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Issue Archive

Volume 6, Issue 13
July 12 2022
Issue Cover

Table of Contents

STIMULUS REPORTS

Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia
Chong Chyn Chua,Danielle Hammond,Andrew Kent,Ing Soo Tiong,Marina Y. Konopleva,Daniel A. Pollyea,Courtney D. DiNardo,Andrew H. Wei
View Articletitled, Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia
Supplemental data
The contribution of rare copy number variants in FAS toward pathogenesis of autoimmune lymphoproliferative syndrome
Kathleen Jevtich,Susan Price,Morgan Similuk,Elaine Kulm,Jia Yan,Michael Setzer,Leila Jamal,Luis M. Franco,Rajarshi Ghosh,Magdalena Walkiewicz,V. Koneti Rao
View Articletitled, The contribution of rare copy number variants in <em>FAS</em> toward pathogenesis of autoimmune lymphoproliferative syndrome
Supplemental data

REVIEW ARTICLE

Bite-size introduction to canine hematologic malignancies
Matthew J. Atherton,Nicola J. Mason
View Articletitled, Bite-size introduction to canine hematologic malignancies

SYSTEMATIC REVIEW

Interaction of von Willebrand factor with blood cells in flow models: a systematic review
Ryanne A. Arisz,Judith J. de Vries,Saskia E. M. Schols,Jeroen C. J. Eikenboom,Moniek P. M. de Maat,,on behalf of the SYMPHONY Consortium
View Articletitled, Interaction of von Willebrand factor with blood cells in flow models: a systematic review
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

SAKK 35/15: a phase 1 trial of obinutuzumab in combination with venetoclax in patients with previously untreated follicular lymphoma
Clinical Trials & Observations
Anastasios Stathis,Ulrich Mey,Sämi Schär,Felicitas Hitz,Christiane Pott,Nicolas Mach,Fatime Krasniqi,Urban Novak,Christian Schmidt,Karin Hohloch,Dirk Lars Kienle,Dagmar Hess,Alden A. Moccia,Michael Unterhalt,Katrin Eckhardt,Stefanie Hayoz,Gabriela Forestieri,Davide Rossi,Stefan Dirnhofer,Luca Ceriani,Giulio Sartori,Francesco Bertoni,Christian Buske,Emanuele Zucca,Wolfgang Hiddemann
View Articletitled, SAKK 35/15: a phase 1 trial of obinutuzumab in combination with venetoclax in patients with previously untreated follicular lymphoma
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Relationship of iothalamate clearance and NRM in patients receiving fludarabine and melphalan reduced-intensity conditioning
Jade L. Kutzke,Julianna A. Merten,Amanda G. Pawlenty,Erin F. Barreto,Gabe T. Bartoo,Kristin C. Mara,Mark R. Litzow,William J. Hogan,Mithun V. Shah,Abhishek A. Mangaonkar,Nelson Leung,Hassan B. Alkhateeb
View Articletitled, Relationship of iothalamate clearance and NRM in patients receiving fludarabine and melphalan reduced-intensity conditioning
Supplemental data
Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation
Nanyan Zhang,Siying Lin,Weiguo Cui,Peter J. Newman
View Articletitled, Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation
Supplemental data
Inflammation accelerates BCR-ABL1+ B-ALL development through upregulation of AID
Ping Zhang,Mengting Qin,Yang Wang,Xiaodong Chen,Yinsha Miao,Meng Yuan,Wen Zhou,Dandan Li,Dan Wang,Mengying Wang,Li Ai,Yunfeng Ma,Yanying Dong,Yanhong Ji
View Articletitled, Inflammation accelerates <em>BCR-ABL1<sup>+</sup></em> B-ALL development through upregulation of AID
Supplemental data

