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Issue Archive

Volume 4, Issue 14
July 28 2020
Issue Cover

Table of Contents

STIMULUS REPORTS

Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy
Clinical Trials & Observations
Jeremy D. Rubinstein,Xiang Zhu,Carolyn Lutzko,Tom Leemhuis,Jose A. Cancelas,Sonata Jodele,Catherine M. Bollard,Patrick J. Hanley,Stella M. Davies,Michael S. Grimley,Adam S. Nelson
View Articletitled, Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy
High-dose chemotherapy and autologous stem cell transplant in elderly patients with primary CNS lymphoma: a pilot study
Clinical Trials & Observations
Elisabeth Schorb,Benjamin Kasenda,Gabriele Ihorst,Florian Scherer,Julia Wendler,Lisa Isbell,Heidi Fricker,Juergen Finke,Gerald Illerhaus
View Articletitled, High-dose chemotherapy and autologous stem cell transplant in elderly patients with primary CNS lymphoma: a pilot study
Supplemental data

REVIEW ARTICLES

Curative vs targeted therapy for SCD: does it make more sense to address the root cause than target downstream events?
Clinical Trials & Observations
Marilyn J. Telen
View Articletitled, Curative vs targeted therapy for SCD: does it make more sense to address the root cause than target downstream events?
T-cell lymphoblastic lymphoma and leukemia: different diseases from a common premalignant progenitor?
Emma Kroeze,Jan L. C. Loeffen,Vera M. Poort,Jules P. P. Meijerink
View Articletitled, T-cell lymphoblastic lymphoma and leukemia: different diseases from a common premalignant progenitor?

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 study of pembrolizumab for measurable residual disease in adults with acute lymphoblastic leukemia
Clinical Trials & Observations
Ryan D. Cassaday,Kelsey-Leigh A. Garcia,Jonathan R. Fromm,Mary-Elizabeth M. Percival,Cameron J. Turtle,Paul T. Nghiem,Phillip A. Stevenson,Elihu H. Estey
View Articletitled, Phase 2 study of pembrolizumab for measurable residual disease in adults with acute lymphoblastic leukemia
Supplemental data
Clinical value of measurable residual disease testing for assessing depth, duration, and direction of response in multiple myeloma
Clinical Trials & Observations
Joaquin Martinez-Lopez,Sandy W. Wong,Nina Shah,Natasha Bahri,Kaili Zhou,Ying Sheng,Chiung-Yu Huang,Thomas Martin,Jeffrey Wolf
View Articletitled, Clinical value of measurable residual disease testing for assessing depth, duration, and direction of response in multiple myeloma
Extra copies of MYC, BCL2, and BCL6 and outcome in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations
David Sermer,Sabela Bobillo,Ahmet Dogan,Yanming Zhang,Venkatraman Seshan,Jessica A. Lavery,Connie Batlevi,Philip Caron,Audrey Hamilton,Paul Hamlin,Steven Horwitz,Erel Joffe,Anita Kumar,Matthew Matasar,Ariela Noy,Colette Owens,Alison Moskowitz,M. Lia Palomba,David Straus,Gottfried von Keudell,Ildefonso Rodriguez-Rivera,Lorenzo Falchi,Andrew Zelenetz,Joachim Yahalom,Anas Younes
View Articletitled, Extra copies of <em>MYC, BCL2,</em> and <em>BCL6</em> and outcome in patients with diffuse large B-cell lymphoma
Supplemental data
Treatment-associated hemolysis in Kawasaki disease: association with blood-group antibody titers in IVIG products
Clinical Trials & Observations
Christine W. Bruggeman,Sietse Q. Nagelkerke,Wendy Lau,Cedric Manlhiot,Masja de Haas,Robin van Bruggen,Brian W. McCrindle,Rae S. M. Yeung,Taco W. Kuijpers
View Articletitled, Treatment-associated hemolysis in Kawasaki disease: association with blood-group antibody titers in IVIG products
Supplemental data

HEMATOPOIESIS AND STEM CELLS

C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells
Atsushi Sato,Naoka Kamio,Asumi Yokota,Yoshihiro Hayashi,Akihiro Tamura,Yasuo Miura,Taira Maekawa,Hideyo Hirai
View Articletitled, C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity
Gloria Castellano-González,Helen M. McGuire,Fabio Luciani,Leighton E. Clancy,Ziduo Li,Selmir Avdic,Brendan Hughes,Mandeep Singh,Barbara Fazekas de St Groth,Giorgia Renga,Marilena Pariano,Marina M. Bellet,Luigina Romani,David J. Gottlieb
View Articletitled, Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity
Supplemental data

