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Issue Archive

Volume 9, Issue 8
April 22 2025
In Progress
Blood Advances Cover Image for Volume 9, Issue 8

THROMBOSIS AND HEMOSTASIS

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS
Quintijn Bonnez,Emily R. Legan,Inge Pareyn,Febe Boudry,Jennifer Anckaert,Claudia Tersteeg,Simon F. De Meyer,Renhao Li,Karen Vanhoorelbeke
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Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis
Jan Zlamal,Vera M. Ripoll,Christine S.M. Lee,Filip Toma,Karina Althaus,Flavianna Rigoni,Andreas Witzemann,Shane Whittaker,David Capraro,Günalp Uzun,Tamam Bakchoul,Vivien M. Chen
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A model of zymogen factor XII: insights into protease activation
Aleksandr Shamanaev,Yujie Ma,Michal B. Ponczek,Mao-fu Sun,Quifang Cheng,S. Kent Dickeson,Owen J. T. McCarty,Jonas Emsley,Bassem M. Mohammed,David Gailani
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RESEARCH LETTER

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma with novel FGFR1 fusion treated with pemigatinib
Carlos A. Torres-Cabala,Julia Arreola Yescas,Yue Zhang,Auris Huen,Gaur Sumit,Kristy Tefft,Guilin Tang,Jonathan L. Curry,Jillian Gunther,Bouthaina Dabaja,Swaminathan Iyer,Roberto N. Miranda,Jaehyuk Choi,Valentina Nardi
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ICE polychemotherapy is an efficient salvage treatment in primary central nervous system lymphoma: an LOC network study
Louis Pérol,Adrien Grenier,Carole Soussain,Khê Hoang-Xuan,Inès Boussen,Marine Baron,Véronique Morel,Nabih Azar,Maya Ouzegdouh,Madalina Uzunov,Magali Le Garff-Tavernier,Laetitia Souchet,Nicolas Gauthier,Marie-Pierre Moles,Thomas Gastinne,Caroline Houillier,Sylvain Choquet,Damien Roos-Weil
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Targeting RNA modification and mitochondrial metabolism cross talk in leukemic stem cells with CDK7 inhibitor TGN-1062
Hyunjun Kang,Lianjun Zhang,Mohan R. Kaadige,Melissa Valerio,Dinh Hoa Hoang,Trason Thode,Alexis Weston,Khyatiben Pathak,Lokesh Nigam,Nathanial P. Hansen,Brooke Lovell,Yuriy Shostak,Wei Li,Lucy Ghoda,Zhuo Li,Bin Zhang,Jianjun Chen,Patrick Pirrotte,Ya-Huei Kuo,Sunil Sharma,Guido Marcucci,Le Xuan Truong Nguyen
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Distress and symptom burden in patients with monoclonal gammopathy of undetermined significance and smoldering myeloma
Clinical Trials & Observations
Elizabeth K. O’Donnell,Jennifer E. Carroll,Jaqueline Perry,Katherine Padgett,Benjamin Harris,Vidhi Patel,Omar Nadeem,Areej El-Jawahri,Irene M. Ghobrial,Catherine R. Marinac
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CLINICAL TRIALS AND OBSERVATIONS