LYMPHOID NEOPLASIA

High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse
Nicholas J. Short,Hagop Kantarjian,Farhad Ravandi,Marina Konopleva,Nitin Jain,Rashmi Kanagal-Shamanna,Keyur P. Patel,Walid Macaron,Tapan M. Kadia,Sa Wang,Jeffrey L. Jorgensen,Joseph D. Khoury,Musa Yilmaz,Partow Kebriaei,Koichi Takahashi,Guillermo Garcia-Manero,Naval Daver,Sean M. Post,Xuelin Huang,Steven M. Kornblau,Sara Pelletier,Wilmer Flores,Jairo Matthews,Rebecca Garris,Elias Jabbour
View Articletitled, High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse
Supplemental data
Landscape of immunoglobulin heavy chain gene repertoire and its clinical relevance to LPL/WM
Jun Wang,Yuting Yan,Wenjie Xiong,Ge Song,Yi Wang,Jiawei Zhao,Yujiao Jia,Chengwen Li,Zhen Yu,Ying Yu,Jiawen Chen,Yang Jiao,Tingyu Wang,Rui Lyu,Qinghua Li,Yueshen Ma,Wei Liu,Dehui Zou,Gang An,Qi Sun,Huijun Wang,Zhijian Xiao,Jianxiang Wang,Lugui Qiu,Shuhua Yi
View Articletitled, Landscape of immunoglobulin heavy chain gene repertoire and its clinical relevance to LPL/WM
Supplemental data

MYELOID NEOPLASIA

A single-arm pilot study of a mobile health exercise intervention (GO-EXCAP) in older patients with myeloid neoplasms
Clinical Trials & Observations
Kah Poh Loh,Chandrika Sanapala,Erin Elizabeth Watson,Marielle Jensen-Battaglia,Michelle C. Janelsins,Heidi D. Klepin,Rebecca Schnall,Eva Culakova,Paula Vertino,Martha Susiarjo,Po-Ju Lin,Jason H. Mendler,Jane L. Liesveld,Eric J. Huselton,Kathryn Taberner,Supriya G. Mohile,Karen Mustian
View Articletitled, A single-arm pilot study of a mobile health exercise intervention (GO-EXCAP) in older patients with myeloid neoplasms
Supplemental data
Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum
Xavier Calvo,David Roman-Bravo,Nieves Garcia-Gisbert,Juan Jose Rodriguez-Sevilla,Sara Garcia-Avila,Lourdes Florensa,Joan Gibert,Concepción Fernández-Rodríguez,Marta Salido,Anna Puiggros,Blanca Espinet,Luis Colomo,Beatriz Bellosillo,Ana Ferrer,Leonor Arenillas
View Articletitled, Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum
Supplemental data
Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia
Andrew H. Matthews,Alexander E. Perl,Selina M. Luger,Alison W. Loren,Saar I. Gill,David L. Porter,Daria V. Babushok,Ivan P. Maillard,Martin P. Carroll,Noelle V. Frey,Elizabeth O. Hexner,Mary Ellen Martin,Shannon R. McCurdy,Edward A. Stadtmauer,Vikram R. Paralkar,Ximena Jordan Bruno,Wei-Ting Hwang,David Margolis,Keith W. Pratz
View Articletitled, Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor
Clinical Trials & Observations
David C. Dale,Audrey Anna Bolyard,James A. Shannon, IV,James A. Connelly,Daniel C. Link,Mary Ann Bonilla,Peter E. Newburger
View Articletitled, Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19
Cédric Garcia,Jonathan Au Duong,Michael Poëtte,Agnès Ribes,Bruno Payre,Vincent Mémier,Pierre Sié,Vincent Minville,Sophie Voisin,Bernard Payrastre,Fanny Vardon-Bounes
View Articletitled, Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion
Sanne de Bruin,Anna-Linda Peters,Marije Wijnberge,Floor E. H. P. van Baarle,Amira H. A. AbdelRahman,Christie Vermeulen,Boukje M. Beuger,Julie A. Reisz,Angelo D’Alessandro,Alexander P. J. Vlaar,Dirk de Korte,Robin van Bruggen
View Articletitled, Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion
Supplemental data

