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Journal Articles

Utilization of Digital Applications to Support Provision of Comprehensive Sickle Cell Disease Management

Duah Dwomoh, Daniel Nana Yaw Abankwah, Amma Benneh-Akwasi Kuma, Jonathan Spector, Jonathan Quartey, Olufolake A. Egbujo, Kwaku Marfo, Solomon Fiifi Ofori-Acquah, Justice Nonvignon

Blood (2024) 144 (Supplement 1): 5349.

https://doi.org/10.1182/blood-2024-209803

Published: 2024

Journal Articles

Effectiveness of Hydroxyurea in Patients with Sickle Cell Disease in Ghana: A Population-Level, Healthcare Facilities-Based Study

Duah Dwomoh, Daniel Nana Yaw Abankwah, Amma Benneh-Akwasi Kuma, Jonathan Spector, Jonathan Quartey, Olufolake A. Egbujo, Kwaku Marfo, Solomon Fiifi Ofori-Acquah, Justice Nonvignon

Blood (2024) 144 (Supplement 1): 2499.

https://doi.org/10.1182/blood-2024-209483

Published: 2024

Journal Articles

Impact of Iron Supplementation in Anemic Voluntary First-Time Blood Donors-Results of a Pilot Trial in Ghana

Yvonne Dei Adomakoh, Edeghonghon Olayemi, Lucy Asamoah-Akuoko, Bernard Appiah, Susan Telke, Catherine I. Segbefia, Tara Tancred, Seth Adu-Afarwuah, Amma A. Benneh-Akwasi Kuma, Alfred Edwin Yawson, Solomon Fiifi Ofori-Acquah, Philip Baba Adongo, Reena Ametorwo, Imelda Bates, Cavan Reilly, The BLOODSAFE Investigators

Blood (2023) 142 (Supplement 1): 1290.

https://doi.org/10.1182/blood-2023-174351

Published: 2023

Journal Articles

Enhanced Expression of Heme Oxygenase-1 (HO-1) Among Children with Sickle Cell Disease: Results of the Sickle Cell Disease Genomics of Africa (SickleGenAfrica) Study

Anna Sowa, William Kudzi, Vivian Paintsil, Amma A. Benneh-Akwasi Kuma, Catherine I. Segbefia, Edeghonghon Olayemi, David Adjei, Anastasia Bruce, Jeff Gruen, Ellis Owusu-Dabo, Solomon Fiifi Ofori-Acquah, The SickleGenAfrica Network

Blood (2023) 142 (Supplement 1): 150.

https://doi.org/10.1182/blood-2023-189608

Published: 2023

Journal Articles

White Matter Injury in Sickle Cell Mice Is Associated with Reduced Neurocognitive Function and Activation of Astrocytes

Rimi Hazra, Hongjan Pu, Lesley M. Foley, T. Kevin Hitchens, Lynda Little-Ihrig, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Xiaoming Hu, Enrico M. Novelli

Blood (2022) 140 (Supplement 1): 441–442.

https://doi.org/10.1182/blood-2022-169094

Published: 2022

Journal Articles

Heme Induced Progressive Loss of Endothelial Protein C Receptor Promotes Development of Chronic Kidney Disease in Sickle Cell Disorders

Rimi Hazra, Qiyang Chen, Danielle Crosby, Diane Lenhart, Roderick Tan, Kang Kim, L. Vijaya Mohan Rao, Solomon Fiifi Ofori-Acquah, Samit Ghosh

Blood (2021) 138 (Supplement 1): 188.

https://doi.org/10.1182/blood-2021-154027

Published: 2021

Journal Articles

Hemoglobin Variants Influence Plasmodium Falciparum Sexual Differentiation

Bethany Flage, Matthew Dent, Jesús Tejero, Solomon Fiifi Ofori-Acquah

Blood (2021) 138 (Supplement 1): 965.

https://doi.org/10.1182/blood-2021-147423

Published: 2021

Journal Articles

The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease

Katherine C Wood, PhD, Heidi M Schmidt, Scott Hahn, MS, Subramaniam Sanker, PhD, Samit Ghosh, PhD, Solomon Fiifi Ofori-Acquah, PhD, Seyed Mehdi Nouraie, MD PhD, Mark T Gladwin, MD, Adam C Straub, PhD

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-142076

Published: 2020

Journal Articles

Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

Maureen Mburu, Samit Ghosh, PhD, Xucai Chen, PhD, Solomon Fiifi Ofori-Acquah, PhD, Flordeliza S Villanueva, MD

Blood (2020) 136 (Supplement 1): 18.

https://doi.org/10.1182/blood-2020-142783

Published: 2020

Journal Articles

Nrf2 Null Mice Are Deficient in CD169 + Macrophages, Associated with Impaired Erythroid Response and Delayed Recovery from Acute Blood Loss

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Mark A Ross, Samit Ghosh, Frances Weidert, MS, Grant C. Bullock, MD PhD, Solomon Fiifi Ofori-Acquah, Gregory J Kato, MD, Simon Watkins

Blood (2019) 134 (Supplement_1): 1038.

https://doi.org/10.1182/blood-2019-127295

Published: 2019

Journal Articles

Macrophage Hypercellularity Accompanies Erythroid Hyperplasia in Sickle Cell Mice and during Recovery from Blood Loss in Wild Type Mice

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Samit Ghosh, Frances Weidert, MS, Grant C. Bullock, MD PhD, Solomon Fiifi Ofori-Acquah, Gregory J Kato, MD

Blood (2019) 134 (Supplement_1): 3528.

https://doi.org/10.1182/blood-2019-127224

Published: 2019

Journal Articles

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Katherine Wood, PhD BA, Brittany Durgin, PhD, Heidi M Schmidt, BSE, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, PhD, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, MD, Mark T Gladwin, MD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3619.

