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Issue Archive

Volume 8, Issue 23
December 10 2024
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Model-based dosing for better survival after transplantation
Jaap Jan Boelens,Michael Scordo
View Articletitled, Model-based dosing for better survival after transplantation
Charting the course for CAR T-cell manufacturing
Magdi Elsallab,Marcela V. Maus
View Articletitled, Charting the course for CAR T-cell manufacturing
Impact of prior treatment on CAR T-cell outcome in adult ALL
Clinical Trials & Observations
David I. Marks,Anna Z. Castleton
View Articletitled, Impact of prior treatment on CAR T-cell outcome in adult ALL

POINT-COUNTERPOINT

Point-of-care CAR T manufacturing solutions: can 1 model fit all?
Álvaro Urbano-Ispizua,Nirav N. Shah,Natasha Kekre
View Articletitled, Point-of-care CAR T manufacturing solutions: can 1 model fit all?

ADVANCES SNAPSHOT

Gene therapy for hemophilia
Peter J. Lenting,Sylvia Fong
View Articletitled, Gene therapy for hemophilia

SYSTEMATIC REVIEWS

Adeno-associated virus–based gene therapy for hemophilia A and B: a systematic review and meta-analysis
Clinical Trials & Observations
Saarang R. Deshpande,Keerthy Joseph,Jiayi Tong,Yong Chen,Allyson Pishko,Adam Cuker
View Articletitled, Adeno-associated virus–based gene therapy for hemophilia A and B: a systematic review and meta-analysis
Supplemental data
Quadruplet regimens for patients with newly diagnosed multiple myeloma: a systematic review and meta-analysis
Mohammad S. Ebraheem,Rajshekhar Chakraborty,Bram Rochwerg,Alissa Visram,Ghulam Rehman Mohyuddin,Christopher P. Venner,Irwindeep Sandhu,Arleigh McCurdy,Thierry Facon,Maria-Victoria Mateos,Hira Mian
View Articletitled, Quadruplet regimens for patients with newly diagnosed multiple myeloma: a systematic review and meta-analysis
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Transformation in marginal zone lymphoma: results from a prospective cohort and a meta-analysis of the literature
Clinical Trials & Observations
Côme Bommier,Brian K. Link,Brianna J. Gysbers,Matthew J. Maurer,Melissa C. Larson,Arushi Khurana,Yucai Wang,Carrie A. Thompson,Dai Chihara,Juan P. Alderuccio,Jean L. Koff,Narendranath Epperla,Annarita Conconi,Izidore S. Lossos,Grzegorz S. Nowakowski,Andrew L. Feldman,Thomas M. Habermann,Rebecca L. King,James R. Cerhan
View Articletitled, Transformation in marginal zone lymphoma: results from a prospective cohort and a meta-analysis of the literature
Supplemental data
Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia
Clinical Trials & Observations
Abi Vijenthira,Virginia O. Volpe,Aswin Sekar,Roberta Santos Azevedo,Mariia Mikhaleva,Christopher J. Gibson,Stephen P. Martindale,Rayan Fardoun,Svitlana Tyekucheva,Yue Ren,Stacey M. Fernandes,Binyamin A. Knisbacher,Cynthia K. Hahn,Gad Getz,Catherine J. Wu,Matthew S. Davids,Jennifer R. Brown
View Articletitled, Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia
Supplemental data
OUTREACH: phase 2 study of lisocabtagene maraleucel as outpatient or inpatient treatment at community sites for R/R LBCL
Clinical Trials & Observations
Yuliya Linhares,Cesar O. Freytes,Mohamad Cherry,Carlos Bachier,Michael Maris,Daanish Hoda,Juan C. Varela,Courtney Bellomo,Scott Cross,James Essell,Suzanne Fanning,Howard Terebelo,Habte Yimer,Jay Courtright,Jeff P. Sharman,Ana Kostic,Min Vedal,Ken Ogasawara,Ariel Avilion,Ricardo Espinola,Brenda Yuan,Bassam Mattar
View Articletitled, OUTREACH: phase 2 study of lisocabtagene maraleucel as outpatient or inpatient treatment at community sites for R/R LBCL
Supplemental data