LYMPHOID NEOPLASIA

Lenalidomide/rituximab induces high molecular response in untreated follicular lymphoma: LYSA ancillary RELEVANCE study
Clinical Trials & Observations
Marie-Helene Delfau-Larue,Marie-Laure Boulland,Asma Beldi-Ferchiou,Pierre Feugier,Hervé Maisonneuve,Rene-Olivier Casasnovas,François Lemonnier,Gian Matteo Pica,Roch Houot,Loic Ysebaert,Hervé Tilly,Jean-Claude Eisenmann,Steven Le Gouill,Vincent Ribrag,Pascal Godmer,Sylvie Glaisner,Guillaume Cartron,Luc Xerri,Gilles André Salles,Thierry Fest,Franck Morschhauser
View Articletitled, Lenalidomide/rituximab induces high molecular response in untreated follicular lymphoma: LYSA ancillary RELEVANCE study
Supplemental data
High metabolic tumor volume is associated with decreased efficacy of axicabtagene ciloleucel in large B-cell lymphoma
Clinical Trials & Observations
Erin A. Dean,Rahul S. Mhaskar,Hong Lu,Mina S. Mousa,Gabriel S. Krivenko,Aleksandr Lazaryan,Christina A. Bachmeier,Julio C. Chavez,Taiga Nishihori,Marco L. Davila,Farhad Khimani,Hien D. Liu,Javier Pinilla-Ibarz,Bijal D. Shah,Michael D. Jain,Yoganand Balagurunathan,Frederick L. Locke
View Articletitled, High metabolic tumor volume is associated with decreased efficacy of axicabtagene ciloleucel in large B-cell lymphoma
Supplemental data
BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression
Thomas E. C. Cummin,Kerry L. Cox,Tom D. Murray,Anna H. Turaj,Lisa Dunning,Vikki L. English,Rachel Fell,Graham Packham,Yan Ma,Ben Powell,Peter W. M. Johnson,Mark S. Cragg,Matthew J. Carter
View Articletitled, BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression
Supplemental data
A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL
Zijun Y. Xu-Monette,Hongwei Zhang,Feng Zhu,Alexandar Tzankov,Govind Bhagat,Carlo Visco,Karen Dybkaer,April Chiu,Wayne Tam,Youli Zu,Eric D. Hsi,Hua You,Jooryung Huh,Maurilio Ponzoni,Andrés J. M. Ferreri,Michael B. Møller,Benjamin M. Parsons,J. Han van Krieken,Miguel A. Piris,Jane N. Winter,Fredrick B. Hagemeister,Babak Shahbaba,Ivan De Dios,Hong Zhang,Yong Li,Bing Xu,Maher Albitar,Ken H. Young
View Articletitled, A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL
Supplemental data

MYELOID NEOPLASIA

Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia
Zhigang Cai,Chi Zhang,Jonathan J. Kotzin,Adam Williams,Jorge Henao-Mejia,Reuben Kapur
View Articletitled, Role of lncRNA <em>Morrbid</em> in <em>PTPN11</em>(<em>Shp2</em>)<sup><em>E76K</em></sup>-driven juvenile myelomonocytic leukemia
Supplemental data
Artificial intelligence–based morphological fingerprinting of megakaryocytes: a new tool for assessing disease in MPN patients
Korsuk Sirinukunwattana,Alan Aberdeen,Helen Theissen,Nikolaos Sousos,Bethan Psaila,Adam J. Mead,Gareth D. H. Turner,Gabrielle Rees,Jens Rittscher,Daniel Royston
View Articletitled, Artificial intelligence–based morphological fingerprinting of megakaryocytes: a new tool for assessing disease in MPN patients
Supplemental data
Survival outcomes in blastic plasmacytoid dendritic cell neoplasm by first-line treatment and stem cell transplant
Clinical Trials & Observations
Seongseok Yun,Onyee Chan,Daniel Kerr,Nicole D. Vincelette,Afshan Idrees,Qianxing Mo,Kendra Sweet,Jeffrey E. Lancet,Mohamed A. Kharfan-Dabaja,Ling Zhang,Lubomir Sokol
View Articletitled, Survival outcomes in blastic plasmacytoid dendritic cell neoplasm by first-line treatment and stem cell transplant
Supplemental data

PLATELETS AND THROMBOPOIESIS

Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome
Clinical Trials & Observations
Jens Kjeldsen-Kragh,Dean A. Fergusson,Mette Kjaer,Lani Lieberman,Andreas Greinacher,Michael F. Murphy,James Bussel,Tamam Bakchoul,Stacy Corke,Gérald Bertrand,Dick Oepkes,Jillian M. Baker,Heather Hume,Edwin Massey,Cecile Kaplan,Donald M. Arnold,Shoma Baidya,Greg Ryan,Helen F. Savoia,Denise Landry,Nadine Shehata
View Articletitled, Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease
Clinical Trials & Observations
Ibrahim M. Idris,Akib Abba,Jamil A. Galadanci,Sharfuddeen A. Mashi,Nafiu Hussaini,Sagir Ahmed Gumel,Arthur L. Burnett,Michael R. DeBaun
View Articletitled, Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease
Supplemental data

