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Journal Articles

Multi-Omics Reveal Immune Microenvironment Alterations in Multiple Myeloma and Its Precursor Stages

Yan Cheng, Fumou Sun, Daisy V. Alapat, Visanu Wanchai, David E. Mery, Eric Siegel, Hongwei Xu, Sarah K. Johnson, Wancheng Guo, Clyde Bailey, Cody Ashby, Michael Anton Bauer, Samer Al Hadidi, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4729.
https://doi.org/10.1182/blood-2024-193583
Published: 2024
Journal Articles

Definition and Clinical Significance of the MGUS-like Phenotype: A Study in 5,114 Patients (Pts) with Monoclonal Gammopathies

Leire Burgos, Luis Esteban Tamariz-Amador, Noemí Puig, María Teresa Cedena, Tomas Jelinek, Sarah K Johnson, Paolo Milani, Lourdes Cordon, José J Pérez, Marta Lasa, Rosalinda Termini, Albert Oriol, Miguel-Teodoro Hernández, Luis Palomera, Rafael Martinez Martinez, Javier de la Rubia, Felipe De Arriba, Rafael Rios, Maria Esther González, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Isabel Krsnik, Albert Pérez, Veronica Gonzalez De La Calle, Paula Rodríguez-Otero, Vladimir Maisnar, Roman Hajek, Frits van Rhee, Victor H Jimenez-Zepeda, Giovanni Palladini, Paolo Milani, Alberto Orfao, Laura Rosinol, Joan Bladé Creixenti, Joaquín Martínez-López, Juan-José Lahuerta, Maria-Victoria Mateos, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (Supplement 1): 541.
https://doi.org/10.1182/blood-2021-150092
Published: 2021
Journal Articles

Improvement in Outcomes of Autologous Stem Cell Transplant in Patients with Lymphoma Older Than 70 Years: The Significance of Age in 2020s?

Kitsada Wudhikarn, Bradley K. Johnson, Jose C. Villasboas, Jonas Paludo, David J. Inwards, Luis F. Porrata, Ivana N. Micallef, Stephen M. Ansell, Patrick B. Johnston
Journal: Blood
Blood (2021) 138 (Supplement 1): 2908.
https://doi.org/10.1182/blood-2021-144507
Published: 2021
Journal Articles

Deep Profiling of the Immune Microenvironment throughout Myeloma Disease Stages

Megan Darrington, Frits van Rhee, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Fenghuang Zhan, Brian A Walker, Gareth J. Morgan, Sarah K Johnson
Journal: Blood
Blood (2021) 138 (Supplement 1): 727.
https://doi.org/10.1182/blood-2021-148590
Published: 2021
Journal Articles

N-Cadherin Stabilizes β-Catenin and Promotes β-Catenin/TCF Transcriptional Activation and Cell Adhesion-Mediated Drug Resistance in Multiple Myeloma

Shiqiao Ye, Yu Chen, Bo Hu, Huayu Huang, Yuxiao Sun, James P Stewart, Sarah K Johnson, Bart Barlogie, Maurizio Zangari, Guido Tricot, Faith E Davies, Gareth J Morgan, Brian A Walker, Fenghuang Zhan, Frits van Rhee, John D Shaughnessy, Jr., Ya-Wei Qiang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2021-148624
Published: 2021
Journal Articles

Iron Trafficking through Macrophages Regulates Signaling Pathways in Myeloma

Xuelian Tan, Timothy Cody Ashby, PhD, Yuqi Zhu, Can Li, MD, Xuxing Shen, MBBS, Qierra Brockman, BA, Dongzheng Gai, MD, Sarah K Johnson, PhD, Donghoon Yong, Carolina D. Schinke, MD, Maurizio Zangari, MD FACP, Frits van Rhee, MD, John Shaughnessy, Jr., PhD, Dingming Huang, PhD, Ivana Frech, DSc, PhD MBA, Guido J. Tricot, MD PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2.
https://doi.org/10.1182/blood-2020-140372
Published: 2020
Journal Articles

The mTOR Component, Rictor, Is Regulated By the Microenvironment to Control Dormancy and Proliferative States in Myeloma Cells

Syed J. Mehdi, PhD, Sarah K Johnson, PhD, Tarun K. Garg, PhD, Cody Ashby, PhD, Maurizio Zangari, MD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Joshua Epstein, DSc, Brian A Walker, PhD, Frits van Rhee, MD PhD, Shmuel Yaccoby, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4412.
https://doi.org/10.1182/blood-2019-127382
Published: 2019
Journal Articles

