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David C. Shyr
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Journal Articles

T-allo10 Immunotherapy Results in Enhanced Early Immune Reconstitution and Reduced GvHD with Excellent Clinical Outcomes Post Αβ-Depleted HSCT in Pediatric and Young Adult Hematologic Malignancy Patients

Alice Bertaina, Rosa Bacchetta, Alma-Martina Cepika, David C Shyr, Giulia Barbarito, Linda Oppizzi, Pauline Chen, Gopin Saini, Jennifer Lee, Karen Kristovich, Rajni Agarwal, Orly Klein, Kathryn Melsop, Keri Tate, Matthew Porteus, Maria Grazia Roncarolo
Journal: Blood
Blood (2024) 144 (Supplement 1): 3525.
https://doi.org/10.1182/blood-2024-194276
Published: 2024
Journal Articles

Rheological Comparison of Red Cells from Individuals with SCD Treated with Gene Therapy, Haploidentical Transplantation or Hydroxyurea

Britney Hernandez, Ashwin P. Patel, Erica N Evans, Jordan Zgodny, Stephen Gottschalk, Brandon M Triplett, Serena De Vita, Kirby Wallace, David C Shyr, Elizabeth O Stenger, Suhag Parikh, Akshay Sharma, Vivien Sheehan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4956.
https://doi.org/10.1182/blood-2024-210578
Published: 2024
Journal Articles

One Year Follow-up on the First Patient Treated with Nula-Cel: An Autologous CRISPR/Cas9 Gene Corrected CD34+ Cell Product to Treat Sickle Cell Disease

David C Shyr, Robert Lowsky, Weston Miller, Mark A. Schroeder, Tonia Buchholz, Kirstin Dougall, Allison Intondi, Alexandra Charles, Josh Lehrer, Ali Bouge, Stacey Wolf, Blair MacDonald, Hena Din, Alana Lerner, Manal Amoury, Sebastien Treusch, Glen Chew, Brian Silva, Haider Mashhedi, Vincent Siu, Ian Perrone, Twaritha Vijay, Aayami Jain, Kristina Krassovsky, William Matern, Premanjali Lahiri, Ryan Rodriguez, Jason Skowronski, Arpit Batish, Dana Margittai, Prachi Wani, Timothy Van Horn, Claudia Flautero, Rosalva Flores, Jade Lee, Keri Tate, Maria-Grazia Roncarolo, Steven Feldman, John DiPersio, Matthew Porteus
Journal: Blood
Blood (2023) 142 (Supplement 1): 5000.
https://doi.org/10.1182/blood-2023-188963
Published: 2023
Journal Articles

Machine Learning Approaches Incorporating High-Dimensional Longitudinal Data Improve the Prediction of Survival after Allogeneic Hematopoietic Cell Transplantation

Yiwang Zhou, Jesse Smith, Dinesh Keerthi, Suraj Sarvode Mothi, David C. Shyr, Barbara Spitzer, Avijit Chatterjee, Subrata Chatterjee, Swati Naik, Li Tang, Akshay Sharma
Journal: Blood
Blood (2022) 140 (Supplement 1): 322–323.
https://doi.org/10.1182/blood-2022-162890
Published: 2022
Journal Articles

Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC

CME Clinical Trials & Observations
Geoffrey D. E. Cuvelier, Brent R. Logan, Susan E. Prockop, Rebecca H. Buckley, Caroline Y. Kuo, Linda M. Griffith, Xuerong Liu, Alison Yip, Michael S. Hershfield, Paul G. Ayoub, Theodore B. Moore, Morna J. Dorsey, Richard J. O’Reilly, Neena Kapoor, Sung-Yun Pai, Malika Kapadia, Christen L. Ebens, Lisa R. Forbes Satter, Lauri M. Burroughs, Aleksandra Petrovic, Deepak Chellapandian, Jennifer Heimall, David C. Shyr, Ahmad Rayes, Jeffrey J. Bednarski, Sharat Chandra, Shanmuganathan Chandrakasan, Alfred P. Gillio, Lisa Madden, Troy C. Quigg, Emi H. Caywood, Blachy J. Dávila Saldaña, Kenneth DeSantes, Hesham Eissa, Frederick D. Goldman, Jacob Rozmus, Ami J. Shah, Mark T. Vander Lugt, Monica S. Thakar, Roberta E. Parrott, Caridad Martinez, Jennifer W. Leiding, Troy R. Torgerson, Michael A. Pulsipher, Luigi D. Notarangelo, Morton J. Cowan, Christopher C. Dvorak, Elie Haddad, Jennifer M. Puck, Donald B. Kohn
Journal: Blood
Blood (2022) 140 (7): 685–705.
https://doi.org/10.1182/blood.2022016196
Published: 2022
Includes: Supplemental data
Journal Articles

