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Issue Archive

Volume 5, Issue 17
September 14 2021
Blood Advances Cover Image for Volume 5, Issue 17

Table of Contents

EXCEPTIONAL CASE REPORT

Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance
Clinical Trials & Observations
Justin Anthony Chen,Yanli Hou,Krishna M. Roskin,Daniel A. Arber,Charles D. Bangs,Linda B. Baughn,Athena M. Cherry,Mark D. Ewalt,Andrew Z. Fire,Laure Fresard,Hutton M. Kearney,Stephen B. Montgomery,Robert S. Ohgami,Kathryn E. Pearce,Beth A. Pitel,Jason D. Merker,Jason Gotlib
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STIMULUS REPORT

Mechanistic ion channel interactions in red cells of patients with Gárdos channelopathy
Julia Jansen,Min Qiao,Laura Hertz,Xijia Wang,Elisa Fermo,Anna Zaninoni,Raffaella Colombatti,Ingolf Bernhardt,Paola Bianchi,Lars Kaestner
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Supplemental data
Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasms
Clinical Trials & Observations
Miriam Elbracht,Robert Meyer,Kim Kricheldorf,Deniz Gezer,Eggermann Thomas,Beate Betz,Ingo Kurth,Lino L. Teichmann,Tim H. Brümmendorf,Ulrich Germing,Susanne Isfort,Steffen Koschmieder
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SYSTEMATIC REVIEW

Current evidence on the efficacy and safety of generic imatinib in CML and the impact of generics on health care costs
Abdülkadir Erçalışkan,Duygu Seyhan Erdoğan,Ahmet Emre Eşkazan
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CLINICAL TRIALS AND OBSERVATIONS

Peripheral blood cytopenias in the aging general population and risk of incident hematological disease and mortality
Clinical Trials & Observations
Isabelle A. van Zeventer,Aniek O. de Graaf,Melanie M. van der Klauw,Edo Vellenga,Bert A. van der Reijden,Jan Jacob Schuringa,Arjan Diepstra,Luca Malcovati,Joop H. Jansen,Gerwin Huls
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Supplemental data
Long-term efficacy and safety of CT-P10 or rituximab in untreated advanced follicular lymphoma: a randomized phase 3 study
Clinical Trials & Observations
Christian Buske,Wojciech Jurczak,Juan-Manuel Sancho,Edvard Zhavrid,Jin Seok Kim,José-Ángel Hernández-Rivas,Aliaksandr Prokharau,Mariana Vasilica,Rajnish Nagarkar,Larry Kwak,Won-Seog Kim,SangJoon Lee,SungHyun Kim,KeumYoung Ahn,Michinori Ogura
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Supplemental data
Avelumab in relapsed/refractory classical Hodgkin lymphoma: phase 1b results from the JAVELIN Hodgkins trial
Clinical Trials & Observations
Alex F. Herrera,Catherine Burton,John Radford,Fiona Miall,William Townsend,Armando Santoro,Pier Luigi Zinzani,David Lewis,Camilla Fowst,Satjit Brar,Bo Huang,Aron Thall,Graham P. Collins
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Supplemental data
Bortezomib and rituximab in de novo adolescent/adult CD20-positive, Ph-negative pre-B-cell acute lymphoblastic leukemia
Clinical Trials & Observations
Hasmukh Jain,Manju Sengar,Vasu Babu Goli,Jayashree Thorat,Prashant Tembhare,Dhanlaxmi Shetty,V. N. Avinash Bonda,Lingaraj Nayak,P. G. Subramanian,Bhausaheb Bagal,Nikhil Patkar,Neha Sharma,Himanshi Gupta,Sumeet Gujral
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GENE THERAPY

Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction
Kristopher A. Knight,Christopher W. Coyle,Caelan E. Radford,Ernest T. Parker,Andrew Fedanov,Jordan M. Shields,Fania Szlam,Anatolii Purchel,Michelle Chen,Gabriela Denning,Roman M. Sniecinski,Pete Lollar,H. Trent Spencer,Eric A. Gaucher,Christopher B. Doering
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HEMATOPOIESIS AND STEM CELLS