Analysis of the Sub-Clonal Structure of Smoldering Myeloma over Time Provides a New Means of Disease Monitoring and Highlights Evolutionary Trajectories Leading to Myeloma

Eileen M Boyle, MD MSc, Faith E. Davies, MD, Shayu Deshpande, Ruslana G. Tytarenko, MS, Cody Ashby, PhD, Yan Wang, Christopher P. Wardell, PhD MSc, BSc, Michael A Bauer, PhD, Sarah K Johnson, PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Louis Williams, MD MBA, Thierry Facon, MD, Charles Dumontet, Bart Barlogie, MD PhD, Gareth Morgan, MDPhDFRCP, Brian A Walker, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4333.
https://doi.org/10.1182/blood-2019-126679
Published: 2019
Journal Articles

A Distinct Oncofetal B-Cell Transcriptional Program Is Activated in Infant Acute Myeloid Leukemia and Reveals Novel Therapeutic Strategies

Hamid Bolouri, PhD, Benjamin K. Johnson, PhD, Rhonda E. Ries, MA, Laura Pardo, Tiffany A. Hylkema, BS, Wanding Zhou, PhD, Jenny L. Smith, MSc, MD, Amanda R. Leonti, MS, Allison Kaeding, MD, Michael R. Loken, PhD, Jason E. Farrar, MD, Soheil Meshinchi, MD PhD, Timothy Junius Triche, Jr., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3768.
https://doi.org/10.1182/blood-2019-123487
Published: 2019
Journal Articles

The genomic landscape of plasma cells in systemic light chain amyloidosis

Eileen M. Boyle, Cody Ashby, Christopher P. Wardell, Dorota Rowczenio, Sajitha Sachchithanantham, Yan Wang, Sarah K. Johnson, Michael A. Bauer, Niels Weinhold, Martin F. Kaiser, David C. Johnson, John R. Jones, Charlotte Pawlyn, Paula Proszek, Carolina Schinke, Thierry Facon, Charles Dumontet, Faith E. Davies, Gareth J. Morgan, Brian A. Walker, Ashutosh D. Wechalekar
Journal: Blood
Blood (2018) 132 (26): 2775–2777.
https://doi.org/10.1182/blood-2018-08-872226
Published: 2018
Includes: Supplemental data
Journal Articles

Expression Signature of Myeloma Residual Cells Is Characterized By Genes Associated with Proliferation, Epigenetic Modification, and Stem Cell Maintenance

Michael A Bauer, PhD, Matthew Henry, M.S., Purvi Patel, Yan Wang, Joshua Epstein, DSc, Faith E. Davies, MD, Carolina D. Schinke, MD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Gareth Morgan, MD, Brian A Walker, PhD, Sarah K Johnson, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4465.
https://doi.org/10.1182/blood-2018-99-119131
Published: 2018
Journal Articles

Characterization of the Immune Impact of Daratumumab By Mass Cytometry in Multiple Myeloma

Sarah K Johnson, PhD, Stephen Burke, PhD, Matthew Henry, M.S., Amy Greenway, Katie Stone, BS, Brian A Walker, PhD, Frits van Rhee, MD PhD, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4466.
https://doi.org/10.1182/blood-2018-99-119241
Published: 2018
Journal Articles

Mesenchymal Stem Cells Gene Signature in High-Risk Myeloma Bone Marrow Linked to Suppression of Distinct IGFBP2-Expressing Small Adipocytes

Syed J. Mehdi, PhD, Sarah K Johnson, PhD, Joshua Epstein, DSc, Maurizio Zangari, MD, Pingping Qu, Antje Hoering, PhD, Frits van Rhee, MD PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Faith E. Davies, MD, Gareth Morgan, MD, Shmuel Yaccoby, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4448.
https://doi.org/10.1182/blood-2018-99-115244
Published: 2018
Journal Articles

Mutations and Copy Number Changes Predict Progression from Smoldering Myeloma to Symptomatic Myeloma in the Era of Novel IMWG Criteria