Stroke prevention in Hispanic children with sickle cell anemia: the SACRED trial
Clinical Trials & Observations
Rosa M. Nieves,Teresa Latham,Nicolle Marte,Melissa Berges,Luisanna M. Sánchez,Gabriela Urcuyo,Carla Florencio,Carla Gonzalez,Paola del Villar,Sheena Chen,Daniel Ramirez,Paula Reyes,Manuel Marinez,Euladys Matos,Neelum D. Jeste,Susan E. Stuber,William H. Schultz,Adam C. Lane,Rafael Mena,Russell E. Ware
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Patient-reported improvements in paroxysmal nocturnal hemoglobinuria treated with iptacopan from 2 phase 3 studies
Clinical Trials & Observations
Antonio M. Risitano,Carlos de Castro,Bing Han,Austin Kulasekararaj,Jaroslaw P. Maciejewski,Phillip Scheinberg,Yasutaka Ueda,Susan Vallow,Georgina Bermann,Marion Dahlke,Rakesh Kumar,Régis Peffault de Latour
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Final analysis of the phase 1b Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT)
Clinical Trials & Observations
Chong Chyn Chua,Sun Loo,Chun Yew Fong,Stephen B. Ting,Ing Soo Tiong,Shaun Fleming,Natasha S. Anstee,Adam Ivey,Michael Ashby,Tse-Chieh Teh,John Reynolds,Andrew W. Roberts,Andrew H. Wei
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C3 as a predictive and prognostic biomarker in adult hemophagocytic lymphohistiocytosis: a large cohort study in China
Clinical Trials & Observations
Xuemei Shu,Xinjie Gao,Yujun Dai,Yuxiang Wang,Yilin Liu,Dawei Wang,Tao Guo
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Phase 1 study of CD19 CAR T-cell therapy harboring a fully human scFv in CAR-naïve adult patients with B-ALL
Clinical Trials & Observations
Jordan Gauthier,Emily C. Liang,Jennifer J. Huang,Erik L. Kimble,Alexandre V. Hirayama,Salvatore Fiorenza,Jenna M. Voutsinas,Qian (Vicky) Wu,Carla A. Jaeger-Ruckstuhl,Barbara S. Pender,Delaney R. Kirchmeier,Aiko Torkelson,Kristina Braathen,Ryan Basom,Mazyar Shadman,Noam E. Kopmar,Ryan D. Cassaday,Stanley R. Riddell,David G. Maloney,Cameron J. Turtle
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Humanizing CAR T-cell therapy in B-ALL
Clinical Trials & Observations
Rawan Faramand,Lori Muffly
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Acquired mutations in patients with relapsed/refractory CLL who progressed in the ALPINE study
Clinical Trials & Observations
Jennifer R. Brown,Jessica Li,Barbara F. Eichhorst,Nicole Lamanna,Susan M. O’Brien,Constantine S. Tam,Lugui Qiu,Ruiqi Huang,Yang Shi,Adam Idoine,Tommi Salmi,Aileen Cleary Cohen,Mazyar Shadman
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Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia
Clinical Trials & Observations
Parinda A. Mehta,Adam Nelson,Sara Loveless,Adam Lane,Tsuyoshi Fukuda,Ashley Teusink-Cross,Deborah Elder,Denise Lagory,Erica Miller,Jose A. Cancelas,Jonathan Howell,Junfang Zhao,Kana Mizuno,Kasiani C. Myers,Kelly Lake,Kelly McIntosh,Kenneth D. R. Setchell,Nathan Luebbering,Stephanie Edwards,Tafadzwa Chihanga,Susanne I. Wells,Stella M. Davies
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Characterizing the heterogeneity of Castleman disease and oligocentric subtype: findings from the ACCELERATE registry
Clinical Trials & Observations
Sheila K. Pierson,Joshua D. Brandstadter,Drew A. Torigian,Adam Bagg,Mary Jo Lechowicz,Daisy Alapat,Corey Casper,Amy Chadburn,Shanmuganathan Chandrakasan,Angela Dispenzieri,Alexander Fosså,Christian Hoffmann,Makoto Ide,Razelle Kurzrock,Sudipto Mukherjee,Sunita Nasta,José-Tomás Navarro,Ariela Noy,Eric Oksenhendler,Mateo Sarmiento Bustamante,Saishravan Shyamsundar,Matthew Streetly,Raymond S. M. Wong,Lu Zhang,Megan S. Lim,Gordan Srkalovic,Frits van Rhee,David C. Fajgenbaum
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Lymphoid Neoplasia