Enhanced self-renewal of human long-term hematopoietic stem cells by a sulfamoyl benzoate derivative targeting p18INK4C
Yinghui Li,Wenshan Zhang,Yu Zhang,Yahui Ding,Ming Yang,Mei He,Xiaolei Liu,Jiali Gu,Shiqi Xu,Zhiwei Feng,Yafang Li,Jingjing Yin,Huier Gao,Henan Song,Hui Xu,Chaoqun Wang,Qing Ji,Shihui Ma,Wanzhu Yang,Weiping Yuan,Xiang-Qun Xie,Tao Cheng,Yingdai Gao
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Mismatch in SIRPα, a regulatory protein in innate immunity, is associated with chronic GVHD in hematopoietic stem cell transplantation
Rima M. Saliba,Uri Greenbaum,Qing Ma,Samer A. Srour,Yudith Carmazzi,Liang Li,Betul Oran,Michael Moller,Janet Wood,Stefan O. Ciurea,Piyanuch Kongtim,Gabriela Rondon,David Partlow,Dan Li,Katayoun Rezvani,Elizabeth J. Shpall,Kai Cao,Richard E. Champlin,Jun Zou
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Development of immunosuppressive myeloid cells to induce tolerance in solid organ and hematopoietic cell transplant recipients
Clinical Trials & Observations
Kent P. Jensen,David A. Hongo,XuHuai Ji,PingPing Zheng,Rahul D. Pawar,Thomas Hsin-Hsu Wu,Stephan Busque,John D. Scandling,Judith A. Shizuru,Robert Lowsky,Asha Shori,Suparna Dutt,Jeffrey Waters,Anirudh Saraswathula,Jeanette Baker,John S. Tamaresis,Philip Lavori,Robert Negrin,Holden Maecker,Edgar G. Engleman,Everett Meyer,Samuel Strober
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Supplemental data
Modified EASIX predicts severe cytokine release syndrome and neurotoxicity after chimeric antigen receptor T cells
Clinical Trials & Observations
Martina Pennisi,Miriam Sanchez-Escamilla,Jessica R. Flynn,Roni Shouval,Ana Alarcon Tomas,Mari Lynn Silverberg,Connie Batlevi,Renier J. Brentjens,Parastoo B. Dahi,Sean M. Devlin,Claudia Diamonte,Sergio Giralt,Elizabeth F. Halton,Tania Jain,Molly Maloy,Elena Mead,Maria Lia Palomba,Josel Ruiz,Bianca Santomasso,Craig S. Sauter,Michael Scordo,Gunjan L. Shah,Jae H. Park,Lucrecia Yanez San Segundo,Miguel-Angel Perales
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Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease
Sheila K. Pierson,Sushila Shenoy,Ana B. Oromendia,Alexander M. Gorzewski,Ruth-Anne Langan Pai,Christopher Shield Nabel,Jason R. Ruth,Sophia A. T. Parente,Daniel J. Arenas,Mary Guilfoyle,Manjula Reddy,Michael Weinblatt,Nancy Shadick,Mark Bower,Alessia Dalla Pria,Yasufumi Masaki,Laura Katz,Jason Mezey,Philip Beineke,David Lee,Craig Tendler,Taku Kambayashi,Alexander Fosså,Frits van Rhee,David C. Fajgenbaum
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IFN-γ signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS
Howard Lin,Brooks P. Scull,Baruch R. Goldberg,Harshal A. Abhyankar,Olive E. Eckstein,Daniel J. Zinn,Joseph Lubega,Jennifer Agrusa,Nader El Mallawaney,Nitya Gulati,Lisa Forbes,Ivan Chinn,Rikhia Chakraborty,Jessica Velasquez,Jordana Goldman,Dalia Bashir,Fong Lam,Eyal Muscal,Michael. M. Henry,Jay N. Greenberg,Stephan Ladisch,Michelle L. Hermiston,Lauren K. Meyer,Michael Jeng,Ahmed Naqvi,Kenneth McClain,Trung Nguyen,Hector Wong,Tsz-Kwong Man,Michael B. Jordan,Carl E. Allen
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LYMPHOID NEOPLASIA

IKZF1 alterations are not associated with outcome in 498 adults with B-precursor ALL enrolled in the UKALL14 trial
Rachel J. Mitchell,Amy A. Kirkwood,Emilio Barretta,Laura Clifton-Hadley,Emma Lawrie,SooWah Lee,Daniel Leongamornlert,David I. Marks,Andrew K. McMillan,Tobias F. Menne,Elli Papaemmanuil,Bela Patel,Pip Patrick,Clare J. Rowntree,Nahid Zareian,Krisztina Zuborne Alapi,Anthony V. Moorman,Adele K. Fielding
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Extrinsic interactions in the microenvironment in vivo activate an antiapoptotic multidrug-resistant phenotype in CLL
Kallesh D. Jayappa,Vicki L. Gordon,Christopher G. Morris,Briana Wilson,B. Dharmaveer Shetty,Konrad J. Cios,Puja C. Arora,Krista M. Isaac,Shekhar Saha,Timothy P. Bender,Michael E. Williams,Craig A. Portell,Michael J. Weber
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MYELOID NEOPLASIA

KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2
Siyuan Xu,Siqing Wang,Shenghui Xing,Dingdang Yu,Bowen Rong,Hai Gao,Mengyao Sheng,Yun Tan,Yifan Zhang,Xiaojian Sun,Kankan Wang,Kai Xue,Zhennan Shi,Fei Lan
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Supplemental data
Splicing factor gene mutations in acute myeloid leukemia offer additive value if incorporated in current risk classification
Clinical Trials & Observations
Inge van der Werf,Anna Wojtuszkiewicz,Manja Meggendorfer,Stephan Hutter,Constance Baer,Martijn Heymans,Peter J. M. Valk,Wolfgang Kern,Claudia Haferlach,Jeroen J. W. M. Janssen,Gert J. Ossenkoppele,Jacqueline Cloos,Torsten Haferlach
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Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia
Clinical Trials & Observations
Sebastian Stasik,Jan-Niklas Eckardt,Michael Kramer,Christoph Röllig,Alwin Krämer,Sebastian Scholl,Andreas Hochhaus,Martina Crysandt,Tim H. Brümmendorf,Ralph Naumann,Björn Steffen,Volker Kunzmann,Hermann Einsele,Markus Schaich,Andreas Burchert,Andreas Neubauer,Kerstin Schäfer-Eckart,Christoph Schliemann,Stefan Krause,Regina Herbst,Mathias Hänel,Norbert Frickhofen,Richard Noppeney,Ulrich Kaiser,Claudia D. Baldus,Martin Kaufmann,Zdenek Rácil,Uwe Platzbecker,Wolfgang E. Berdel,Jiri Mayer,Hubert Serve,Carsten Müller-Tidow,Gerhard Ehninger,Martin Bornhäuser,Johannes Schetelig,Jan M. Middeke,Christian Thiede,on behalf of the Study Alliance Leukemia (SAL)
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THROMBOSIS AND HEMOSTASIS

Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura
Kadri Kangro,Elien Roose,Bérangère S. Joly,György Sinkovits,Tanja Falter,Charis von Auer,Heidi Rossmann,Marienn Reti,Jan Voorberg,Zoltán Prohászka,Bernhard Lämmle,Paul Coppo,Agnès Veyradier,Simon F. De Meyer,Andres Männik,Karen Vanhoorelbeke
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Supplemental data
High fibrinogen γ′ levels in patient plasma increase clot formation at arterial and venous shear
Fraser L. Macrae,Frauke Swieringa,Johan W. M. Heemskerk,Robert A. S. Ariëns
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Plasma and rhADAMTS13 reduce trauma-induced organ failure by restoring the ADAMTS13-VWF axis
Derek J. B. Kleinveld,Derek D. G. Simons,Charlotte Dekimpe,Shannen J. Deconinck,Pieter H. Sloos,M. Adrie W. Maas,Jesper Kers,Joshua Muia,Karim Brohi,Jan Voorberg,Karen Vanhoorelbeke,Markus W. Hollmann,Nicole P. Juffermans,on behalf of BloodNet
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TRANSPLANTATION

Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted
Clinical Trials & Observations
Jeremy D. Rubinstein,Xiang Zhu,Thomas Leemhuis,Giang Pham,Lorraine Ray,Sana Emberesh,Sonata Jodele,Shawn Thomas,Jose A. Cancelas,Catherine M. Bollard,Patrick J. Hanley,Michael D. Keller,Olivia Grimley,Diana Clark,Teri Clark,Cecilia S. Lindestam Arlehamn,Alessandro Sette,Stella M. Davies,Adam S. Nelson,Michael S. Grimley,Carolyn Lutzko
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Analysis of biological models to predict clinical outcomes based on HLA-DPB1 disparities in unrelated transplantation
Clinical Trials & Observations
Stéphane Buhler,Helen Baldomero,Sylvie Ferrari-Lacraz,Anne-Claire Mamez,Stavroula Masouridi-Levrat,Dominik Heim,Jörg Halter,Gayathri Nair,Yves Chalandon,Urs Schanz,Tayfun Güngör,Grazia Nicoloso,Jakob R. Passweg,Jean Villard,on behalf of the Swiss Blood Stem Cell Transplantation Group
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Pretransplantation EASIX predicts intensive care unit admission in allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Marta Peña,Maria Queralt Salas,Alberto Mussetti,Gabriel Moreno-Gonzalez,Anna Bosch,Beatriz Patiño,Laura Jiménez,Meriem Kara,Rocío Parody,Anna Sureda
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  • Cover Image

    Cover Image

    issue cover

    Laser scanning confocal micrograph of a human plasma blood clot with fluorescently labeled fibrin. The plasma for this clot was from a volunteer with a high percentage of the fibrinogen splice variant fibrinogen γ′. An increased percentage of fibrinogen γ′ results in the formation of blood clots with denser fibrin networks that are harder to break down. See the article by Macrae et al.

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