multi-Omic Analysis of Responders on the Phase Ib Phazar Study

Charlotte K Brierley, Charlotte Gaskell, Claire Harrison, Christina Yap, Aimee Jackson, Jennifer Byrne, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Alba Rodriguez-Meira, Lauren Murphy, Fiona Jane Clarke, Srinivasan Narayanan, David T. Bowen, Emma Gudgin, Dragana Milojkovic, Rebecca Collings, Bethan Psaila, Steve Knapper, Mark W. Drummond, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 3146.
https://doi.org/10.1182/blood-2024-204818
Published: 2024
Journal Articles

Somatic Mutations and DNA Hypermethylation at Enhancers and Promoters Identify Distinct Subtypes within Lower-Risk Myelodysplastic Syndromes

David Rombaut, Tobias Tekath, Sarah Sandmann, Simon Crouch, Aniek O. de Graaf, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson, Bert A. Van der Reijden, Sophie Park, Maud D'Aveni, Bohrane Slama, Emmanuelle Clappier, Pierre Fenaux, Lionel Ades, Arjan A. van de Loosdrecht, Saskia MC Langemeijer, Argiris S. Symeonidis, Jaroslav Čermák, Claude Preudhomme, Aleksandar Savic, Ulrich Germing, Reinhard Stauder, David T. Bowen, Corine J. Van Marrewijk, Elsa Bernard, Alexandra Smith, Daniel Painter, Theo J.M. de Witte, Eva Hellstrom Lindberg, Julian Varghese, Martin Dugas, Joost H.A. Martens, Luca Malcovati, Joop H. Jansen, Michaela Fontenay
Journal: Blood
Blood (2023) 142 (Supplement 1): 4587.
https://doi.org/10.1182/blood-2023-180071
Published: 2023
Journal Articles

Novel somatic mutations in UBA1 as a cause of VEXAS syndrome

James A. Poulter, Jason C. Collins, Catherine Cargo, Ruth M. De Tute, Paul Evans, Daniela Ospina Cardona, David T. Bowen, Joanna R. Cunnington, Elaine Baguley, Mark Quinn, Michael Green, Dennis McGonagle, David B. Beck, Achim Werner, Sinisa Savic
Journal: Blood
Blood (2021) 137 (26): 3676–3681.
https://doi.org/10.1182/blood.2020010286
Published: 2021
Includes: Supplemental data
Journal Articles

SF3B1 -mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS

Clinical Trials & Observations
Luca Malcovati, Kristen Stevenson, Elli Papaemmanuil, Donna Neuberg, Rafael Bejar, Jacqueline Boultwood, David T. Bowen, Peter J. Campbell, Benjamin L. Ebert, Pierre Fenaux, Torsten Haferlach, Michael Heuser, Joop H. Jansen, Rami S. Komrokji, Jaroslaw P. Maciejewski, Matthew J. Walter, Michaela Fontenay, Guillermo Garcia-Manero, Timothy A. Graubert, Aly Karsan, Manja Meggendorfer, Andrea Pellagatti, David A. Sallman, Michael R. Savona, Mikkael A. Sekeres, David P. Steensma, Sudhir Tauro, Felicitas Thol, Paresh Vyas, Arjan A. Van de Loosdrecht, Detlef Haase, Heinz Tüchler, Peter L. Greenberg, Seishi Ogawa, Eva Hellstrom-Lindberg, Mario Cazzola
Journal: Blood
Blood (2020) 136 (2): 157–170.
https://doi.org/10.1182/blood.2020004850
Published: 2020
Journal Articles

Impact of Red Blood Cell Transfusion Intensity on Progression-Free Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS Registry

Louise De Swart, MD, Simon Crouch, MSc, PhD, Marlijn Hoeks, MD, Alex Smith, PhD, Saskia Langemeijer, MD PhD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Reinhard Stauder, MD, Moshe Mittelman, MD, Guillermo Sanz, MD, Eva Hellstrom-Lindberg, MD PhD, Luca Malcovati, MD, Mette Skov Holm, MD PhD, Ulrich Germing, MD, Krzysztof Madry, MD PhD, Antonio Medina de Almeida, MD PhD, Aurelia Tatic, MD, Aleksandar Savic, Njetočka Gredelj-Šimec, MD, Agnes Guerci Bresler, Dominic Culligan, MD, Raphael Itzykson, MD PhD, Odile Beyne-Rauzy, MD, Sophie Park, MD PhD, Corine van Marrewijk, PhD, Nicole M A Blijlevens, David T. Bowen, MD, T. M. de Witte, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1690.
https://doi.org/10.1182/blood.V130.Suppl_1.1690.1690
Published: 2017
Journal Articles

The Impact of Diabetes Mellitus As Comorbid Condition, in Patients with Lower-Risk Myelodysplastic Syndromes (MDS)— a Study of the European Leukemianet-Based MDS (EUMDS) Registry