THROMBOSIS AND HEMOSTASIS

Structural, functional, and immunogenicity implications of F9 gene recoding
Upendra K. Katneni,Aikaterini Alexaki,Ryan C. Hunt,Nobuko Hamasaki-Katagiri,Gaya K. Hettiarachchi,Jacob M. Kames,Joseph R. McGill,David D. Holcomb,John C. Athey,Brian Lin,Leonid A. Parunov,Tal Kafri,Qi Lu,Robert Peters,Mikhail V. Ovanesov,Darón I. Freedberg,Haim Bar,Anton A. Komar,Zuben E. Sauna,Chava Kimchi-Sarfaty
View Articletitled, Structural, functional, and immunogenicity implications of <em>F9</em> gene recoding
Supplemental data
Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variation
Katie E. Joyce,Ebun Onabanjo,Sheila Brownlow,Fadumo Nur,Kike Olupona,Kehinde Fakayode,Manveer Sroya,Geraldine A. Thomas,Teena Ferguson,Julian Redhead,Carolyn M. Millar,Nichola Cooper,D. Mark Layton,Freya Boardman-Pretty,Mark J. Caulfield,Genomics England Research Consortium,Claire L. Shovlin
View Articletitled, Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variation
Supplemental data
Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds
Nathan L. Asquith,Cédric Duval,Artem Zhmurov,Stephen R. Baker,Helen R. McPherson,Marco M. Domingues,Simon D. A. Connell,Valeri Barsegov,Robert A. S. Ariëns
View Articletitled, Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds
Supplemental data
Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2
Omid Seidizadeh,Luciano Baronciani,Maria Teresa Pagliari,Giovanna Cozzi,Paola Colpani,Andrea Cairo,Simona Maria Siboni,Eugenia Biguzzi,Flora Peyvandi
View Articletitled, Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2
Supplemental data
Impaired exercise capacity in post–COVID-19 syndrome: the role of VWF-ADAMTS13 axis
Nithya Prasannan,Melissa Heightman,Toby Hillman,Emma Wall,Robert Bell,Anna Kessler,Lucy Neave,Andrew Doyle,Akshitha Devaraj,Deepak Singh,Hakim-Moulay Dehbi,Marie Scully
View Articletitled, Impaired exercise capacity in post–COVID-19 syndrome: the role of VWF-ADAMTS13 axis

