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Journal Articles

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Yusuke Tarumoto, Shan Lin, Jinhua Wang, Joseph P. Milazzo, Yali Xu, Bin Lu, Zhaolin Yang, Yiliang Wei, Sofya Polyanskaya, Mark Wunderlich, Nathanael S. Gray, Kimberly Stegmaier, Christopher R. Vakoc

Blood (2020) 135 (1): 56–70.

https://doi.org/10.1182/blood.2019001576

Published: 2020

Includes: Supplemental data

Journal Articles

Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Transfusion Recovery in a Humanized Mouse Model

Ling Wang, MD PhD, Benjamin Zuchelkowski, Derek Sinchar, Minying Yang, Sebastien Gingras, Tamir Kanias, PhD, Janet S Lee, Daniel Kim-Shapiro, Grier Page, PhD BS, MS, Mark T Gladwin, MD

Blood (2019) 134 (Supplement_1): 102.

https://doi.org/10.1182/blood-2019-124926

Published: 2019

Journal Articles

Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice

Tomasz W. Kaminski, PharmD, Egemen Tutuncuoglu, MSc, Margaret V. Ragni, MD MPH, Mark T Gladwin, MD, Prithu Sundd, PhD

Blood (2019) 134 (Supplement_1): 1043.

https://doi.org/10.1182/blood-2019-130471

Published: 2019

Journal Articles

X-Ray Crystallographic and Single-Molecule Fluorescence Studies of Beta-2 Glycoprotein I Reveal an Alternative Mechanism of Autoantibody Recognition

William Planer, M.S., Zhiwei Chen, M.S., Mathivanan Chinnaraj, PhD, Xiaobing Zuo, PhD, Vittorio Pengo, MD, Paolo Macor, PhD, Francesco Tedesco, MD, Nicola Pozzi, PhD

Blood (2019) 134 (Supplement_1): 91.

https://doi.org/10.1182/blood-2019-122064

Published: 2019

Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD

Blood (2019) 134 (Supplement_1): 3941.

https://doi.org/10.1182/blood-2019-125278

Published: 2019

Journal Articles

CD39 As a Master Regulator of Pulmonary Thrombosis in Sickle Cell Disease

Tomasz Brzoska, PhD, Egemen Tutuncuoglu, MSc, Stevan P. Tofovic, Edwin K. Jackson, Mark T Gladwin, MD, Prithu Sundd, PhD

Blood (2019) 134 (Supplement_1): 2266.

https://doi.org/10.1182/blood-2019-130882

Published: 2019

Journal Articles

Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia

Santosh L. Saraf, MD, Vimal K. Derebail, MD, Xu Zhang, PhD, Mark T Gladwin, MD, Victor R Gordeuk, MD, Jane A. Little, MD

Blood (2019) 134 (Supplement_1): 2268.

https://doi.org/10.1182/blood-2019-124737

Published: 2019

Journal Articles

Risk Factors for Kidney Disease in Hb SC and Hb Sβ + -Thalassemia Sickle Cell Disease

Mandella Mensah, Binal N. Shah, Xu Zhang, PhD, Jin Han, PharmD, PhD, Michel Gowhari, DO, Robert E. Molokie, MD, Mark T Gladwin, MD, Victor R Gordeuk, MD, Santosh L. Saraf, MD

Blood (2019) 134 (Supplement_1): 2299.

https://doi.org/10.1182/blood-2019-128668

Published: 2019

Journal Articles

Mice Deficient in ß2-Glycoprotein I Have a Delayed Time to Thrombosis

Ravi Kumar Alluri, PhD, Gabriel L Forbes, Suman Kundu, MBA, Alvin H. Schmaier, MD, Keith R McCrae, MD

Blood (2019) 134 (Supplement_1): 2423.

https://doi.org/10.1182/blood-2019-130521

Published: 2019

Journal Articles

Circulating Neutrophil Extracellular Traps in the Pathogenesis of Acute Chest Syndrome of Sickle Cell Disease

Ravi Vats, MSc, Egemen Tutuncuoglu, MSc, Jesus Tejero, PhD, Cheryl A Hillery, MD, Mark T Gladwin, MD, Prithu Sundd, PhD

Blood (2019) 134 (Supplement_1): 3556.

https://doi.org/10.1182/blood-2019-130574

Published: 2019

Journal Articles

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Katherine Wood, PhD BA, Brittany Durgin, PhD, Heidi M Schmidt, BSE, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, PhD, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, MD, Mark T Gladwin, MD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3619.

https://doi.org/10.1182/blood-2019-124159

Published: 2019

Journal Articles

Defibrotide Inhibits Endothelial Cell Injury Induced By Plasmas of Patients with Thrombotic Microangiopathies

Jeffrey Laurence, MD, Sonia Elhadad, PhD

Blood (2019) 134 (Supplement_1): 3676.

https://doi.org/10.1182/blood-2019-124158

Published: 2019

Journal Articles

Impaired Bile Secretion Promotes Chronic Liver Injury in Sickle Cell Disease

Tirthadipa Pradhan, Prithu Sundd, PhD, Mark T Gladwin, MD, Satdarshan Pal Monga, Gregory J Kato, MD

Blood (2019) 134 (Supplement_1): 3536.