Argiris Symeonidis, MD PhD, Ge Yu, PhD, Alexandra Smith, PhD, Pierre Fenaux, MD PhD, Moshe Mittelman, MD, Reinhard Stauder, MD, Guillermo Sanz, MD, Jaroslav Cermak, MD PhD, Eva Hellstrom-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Krzysztof Madry, MD PhD, Mette Skov Holm, MD PhD, Aurelia Tatic, MD, Antonio Medina de Almeida, MD PhD, Aleksandar Savic, MD PhD, Njetocka Gredelj Simec, Agnes Guerci-Bresler, Jackie Droste, PhD, T. M. M de Witte, MD PhD, David T. Bowen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4264.
https://doi.org/10.1182/blood.V130.Suppl_1.4264.4264
Published: 2017
Journal Articles

Impact of Treatment with Iron Chelation Therapy in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Marlijn Hoeks, MD, Ge Yu, MSc., Saskia Langemeijer, MD PhD, Simon Crouch, MSc, PhD, Louise De Swart, MD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Eva Hellstrom-Lindberg, MD PhD, Guillermo Sanz, MD, Reinhard Stauder, MD, Mette skov-Holm, Moshe Mittelman, MD, Krzysztof Madry, MD PhD, Luca Malcovati, MD, Aurelia Tatic, MD, Antonio Medina de Almeida, MD PhD, Ulrich Germing, MD, Aleksandar Savic, MD PhD, Njetočka Gredelj-Šimec, MD, Dominic Culligan, MD, Raphael Itzykson, MD PhD, Agnes Guerci-Bresler, Borhane Slama, MD, Corine van Marrewijk, PhD, Jackie Droste, PhD, Marian van Kraaij, MD PhD, David T. Bowen, MD, T. M. M de Witte, MD PhD, Alex Smith, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 425.
https://doi.org/10.1182/blood.V130.Suppl_1.425.425
Published: 2017
Journal Articles

Can We Diagnose MDS without Bone Marrow Examination? a Proposed EUMDS-Based Non-Invasive Diagnostic Model

Howard S. Oster, MD PhD, Bander Abu Shrkihe, MD, Simon Crouch, MSc, PhD, Alexandra Smith, PhD, Ge Yu, PhD, Gal Carmi, MD, Jonathan Ben-Ezra, MD, Shachar Naor, MD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Reinhard Stauder, MD, Jaroslav Cermak, MD PhD, Guillermo Sanz, MD, Eva Hellstrom-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Mette Skov Holm, MD PhD, Krzysztof Madry, MD PhD, Aurelia Tatic, MD, Antonio Medina de Almeida, MD PhD, Aleksandar Savic, MD PhD, Njetočka Gredelj-Šimec, MD, Agnes Guerci Bresler, Corine van Marrewijk, PhD, David T. Bowen, MD, T. M. M de Witte, MD PhD, Moshe Mittelman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2975.
https://doi.org/10.1182/blood.V130.Suppl_1.2975.2975
Published: 2017
Journal Articles

A Prognostic Classifier Based on Early Platelet Drop in Lower-Risk MDS. a Study from the European Leukemianet Lower-Risk MDS (EUMDS) Registry

Raphael Itzykson, MD PhD, Simon Crouch, MSc, PhD, Alex Smith, PhD, Argiris Symeonidis, MD PhD, Eva Hellstrom-Lindberg, MD PhD, Guillermo Sanz, MD, Jaroslav Cermak, MD PhD, Reinhard Stauder, MD, Luca Malcovati, MD, Ulrich Germing, MD, Moshe Mittelman, MD, Saskia Langemeijer, MD PhD, Krzysztof Madry, MD PhD, Aurelia Tatic, MD, Mette Skov Holm, MD PhD, Antonio Medina de Almeida, MD PhD, Aleksandar Savic, MD PhD, Njetočka Gredelj-Šimec, MD, Elisa Luño Fernandez, MD, Dominic Culligan, MD, Agnes Guerci Bresler, Corine van Marrewijk, PhD, David T. Bowen, MD, T. M. M de Witte, MD PhD, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 158.
https://doi.org/10.1182/blood.V130.Suppl_1.158.158
Published: 2017
Journal Articles

Targeted sequencing identifies patients with preclinical MDS at high risk of disease progression

Clinical Trials & Observations Brief Report
Catherine A. Cargo, Nicola Rowbotham, Paul A. Evans, Sharon L. Barrans, David T. Bowen, Simon Crouch, Andrew S. Jack
Journal: Blood
Blood (2015) 126 (21): 2362–2365.
https://doi.org/10.1182/blood-2015-08-663237
Published: 2015
Includes: Supplemental data
Journal Articles

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Luca Malcovati, Elli Papaemmanuil, David T. Bowen, Jacqueline Boultwood, Matteo G. Della Porta, Cristiana Pascutto, Erica Travaglino, Michael J. Groves, Anna L. Godfrey, Ilaria Ambaglio, Anna Gallì, Matteo C. Da Vià, Simona Conte, Sudhir Tauro, Norene Keenan, Ann Hyslop, Jonathan Hinton, Laura J. Mudie, James S. Wainscoat, P. Andrew Futreal, Michael R. Stratton, Peter J. Campbell, Eva Hellström-Lindberg, Mario Cazzola, on behalf of the Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium and of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative
Journal: Blood
Blood (2011) 118 (24): 6239–6246.
https://doi.org/10.1182/blood-2011-09-377275
Published: 2011
Includes: Supplemental data
Journal Articles

European Registry for Low Risk and Intermediate-1 Risk MDS: Base Line Report On First 400 Registered Patients.