RESEARCH LETTERS

1.5 million platelet count limit at essential thrombocythemia diagnosis: correlations and relevance to vascular events
Clinical Trials & Observations
Naseema Gangat,Natasha Szuber,Yamna Jadoon,Faiqa Farrukh,Kebede Begna,Michelle A. Elliott,Alexandra P. Wolanskyj-Spinner,Curtis A. Hanson,Animesh D. Pardanani,Valerio De Stefano,Tiziano Barbui,Alessandro Maria Vannucchi,Ayalew Tefferi
View Articletitled, 1.5 million platelet count limit at essential thrombocythemia diagnosis: correlations and relevance to vascular events
Supplemental data
SARS-CoV-2 infection associated with aplastic anemia and pure red cell aplasia
Nicholas C. J. Lee,Bhavisha Patel,Aaron Etra,Taha Bat,Ibrahim F. Ibrahim,Madhuri Vusirikala,Mingyi Chen,Flavia Rosado,Jesse Manuel Jaso,Neal S. Young,Weina Chen
View Articletitled, SARS-CoV-2 infection associated with aplastic anemia and pure red cell aplasia
COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey
Clinical Trials & Observations
Sylvain Lamure,Jon Salmanton-García,Elena Robin-Marieton,Ozren Jaksic,Milena Kohn,Francesco Marchesi,Monia Marchetti,Shaimaa El-Ashwah,Fatih Demirkan,Toni Valković,Noemí Fernández,Maria Chiara Tisi,Zlate Stojanoski,Guldane Cengiz Seval,Osman Ilhan,Lucia Prezioso,Maria Merelli,Alberto López-García,Marie-Pierre Ledoux,Austin Kulasekararaj,Tomás-José González-López,Maria Gomes da Silva,Ziad Emarah,Rafael F. Duarte,Chiara Cattaneo,Ola Blennow,Yavuz M. Bilgin,Rui Bergantim,Josip Batinić,Raul Cordoba,Jenna Essame,Anna Nordlander,Raquel Nunes Rodrigues,Maria Vittoria Sacchi,Sofia Zompi,Alessandro Busca,Paolo Corradini,Martin Hoenigl,Nikolai Klimko,Philipp Koehler,Antonio Pagliuca,Francesco Passamonti,Rémy Duléry,Oliver A. Cornely,Caroline Besson,Livio Pagano
View Articletitled, COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey
Supplemental data
Relative dose intensity of obinutuzumab-chlorambucil in chronic lymphocytic leukemia: a multicenter Italian study
Alberto Fresa,Francesco Autore,Alfonso Piciocchi,Gioacchino Catania,Andrea Visentin,Annamaria Tomasso,Marina Moretti,Candida Vitale,Annalisa Chiarenza,Francesca Morelli,Paolo Sportoletti,Roberto Marasca,Giuseppe Sapienza,Annarosa Cuccaro,Roberta Murru,Alessandro Sanna,Caterina Patti,Ilaria Angeletti,Marta Coscia,Livio Trentin,Daniela Pietrasanta,Idanna Innocenti,Luca Laurenti
View Articletitled, Relative dose intensity of obinutuzumab-chlorambucil in chronic lymphocytic leukemia: a multicenter Italian study
Supplemental data
Primary progression during frontline CIT associates with decreased efficacy of subsequent CD19 CAR T-cell therapy in LBCL
Ariel Perez,Grace Johnson,Kedar Patel,Brian Arciola,Anthony Wood,Christina A. Bachmeier,Julio C. Chavez,Bijal D. Shah,Farhad Khimani,Taiga Nishihori,Aleksandr Lazaryan,Marco L. Davila,Rahul Mhaskar,Frederick L. Locke,Sameh Gaballa,Michael D. Jain
View Articletitled, Primary progression during frontline CIT associates with decreased efficacy of subsequent CD19 CAR T-cell therapy in LBCL
Supplemental data
Outcomes after autologous hematopoietic cell transplantation in POEMS syndrome and comparison with multiple myeloma
Ankit Kansagra,Angela Dispenzieri,Raphael Fraser,Noel Estrada-Merly,Surbhi Sidana,Taiga Nishihori,Doris K. Hansen,Larry D. Anderson, Jr.,Rahul Banerjee,Naresh Bumma,Binod Dhakal,Jack Khouri,Heather Landau,Cindy Lee,Hira Mian,Sunita Nathan,Bipin Savani,Shaji Kumar,Muzaffar Qazilbash,Nina Shah,Anita D’Souza
View Articletitled, Outcomes after autologous hematopoietic cell transplantation in POEMS syndrome and comparison with multiple myeloma
Supplemental data

COMMENTARY

The antagonistic duality of NPM1 mutations in AML
Irum Khan,Andrei L. Gartel
View Articletitled, The antagonistic duality of NPM1 mutations in AML

ERRATUM

Shouval R, Fein JA, Cho C, et al. The Simplified Comorbidity Index: a new tool for prediction of nonrelapse mortality in allo-HCT. Blood Adv. 2022;6(5):1525-1535.
View Articletitled, Shouval R, Fein JA, Cho C, et al. The Simplified Comorbidity Index: a new tool for prediction of nonrelapse mortality in allo-HCT. <em>Blood Adv.</em> 2022;6(5):1525-1535.
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Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy
Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
Unleashed monocytic engagement in Sézary syndrome during the combination of anti-CCR4 antibody with type I interferon
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Race and ethnicity reporting and representation in hemophilia clinical trials

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