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Journal Articles

N-Cadherin Stabilizes β-Catenin and Promotes β-Catenin/TCF Transcriptional Activation and Cell Adhesion-Mediated Drug Resistance in Multiple Myeloma

Shiqiao Ye, Yu Chen, Bo Hu, Huayu Huang, Yuxiao Sun, James P Stewart, Sarah K Johnson, Bart Barlogie, Maurizio Zangari, Guido Tricot, Faith E Davies, Gareth J Morgan, Brian A Walker, Fenghuang Zhan, Frits van Rhee, John D Shaughnessy, Jr., Ya-Wei Qiang

Blood (2021) 138 (Supplement 1): 1572.

https://doi.org/10.1182/blood-2021-148624

Published: 2021

Journal Articles

CST6 Is a Small Autocrine Molecule That Targets Myeloma Growth and Bone Destruction

Dongzheng Gai, MD, Stewart JP, Xuxing Shen, Jin-Ran Chen, PhD, Can Li, MD, Bailu Peng, PhD, Ya-Wei Qiang, MD PhD, Shmuel Yaccoby, PhD, Maurizio Zangari, MD FACP, Frits van Rhee, MD, Guido J. Tricot, MD PhD, Lijuan Chen, MDPhD, John Shaughnessy, Jr., PhD, Fenghuang Zhan, MD PhD

Blood (2020) 136 (Supplement 1): 21.

https://doi.org/10.1182/blood-2020-140568

Published: 2020

Journal Articles

Mutant KRAS Enhances Stress Granules and Resistance to Proteasome Inhibition Via 15-d-PGJ2 in Multiple Myeloma

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD BSc, MSc, Yu Chen, Joshua Epstein, DSc, Faith E. Davies, MD, Gareth Morgan, MD PhD, Brian A Walker, PhD, Frits van Rhee, MD PhD

Blood (2019) 134 (Supplement_1): 4383.

https://doi.org/10.1182/blood-2019-130493

Published: 2019

Journal Articles

Mutant KRAS and Brafs Upregulate Stress Granules and Mediate Drug Resistance, Which Can be Modulated By Cox2 Inhibition in Multiple Myeloma

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD BSc, MSc, Yu Chen, Joshua Epstein, DSc, Brian A Walker, PhD, Frits van Rhee, MD PhD, Gareth Morgan, MD, Faith E. Davies, MD

Blood (2018) 132 (Supplement 1): 3166.

https://doi.org/10.1182/blood-2018-99-117459

Published: 2018

Journal Articles

MAFA Expression Promotes Proliferation of Myeloma Cells and Its Protein Stability Is Regulated By Proteasome Inhibitors

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD BSc, MSc, Yu Chen, Ichiro Hanamura, MD PhD, Brian A Walker, PhD, Gareth J. Morgan, MD PhD, Faith E. Davies, MD

Blood (2017) 130 (Supplement 1): 4394.

https://doi.org/10.1182/blood.V130.Suppl_1.4394.4394

Published: 2017

Journal Articles

MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma

Ya-Wei Qiang, Shiqiao Ye, Yu Chen, Amy F. Buros, Ricky Edmonson, Frits van Rhee, Bart Barlogie, Joshua Epstein, Gareth J. Morgan, Faith E. Davies

Blood (2016) 128 (25): 2919–2930.

https://doi.org/10.1182/blood-2016-03-706077

Published: 2016

Includes: Supplemental data

Journal Articles

The Co-Occurrence of MAF Translocations in RAS Mutated Multiple Myeloma Confers Resistance to MEK Inhibition

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD BSc, MSc, Yu Chen, Amy Buros, PhD, Frits van Rhee, MD PhD, Joshua Epstein, DSc, Gareth J Morgan, MD PhD, Faith E Davies, MD

Blood (2016) 128 (22): 1138.

https://doi.org/10.1182/blood.V128.22.1138.1138

Published: 2016

Journal Articles

Identification of Biomarkers Associated with MAF-Mediated Resistance to Proteasome Inhibitors in t(14;16) Multiple Myeloma

Ya-Wei Qiang, Shiqiao Ye, PhD BSc, MSc, Ricky D Edmondson, PhD, Yuhua Huang, Sarah K. Johnson, PhD, Caleb K. Stein, MS, Bart Barlogie, MD PhD, Joshua Epstein, DSc, Gareth J Morgan, MDPhD, Faith E Davies, MD