The Determinative Role of Hematopoietic Stem and Progenitor Cell Graft Composition on the Engraftment Kinetics after HSCT

Giulia Barbarito, Beruh Dejene, Gopin Saini, Rachana Patil, David C. Shyr, Robertson Parkman, Alice Bertaina, Kenneth I. Weinberg
Journal: Blood
Blood (2021) 138 (Supplement 1): 1794.
https://doi.org/10.1182/blood-2021-149690
Published: 2021
Journal Articles

Cedar Trial in Progress: A First in Human, Phase 1/2 Study of the Correction of a Single Nucleotide Mutation in Autologous HSCs (GPH101) to Convert HbS to HbA for Treating Severe SCD

Julie Kanter, John F. DiPersio, Patrick Leavey, David C. Shyr, Alexis A Thompson, Matthew H. Porteus, Allison Intondi, Premanjali Lahiri, Daniel P. Dever, Alexandria Petrusich, Joshua Lehrer-Graiwer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1864.
https://doi.org/10.1182/blood-2021-152892
Published: 2021
Journal Articles

Combinatorial Cytokine Secretion Signature of Donor-Derived T Cells Infused with the Graft: A New Potential Biomarker of Acute Graft-Versus-Host Disease in Αβt-Cell/CD19 B-Cell Depleted Hematopoietic Stem Cell Transplant Recipients

Raul Montiel-Esparza, Giulia Barbarito, Samantha Peck, Magali Bazzano, Rachana Patil, David C. Shyr, Gopin Saini, Robertson Parkman, Y. Lucy Liu, Alice Bertaina
Journal: Blood
Blood (2021) 138 (Supplement 1): 1684.
https://doi.org/10.1182/blood-2021-149948
Published: 2021
Journal Articles

Machine Learning Methods to Better Predict Post-Hematopoietic Stem Cell Transplant (HSCT) Leukemic Relapse in Pediatric Patients with Acute Lymphoblastic Leukemia: Random Forest (RF) Classification Featuring Serial Post-Transplant Lineage-Specific Chimerism

David C Shyr, MD, Bing Melody Zhang, Robertson Parkman, MD, Simon E. Brewer, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-139104
Published: 2020
Journal Articles

Heterogeneity of Hematopoietic Stem and Progenitor Cell (HSPC) Composition in Αβ T-Cell/CD19 B-Cell Depleted Peripheral Blood Cell Stem Cell (PBSC) Transplant Grafts and Correlation with Immune and Hematopoietic Recovery

Giulia Barbarito, Beruch Dejene, BS, David C Shyr, MD, Gopin Saini, MBBS, Linda Oppizzi, BS, Sruthi Mantri, Hye-Sook Kwon, PhD, Matthew H. Porteus, MD PhD, Kenneth I. Weinberg, MD, Alice Bertaina, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-143214
Published: 2020
Journal Articles

Comparison of Fixed Vs ALC-Based Doses of Thymoglobulin ® (ATG) in Pediatric Patients with Acute Leukemia Given αβhaplo-HSCT: Impact on Immune Reconstitution at Day 90

Giulia Barbarito, David C Shyr, MD, Gopin Saini, MBBS, Linda Oppizzi, BS, Y. Lucy Liu, MDPhD, Rachana Patil, MS, Jaap-Jan Boelens, MD PhD, Alice Bertaina, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16.
https://doi.org/10.1182/blood-2020-140461
Published: 2020
Journal Articles

First Report of Non-Genotoxic Conditioning with JSP191 (anti-CD117) and Hematopoietic Stem Cell Transplantation in a Newly Diagnosed Patient with Severe Combined Immune Deficiency