https://doi.org/10.1182/blood-2019-131915

Published: 2019

Journal Articles

Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies

Leah Fung, PhD, Aparajita Hoskote Chourasia, PhD, Eduardo Torres, MSc, Imelda Lam, BSc, Paul Erdman, MSc, David Hecht, PhD, Robert Sullivan, PhD, Brooke McElwee, BSc, Normand Richard, MSc, Avanthika Venkatachalam, MSc, Irit Snir-Alkalay, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, Yinon Ben-Neriah, MD PhD, David I Stirling, PhD

Blood (2019) 134 (Supplement_1): 4643.

https://doi.org/10.1182/blood-2019-131834

Published: 2019

Journal Articles

Mechanism of Pulmonary Thrombosis in Hemolytic Disorders

Tomasz Brzoska, PhD, Margaret F. Bennewitz, PhD, Egemen Tutuncuoglu, MSc, Margaret V. Ragni, MD MPH, Matthew D Neal, MD, Mark T Gladwin, MD, Prithu Sundd, PhD

Blood (2019) 134 (Supplement_1): 976.

https://doi.org/10.1182/blood-2019-130592

Published: 2019

Journal Articles

Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin Expression

Tirthadipa Pradhan, Prithu Sundd, PhD, Satdarshan Pal Monga, Mark T Gladwin, MD, Gregory J Kato, MD

Blood (2019) 134 (Supplement_1): 958.

https://doi.org/10.1182/blood-2019-131921

Published: 2019

Journal Articles

Proton Pump Inhibition for Secondary Hemochromatosis in Hereditary Anemia, a Phase III Placebo Controlled Randomized Cross-over Trial in Progress

Annelies J. Van Vuren, MD, Bart J. Biemond, MD PhD, Jean-Louis Kerkhoffs, MD PhD, Saskia E.M. Schols, MD PhD, A. W. Rijneveld, MD PhD, Erfan Nur, MD PhD, Richard van Wijk, PhD, Tim Leiner, MD PhD, Joannes J.M. Marx, Emeritus Professor, Eduard J. van Beers, MD PhD

Blood (2019) 134 (Supplement_1): 960.

https://doi.org/10.1182/blood-2019-124059

Published: 2019

Journal Articles

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Brandi Reeves, MD, Soo Jin Kim, MS, Jihyun Song, PhD, Radhika Gangaraju, MD, Rafal Pawlinski, PhD, Perumal Thiagarajan, MD, Victor R. Gordeuk, MD, Nigel S. Key, MBChB, FRCP, Josef T. Prchal, MD

Blood (2018) 132 (Supplement 1): 2513.

https://doi.org/10.1182/blood-2018-99-117812

Published: 2018

Journal Articles

Heterogeneous Hypoxia-Mediated Neutrophil and Red Blood Cell Adhesion to E-Selectin in Microscale Flow

Yuncheng Man, Erdem Kucukal, MS, Shichen Liu, Deepa Manwani, MD, Jane Little, MD, Umut A. Gurkan, PhD

Blood (2018) 132 (Supplement 1): 3671.

https://doi.org/10.1182/blood-2018-99-119353

Published: 2018

Journal Articles

Preliminary Safety, Pharmacokinetic, and Pharmacodynamic Results from a Phase 1b/2 Dose-Escalation and Cohort-Expansion Study of the Noncovalent, Reversible Bruton's Tyrosine Kinase Inhibitor (BTKi), Vecabrutinib, in B-Lymphoid Malignancies

John N. Allan, MD, William G. Wierda, MD PhD, Krish Patel, MD, Susan M. O'Brien, MD, Anthony R Mato, MD, Matthew S Davids, Richard R. Furman, MD, John M. Pagel, MD PhD, Judith A. Fox, PhD, Renee Ward, MD PhD, Pietro Taverna, PhD, Jennifer R. Brown, MD PhD

Blood (2018) 132 (Supplement 1): 3141.

https://doi.org/10.1182/blood-2018-99-116382

Published: 2018

NARROW

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Transfusion Recovery in a Humanized Mouse Model

Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice

X-Ray Crystallographic and Single-Molecule Fluorescence Studies of Beta-2 Glycoprotein I Reveal an Alternative Mechanism of Autoantibody Recognition

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

CD39 As a Master Regulator of Pulmonary Thrombosis in Sickle Cell Disease

Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia

Risk Factors for Kidney Disease in Hb SC and Hb Sβ + -Thalassemia Sickle Cell Disease

Mice Deficient in ß2-Glycoprotein I Have a Delayed Time to Thrombosis

Circulating Neutrophil Extracellular Traps in the Pathogenesis of Acute Chest Syndrome of Sickle Cell Disease

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Defibrotide Inhibits Endothelial Cell Injury Induced By Plasmas of Patients with Thrombotic Microangiopathies

Impaired Bile Secretion Promotes Chronic Liver Injury in Sickle Cell Disease

Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies

Mechanism of Pulmonary Thrombosis in Hemolytic Disorders

Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin Expression

Proton Pump Inhibition for Secondary Hemochromatosis in Hereditary Anemia, a Phase III Placebo Controlled Randomized Cross-over Trial in Progress

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Heterogeneous Hypoxia-Mediated Neutrophil and Red Blood Cell Adhesion to E-Selectin in Microscale Flow

Preliminary Safety, Pharmacokinetic, and Pharmacodynamic Results from a Phase 1b/2 Dose-Escalation and Cohort-Expansion Study of the Noncovalent, Reversible Bruton's Tyrosine Kinase Inhibitor (BTKi), Vecabrutinib, in B-Lymphoid Malignancies

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American Society of Hematology

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ASH Publications

American Society of Hematology

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