Large clones of clonal hematopoiesis affect outcome in mantle cell lymphoma: results from the FIL MCL0208 clinical trial
Simone Ragaini,Anna Galli,Elisa Genuardi,Martina Gandossini,Beatrice Alessandria,Aurora Maria Civita,Andrea Evangelista,Enrico Amaducci,Vittorio Stefoni,Federica Cavallo,Filippo Ballerini,Benedetta Puccini,Daniele Vallisa,Mariagrazia Michieli,Anna Pascarella,Angelo Palmas,Caterina Patti,Elisa Lucchini,Maria Grazia Careddu,Michele Merli,Massimiliano Postorino,Carola Boccomini,Monica Balzarotti,Vittorio Ruggero Zilioli,Maria Gomes da Silva,Benedetto Bruno,Ettore Rizzo,Marco Ladetto,Luca Malcovati,Simone Ferrero
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REVIEW ARTICLE

Hepatosplenic T-cell lymphoma in children and adolescents
Clinical Trials & Observations
Lindsay F. Schwartz,Kaitlin J. Devine,Ana C. Xavier
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Fedratinib in 2025 and beyond: indications and future applications
Alexander Coltoff,John Mascarenhas
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Inside Blood Advances

Sickle cell care and implementation science
Clinical Trials & Observations
Halima Bello-Manga,Allison A. King
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Humanizing CAR T-cell therapy in B-ALL
Clinical Trials & Observations
Rawan Faramand,Lori Muffly
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MYELOID NEOPLASIA

Deciphering the complex clonal heterogeneity of polycythemia vera and the response to interferon alfa
Milena Kalmer,Martin Grasshoff,Tiago Maié,Kristina Pannen,Marcelo A.S. Toledo,Margherita Vieri,Kathrin Olschok,Rebecca Lemanzyk,Jelena Lazarevic,Baerbel Junge,Julian Baumeister,Angela Galauner,Noa Chapal Ilani,Dror Bar,Elia Colin,Mingbo Cheng,Joelle Schifflers,Kim Kricheldorf,Mirle Schemionek,Tim H. Brümmendorf,Ralf Weiskirchen,Liran Shlush,Martin Zenke,Nicolas Chatain,Ivan G. Costa,Steffen Koschmieder
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Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia
Ryan D. Chow,Priya Velu,Safoora Deihimi,Jonathan Belman,Angela Youn,Nisargbhai Shah,Selina M. Luger,Martin P. Carroll,Jennifer Morrissette,Robert L. Bowman
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TRANSPLANTATION

Posttransplant cyclophosphamide as GVHD prophylaxis in patients receiving mismatched unrelated HCT: the PHYLOS trial
Anna Maria Raiola,Benedetto Bruno,Antonio Maria Risitano,Federico Mosna,Irene Maria Cavattoni,Francesco Onida,Giorgia Saporiti,Francesca Patriarca,Marta Lisa Battista,Vincenzo Pavone,Anna Mele,Patrizia Chiusolo,Simona Sica,Barbara Loteta,Carmen di Grazia,Angelo Michele Carella,Dalila Salvatore,Enrico Morello,Alessandro Leoni,Luisa Giaccone,Paolo Bernasconi,Elisabetta Terruzzi,Nicola Mordini,Carlo Borghero,Francesco Zallio,Mario Luppi,Anna Grassi,Attilio Olivieri,Eugenia Piras,Nicoletta Sacchi,Giovannino Ciccone,Anna Castiglione,Eliana Degrandi,Emanuele Angelucci,Massimo Martino,Francesca Bonifazi
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PLATELETS AND THROMBOPOIESIS

Efficacy and safety of dapsone in adult primary immune thrombocytopenia
Marion Larue,Guillaume Moulis,Manuela Rueter,Sylvain Audia,Thibault Comont,Louis Terriou,Jean-François Viallard,Brigitte Pan-Petesch,Bruno Royer,Bernard Bonnotte,Lionel Galicier,Olivier Lambotte,François Lefrere,Stéphane Cheze,Mikael Ebbo,Tu-Ahn Duong,Emmanuelle Boutin,Laetitia Languille,Matthieu Mahevas,Bertrand Godeau,Florence Canoui-Poitrine,Marc Michel
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All Issues

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Sickle cell care and implementation science
Humanizing CAR T-cell therapy in B-ALL
Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia
Characterizing the heterogeneity of Castleman disease and oligocentric subtype: findings from the ACCELERATE registry
Fedratinib in 2025 and beyond: indications and future applications

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