Eileen M Boyle, MD MSc, Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Yan Wang, Michael A Bauer, PhD, Shayu Deshpande, Sarah K Johnson, PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Christopher Wardell, PhD, Niels Weinhold, PhD, Thierry Facon, Charles Dumontet, Gareth Morgan, MD, Faith E. Davies, MD, Brian A Walker, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4456.
https://doi.org/10.1182/blood-2018-99-117193
Published: 2018
Journal Articles

Global Expression Changes of Malignant Plasma Cells over Time Reveals the Evolutionary Development of Signatures of Aggressive Clinical Behavior

Eileen M Boyle, MD MSc, Adam Rosenthal, MS, Yan Wang, Phil Farmer, Michael W Rutherford, Cody Ashby, PhD, Michael A Bauer, PhD, Sarah K Johnson, PhD, Christopher P. Wardell, PhD MSc, BSc, Niels Weinhold, PhD, Antje Hoering, PhD, Charles Dumontet, Thierry Facon, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Bart Barlogie, MD PhD, Faith E. Davies, MD, Brian A Walker, PhD, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4457.
https://doi.org/10.1182/blood-2018-99-119113
Published: 2018
Journal Articles

Selective Pressure from Chemotherapy Drives Convergent Evolution in Relapsing and Refractory AML across Age Groups

Timothy Junius Triche, Jr., PhD, Benjamin K. Johnson, PhD, Lyong Heo, MS, Yizhou Peter Huang, BS, Rhonda E. Ries, MA, Hamid Bolouri, PhD, Jason E. Farrar, MD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2609.
https://doi.org/10.1182/blood-2018-99-119323
Published: 2018
Journal Articles

Deep Immunoprofiling of the Bone Marrow Microenvironmental Changes Underlying the Multistep Progression of Multiple Myeloma

Mary H Young, PhD, Sam A Danziger, Alison Fitch, Frank Schmitz, MD PhD, Jake Gockley, PhD, Mark McConnell, PhD, David Reiss, PhD, Wilbert B. Copeland, PhD, Sarah K Johnson, PhD, Katie Newhall, PhD, Robert Hershberg, MD PhD, Teri Foy, PhD, Alexander Ratushny, PhD, Brian A Walker, PhD, Andrew Dervan, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 243.
https://doi.org/10.1182/blood-2018-99-113042
Published: 2018
Journal Articles

Proliferation and Molecular Risk Score of Low Risk Myeloma Cells Are Increased in High Risk Microenvironment Via Augmented Bioavailability of Growth Factors

Syed J. Mehdi, PhD, Sarah K Johnson, PhD, Sharmin Khan, Wen Ling, PhD, Randal Shelton, Joshua Epstein, DSc, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Brian A Walker, PhD, Cody Ashby, PhD, Faith E. Davies, MD, Gareth Morgan, MD, Shmuel Yaccoby, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1929.
https://doi.org/10.1182/blood-2018-99-116455
Published: 2018
Journal Articles

Whole-Genome Mate Pair Sequencing Transforms Cytogenetic Analysis of Hematologic Malignancies: Development of a Targeted Panel to Detect Diagnostic/Prognostic Chromosomal Rearrangements and Copy Number Changes in AML

Umut Aypar, PhD, George Vasmatzis, PhD, Sarah K Johnson, PhD, James Smadbeck, PhD, Stephanie A. Smoley, BA, Hutton Kearney, PhD, William Sukov, MD, Rhett P. Ketterling, MD, Katherine Geiersbach, MD, Daniel L. Van Dyke, PhD, Robert Jenkins, MD PhD, Patricia Greipp, DO, Erik Thorland, PhD, Nicole Hoppman, PhD, Linda B Baughn, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1387.
https://doi.org/10.1182/blood.V130.Suppl_1.1387.1387
Published: 2017
Journal Articles

Functional Imaging Detects Residual Disease in MRD-Negative Multiple Myeloma Patients Who Subsequently Relapse

Leo Rasche, MD, Carolina D. Schinke, MD, Daisy Alapat, MD, Grant Gershner, Sarah K Johnson, PhD, Sharmilan Thanendrarajan, MD, Joshua Epstein, DSc, Frits van Rhee, MD PhD, Maurizio Zangari, MD, James E McDonald, BS, MD, Rohan Samant, MD, Edgardo Angtuaco, MD, Brian A Walker, PhD, Bart Barlogie, MD PhD, Faith E. Davies, MD, Gareth J. Morgan, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4510.
https://doi.org/10.1182/blood.V130.Suppl_1.4510.4510
Published: 2017