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Volume 132, Issue 15
October 11 2018
Issue Cover

Table of Contents

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS
A new triple threat to CLL
Clinical Trials & Observations
Benjamin L. Lampson,Matthew S. Davids
View Articletitled, A new triple threat to CLL
THROMBOSIS AND HEMOSTASIS
Three strikes to a hemophilic joint bleed
Ton Lisman
View Articletitled, Three strikes to a hemophilic joint bleed
Red Cells, Iron, and Erythropoiesis
Brain iron in sickle cell disease?
Fenella J. Kirkham,Karin Shmueli
View Articletitled, Brain iron in sickle cell disease?

BLOOD SPOTLIGHT

Chronic immune response dysregulation in MDS pathogenesis
Laura Barreyro,Timothy M. Chlon,Daniel T. Starczynowski
View Articletitled, Chronic immune response dysregulation in MDS pathogenesis

REVIEW ARTICLE

Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks
Maurilio Ponzoni,Elias Campo,Shigeo Nakamura
View Articletitled, Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks

CLINICAL TRIALS AND OBSERVATIONS

Phase 1b study of obinutuzumab, ibrutinib, and venetoclax in relapsed and refractory chronic lymphocytic leukemia
Clinical Trials & Observations
Kerry A. Rogers,Ying Huang,Amy S. Ruppert,Farrukh T. Awan,Nyla A. Heerema,Corinne Hoffman,Gerard Lozanski,Kami J. Maddocks,Mollie E. Moran,Mark A. Reid,Margaret Lucas,Jennifer A. Woyach,W. Thomas Whitlow,Jeffrey A. Jones,John C. Byrd
View Articletitled, Phase 1b study of obinutuzumab, ibrutinib, and venetoclax in relapsed and refractory chronic lymphocytic leukemia
Supplemental data

LYMPHOID NEOPLASIA

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use
Margs S. Brennan,Catherine Chang,Lin Tai,Guillaume Lessene,Andreas Strasser,Grant Dewson,Gemma L. Kelly,Marco J. Herold
View Articletitled, Humanized <em>Mcl-1</em> mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use
Supplemental data

MYELOID NEOPLASIA

Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group
Clinical Trials & Observations
Sanne Noort,Martin Zimmermann,Dirk Reinhardt,Wendy Cuccuini,Martina Pigazzi,Jenny Smith,Rhonda E. Ries,Todd A. Alonzo,Betsy Hirsch,Daisuke Tomizawa,Franco Locatelli,Tanja A. Gruber,Susana Raimondi,Edwin Sonneveld,Daniel K. Cheuk,Michael Dworzak,Jan Stary,Jonas Abrahamsson,Nira Arad-Cohen,Malgorzata Czogala,Barbara De Moerloose,Henrik Hasle,Soheil Meshinchi,Marry van den Heuvel-Eibrink,C. Michel Zwaan
View Articletitled, Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group
Supplemental data

THROMBOSIS AND HEMOSTASIS

Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding
Tine Wyseure,Esther J. Cooke,Paul J. Declerck,Niels Behrendt,Joost C. M. Meijers,Annette von Drygalski,Laurent O. Mosnier
View Articletitled, Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding
Supplemental data

TRANSPLANTATION

Next-generation sequencing–based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse
Clinical Trials & Observations
TaeHyung Kim,Joon Ho Moon,Jae-Sook Ahn,Yeo-Kyeoung Kim,Seung-Shin Lee,Seo-Yeon Ahn,Sung-Hoon Jung,Deok-Hwan Yang,Je-Jung Lee,Seung Hyun Choi,Ja-yeon Lee,Marc S. Tyndel,Myung-Geun Shin,Yoo Jin Lee,Sang Kyun Sohn,Seong-Kyu Park,Zhaolei Zhang,Hyeoung-Joon Kim,Dennis Dong Hwan Kim
View Articletitled, Next-generation sequencing–based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse
Supplemental data

LETTERS TO BLOOD

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia
Ameera Alsadeq,Lennart Lenk,Anila Vadakumchery,Antony Cousins,Christian Vokuhl,Ahmad Khadour,Fotini Vogiatzi,Felix Seyfried,Lueder-Hinrich Meyer,Gunnar Cario,Elias Hobeika,Klaus-Michael Debatin,Christina Halsey,Martin Schrappe,Denis M. Schewe,Hassan Jumaa
View Articletitled, IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia
Supplemental data
Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study
Xin Miao,Soyoung Choi,Benita Tamrazi,Yaqiong Chai,Chau Vu,Thomas D. Coates,John C. Wood
View Articletitled, Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study
Supplemental data
HMOX1 and acute kidney injury in sickle cell anemia
Santosh L. Saraf,Maya Viner,Ariel Rischall,Rasha Raslan,Binal N. Shah,Xu Zhang,Jin Han,Michel Gowhari,Shivi Jain,Robert E. Molokie,Roberto F. Machado,James P. Lash,Victor R. Gordeuk
View Articletitled, <em>HMOX1</em> and acute kidney injury in sickle cell anemia
Supplemental data

BLOOD WORK

Patchy hematopoiesis mimicking bone metastasis
A. C. Cornelisse,Peter A. W. te Boekhorst
View Articletitled, Patchy hematopoiesis mimicking bone metastasis
Hyperviscosity syndrome in splenic marginal zone lymphoma
Raeye Daniel,Randall Y. Chan
View Articletitled, Hyperviscosity syndrome in splenic marginal zone lymphoma
  • Cover Image

    Cover Image

    issue cover

    Safranin O–fast green–hematoxylin-stained knee joint from an injured FVIII−/− mouse, showing extravasated and pooled erythrocytes (dark green), resulting in inflammation and joint swelling. This model was used to uncover that defective thrombin-activatable fibrinolysis inhibitor (TAFI) activation contributes to hemophilic joint bleeding. See the article by Wyseure et al on page 1593.

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Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies

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