THROMBOSIS AND HEMOSTASIS

Recombinant vs plasma-derived von Willebrand factor to prevent postpartum hemorrhage in von Willebrand disease
Clinical Trials & Observations
Nicoletta Machin,Margaret V. Ragni
View Articletitled, Recombinant vs plasma-derived von Willebrand factor to prevent postpartum hemorrhage in von Willebrand disease
Platelet α-granules are required for occlusive high-shear-rate thrombosis
Dongjune A. Kim,Katrina J. Ashworth,Jorge Di Paola,David N. Ku
View Articletitled, Platelet α-granules are required for occlusive high-shear-rate thrombosis
OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer
Biswajit Saha,Tanmay Mathur,Katelyn F. Handley,Wei Hu,Vahid Afshar-Kharghan,Anil K. Sood,Abhishek Jain
View Articletitled, OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer
Supplemental data
Noncanonical type 2B von Willebrand disease associated with mutations in the VWF D′D3 and D4 domains
Monica Sacco,Stefano Lancellotti,Mattia Ferrarese,Francesco Bernardi,Mirko Pinotti,Maira Tardugno,Erica De Candia,Leonardo Di Gennaro,Maria Basso,Betti Giusti,Massimiliano Papi,Giordano Perini,Giancarlo Castaman,Raimondo De Cristofaro
View Articletitled, Noncanonical type 2B von Willebrand disease associated with mutations in the VWF D′D3 and D4 domains
Supplemental data
Ischemic stroke in patients with POEMS syndrome
Clinical Trials & Observations
Jun Feng,Xue-min Gao,Hao Zhao,Tian-hua He,Cong-li Zhang,Kai-ni Shen,Lu Zhang,Xin-xin Cao,Ming Qian,Dao-bin Zhou,Jian Li
View Articletitled, Ischemic stroke in patients with POEMS syndrome

TRANSPLANTATION

Recipient and donor genetic variants associated with mortality after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Paul J. Martin,David M. Levine,Barry E. Storer,Sarah C. Nelson,Xinyuan Dong,John A. Hansen
View Articletitled, Recipient and donor genetic variants associated with mortality after allogeneic hematopoietic cell transplantation
Supplemental data
Treosulfan-based conditioning is feasible and effective for cord blood recipients: a phase 2 multicenter study
Clinical Trials & Observations
Filippo Milano,Jonathan A. Gutman,H. Joachim Deeg,Eneida R. Nemecek,Joachim Baumgart,Laurel Thur,Ann Dahlberg,Rachel B. Salit,Corinne Summers,Frederick R. Appelbaum,Colleen Delaney
View Articletitled, Treosulfan-based conditioning is feasible and effective for cord blood recipients: a phase 2 multicenter study
Supplemental data
Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells
Rafet Basar,May Daher,Nadima Uprety,Elif Gokdemir,Abdullah Alsuliman,Emily Ensley,Gonca Ozcan,Mayela Mendt,Mayra Hernandez Sanabria,Lucila Nassif Kerbauy,Ana Karen Nunez Cortes,Li Li,Pinaki P. Banerjee,Luis Muniz-Feliciano,Sunil Acharya,Natalie W. Fowlkes,Junjun Lu,Sufang Li,Stephan Mielke,Mecit Kaplan,Vandana Nandivada,Mustafa Bdaiwi,Alexander D. Kontoyiannis,Ye Li,Enli Liu,Sonny Ang,David Marin,Lorenzo Brunetti,Michael C. Gundry,Rolf Turk,Mollie S. Schubert,Garrett R. Rettig,Matthew S. McNeill,Gavin Kurgan,Mark A. Behlke,Richard Champlin,Elizabeth J. Shpall,Katayoun Rezvani
View Articletitled, Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells
Supplemental data

COMMENTARY

Influence of single parenthood on cardiopulmonary function in pediatric patients with sickle cell anemia
Xu Zhang,Kiarri N. Kershaw,Caterina P. Minniti,Andrew Campbell,Sohail R. Rana,Deepika S. Darbari,Lori Luchtman-Jones,Craig Sable,Niti Dham,Gregory Ensing,Manuel Arteta,James G. Taylor, VI,Lewis L. Hsu,Sergei Nekhai,Victor R. Gordeuk
View Articletitled, Influence of single parenthood on cardiopulmonary function in pediatric patients with sickle cell anemia

ERRATUM

Mullally A, Hood J, Harrison C, Mesa R. Fedratinib in myelofibrosis. Blood Adv. 2020;4(8):1792-1800.
View Articletitled, Mullally A, Hood J, Harrison C, Mesa R. Fedratinib in myelofibrosis. <em>Blood Adv.</em> 2020;4(8):1792-1800.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Nbeal2−/− mouse carotid artery showing an absence of thrombi after localized stenosis injury where a normal mouse has an occluding thrombus. Nbeal2−/− mice have defective α-granules that do not release platelet von Willebrand factor (VWF) but have normal plasma VWF levels, showing the requirement of platelet VWF for an arterial occlusive thrombus under high shear. See the article by Kim et al.

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