T. M. de Witte, Alex Smith, Jackie Droste, Pierre Fenaux, Argyris Symeonidis, Eva Hellstrom-Lindberg, MD, PhD, Guillermo Sanz, Jaroslav Cermak, Otilia Georgescu, Ulrich Germing, Marius MacKenzie, Reinhard Stauder, MD, Odile Beyne Rauzy, David T. Bowen, MD
Journal: Blood
Blood (2009) 114 (22): 3811.
https://doi.org/10.1182/blood.V114.22.3811.3811
Published: 2009
Journal Articles

Low Dose Ara-C Versus Low Dose Ara-C and Arsenic Trioxide: the UK NCRI AML16 “Pick a Winner” Comparison.

Nigel H. Russell, MD, Robert K Hills, Ann E. Hunter, MBBS, FRCP, FRCPath, Donald Milligan, MD, MBChB, William J. Kell, MD, MB, Keith Wheatley, DPhil, Mary Frances McMullin, John AL Yin, David T. Bowen, MD, A. Burnett, MD, FRCP
Journal: Blood
Blood (2009) 114 (22): 486.
https://doi.org/10.1182/blood.V114.22.486.486
Published: 2009
Journal Articles

Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome

Ken I. Mills, Alexander Kohlmann, P. Mickey Williams, Lothar Wieczorek, Wei-min Liu, Rachel Li, Wen Wei, David T. Bowen, Helmut Loeffler, Jesus M. Hernandez, Wolf-Karsten Hofmann, Torsten Haferlach
Journal: Blood
Blood (2009) 114 (5): 1063–1072.
https://doi.org/10.1182/blood-2008-10-187203
Published: 2009
Includes: Supplemental data
Journal Articles

Microarray Classification of Myelodysplastic Syndrome (MDS) Identifies Subgroups with Distinct Clinical Outcomes.

Ken I. Mills, PhD, Alex Kohlmann, Ph.D., Mickey Williams, Ph.D., Wei-Min Liu, Ph.D., Rachel Li, David T. Bowen, M.D., Helmut Loeffler, M.D., Jesus M. Hernandez, M.D., Wolf-Karsten Hofmann, M.D., Torsten Haferlach, M.D., Lothar Wieczirek, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 2426.
https://doi.org/10.1182/blood.V110.11.2426.2426
Published: 2007
Journal Articles

Rimcazole - A Sigma Receptor Antagonist - As a Potential Novel Therapy for Acute Myeloid Leukemia and Myeloma.

Yogesh Upadhye, MRCP, Stephen Watt, Ph.D, Barbara A. Spruce, MRCP, Ph.D, David T. Bowen, FRCP, MD
Journal: Blood
Blood (2005) 106 (11): 2486.
https://doi.org/10.1182/blood.V106.11.2486.2486
Published: 2005
Journal Articles

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

Clinical Trials & Observations
David T. Bowen, Marion E. Frew, Robert Hills, Rosemary E. Gale, Keith Wheatley, Michael J. Groves, Stephen E. Langabeer, Panagiotis D. Kottaridis, Anthony V. Moorman, Alan K. Burnett, David C. Linch
Journal: Blood
Blood (2005) 106 (6): 2113–2119.
https://doi.org/10.1182/blood-2005-03-0867
Published: 2005
Journal Articles

Promoter Methylation of RASSFIA , SHP1 and SOCS1 Genes in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS).

M. Farid Johan, Anne C. Goodeve, David T. Bowen, John T. Reilly
Journal: Blood
Blood (2004) 104 (11): 2999.
https://doi.org/10.1182/blood.V104.11.2999.2999
Published: 2004
Journal Articles

Quality of Life and Economic Impact of Red Blood Cell (RBC) Transfusions on Patients with Myelodysplastic Syndromes (MDS).

S. Brechignac, E. Hellstrom-Lindberg, D. T. Bowen, T. M. DeWitte, M. Cazzola, P. Fenaux
Journal: Blood
Blood (2004) 104 (11): 4716.
https://doi.org/10.1182/blood.V104.11.4716.4716
Published: 2004
Journal Articles

Trisenox® (arsenic trioxide) in Patients with Myelodysplastic Syndromes (MDS): Preliminary Results of a Phase I/II Study.

Norbert Vey, MD, Francois Dreyfus, MD, Agnes Guerci, MD, Pierre Fenaux, MD, Herve Dombret, MD, Alan K. Burnett, MD, Andre Bosly, MD, Walter Feremans, MD, David T. Bowen, MD, Marja Heiskala, MD
Journal: Blood
Blood (2004) 104 (11): 1433.
https://doi.org/10.1182/blood.V104.11.1433.1433
Published: 2004