Blood (2015) 126 (23): 3020.

https://doi.org/10.1182/blood.V126.23.3020.3020

Published: 2015

Journal Articles

Mafb Protein Confers Primary Resistance of Myeloma to Proteasome Inhibitors

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD, Faith E Davies, MD, Bart Barlogie, MD PhD, Joshua Epstein, DSc, Gareth J Morgan, MD PhD

Blood (2014) 124 (21): 2091.

https://doi.org/10.1182/blood.V124.21.2091.2091

Published: 2014

Journal Articles

Apobec Family Mutational Signatures Are Associated with Poor Prognosis Translocations in Multiple Myeloma

Blood (2014) 124 (21): 723.

https://doi.org/10.1182/blood.V124.21.723.723

Published: 2014

Journal Articles

MAF Protein Elicits Innate Resistance To Bortezomib In Multiple Myeloma

Shiqiao Ye, PhD, Wei Qiang, MD, Yu Chen, Bo Hu, PhD, Qing Zhang, PhD, Shmuel Yaccoby, PhD, Frits van Rhee, MD, PhD, Bart Barlogie, MD, PhD, Joshua Epstein, DSc, Ya-Wei Qiang, MD, PhD

Blood (2013) 122 (21): 281.

https://doi.org/10.1182/blood.V122.21.281.281

Published: 2013

Journal Articles

Carfilzomib Induces Differentiation of Mesenchymal Stromal Cells Toward Osteoblast Via Activation of β-Catenin/TCF Signaling

Yu Chen, Saad Z Usmani, MD FACP, Bo Hu, PhD, Xenofon Papanikolaou, Christoph Heuck, MD, Joshua Epstein, DSc, Bart Barlogie, MD, PhD, Ya-Wei Qiang, MD, PhD

Blood (2012) 120 (21): 4008.

https://doi.org/10.1182/blood.V120.21.4008.4008

Published: 2012

Journal Articles

Lenalidomide Suppression of Multiple Myeloma Cell Proliferation Is Associated with Downregulation of LEF/TCF Activity

Bo Hu, PhD, Bart Barlogie, MD, PhD, Yu Chen, Joshua Epstein, DSc, Ya-Wei Qiang, MD, PhD

Blood (2012) 120 (21): 5014.

https://doi.org/10.1182/blood.V120.21.5014.5014

Published: 2012

Journal Articles

Pharmacogenomic Study of Carfilzomib in Relapsed/Refractory Multiple Myeloma Suggests That Carfilzomib Is a More Potent Proteasome Inhibitor Than Bortezomib

Qing Zhang, PhD, Christoph Heuck, MD, Ya-Wei Qiang, MD, PhD, Frits van Rhee, MD, PhD, Sarah Waheed, MD, Clyde Bailey, Susan B. Panozzo, Joshua Epstein, DSc, Bart Barlogie, MD, PhD, Saad Z Usmani, MD FACP

Blood (2012) 120 (21): 5015.

https://doi.org/10.1182/blood.V120.21.5015.5015

Published: 2012

Journal Articles

Bortezomib Induces Activation of b-Catenin/TCF Signaling Pathway in Multiple Myeloma

Ya-Wei Qiang, MD. PhD, Bo Hu, PhD, Yu Chen, Wei Qiang, MD, Christoph Heuck, MD, Bart Barlogie, MD, PhD, John D Shaughnessy, Jr., PhD

Blood (2011) 118 (21): 1851.

https://doi.org/10.1182/blood.V118.21.1851.1851

Published: 2011

Journal Articles

Secreted Frizzled-Related Protein-3 (sFRP3) Is Produced by Myeloma Cells and Augments Wnt3a-Induced Differentiation of Mesenchymal Stem Cells and OPG Production in Osteoblasts

Ya-Wei Qiang, MD, PhD, Yu Chen, Bo Hu, PhD, Wei Qiang, MD, Christoph Heuck, MD, Shmuel Yaccoby, PhD, Joshua Epstein, DSc, Bart Barlogie, MD, PhD, John D Shaughnessy, Jr., PhD

Blood (2011) 118 (21): 808.

