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Journal Articles

Talin-1 is the principal platelet Rap1 effector of integrin activation

Frederic Lagarrigue, David S. Paul, Alexandre R. Gingras, Andrew J. Valadez, Hao Sun, Jenny Lin, Monica N. Cuevas, Jailal N. Ablack, Miguel Alejandro Lopez-Ramirez, Wolfgang Bergmeier, Mark H. Ginsberg

Blood (2020) 136 (10): 1180–1190.

https://doi.org/10.1182/blood.2020005348

Published: 2020

Includes: Supplemental data

Journal Articles

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Hisashi Kato, MD PhD, Shigenori Honda, MD, Hirokazu Kashiwagi, Nobuko Nishiura, Keigo Akuta, Koichi Kokame, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2019) 134 (Supplement_1): 1062.

https://doi.org/10.1182/blood-2019-129668

Published: 2019

Journal Articles

Thrombospondin-1, Platelet Factor 4, and Galectin-1 Are Associated with Engraftment in Patients with Sickle Cell Disease Who Underwent Haploidentical HSCT

Ahmad Shaikh, Purevdorj Olkhanud, MD PhD, Marjan Gucek, PhD, Sajni Patel, MS, Courtney D. Fitzhugh, MD

Blood (2018) 132 (Supplement 1): 201.

https://doi.org/10.1182/blood-2018-99-118654

Published: 2018

Journal Articles

The Rap1-RIAM Pathway Regulates the Expression of Integrins αEβ7(CD103) and α4β7, Which Guide T Cell Homing to Intestinal Compartments

Yavuz-Furkan Yazicioglu, Halil-Ibrahim Aksoylar, PhD, Rinku Pal, MS, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 864.

https://doi.org/10.1182/blood-2018-99-119450

Published: 2018

Journal Articles

Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Outside-in Signaling through Targeting cAMP/PKA Pathway and Inhibits Atherosclerosis

Yan Yang, MD PhD, Xiaohong Ruby Xu, MD PhD, Heyu Ni, MD MSc, PhD, Liping Ma, MD, Wenhua Ling, Fuli Ya

Blood (2018) 132 (Supplement 1): 2423.

https://doi.org/10.1182/blood-2018-99-120196

Published: 2018

Journal Articles

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Rustem I. Litvinov, Karen Pei Yi Fong, PhD BS, Oleg V. Kim, PhD, Kathleen I. Molnar, PhD, Paul C. Billings, PhD, Alex Sternisha, BS, James A. Wells, PhD, John W. Weisel, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2018) 132 (Supplement 1): 1128.

https://doi.org/10.1182/blood-2018-99-113063

Published: 2018

Journal Articles

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Hisashi Kato, MDPhD, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 1136.

https://doi.org/10.1182/blood-2018-99-112852

Published: 2018

Journal Articles

Structure of an Extended β Integrin

Dongwen Zhou, PhD, Aye Myat Myat Thinn, BS, Yan Zhao, MD, Zhengli Wang, PhD, Jieqing Zhu, PhD

Blood (2017) 130 (Supplement 1): 550.

https://doi.org/10.1182/blood.V130.Suppl_1.550.550

Published: 2017

Journal Articles

Structural and Functional Characterization of a Single Chain Î²3 Integrin in Solution and on the Cell Surface and the Implications on Integrin Activation and Pathogenesis of Anti-HPA-1a Alloantibodies

Aye Myat Myat Thinn, BS, Zhengli Wang, PhD, Dongwen Zhou, PhD, Yan Zhao, MD, Brian R. Curtis, PhDMT(ASCP), Jieqing Zhu, PhD

Blood (2017) 130 (Supplement 1): 2295.

https://doi.org/10.1182/blood.V130.Suppl_1.2295.2295

Published: 2017

Journal Articles

Proteotoxicity in Cardiac Amyloidosis: Amyloidogenic Light Chains Affect the Levels of Iintracellular Proteins in Human Heart Cells

Esther Imperlini, PhD, Massimiliano Gnecchi, MD PhD, Paola Rognoni, PhD, Eduard Sabidò, PhD, Maria Chiara Ciuffreda, Giovanni Palladini, MDPhD, Guadalupe Espadas, Giuseppina Palladini, Stefania Orrù, PhD, Paolo Milani, MD PhD, Stefano Perlini, MD PhD, Francesco Salvatore, MD PhD, Giampaolo Merlini, MD, Francesca Lavatelli, MD PhD

Blood (2017) 130 (Supplement 1): 4393.

https://doi.org/10.1182/blood.V130.Suppl_1.4393.4393

Published: 2017

Journal Articles

Murine Studies to Test the Efficacy of Platelet Transfusions in the Management of Platelet Function Disorders

Raymond Piatt, BS, Robert Hugh Lee, PhD, David Paul, PhD, Wolfgang Bergmeier, PhD

Blood (2017) 130 (Supplement 1): 1123.

https://doi.org/10.1182/blood.V130.Suppl_1.1123.1123

Published: 2017

Journal Articles

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Hisashi Kato, Yozo Nakazawa, Yumi Kurokawa, Hirokazu Kashiwagi, Yoichiro Morikawa, Daisuke Morita, Fumiaki Banno, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2016) 128 (23): 2729–2733.

