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Hugh Young Rienhoff, Jr.
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Journal Articles

The Transcription Factor IRF8 Regulates the Sensitivity of AML Cells to LSD1 Inhibition and All-Trans Retinoic Acid

Emily E Hartung, Kanwaldeep Singh, Sarah Coopersmith, Jamie Avrumutsoae, Siddaarth Varatharajan, Sara Pishyar, Pradhariny Prabagaran, Dina Khalaf, Alejandro Garcia-Horton, Ronan Foley, Brian Leber, Irwin Walker, Kylie L. Lepic, Maria Kleppe, Hugh Young Rienhoff, Jr., Tobias Berg
Journal: Blood
Blood (2024) 144 (Supplement 1): 2764.
https://doi.org/10.1182/blood-2024-199648
Published: 2024
Journal Articles

Bomedemstat (MK3543) in Combination with Ruxolitinib in Patients with Advanced Myelofibrosis

Harinder Gill, Lester Au, Dorothy Tsai, Rita Yim, Vivian Li, Paul Lee, Lynn Chin, Qi Zhang, Garret Man Kit Leung, Tony Kwun Yat Wu, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2024) 144 (Supplement 1): 1796.
https://doi.org/10.1182/blood-2024-208038
Published: 2024
Journal Articles

Phase 1/2a Trial of Bomedemstat with or without All- Trans Retinoic Acid (ATRA) in Advanced Myeloid Malignancies

David M. Ross, William S. Stevenson, Jake Shortt, Julian Cooney, Ian Lewis, Hugh Young Rienhoff Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 6494.
https://doi.org/10.1182/blood-2023-180924
Published: 2023
Journal Articles

Phase 2 Study to Assess the Safety and Efficacy of Bomedemstat (MK3543) in Combination with Ruxolitinib in Patients with Myelofibrosis

Harinder Gill, Lester Au, Garret Man Kit Leung, Dorothy Tsai, Rita Yim, Lynn Chin, Vivian Li, Paul Lee, Rock Yuk Yan Leung, Elaine Lee, Hugh Young Rienhoff Jr., Yok Lam Kwong
Journal: Blood
Blood (2023) 142 (Supplement 1): 621.
https://doi.org/10.1182/blood-2023-181971
Published: 2023
Journal Articles

Bomedemstat (IMG-7289), an LSD1 Inhibitor, Manages the Signs and Symptoms of Essential Thrombocythemia (ET) While Reducing the Burden of Cells Homozygous for Driver Mutations

Joachim R. Goethert, Harinder Gill, Francesca Palandri, David M. Ross, Tara Cochrane, Stephen R. Larsen, Anna B. Halpern, Jake Shortt, James M. Rossetti, James Liang, Monia Marchetti, Andrew J. Wilson, Andrew Innes, Merit Hanna, William S. Stevenson, Alessandro M. Vannucchi, Maria Kleppe, Georges Natsoulis, Claire N Harrison, Hugh Young Rienhoff Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 747.
https://doi.org/10.1182/blood-2023-179329
Published: 2023
Journal Articles

LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism

Kanwaldeep Singh, Emily Hartung, Christina Muhs, Islam Alshamleh, Monisha Divakaran, Anna Dvorkin-Gheva, Sara Pishyar, Pradhariny Prabagaran, Dina Khalaf, Alejandro Garcia-Horton, Stephen Ronan Foley, Brian Leber, Irwin Walker, Kylie Lepic, Harald Schwalbe, Hubert Serve, Maria Kleppe, Hugh Young Rienhoff, Jr., Tobias Berg
Journal: Blood
Blood (2023) 142 (Supplement 1): 4156.
https://doi.org/10.1182/blood-2023-189515
Published: 2023
Journal Articles

MSC Reprogramming and Aberrant Inflammatory Signaling in Myelofibrosis: Insights from Single-Cell RNA-Sequencing of Trephine Bone Marrow Cells

Naseer J Basma, Alexia J Strickson, Kristian Gurashi, Maria Kleppe, Hugh Young Rienhoff Jr., Jr., Tim CP Somervaille
Journal: Blood
Blood (2023) 142 (Supplement 1): 743.
https://doi.org/10.1182/blood-2023-181674
Published: 2023
Journal Articles

Mutational Analysis of the Genome Stability Factor BOD1L1 in Myeloproliferative Neoplasm

Martin R Higgs, Sofia Browne, Ryan Collinson, Kathy Fuller, Wendy N. Erber, Maria Kleppe, Ben Sirnosian, Georges Natsoulis, Belinda Guo, Hugh Young Rienhoff Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 5677.
https://doi.org/10.1182/blood-2023-179125
Published: 2023
Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Bomedemstat (IMG-7289) for the Treatment of Advanced Myelofibrosis (MF): Updated Results and Genomic Analyses

Kristen M. Pettit, Harinder Gill, Abdulraheem Yacoub, Terrence Bradley, Aaron T. Gerds, Maciej Tatarczuch, Jake Shortt, Natasha Joan Curtin, James M. Rossetti, Kate Burbury, Adam J Mead, Joachim R Göthert, Steffen Koschmieder, Matt Reyer, Benjamin Siranosian, Georges Natsoulis, William S Stevenson, Joanne Ewing, Joseph M. Chacko, Elisa Rumi, Anna B. Halpern, Francesca Palandri, Nicola Vianelli, Francesco Passamonti, Ruben Mesa, Monia Marchetti, Claire Harrison, Alessandro M. Vannucchi, Justin Watts, David M Ross, Moshe Talpaz, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 9717–9720.
https://doi.org/10.1182/blood-2022-167122
Published: 2022
Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Bomedemstat (IMG-7289) for the Treatment of Essential Thrombocythemia (ET)