Rajni Agarwal, MD, Kenneth I. Weinberg, MD, Hye-Sook Kwon, PhD, Anne Le, Janel R Long-Boyle, PharmD, PhD, Donald B. Kohn, MD, Kathryn Bradford, MD, Satiro De Oliveira, MD, Alice Bertaina, MD PhD, Agnieszka Czechowicz, MDPhD, Matt Porteus, MD PhD, David C Shyr, MD, Katja G Weinacht, MD PhD, Ami J Shah, MD, Melissa Mavers, MD PhD, Elisabeth Merkel, RN, Janice W Brown, MD, Christopher C. Dvorak, MD, Robertson Parkman, MD, Maria Grazia Roncarolo, MD, Judith A Shizuru, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10.
https://doi.org/10.1182/blood-2020-137762
Published: 2020
Journal Articles

Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report

Clinical Trials & Observations
Lauri M. Burroughs, Aleksandra Petrovic, Ruta Brazauskas, Xuerong Liu, Linda M. Griffith, Hans D. Ochs, Jack J. Bleesing, Stephanie Edwards, Christopher C. Dvorak, Sonali Chaudhury, Susan E. Prockop, Ralph Quinones, Frederick D. Goldman, Troy C. Quigg, Shanmuganathan Chandrakasan, Angela R. Smith, Suhag Parikh, Blachy J. Dávila Saldaña, Monica S. Thakar, Rachel Phelan, Shalini Shenoy, Lisa R. Forbes, Caridad Martinez, Deepak Chellapandian, Evan Shereck, Holly K. Miller, Neena Kapoor, Jessie L. Barnum, Hey Chong, David C. Shyr, Karin Chen, Rolla Abu-Arja, Ami J. Shah, Katja G. Weinacht, Theodore B. Moore, Avni Joshi, Kenneth B. DeSantes, Alfred P. Gillio, Geoffrey D. E. Cuvelier, Michael D. Keller, Jacob Rozmus, Troy Torgerson, Michael A. Pulsipher, Elie Haddad, Kathleen E. Sullivan, Brent R. Logan, Donald B. Kohn, Jennifer M. Puck, Luigi D. Notarangelo, Sung-Yun Pai, David J. Rawlings, Morton J. Cowan
Journal: Blood
Blood (2020) 135 (23): 2094–2105.
https://doi.org/10.1182/blood.2019002939
Published: 2020
Journal Articles

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery

Elie Haddad, Brent R. Logan, Linda M. Griffith, Rebecca H. Buckley, Roberta E. Parrott, Susan E. Prockop, Trudy N. Small, Jessica Chaisson, Christopher C. Dvorak, Megan Murnane, Neena Kapoor, Hisham Abdel-Azim, Imelda C. Hanson, Caridad Martinez, Jack J. H. Bleesing, Sharat Chandra, Angela R. Smith, Matthew E. Cavanaugh, Soma Jyonouchi, Kathleen E. Sullivan, Lauri Burroughs, Suzanne Skoda-Smith, Ann E. Haight, Audrey G. Tumlin, Troy C. Quigg, Candace Taylor, Blachy J. Dávila Saldaña, Michael D. Keller, Christine M. Seroogy, Kenneth B. Desantes, Aleksandra Petrovic, Jennifer W. Leiding, David C. Shyr, Hélène Decaluwe, Pierre Teira, Alfred P. Gillio, Alan P. Knutsen, Theodore B. Moore, Morris Kletzel, John A. Craddock, Victor Aquino, Jeffrey H. Davis, Lolie C. Yu, Geoffrey D. E. Cuvelier, Jeffrey J. Bednarski, Frederick D. Goldman, Elizabeth M. Kang, Evan Shereck, Matthew H. Porteus, James A. Connelly, Thomas A. Fleisher, Harry L. Malech, William T. Shearer, Paul Szabolcs, Monica S. Thakar, Mark T. Vander Lugt, Jennifer Heimall, Ziyan Yin, Michael A. Pulsipher, Sung-Yun Pai, Donald B. Kohn, Jennifer M. Puck, Morton J. Cowan, Richard J. O'Reilly, Luigi D. Notarangelo
Journal: Blood
Blood (2018) 132 (17): 1737–1749.
https://doi.org/10.1182/blood-2018-03-840702
Published: 2018
Includes: Supplemental data