https://doi.org/10.1182/blood-2016-03-704825

Published: 2016

Includes: Supplemental data

Journal Articles

Gα 13 Switch Region 2 Relieves Talin Autoinhibition to Activate Platelet αIIbβ3 Integrin

James Schiemer, BS, Andrew Bohm, PhD, Glenn Merrill-Skoloff, PhD, Robert C. Flaumenhaft, MD PhD, Guy Le Breton, PhD, Athar Chishti, PhD

Blood (2016) 128 (22): 712.

https://doi.org/10.1182/blood.V128.22.712.712

Published: 2016

Journal Articles

In Vivo modeling of Resistance to PI3Kδ Inhibitor Treatment Using EµTCL1-Tg Tumor Transfer Model

Annika Scheffold, Billy Michael Chelliah Jebaraj, Eugen Tausch, Anella Yahiaoui, Anna Dolnik, PhD, Tamara Jacqueline Blaette, M.sc., Lars Bullinger, MD, Christof Schneider, MD, Daniel Mertens, PhD, Veerendra Munugalavadla, Shih-Shih Chen, PhD, Nicholas Chiorazzi, MD, Stacey Tannheimer, Hartmut Döhner, MD, Stephan Stilgenbauer

Blood (2016) 128 (22): 190.

https://doi.org/10.1182/blood.V128.22.190.190

Published: 2016

Journal Articles

Identification of Kinase-Dependent Signaling Pathways Regulated By Rap1b in Murine Platelets

Luis Paniagua, Xiaogang Wu, PhD, Michael Pereckas, Kathleen Noon, Gilbert White, II, MD

Blood (2016) 128 (22): 3717.

https://doi.org/10.1182/blood.V128.22.3717.3717

Published: 2016

Journal Articles

The Rap1-RIAM-talin axis of integrin activation and blood cell function

Frederic Lagarrigue, Chungho Kim, Mark H. Ginsberg

Blood (2016) 128 (4): 479–487.

https://doi.org/10.1182/blood-2015-12-638700

Published: 2016

Journal Articles

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

Sarah Klapproth, Markus Sperandio, Elaine M. Pinheiro, Monika Prünster, Oliver Soehnlein, Frank B. Gertler, Reinhard Fässler, Markus Moser

Blood (2015) 126 (25): 2704–2712.

https://doi.org/10.1182/blood-2015-05-647453

Published: 2015

Includes: Supplemental data

Journal Articles

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

Sarah Klapproth, Federico A. Moretti, Marlis Zeiler, Raphael Ruppert, Ute Breithaupt, Susanna Mueller, Rainer Haas, Matthias Mann, Markus Sperandio, Reinhard Fässler, Markus Moser

Blood (2015) 126 (24): 2592–2600.

https://doi.org/10.1182/blood-2015-04-639310

Published: 2015

Includes: Supplemental data

Journal Articles

A little bit of kindlin goes a long way

Joel S. Bennett

Blood (2015) 126 (24): 2535–2536.

https://doi.org/10.1182/blood-2015-10-675454

Published: 2015

Journal Articles

Structure and Sequence Diversity of the Membrane Distal Region of α-Cytoplasmic Tail in Integrin Activation

Aye Myat Myat Thinn, Jieqing Zhu, PhD

Blood (2015) 126 (23): 3453.

https://doi.org/10.1182/blood.V126.23.3453.3453

Published: 2015

NARROW

Talin-1 is the principal platelet Rap1 effector of integrin activation

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Thrombospondin-1, Platelet Factor 4, and Galectin-1 Are Associated with Engraftment in Patients with Sickle Cell Disease Who Underwent Haploidentical HSCT

The Rap1-RIAM Pathway Regulates the Expression of Integrins αEβ7(CD103) and α4β7, Which Guide T Cell Homing to Intestinal Compartments

Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Outside-in Signaling through Targeting cAMP/PKA Pathway and Inhibits Atherosclerosis

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Structure of an Extended β Integrin

Structural and Functional Characterization of a Single Chain Î²3 Integrin in Solution and on the Cell Surface and the Implications on Integrin Activation and Pathogenesis of Anti-HPA-1a Alloantibodies

Proteotoxicity in Cardiac Amyloidosis: Amyloidogenic Light Chains Affect the Levels of Iintracellular Proteins in Human Heart Cells

Murine Studies to Test the Efficacy of Platelet Transfusions in the Management of Platelet Function Disorders

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Gα 13 Switch Region 2 Relieves Talin Autoinhibition to Activate Platelet αIIbβ3 Integrin

In Vivo modeling of Resistance to PI3Kδ Inhibitor Treatment Using EµTCL1-Tg Tumor Transfer Model

Identification of Kinase-Dependent Signaling Pathways Regulated By Rap1b in Murine Platelets

The Rap1-RIAM-talin axis of integrin activation and blood cell function

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

A little bit of kindlin goes a long way

Structure and Sequence Diversity of the Membrane Distal Region of α-Cytoplasmic Tail in Integrin Activation

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American Society of Hematology

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American Society of Hematology

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