https://doi.org/10.1182/blood.V118.21.808.808

Published: 2011

Journal Articles

N-Cadherin Expressing MM Cells Form Calcium-Dependent, Adherent Junctions That Likely Contribute to Focal Lesions and Nodular Growth of Multiple Myeloma Cells

Ya-Wei Qiang, MD, PhD, Bo Hu, Yu Chen, Erming Tian, Joshua Epstein, DSc, Bart Barlogie, MD, PhD, John Shaughnessy, Jr, PhD

Blood (2010) 116 (21): 979.

https://doi.org/10.1182/blood.V116.21.979.979

Published: 2010

Journal Articles

Abnormally High Levels of E- and N-Cadherin Expression Add to Altered Regulation of b-Catenin In Multiple Myeloma

Ya-Wei Qiang, MD, PhD, Peter Stewart, PhD, Yu Chen, Bo Hu, John Shaughnessy, Jr., PhD, Bart Barlogie, MD, PhD

Blood (2010) 116 (21): 2982.

https://doi.org/10.1182/blood.V116.21.2982.2982

Published: 2010

Journal Articles

Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling

Ya-Wei Qiang, Bo Hu, Yu Chen, Ying Zhong, Bingyin Shi, Bart Barlogie, John D. Shaughnessy, Jr

Blood (2009) 113 (18): 4319–4330.

https://doi.org/10.1182/blood-2008-08-174300

Published: 2009

Journal Articles

The role of Dickkopf-1 in bone development, homeostasis, and disease

Joseph J. Pinzone, Brett M. Hall, Nanda K. Thudi, Martin Vonau, Ya-Wei Qiang, Thomas J. Rosol, John D. Shaughnessy, Jr

Blood (2009) 113 (3): 517–525.

https://doi.org/10.1182/blood-2008-03-145169

Published: 2009

NARROW

N-Cadherin Stabilizes β-Catenin and Promotes β-Catenin/TCF Transcriptional Activation and Cell Adhesion-Mediated Drug Resistance in Multiple Myeloma

CST6 Is a Small Autocrine Molecule That Targets Myeloma Growth and Bone Destruction

Mutant KRAS Enhances Stress Granules and Resistance to Proteasome Inhibition Via 15-d-PGJ2 in Multiple Myeloma

Mutant KRAS and Brafs Upregulate Stress Granules and Mediate Drug Resistance, Which Can be Modulated By Cox2 Inhibition in Multiple Myeloma

MAFA Expression Promotes Proliferation of Myeloma Cells and Its Protein Stability Is Regulated By Proteasome Inhibitors

MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma

The Co-Occurrence of MAF Translocations in RAS Mutated Multiple Myeloma Confers Resistance to MEK Inhibition

Identification of Biomarkers Associated with MAF-Mediated Resistance to Proteasome Inhibitors in t(14;16) Multiple Myeloma

Mafb Protein Confers Primary Resistance of Myeloma to Proteasome Inhibitors

Apobec Family Mutational Signatures Are Associated with Poor Prognosis Translocations in Multiple Myeloma

MAF Protein Elicits Innate Resistance To Bortezomib In Multiple Myeloma

Carfilzomib Induces Differentiation of Mesenchymal Stromal Cells Toward Osteoblast Via Activation of β-Catenin/TCF Signaling

Lenalidomide Suppression of Multiple Myeloma Cell Proliferation Is Associated with Downregulation of LEF/TCF Activity

Pharmacogenomic Study of Carfilzomib in Relapsed/Refractory Multiple Myeloma Suggests That Carfilzomib Is a More Potent Proteasome Inhibitor Than Bortezomib

Bortezomib Induces Activation of b-Catenin/TCF Signaling Pathway in Multiple Myeloma

Secreted Frizzled-Related Protein-3 (sFRP3) Is Produced by Myeloma Cells and Augments Wnt3a-Induced Differentiation of Mesenchymal Stem Cells and OPG Production in Osteoblasts

N-Cadherin Expressing MM Cells Form Calcium-Dependent, Adherent Junctions That Likely Contribute to Focal Lesions and Nodular Growth of Multiple Myeloma Cells

Abnormally High Levels of E- and N-Cadherin Expression Add to Altered Regulation of b-Catenin In Multiple Myeloma

Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling

The role of Dickkopf-1 in bone development, homeostasis, and disease

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American Society of Hematology

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ASH Publications

American Society of Hematology

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