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César Alexander Ortiz Rojas
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Journal Articles

MLL5-Driven Leukemic Transformation Is Linked to Chromatin Remodeling and Can be Targeted with ATRA in Combination with PARP1 Inhibition

Luise Araujo De Albuquerque Simoes, Isabel Weinhäuser, Diego A Pereira-Martins, Luciana Yamamoto Almeida, Vincent Van Den Boom, Fatemeh Mojallali, Dominique Sternadt, Prodromos Chatzikyriakou, Xuesen Zheng, César Alexander Ortiz Rojas, Ghulam Jeelani Mufti, Lucio Henrique Pinheiro, Lynn Quek, Gerwin A. Huls, Eduardo M. Rego, Jan Jacob Schuringa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1539.
https://doi.org/10.1182/blood-2024-209817
Published: 2024
Journal Articles

The Oncogenic ΔNp73α Isoform Contributes to Aggressiveness in APL By Leading to ATRA Resistance through NANOG/BMP4 Axis Upregulation

César Alexander Ortiz Rojas, Diego A. Pereira-Martins, Carol Thomé, Germano Ferreira, Thiago Mantello Bianco, Isabel Weinhäuser, Cleide Lúcia Araújo Silva, Lorena Pontes, Vitor Faça, Emanuele Ammatuna, Gerwin Huls, Jan Jacob Schuringa, Eduardo M. Rego
Journal: Blood
Blood (2024) 144 (Supplement 1): 1350.
https://doi.org/10.1182/blood-2024-205613
Published: 2024
Journal Articles

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

Diego A. Pereira-Martins, Vincent Van Den Boom, Isabel Weinhaeuser, Nisha van der Meer, Prodromos Chatzikyriakou, Noortje van Dijk, Xuesen Zheng, Lucio H Pinheiro, Douglas RA Silveira, Thiago Mantello Bianco, César Alexander Ortiz Rojas, Eduardo M. Rego, Stuart A Rushworth, Antonio R. Lucena-Araujo, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa
Journal: Blood
Blood (2024) 144 (Supplement 1): 4321.
https://doi.org/10.1182/blood-2024-207421
Published: 2024
Journal Articles

Impact of Ph-like Gene Signatures on Clinical Outcomes in Adult B-ALL Patients in Resource-Constrained Settings

Keli Lima, César Alexander Ortiz Rojas, Frederico Lisboa Nogueira, Wellington F. Silva, Rita de Cássia Cavaglieri Medeiros, Luciana Nardinelli, Aline de Medeiros Leal, Elvira D. R. P. Velloso, Israel Bendit, Alvaro J Alencar, Charles G. Mullighan, João Agostinho Machado-Neto, Eduardo M. Rego
Journal: Blood
Blood (2024) 144 (Supplement 1): 2802.
https://doi.org/10.1182/blood-2024-208763
Published: 2024
Journal Articles

CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia

Diego Pereira-Martins, César Alexander Ortiz Rojas, Isabel Weinhaeuser, Bart-Jan Wierenga, Vincent Van Den Boom, Fatemeh Mojallali, Dominique Sternadt, Thiago Mantello Bianco, Nisha van der Meer, Douglas RA Silveira, Lynn Quek, Emanuele Ammatuna, Antonio R Lucena-Araujo, Gerwin A. Huls, Eduardo Magalhães Rego, Jan Jacob Schuringa
Journal: Blood
Blood (2023) 142 (Supplement 1): 839.
https://doi.org/10.1182/blood-2023-186399
Published: 2023
Journal Articles

Treatment with the Recombinant SLIT2 Protein Delays AML Leukemogenesis In Vivo

Luise A de Albuquerque Simoes, Isabel Weinhäuser, Diego A Pereira-Martins, César Alexander Ortiz Rojas, Thiago Mantello Bianco, Rita de Cassia Cavaglieri, Eduardo M Rego
Journal: Blood
Blood (2021) 138 (Supplement 1): 2368.
https://doi.org/10.1182/blood-2021-151069
Published: 2021
Journal Articles

Reduced SLIT2 Are Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in APL Cells

Isabel Weinhäuser, MSc, Diego A Pereira-Martins, MSc, Luíse A A Simões, BSc, César Alexander Ortiz Rojas, BSc, Thiago Mantello Bianco, MSc, Cleide Lucia Silva, MSc, Mariane Cristina Do Nascimento, BSc, Lorena Lobo Figueiredo-Pontes, MD PhD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5165.
https://doi.org/10.1182/blood-2019-131496
Published: 2019
Journal Articles

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Juan L Coelho-Silva, BSc, MSc, Douglas R. A. Silveira, Diego A Pereira-Martins, MSc, César Alexander Ortiz Rojas, BSc, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD, João Agostinho Machado-Neto, PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4257.
https://doi.org/10.1182/blood-2019-132141
Published: 2019
Journal Articles

Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia

César Alexander Ortiz Rojas, BSc, Diego A Pereira-Martins, MSc, Isabel Weinhäuser, MSc, Luciana Yamamoto Almeida, PhD, Thiago Mantello Bianco, MSc, Lorena Lobo Figueiredo-Pontes, MD PhD, Luisa C A Koury, MD, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, Katia B Pagnano, MD PhD, Ricardo Pasquini, MD, Elenaide C. Nunes, MD, Evandro Maranhão Fagundes, MD, Ana Beatriz F. Gloria, MD, Fabio R. Kerbauy, MD, Armand Keating, MD, Martin S. Tallman, MD, Raul Ribeiro, MD, Richard Dillon, MA, PhD MRCP, FRCPath, Arnold Ganser, MD, Bob Löwenberg, MD PhD, Peter Valk, PhD, Miguel A. Sanz, Nancy Berliner, MD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2719.
https://doi.org/10.1182/blood-2019-131211
Published: 2019
Journal Articles

MN1 Expression Is an Indepedent Prognostic Marker in FLT3-Mutated Acute Myeloid Leukemia and Is Involved in the Resistance to FLT3 Inhibitors

Diego A Pereira-Martins, MSc, Juan L Coelho-Silva, BSc, MSc, Isabel Weinhäuser, MSc, Carol Hassibe Thomé, César Alexander Ortiz Rojas, BSc, Luíse A A Simões, BSc, Fabiola Traina, MD PhD, Michael Heuser, MD, Arnold Ganser, MD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1403.
https://doi.org/10.1182/blood-2019-131542
Published: 2019