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Journal Articles

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Ernesto Diaz-Flores, PhD, Evan Q. Comeaux, PhD, Kailyn Kim, Kyle Beckman, BS, Kara L. Davis, DO, Kevin Wu, Jon Akutagawa, Linda Holmfeldt, PhD, Benjamin S. Braun, MD PhD, Charles Mullighan, MBBS, MSc, MD, Mignon L. Loh, MD

Blood (2016) 128 (22): 280.

https://doi.org/10.1182/blood.V128.22.280.280

Published: 2016

Journal Articles

Negative Feedback By Dusp6 Modulates Myeloproliferation Induced By Oncogenic Nras

Charisa Cottonham, PhD, Jon Akutagawa, Inbal Epstein, Lana Bogdanova, Benjamin S. Braun, MD PhD

Blood (2015) 126 (23): 1256.

https://doi.org/10.1182/blood.V126.23.1256.1256

Published: 2015

Journal Articles

Inhibition of Akt Signaling Alleviates MDS/MPN Driven By Kras D12 or Nf1 Loss

Tannie Huang, MD, Jon Akutagawa, Inbal Epstein, Charisa Cottonham, PhD, Maricel Quirindongo-Crespo, Benjamin S. Braun, MD PhD

Blood (2015) 126 (23): 360.

https://doi.org/10.1182/blood.V126.23.360.360

Published: 2015

Journal Articles

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia

Elliot Stieglitz, Camille B. Troup, Laura C. Gelston, John Haliburton, Eric D. Chow, Kristie B. Yu, Jon Akutagawa, Amaro N. Taylor-Weiner, Y. Lucy Liu, Yong-Dong Wang, Kyle Beckman, Peter D. Emanuel, Benjamin S. Braun, Adam Abate, Robert B. Gerbing, Todd A. Alonzo, Mignon L. Loh

Blood (2015) 125 (3): 516–524.

https://doi.org/10.1182/blood-2014-09-601690

Published: 2015

Includes: Supplemental data

Journal Articles

Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia

Elliot Stieglitz, MD, Camille B Troup, PhD, Laura C Gelston, ScM, Eric D Chow, PhD, Kristie B Yu, Jon Akutagawa, BS, Amaro N Taylor-Weiner, BS, Y. Lucy Liu, MD PhD, Peter D Emanuel, MD, Benjamin S Braun, MD PhD, Robert B. Gerbing, MA, Todd A. Alonzo, PhD, Mignon L. Loh, MD

Blood (2014) 124 (21): 410.

https://doi.org/10.1182/blood.V124.21.410.410

Published: 2014

Journal Articles

Feedback Through Dusp6 Modulates Ineffective Erythropoiesis Caused By Mutant Kras

Charisa Cottonham, Ph.D., Roeltje R. Maas, Benjamin S. Braun, MD, PhD

Blood (2013) 122 (21): 750.

https://doi.org/10.1182/blood.V122.21.750.750

Published: 2013

Journal Articles

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Jon Akutagawa, B.S., Monique Dail, PhD, Lori S Friedman, PhD, Kevin M. Shannon, MD, Deepak Sampath, PhD, Benjamin S. Braun, MD, PhD

Blood (2012) 120 (21): 2862.

https://doi.org/10.1182/blood.V120.21.2862.2862

Published: 2012

Journal Articles

An In Vitro Library Screen to Rapidly Determine Activity Against Normal and Mutant Bone Marrow Progenitor Cells

Wan Xing Hong, M.S., B.A., Steven Chen, B.S., Jon Akutagawa, B.S., Michelle Arkin, PhD, Benjamin S. Braun, MD, PhD

Blood (2012) 120 (21): 4916.

https://doi.org/10.1182/blood.V120.21.4916.4916

Published: 2012

Journal Articles

Targeting oncogenic Ras signaling in hematologic malignancies

Ashley F. Ward, Benjamin S. Braun, Kevin M. Shannon

Blood (2012) 120 (17): 3397–3406.

https://doi.org/10.1182/blood-2012-05-378596

Published: 2012

Includes: Supplemental data

Journal Articles

KIT's ship comes in

Benjamin S. Braun

Blood (2012) 120 (13): 2541–2542.

https://doi.org/10.1182/blood-2012-08-445247

Published: 2012

Journal Articles

MEK Inhibition Modulates the Growth of Nf1 mutant Hematopoietic Cells and Induces Clinical Improvement in a Murine Model of Juvenile Myelomonocytic Leukemia (JMML)

Tiffany Y. Chang, MD, Kimberly Krisman, BA, Emily Rose Harding-Theobald, BA, Benjamin S. Braun, MD, PhD, Kevin M. Shannon, MD

Blood (2011) 118 (21): 797.

https://doi.org/10.1182/blood.V118.21.797.797

Published: 2011

Journal Articles

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Gordon Chan, Laurene S. Cheung, Wentian Yang, Michael Milyavsky, Ashley D. Sanders, Shengqing Gu, Wan Xing Hong, Aurora X. Liu, Xiaonan Wang, Mary Barbara, Tarun Sharma, Joehleen Gavin, Jeffery L. Kutok, Norman N. Iscove, Kevin M. Shannon, John E. Dick, Benjamin G. Neel, Benjamin S. Braun