Harinder Gill, Francesca Palandri, David M Ross, Tara Cochrane, Courtney Tate, Steven W Lane, Stephen R Larsen, Aaron T. Gerds, Anna B. Halpern, Jake Shortt, James M. Rossetti, Kristen M. Pettit, James Liang, Adam J Mead, Monia Marchetti, Alessandro M. Vannucchi, Andrew J Wilson, Joachim R Göthert, Merit Hanna, Francesco Passamonti, William S Stevenson, Claire Harrison, Moshe Talpaz, Nicola Vianelli, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 1784–1787.
https://doi.org/10.1182/blood-2022-159047
Published: 2022
Journal Articles

Somatic Mutational Landscape of Hereditary Hematopoietic Malignancies Associated with Germline Variants in RUNX1 , GATA2 and DDX41

Anna L. Brown, Claire Homan, Michael W. Drazer, Kai Yu, David Lawrence, Jinghua Feng, Luis Arriola-Martinez, Matthew Pozsgai, Kelsey McNeely, Thuong Ha, Parvathy Venugopal, Peer Arts, Sarah King-Smith, Jesse JC Cheah, Mark Armstrong, Csaba Bödör, Paul Wang, Alan B. Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Ana Rio-Machin, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Young Rienhoff, Jr., Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Deolinda Rodrigues Pereira Velloso, Benedict Yan, Raman Sood, Amy Hsu, Steven M. Holland, Kerry Phillips, Nicola Poplawski, Milena Babic, Erika M Kwon Kim, Andrew H. Wei, Cecily Forsyth, Helen Mar Fan, Ian D Lewis, Julian Cooney, Rachel Susman, Lucy C Fox, Piers Blombery, Deepak Singhal, Devendra Hiwase, Andreas W Schreiber, Christopher N Hahn, Hamish S Scott, Paul P. Liu, Lucy A. Godley
Journal: Blood
Blood (2022) 140 (Supplement 1): 4030–4033.
https://doi.org/10.1182/blood-2022-167600
Published: 2022
Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)

Francesca Palandri, Nicola Vianelli, David M Ross, Tara Cochrane, Steven W Lane, Stephen R Larsen, Aaron T. Gerds, Anna B. Halpern, Jake Shortt, James M. Rossetti, Kristen M. Pettit, Amber Jones, Jennifer Peppe, Georges Natsoulis, Willis Navarro, Wan-Jen Hong, William S. Stevenson, Claire N. Harrison, Moshe Talpaz, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2021) 138 (Supplement 1): 386.
https://doi.org/10.1182/blood-2021-148210
Published: 2021
Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Advanced Myelofibrosis

Harinder Gill, Abdulraheem Yacoub, Kristen M. Pettit, Terrence Bradley, Aaron T. Gerds, Maciej Tatarczuch, Jake Shortt, Natasha Joan Curtin, James M. Rossetti, Kate Burbury, Adam J. Mead, Joachim R. Göthert, Steffen Koschmieder, Amber Jones, Jennifer Peppe, Georges Natsoulis, Wan-Jen Hong, William S. Stevenson, Joanne Ewing, Claire N. Harrison, Alessandro Vannucchi, Justin Watts, David M Ross, Moshe Talpaz, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2021) 138 (Supplement 1): 139.
https://doi.org/10.1182/blood-2021-148682
Published: 2021
Journal Articles

LSD1 Inhibition with IMG7289 (bomedemstat) Rebalances Megakaryopoiesis and Erythropoiesis in a Patient with MPN/MDS with Refractory Anemia with Ringed Sideroblast and Marked Thrombocytosis with JAK2 and SF3B1 Mutations

Abdulraheem Yacoub, MD, Hugh Young Rienhoff, Jr., MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-141989
Published: 2020
Journal Articles

A Phase 2a Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Myelofibrosis

Kristen Pettit, MD, Aaron T. Gerds, MD MS, Abdulraheem Yacoub, MD, Justin M. Watts, MD, Maciej Tartaczuch, MD, Terrence J Bradley, MD, Jake Shortt, MBBS FRACP FRCPA PhD, William S. Stevenson, MBBS,PhD, Natasha Joan Curtin, MDFRACP,FRCPA, James M. Rossetti, DO, Kate Burbury, MBBS, FRACP, FRCPA, DPhil, Georges Natsoulis, PhD, Amber Jones, MA, Moshe Talpaz, MD, Jennifer Peppe, BS, David M Ross, MD PhD, Hugh Young Rienhoff, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 556.
https://doi.org/10.1182/blood-2019-123244
Published: 2019
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload

Clinical Trials & Observations
Ellis J. Neufeld, Renzo Galanello, Vip Viprakasit, Yesim Aydinok, Antonio Piga, Paul Harmatz, Gian Luca Forni, Farrukh T. Shah, Rachael F. Grace, John B. Porter, John C. Wood, Jennifer Peppe, Amber Jones, Hugh Young Rienhoff, Jr
Journal: Blood
Blood (2012) 119 (14): 3263–3268.
https://doi.org/10.1182/blood-2011-10-386268
Published: 2012
Includes: Supplemental data