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Journal Articles

AZD4573 Effectively Induces Apoptosis in r/r MCL As a Monotherapy or in Combination with Acalabrutinib

Justine Roderick, Scott Boiko, Courtney L Andersen, Huiling Liang, Gregory Dowdell, Corinne Reimer, Lisa Drew, Danielle M Townsley, Justin Cidado

Blood (2021) 138 (Supplement 1): 2255.

https://doi.org/10.1182/blood-2021-151725

Published: 2021

Journal Articles

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

Thomas Winkler, Xing Fan, James Cooper, Ronan Desmond, David J. Young, Danielle M. Townsley, Phillip Scheinberg, Sophia Grasmeder, Andre Larochelle, Marie Desierto, Janet Valdez, Jennifer Lotter, Colin Wu, Ruba N. Shalhoub, Katherine R. Calvo, Neal S. Young, Cynthia E. Dunbar

Blood (2019) 133 (24): 2575–2585.

https://doi.org/10.1182/blood.2019000478

Published: 2019

Journal Articles

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ

Luigi J. Alvarado, Heather D. Huntsman, Hai Cheng, Danielle M. Townsley, Thomas Winkler, Xingmin Feng, Cynthia E. Dunbar, Neal S. Young, Andre Larochelle

Blood (2019) 133 (19): 2043–2055.

https://doi.org/10.1182/blood-2018-11-884486

Published: 2019

Includes: Supplemental data

Journal Articles

Discovery and Development of MEDI7247, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate Targeting ASCT2, for Treating Hematological Cancers

Nabendu Pore, Kevin P Schifferli, Noel R Monks, Ravinder Tammali, Martin Borrok, Elaine Hurt, Matt Flynn, Marlon Rebelatto, Danielle M. Townsley, MD MSc, Mary Jane Hinrichs, Rakesh Dixit, Steven Coats, Ronald Herbst, David Tice

Blood (2018) 132 (Supplement 1): 4071.

https://doi.org/10.1182/blood-2018-99-119836

Published: 2018

Journal Articles

Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies

Fernanda Gutierrez-Rodrigues, PhD, Flávia S Donaires, PhD, André Pinto, Alana Vicente, MD, Laura Dillon, PhD, Diego V Clé, MDPhD, Bárbara Santana, Maria del Pilar Fernandez Ibanez, Danielle M. Townsley, MD MSc, Sachiko Kajigaya, PhD, Christopher S. Hourigan, DPhil FACP FRCP, James N. Cooper, MD, Rodrigo T. Calado, MD PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 539.

https://doi.org/10.1182/blood-2018-99-115430

Published: 2018

Journal Articles

Single Cell Transcriptome Analysis of GATA2 Deficiency in Hematopoiesis Modeled with Induced Pluripotent Stem Cells

Francis Guitart, BA, Moonjung Jung, MD, Stefan Cordes, MD PhD, Shiqin Yu, Jizhong Zou, So Gun Hong, PhD, Vinh Dang, Diego A Espinoza, BA, Amy Hsu, Steven M. Holland, MD, Danielle M. Townsley, MD MSc, Cynthia E. Dunbar, MD, Thomas Winkler, MD

Blood (2018) 132 (Supplement 1): 5087.

https://doi.org/10.1182/blood-2018-99-118410

Published: 2018

Journal Articles

Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Xing Fan, MD, Thomas Winkler, MD, Ronan Desmond, MD, Bogdan Dumitriu, MD, Danielle M. Townsley, MD MSc, Maria del Pilar Fernandez Ibanez, Fernanda Gutierrez-Rodrigues, PhD, Sophia Grasmeder, RN, Ma Evette Barranta, Diane Madey, Jennifer Lotter, Janet Valdez, Katherine R. Calvo, MD PhD, Colin Wu, PhD, Neal S. Young, MD, Cynthia E. Dunbar, MD

Blood (2018) 132 (Supplement 1): 538.