HEALTH SERVICES AND OUTCOMES

Iron deficiency resolution and time to resolution in an American health system
Jacob C. Cogan,Julia Meyer,Ziou Jiang,Michelle Sholzberg
View Articletitled, Iron deficiency resolution and time to resolution in an American health system

LYMPHOID NEOPLASIA

Immune reconstitution and evolution of B-cell–stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL
Raphaël Liévin,Alexis Maillard,Houria Hendel-Chavez,Roman Krzysiek,Remi Lancar,Michele Algarte-Genin,Dominique Costagliola,Lambert Assoumou,Yassine Taoufik,Caroline Besson
View Articletitled, Immune reconstitution and evolution of B-cell–stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL
Supplemental data
Impact of prior inotuzumab ozogamicin treatment on brexucabtagene autoleucel outcomes in adults with B-cell ALL
Clinical Trials & Observations
Ibrahim Aldoss,Gregory W. Roloff,Rawan Faramand,Noam E. Kopmar,Chenyu Lin,Anjali S. Advani,Simone E. Dekker,Vishal K. Gupta,Timothy E. O'Connor,Nikeshan Jeyakumar,Ibrahim N. Muhsen,Yannis Valtis,Amy Zhang,Katharine Miller,Katherine Sutherland,Kaitlyn C. Dykes,Mohamed Ahmed,Evan Chen,Hector Zambrano,Danielle Bradshaw,Santiago Mercadal,Marc Schwartz,Sean Tracy,Bhagirathbhai Dholaria,Michal Kubiak,Akash Mukherjee,Navneet Majhail,Minoo Battiwalla,Luke Mountjoy,Shahbaz A. Malik,John Mathews,Paul Shaughnessy,Aaron C. Logan,Abdullah Ladha,Maryann Stefan,Caitlin Guzowski,Rasmus T. Hoeg,Talal Hilal,Jozal Moore,Matthew Connor,Kristen M. O'Dwyer,LaQuisa C. Hill,Stephanie B. Tsai,Joshua Sasine,Melhem M. Solh,Catherine J. Lee,Vamsi K. Kota,Divya Koura,Muthu Veeraputhiran,Betsy Blunk,Caspian Oliai,Jessica T. Leonard,Noelle V. Frey,Jae H. Park,Marlise R. Luskin,Veronika Bachanova,Ahmed Galal,Michael R. Bishop,Wendy Stock,Ryan D. Cassaday,Vinod Pullarkat,Bijal D. Shah,Lori S. Muffly
View Articletitled, Impact of prior inotuzumab ozogamicin treatment on brexucabtagene autoleucel outcomes in adults with B-cell ALL
Supplemental data

