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Journal Articles

Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy

Padmavathi Kavadipula, Shiva Keshava, Kaushik Das, Jhansi Magisetty, Christian DeJong, Josthna Penchalaneni, Usha Pendurthi, L. Vijaya Mohan Rao

Blood blood.2024027143.

https://doi.org/10.1182/blood.2024027143

Published: 2025

Includes: Supplemental data

Journal Articles

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Qiyang Chen, Rimi Hazra, Danielle Crosby, Diane Lenhart, Shane C. Lenhart, Paritosh Mondal, Yingze Zhang, Seyed M. Nouraie, Roderick J. Tan, Charles T. Esmon, L. Vijay Mohan Rao, Kang Kim, Samit Ghosh

Blood (2024) 144 (5): 552–564.

https://doi.org/10.1182/blood.2023023528

Published: 2024

Includes: Supplemental data

Journal Articles

A potential mechanism for the cytoprotective effects of activated protein C–released endothelial extracellular vesicles

Kaushik Das, Shiva Keshava, Tanmoy Mukherjee, L. Vijaya Mohan Rao

Blood (2024) 143 (16): 1670–1675.

https://doi.org/10.1182/blood.2023023518

Published: 2024

Journal Articles

The Gab2–MALT1 axis regulates thromboinflammation and deep vein thrombosis

Vijay Kondreddy, Shiva Keshava, Kaushik Das, Jhansi Magisetty, L. Vijaya Mohan Rao, Usha R. Pendurthi

Blood (2022) 140 (13): 1549–1564.

https://doi.org/10.1182/blood.2022016424

Published: 2022

Includes: Supplemental data

Journal Articles

Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice

Jhansi Magisetty, Vijay Kondreddy, Shiva Keshava, Kaushik Das, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2022) 139 (18): 2830–2841.

https://doi.org/10.1182/blood.2021013119

Published: 2022

Includes: Supplemental data

Journal Articles

Factor VIIa suppresses inflammation and barrier disruption through the release of EEVs and transfer of microRNA 10a

Kaushik Das, Shiva Keshava, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2022) 139 (1): 118–133.

https://doi.org/10.1182/blood.2021012358

Published: 2022

Includes: Supplemental data

Journal Articles

Heme Induced Progressive Loss of Endothelial Protein C Receptor Promotes Development of Chronic Kidney Disease in Sickle Cell Disorders

Rimi Hazra, Qiyang Chen, Danielle Crosby, Diane Lenhart, Roderick Tan, Kang Kim, L. Vijaya Mohan Rao, Solomon Fiifi Ofori-Acquah, Samit Ghosh

Blood (2021) 138 (Supplement 1): 188.

https://doi.org/10.1182/blood-2021-154027

Published: 2021

Journal Articles

SARS-CoV-2 infection induces the activation of tissue factor–mediated coagulation via activation of acid sphingomyelinase

Jue Wang, Usha R. Pendurthi, Guohua Yi, L. Vijaya Mohan Rao

Blood (2021) 138 (4): 344–349.

https://doi.org/10.1182/blood.2021010685

Published: 2021

Includes: Supplemental data

Journal Articles

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

Kaushik Das, Shiva Keshava, Shabbir A. Ansari, Vijay Kondreddy, Charles T. Esmon, John H. Griffin, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2021) 137 (24): 3428–3442.

https://doi.org/10.1182/blood.2020008417

Published: 2021

Includes: Supplemental data

Journal Articles

EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice

Jhansi Magisetty, Usha R. Pendurthi, Charles T. Esmon, L. Vijaya Mohan Rao

Blood (2020) 135 (25): 2211–2223.

https://doi.org/10.1182/blood.2019003824

Published: 2020

Includes: Supplemental data

Journal Articles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Vijay Kumar Reddy Kondreddy, MSc,PhD, Usha R. Pendurthi, PhD, Xiao Xu, John H. Griffin, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 481.

https://doi.org/10.1182/blood-2019-124976

Published: 2019

Journal Articles

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Jue Wang, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 1103.

https://doi.org/10.1182/blood-2019-125933

Published: 2019

Journal Articles

Therapeutic Doses of Recombinant FVIIa in Hemophilia Generates Thrombin in Platelet-Dependent and -Independent Manner

Shiva Keshava Gaddam Bala Krishna, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 1136.

https://doi.org/10.1182/blood-2019-128474

Published: 2019

Journal Articles

A Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, Triggers Intravascular Coagulation and Inflammation through Generation of Tissue Factor-Positive Microvesicles

Shabbir Ansari, PhD, Shiva Keshava Gaddam Bala Krishna, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 2383.

https://doi.org/10.1182/blood-2019-124498

Published: 2019

Journal Articles

EPCR Deficiency Prevents Development of Hemophilic Arthropathy

Jhansi Magisetty, PhD MSc, Usha Pendurthi, PhD, Charles T. Esmon, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 159.

https://doi.org/10.1182/blood-2019-124972

Published: 2019

Journal Articles

Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity

Jue Wang, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2019) 134 (7): 645–655.

https://doi.org/10.1182/blood.2019001400

Published: 2019

Includes: Supplemental data

Journal Articles

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Vijay Kondreddy, Jue Wang, Shiva Keshava, Charles T. Esmon, L. Vijaya Mohan Rao, Usha R. Pendurthi

Blood (2018) 131 (21): 2379–2392.

https://doi.org/10.1182/blood-2017-10-813527

Published: 2018

Includes: Supplemental data

Journal Articles

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

Jue Wang, PhD, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 16.

https://doi.org/10.1182/blood.V128.22.16.16

Published: 2016

Journal Articles

4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption By Two Independent Mechanisms

Shabbir Ansari, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 1382.

https://doi.org/10.1182/blood.V128.22.1382.1382

Published: 2016

Journal Articles

Factor VIIa Interaction with Endothelial Cell Protein C Receptor: Its Role in Hemostatic Effect of rFVIIa in Treating Hemophilia

Shiva Keshava, PhD, Jagan Sundaram, PhD, Anuradha Rajulapati, M.S., Charles T. Esmon, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 562.

https://doi.org/10.1182/blood.V128.22.562.562

Published: 2016

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Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

A potential mechanism for the cytoprotective effects of activated protein C–released endothelial extracellular vesicles

The Gab2–MALT1 axis regulates thromboinflammation and deep vein thrombosis

Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice

Factor VIIa suppresses inflammation and barrier disruption through the release of EEVs and transfer of microRNA 10a

Heme Induced Progressive Loss of Endothelial Protein C Receptor Promotes Development of Chronic Kidney Disease in Sickle Cell Disorders

SARS-CoV-2 infection induces the activation of tissue factor–mediated coagulation via activation of acid sphingomyelinase

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Therapeutic Doses of Recombinant FVIIa in Hemophilia Generates Thrombin in Platelet-Dependent and -Independent Manner

A Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, Triggers Intravascular Coagulation and Inflammation through Generation of Tissue Factor-Positive Microvesicles

EPCR Deficiency Prevents Development of Hemophilic Arthropathy

Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption By Two Independent Mechanisms

Factor VIIa Interaction with Endothelial Cell Protein C Receptor: Its Role in Hemostatic Effect of rFVIIa in Treating Hemophilia

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