https://doi.org/10.1182/blood-2018-99-112994

Published: 2018

Journal Articles

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Fernanda Gutierrez-Rodrigues, PhD, Carrie Diamond, MD, Ruba Shalhoub, André Pinto, Flávia S Donaires, PhD, Diego V Clé, MD PhD, Luiz Guilherme Darrigo, PhD, Luiz Fernando Catto, MD, Xing Fan, MD, Maria del Pilar Fernandez Ibanez, Sachiko Kajigaya, PhD, Cynthia E. Dunbar, MD, Carmem M. S. Bonfim, MD, Danielle M. Townsley, MD MSc, Rodrigo T. Calado, MD PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 2587.

https://doi.org/10.1182/blood-2018-99-115026

Published: 2018

Journal Articles

Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)

Alana Vicente, MD, Fernanda Gutierrez-Rodrigues, PhD, Valentina Giudice, MD, Zhijie Wu, MD PhD, Sachiko Kajigaya, PhD, Maria del Pilar Fernandez Ibanez, Maher Albitar, MD, Barbara Weinstein, RN, Katherine R. Calvo, MD PhD, Danielle M. Townsley, MDMSc, Phillip Scheinberg, MD, Cynthia E. Dunbar, MD, Neal S. Young, MD, Thomas Winkler, MD

Blood (2018) 132 (Supplement 1): 229.

https://doi.org/10.1182/blood-2018-99-119780

Published: 2018

Journal Articles

Eltrombopag mobilizes iron in patients with aplastic anemia

Zhen Zhao, Qian Sun, Lori J. Sokoll, Michael Streiff, Zhe Cheng, Sophie Grasmeder, Danielle M. Townsley, Neal S. Young, Cynthia E. Dunbar, Thomas Winkler

Blood (2018) 131 (21): 2399–2402.

https://doi.org/10.1182/blood-2018-01-826784

Published: 2018

Includes: Supplemental data

Journal Articles

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells

Xin Zhao, Shouguo Gao, Zhijie Wu, Sachiko Kajigaya, Xingmin Feng, Qingguo Liu, Danielle M. Townsley, James Cooper, Jinguo Chen, Keyvan Keyvanfar, Maria del Pilar Fernandez Ibanez, Xujing Wang, Neal S. Young

Blood (2017) 130 (25): 2762–2773.

https://doi.org/10.1182/blood-2017-08-803353

Published: 2017

Includes: Supplemental data

Journal Articles

Eltrombopag for Refractory Severe Aplastic Anemia: Dosing Regimens, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Thomas Winkler, MD, James N. Cooper, MD, Danielle M. Townsley, MDMSc, Phillip Scheinberg, MD, Sophia Grasmeder, RN, Colin Wu, PhD, Jennifer Lotter, Marie J Desierto, MS, Ronan Desmond, MD, Matthew J. Olnes, MD PhD, Katherine R Calvo, MD PhD, Neal S. Young, MD, Cynthia E Dunbar, MD

Blood (2017) 130 (Supplement 1): 777.

https://doi.org/10.1182/blood.V130.Suppl_1.777.777

Published: 2017

Journal Articles

Germline Mutations in CTLA4 and Spectrum of Bone Marrow Features Overlapping with Aplastic Anemia and Large Granular Lymphocyte Lymphocytosis

Laura M Wake, MD, Changqing Xie, MD, Weixin Wang, PhD, Kristian T. Schafernak, MD MPH, V. Koneti Rao, MD FRCPA, Neal S. Young, MD, Danielle M. Townsley, MDMSc, Gulbu Uzel, MD, Katherine R Calvo, MD PhD

Blood (2017) 130 (Supplement 1): 2448.

https://doi.org/10.1182/blood.V130.Suppl_1.2448.2448

Published: 2017

Journal Articles

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs

Marcus A. F. Corat, Heinrich Schlums, Chuanfeng Wu, Jakob Theorell, Diego A. Espinoza, Stephanie E. Sellers, Danielle M. Townsley, Neal S. Young, Yenan T. Bryceson, Cynthia E. Dunbar, Thomas Winkler

Blood (2017) 129 (14): 1940–1946.