MYELOID NEOPLASIA

Risk of bleeding in patients with essential thrombocythemia and extreme thrombocytosis
Rathnam K. Venkat,Robert A. Redd,Amyah C. Harris,Martin J. Aryee,Anna E. Marneth,Baransel Kamaz,Chulwoo J. Kim,Mohammed Wazir,Lachelle D. Weeks,Maximilian Stahl,Daniel J. DeAngelo,R. Coleman Lindsley,Marlise R. Luskin,Gabriela S. Hobbs,Joan How
View Articletitled, Risk of bleeding in patients with essential thrombocythemia and extreme thrombocytosis
Supplemental data
Measurable residual disease monitoring in AML with FLT3-ITD treated with intensive chemotherapy plus midostaurin
Frank G. Rücker,Lars Bullinger,Sibylle Cocciardi,Sabrina Skambraks,Tamara J. Luck,Daniela Weber,Julia Krzykalla,Ema Pozek,Isabelle Schneider,Andrea Corbacioglu,Verena I. Gaidzik,Annika Meid,Sophia Aicher,Frank Stegelmann,Anika Schrade,Frauke Theis,Walter Fiedler,Helmut R. Salih,Gerald Wulf,Hans Salwender,Thomas Schroeder,Katharina S. Götze,Michael W. M. Kühn,Michael Lübbert,Richard F. Schlenk,Axel Benner,Felicitas Thol,Michael Heuser,Arnold Ganser,Hartmut Döhner,Konstanze Döhner
View Articletitled, Measurable residual disease monitoring in AML with <em>FLT3</em>-ITD treated with intensive chemotherapy plus midostaurin
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency
Aditi Khatri Patel,Kyle Trageser,Hyunjin Kim,Weikeat Lim,Christina Adler,Brace Porter,Min Ni,Yi Wei,Gurinder S. Atwal,Parnian Bigdelou,Vikas Kulshreshtha,Dharani Ajithdoss,Jun Zhong,Naxin Tu,Lynn Macdonald,Andrew Murphy,Davor Frleta
View Articletitled, Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency
Supplemental data
Social determinants of health affect disease severity among preschool children with sickle cell disease
Hamda Khan,Guolian Kang,Jerlym S. Porter,Juan Ding,Winfred C. Wang,Jeremie H. Estepp,James G. Gurney,Robert Davis,Jane S. Hankins,Jason R. Hodges
View Articletitled, Social determinants of health affect disease severity among preschool children with sickle cell disease
Supplemental data

TRANSPLANTATION

Effect of rabbit ATG PK on outcomes after TCR-αβ/CD19–depleted pediatric haploidentical HCT for hematologic malignancy
Clinical Trials & Observations
Christopher C. Dvorak,Janel R. Long-Boyle,Lucia Holbrook-Brown,Hisham Abdel-Azim,Alice Bertaina,Anant Vatsayan,Julie-An Talano,Nancy Bunin,Eric Anderson,Allyson Flower,Nahal Lalefar,Christine S. Higham,Neena Kapoor,Orly Klein,Maryanne C. Odinakachukwu,Soohee Cho,David A. Jacobsohn,Willem Collier,Michael A. Pulsipher
View Articletitled, Effect of rabbit ATG PK on outcomes after TCR-αβ/CD19–depleted pediatric haploidentical HCT for hematologic malignancy
Supplemental data
Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease
Clinical Trials & Observations
Tami D. John,Mark C. Walters,Hemalatha G. Rangarajan,Mahvish Q. Rahim,Christopher McKinney,Catherine M. Bollard,Ghada Abusin,Mary Eapen,Adetola A. Kassim,Michael R. DeBaun
View Articletitled, Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease
Supplemental data
Novel machine learning technique further clarifies unrelated donor selection to optimize transplantation outcomes
Stephen R. Spellman,Rodney Sparapani,Martin Maiers,Bronwen E. Shaw,Purushottam Laud,Caitrin Bupp,Meilun He,Steven M. Devine,Brent R. Logan
View Articletitled, Novel machine learning technique further clarifies unrelated donor selection to optimize transplantation outcomes
Outcomes of haploidentical transplants with PT-CY vs 10/10 MUD transplants with ATG in Germany
Aysenur Arslan,Svenja Labuhn,Elisa Sala,Mark Ringhoffer,Johannes Schetelig,Thomas Schröder,Gesine Bug,Georg-Nikolaus Franke,Matthias Stelljes,Peter Dreger,Robert Zeiser,Daniel Teschner,Wolfgang Bethge,Matthias Eder,Matthias Edinger,Elisa Maria Amann,Christine Neuchel,Amelie Schmid-Möglich,Sandra Schmeller,Jan Beyersmann,Hubert Schrezenmeier,Joannis Mytilineos,Nicolaus Kröger,Daniel Fürst,on behalf of the German Registry for Stem Cell Transplantation
View Articletitled, Outcomes of haploidentical transplants with PT-CY vs 10/10 MUD transplants with ATG in Germany
Supplemental data