Blood (2011) 117 (16): 4253–4261.

https://doi.org/10.1182/blood-2010-11-319517

Published: 2011

Includes: Supplemental data

Journal Articles

Hematopoiesis and leukemogenesis in mice expressing oncogenic Nras G12D from the endogenous locus

Qing Li, Kevin M. Haigis, Andrew McDaniel, Emily Harding-Theobald, Scott C. Kogan, Keiko Akagi, Jasmine C. Y. Wong, Benjamin S. Braun, Linda Wolff, Tyler Jacks, Kevin Shannon

Blood (2011) 117 (6): 2022–2032.

https://doi.org/10.1182/blood-2010-04-280750

Published: 2011

Includes: Supplemental data

Journal Articles

Treatment with a MEK Inhibitor Improves Myeloproliferation, Anemia and Survival in a Mouse Model of CMML and JMML.

Natalya Lyubynska, Jennifer Lauchle, MD, Kevin Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2009) 114 (22): 966.

https://doi.org/10.1182/blood.V114.22.966.966

Published: 2009

Journal Articles

PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.

Ernesto Diaz-Flores, PhD, Hana Leah Goldschmidt, BA, Philippe Depeille, Ph.D, Victor Ng, BA, Jeroen Roose, Assistant, Professor, Kevan Shokat, Ph.D., Benjamin S. Braun, MD, PhD, Kevin Shannon, MD

Blood (2009) 114 (22): 2512.

https://doi.org/10.1182/blood.V114.22.2512.2512

Published: 2009

Journal Articles

Germline Mutations in CBL Cause a Predisposition to Juvenile Myelomonocytic Leukemia.

Blood (2009) 114 (22): 310.

https://doi.org/10.1182/blood.V114.22.310.310

Published: 2009

Journal Articles

Intracellular Signals as Molecular Biomarkers for Therapeutic Responses in Kras Mutant Myeloid Cells.

Ernesto Diaz-Flores, PhD, Margaret VanMeter, BS, Jennifer O. Lauchle, M.D., Benjamin S. Braun, M.D.-Ph.D, Kevin M. Shannon, M.D.

Blood (2007) 110 (11): 2196.

https://doi.org/10.1182/blood.V110.11.2196.2196

Published: 2007

Journal Articles

A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.

Benjamin S. Braun, MD, PhD, Laurene S. Cheung, Gordon G. Chan, PhD, Wentian A. Yang, PhD, Joehleen A. Archard, Benjamin G. Neel, MD, PhD, Kevin Shannon, MD

Blood (2007) 110 (11): 85.

https://doi.org/10.1182/blood.V110.11.85.85

Published: 2007

Journal Articles

Leukemogenic K-Ras G12D Induces Cell Cycle Entry and Clonal Dominance in Hematopoietic Stem Cells.

Amit J. Sabnis, MS, Laurene S. Cheung, BA, Kevin Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2007) 110 (11): 778.

https://doi.org/10.1182/blood.V110.11.778.778

Published: 2007

Journal Articles

K-Ras G12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

Margaret E. M. Van Meter, Ernesto Díaz-Flores, Joehleen A. Archard, Emmanuelle Passegué, Jonathan M. Irish, Nikesh Kotecha, Garry P. Nolan, Kevin Shannon, Benjamin S. Braun

Blood (2006) 109 (9): 3945–3952.

https://doi.org/10.1182/blood-2006-09-047530

Published: 2006

Includes: Supplemental data

NARROW

BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia

Negative Feedback By Dusp6 Modulates Myeloproliferation Induced By Oncogenic Nras

Inhibition of Akt Signaling Alleviates MDS/MPN Driven By Kras D12 or Nf1 Loss

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia

Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia

Feedback Through Dusp6 Modulates Ineffective Erythropoiesis Caused By Mutant Kras

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

An In Vitro Library Screen to Rapidly Determine Activity Against Normal and Mutant Bone Marrow Progenitor Cells

Targeting oncogenic Ras signaling in hematologic malignancies

KIT's ship comes in

MEK Inhibition Modulates the Growth of Nf1 mutant Hematopoietic Cells and Induces Clinical Improvement in a Murine Model of Juvenile Myelomonocytic Leukemia (JMML)

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Hematopoiesis and leukemogenesis in mice expressing oncogenic Nras G12D from the endogenous locus

Treatment with a MEK Inhibitor Improves Myeloproliferation, Anemia and Survival in a Mouse Model of CMML and JMML.

PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells.

Germline Mutations in CBL Cause a Predisposition to Juvenile Myelomonocytic Leukemia.

Intracellular Signals as Molecular Biomarkers for Therapeutic Responses in Kras Mutant Myeloid Cells.

A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.

Leukemogenic K-Ras G12D Induces Cell Cycle Entry and Clonal Dominance in Hematopoietic Stem Cells.

K-Ras G12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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