https://doi.org/10.1182/blood-2016-08-734285

Published: 2017

Includes: Supplemental data

Journal Articles

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Xingmin Feng, PhD, Delong Liu, PhD, Sachiko Kajigaya, PhD, Zhijie Wu, MD, Qingguo Liu, MD, Keyvan Keyvanfar, BS, Marie J. Desierto, BS, Danielle M. Townsley, MD, Xujing Wang, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 574.

https://doi.org/10.1182/blood.V128.22.574.574

Published: 2016

Journal Articles

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Kohei Hosokawa, MDPhD, Sachiko Kajigaya, PhD, Keyvan Keyvanfar, BS, Qiao Wangmin, BS, Yanling Xie, MS, Olga Rios, RN, Barbara Weinstein, RN, Maria del Pilar Fernandez Ibanez, BS, Danielle M. Townsley, MD, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1042.

https://doi.org/10.1182/blood.V128.22.1042.1042

Published: 2016

Journal Articles

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Fernanda Gutierrez-Rodrigues, MSc, PharmD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Maria del Pilar Fernandez Ibanez, MS, Marie J. Desierto, BS, Keyvan Keyvanfar, BS, Zejuan Li, MD PhD, Soma Das, PhD, Rodrigo T. Calado, MD PhD, Danielle M. Townsley, MD, Neal S. Young

Blood (2016) 128 (22): 1044.

https://doi.org/10.1182/blood.V128.22.1044.1044

Published: 2016

Journal Articles

Myeloid Neoplasm Gene Somatic Mutations in Patients with Severe Aplastic Anemia Treated with Eltrombopag and Standard Immunosuppression

Danielle M. Townsley, MD, James N. Cooper, MD, Thomas Winkler, MD, Phillip Scheinberg, MD, Olga Rios, RN, Barbara Weinstein, RN, Janet Valdez, Jennifer Lotter, Marie J. Desierto, BS, Maria del Pilar Fernandez Ibanez, MS, Colin Wu, PhD, Cynthia E. Dunbar, MD, Wanlong Ma, BS, Maher Albitar, MD, Neal S. Young

Blood (2016) 128 (22): 727.

https://doi.org/10.1182/blood.V128.22.727.727

Published: 2016

Journal Articles

A Plasma microRNA Signature As a Biomarker for Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Marie J. Desierto, BS, Maria del Pilar Fernandez Ibanez, BS, Olga Rios, RN, Barbara Weinstein, RN, Phillip Scheinberg, MD, Danielle M. Townsley, MD, Neal S. Young, MD

Blood (2016) 128 (22): 728.

https://doi.org/10.1182/blood.V128.22.728.728

Published: 2016

Journal Articles

Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status

Caroline R Cantilena, BA, Xin Zhao, MD PhD, Sachiko Kajigaya, PhD, Neil Dunavin, MD, Xin Tian, PhD, Stephen A. Strickland, MD, Bipin N. Savani, MD, Sanjay R. Mohan, MD, Katayoun Rezvani, MDPhD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Minoo Battiwalla, MDMS, Sawa Ito, MD, Austin John Barrett, MDFRCP,FRCPath

Blood (2015) 126 (23): 1267.

https://doi.org/10.1182/blood.V126.23.1267.1267

Published: 2015

NARROW

AZD4573 Effectively Induces Apoptosis in r/r MCL As a Monotherapy or in Combination with Acalabrutinib

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ

Discovery and Development of MEDI7247, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate Targeting ASCT2, for Treating Hematological Cancers

Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies

Single Cell Transcriptome Analysis of GATA2 Deficiency in Hematopoiesis Modeled with Induced Pluripotent Stem Cells

Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)

Eltrombopag mobilizes iron in patients with aplastic anemia

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells

Eltrombopag for Refractory Severe Aplastic Anemia: Dosing Regimens, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Germline Mutations in CTLA4 and Spectrum of Bone Marrow Features Overlapping with Aplastic Anemia and Large Granular Lymphocyte Lymphocytosis

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Myeloid Neoplasm Gene Somatic Mutations in Patients with Severe Aplastic Anemia Treated with Eltrombopag and Standard Immunosuppression

A Plasma microRNA Signature As a Biomarker for Acquired Aplastic Anemia

Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status

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American Society of Hematology

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ASH Publications

American Society of Hematology

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