RESEARCH LETTERS

Febrile neutropenia in patients with Duffy-null–associated neutrophil counts and multiple myeloma or AL amyloidosis
Maya Abdallah,Frances Arters,Jasmine Patel,Camille Edwards,Adam Lerner,Fabio Petrocca,Margaux Dockerty,Brittany Fuller,Alicia Godfrey,Andrew Staron,Vaishali Sanchorawala,J. Mark Sloan,Kimberly Bertrand,Raphael Szalat
View Articletitled, Febrile neutropenia in patients with Duffy-null–associated neutrophil counts and multiple myeloma or AL amyloidosis
Supplemental data
Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model
Christophe Lechauve,Julia Keith,Michael W. Dudley,Alfonso G. Fernandez,Eugene Khandros,Kalin Mayberry,Thiyagaraj Mayuranathan,Lance Palmer,Xiaohui Qiu,Heather Sheppard,Rahul Telange,Hans-Martin Herz,Mitchell J. Weiss
View Articletitled, Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model
Supplemental data
The dual BCL-2 and BCL-XL inhibitor AZD4320 acts on-target and synergizes with MCL-1 inhibition in B-cell precursor ALL
Maren Christiane Wichert,Colin Fortner,Alexandra Niedermayer,Johanna Bender,Stefanie Enzenmüller,Klaus-Michael Debatin,Lüder Hinrich Meyer,Felix Seyfried
View Articletitled, The dual BCL-2 and BCL-XL inhibitor AZD4320 acts on-target and synergizes with MCL-1 inhibition in B-cell precursor ALL
Supplemental data
CYB5R3 T117S tempers fetal hemoglobin induction by hydroxyurea in patients with sickle cell disease
Clinical Trials & Observations
Fabliha A. Chowdhury,Malini Sharma,Desiree Schafer,Seyed M. Nouraie,Mark T. Gladwin,Adam C. Straub,Katherine C. Wood
View Articletitled, CYB5R3 T117S tempers fetal hemoglobin induction by hydroxyurea in patients with sickle cell disease
Supplemental data

LETTERS TO THE EDITOR

Guidelines are needed to advance health equity in hematology
Warren B. Fingrut,Angela C. Weyand
View Articletitled, Guidelines are needed to advance health equity in hematology
Management of iron deficiency in women in Scotland
Beth MacLean
View Articletitled, Management of iron deficiency in women in Scotland
The duration of iron deficiency burden
Clinical Trials & Observations
Beth MacLean,Mubashshira Ahmed,Jayne Lim,Toby Richards
View Articletitled, The duration of iron deficiency burden

RESPONSE

The promises and potential pitfalls of pharmacokinetic model–based dosing in cellular therapy
Clinical Trials & Observations
Michael Scordo
View Articletitled, The promises and potential pitfalls of pharmacokinetic model–based dosing in cellular therapy

ERRATA

Lezina L, Spriggs RV, Beck D, et al. CD40L/IL-4–stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM. Blood Adv. 2018;2(15):1869-1881.
View Articletitled, Lezina L, Spriggs RV, Beck D, et al. CD40L/IL-4–stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM. <em>Blood Adv.</em> 2018;2(15):1869-1881.
Mitani K, Lee JW, Jang JH, et al. Long-term efficacy and safety of romiplostim in refractory aplastic anemia: follow-up of a phase 2/3 study. Blood Adv. 2024;8(6):1415-1419.
View Articletitled, Mitani K, Lee JW, Jang JH, et al. Long-term efficacy and safety of romiplostim in refractory aplastic anemia: follow-up of a phase 2/3 study. <em>Blood Adv</em>. 2024;8(6):1415-1419.
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Artistic representation of red blood cells. Source: Kketti45 | Dreamstime.com. ID 331134395.

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