https://doi.org/10.1182/blood-2019-124159

Published: 2019

Journal Articles

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Samit Ghosh, Oluwaseun Orikogbo, Rimi Hazra, Bethany Flage, Danielle Crosby, Solomon Fiifi Ofori-Acquah

Blood (2019) 134 (Supplement_1): 78.

https://doi.org/10.1182/blood-2019-127161

Published: 2019

Journal Articles

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Rimi Hazra, Samit Ghosh, Bethany Flage, Matthew Crouthamel, Clark Pan, Xiuxia Sun, Bohong Zhang, Joseph Sypek, Solomon Fiifi Ofori-Acquah

Blood (2019) 134 (Supplement_1): 74.

https://doi.org/10.1182/blood-2019-127198

Published: 2019

Journal Articles

Heterogeneity in Multi-Organ Expression of HO-1 and PlGF in Sickle Mice Mimic Exposure of Non-Sickle Mice to Extracellular Heme Via Nrf2-Dependent Pathways

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Samit Ghosh, PhD, Yu Lin, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Gregory J. Kato, MD

Blood (2018) 132 (Supplement 1): 2392.

https://doi.org/10.1182/blood-2018-99-113451

Published: 2018

Journal Articles

Heme Regulates the Expression in Erythroblasts of Placenta Growth Factor, a Contributor to Pulmonary Hypertension in Sickle Cell Disease, through the Oxidant Response Transcription Factor NRF2

Maria G Kapetanaki, PhD, Oluwabukola Gbotosho, BSc, MSc, PhD, Deva Sharma, MD MS, Schrott Valerie, MS, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Grant C. Bullock, MD PhD, Gregory J. Kato, MD

Blood (2017) 130 (Supplement 1): 3496.

https://doi.org/10.1182/blood.V130.Suppl_1.3496.3496

Published: 2017

Journal Articles

Cardiomyopathy Associated with Worsening Intravascular Hemolysis in Transgenic Knock-in Mouse Model of Sickle Cell Disease

Maureen Mburu, MD, Rafey Feroze, BS, Daniel Whitehurst, BS, Xucai Chen, PhD, Samit Ghosh, PhD, Solomon Fiifi Ofori-Acquah, PhD, Flordeliza S Villanueva, MD

Blood (2017) 130 (Supplement 1): 3512.

https://doi.org/10.1182/blood.V130.Suppl_1.3512.3512

Published: 2017

Journal Articles

Free Heme Induces a Heme Importer, Heme Catabolism and an Angiogenic Factor in Multiple Organs in Mice: Implications for Organ-Specific Response to Intravascular Hemolysis

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Yu Lin, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Gregory J. Kato, MD

Blood (2017) 130 (Supplement 1): 3468.

https://doi.org/10.1182/blood.V130.Suppl_1.3468.3468

Published: 2017

Journal Articles

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

Samit Ghosh, PhD, Vivian Paintsil, MD, Rimi Hazra, PhD, Oluowaseun O. Orikogbo, Bethany Flage, Ezekiel Bonwin Ackah, Ellis Owusu-Dabo, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2017) 130 (Supplement 1): 441.

https://doi.org/10.1182/blood.V130.Suppl_1.441.441

Published: 2017

Journal Articles

Moderate Exercise Training Attenuates Inflammation in Transgenic Sickle Cell Mice

Emmanuelle Charrin, Cyril Martin, PhD, John Dube, PhD, Philippe Connes, PhD, Vincent Pialoux, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2015) 126 (23): 976.

https://doi.org/10.1182/blood.V126.23.976.976

Published: 2015

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Utilization of Digital Applications to Support Provision of Comprehensive Sickle Cell Disease Management

Effectiveness of Hydroxyurea in Patients with Sickle Cell Disease in Ghana: A Population-Level, Healthcare Facilities-Based Study

Impact of Iron Supplementation in Anemic Voluntary First-Time Blood Donors-Results of a Pilot Trial in Ghana

Enhanced Expression of Heme Oxygenase-1 (HO-1) Among Children with Sickle Cell Disease: Results of the Sickle Cell Disease Genomics of Africa (SickleGenAfrica) Study

White Matter Injury in Sickle Cell Mice Is Associated with Reduced Neurocognitive Function and Activation of Astrocytes

Heme Induced Progressive Loss of Endothelial Protein C Receptor Promotes Development of Chronic Kidney Disease in Sickle Cell Disorders

Hemoglobin Variants Influence Plasmodium Falciparum Sexual Differentiation

The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease

Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

Nrf2 Null Mice Are Deficient in CD169 + Macrophages, Associated with Impaired Erythroid Response and Delayed Recovery from Acute Blood Loss

Macrophage Hypercellularity Accompanies Erythroid Hyperplasia in Sickle Cell Mice and during Recovery from Blood Loss in Wild Type Mice

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Heterogeneity in Multi-Organ Expression of HO-1 and PlGF in Sickle Mice Mimic Exposure of Non-Sickle Mice to Extracellular Heme Via Nrf2-Dependent Pathways

Heme Regulates the Expression in Erythroblasts of Placenta Growth Factor, a Contributor to Pulmonary Hypertension in Sickle Cell Disease, through the Oxidant Response Transcription Factor NRF2

Cardiomyopathy Associated with Worsening Intravascular Hemolysis in Transgenic Knock-in Mouse Model of Sickle Cell Disease

Free Heme Induces a Heme Importer, Heme Catabolism and an Angiogenic Factor in Multiple Organs in Mice: Implications for Organ-Specific Response to Intravascular Hemolysis

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

Moderate Exercise Training Attenuates Inflammation in Transgenic Sickle Cell Mice

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