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Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Blood (2019) 134 (Supplement_1): 877.

https://doi.org/10.1182/blood-2019-131255

Published: 2019

Journal Articles

Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing By Self-Renewing Hematopoietic Stem and Progenitor Cells

Tomer Itkin, PhD, Chaitanya R Badwe, PhD, Sean Houghton, MSc, Yang Lin, PhD, Ying Liu, PhD, Peipei Guo, PhD, Jesus M Gomez-Salinero, PhD, Fuqiang Geng, PhD, Jae-Hung Shieh, PhD, David Redmond, PhD, Yen-Michael S. Hsu, MD PhD, Brandon Hadland, MD PhD, Shahin Rafii, MD

Blood (2019) 134 (Supplement_1): 725.

https://doi.org/10.1182/blood-2019-126190

Published: 2019

Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD

Blood (2019) 134 (Supplement_1): 1240.

https://doi.org/10.1182/blood-2019-125207

Published: 2019

Journal Articles

Glucocorticoids Regulate the Splicing Factor MBNL1, a Potential Control Point for B-Cell Specification

Miles A. Pufall, PhD, Mimi Fang, Robert K. Bradley, PhD, Chew Guo-Liang, Ross Lanier, Sarah K. Tasian, MD

Blood (2019) 134 (Supplement_1): 2478.

https://doi.org/10.1182/blood-2019-131322

Published: 2019

Journal Articles

Untangling the Transcriptional Mis-Regulation Driven By Pml;rara

William Villiers, MSc, Paul Lavender, PhD, Audrey Kelly, PhD, Michael Lim, MD PhD, Cameron Osborne, PhD, Richard Dillon, MA, PhD MRCP, FRCPath

Blood (2019) 134 (Supplement_1): 282.

https://doi.org/10.1182/blood-2019-125555

Published: 2019

Journal Articles

Inducible Expression of Mutant ELANE Correlates with Disruption of Differentiation Program, but Not the Unfolded Protein Response

Bhavuk Garg, PhD, Hrishikesh M Mehta, PhD, Ralph Kamel, Marshall S. Horwitz, MD PhD, Seth J. Corey, MD

Blood (2019) 134 (Supplement_1): 103.

https://doi.org/10.1182/blood-2019-127409

Published: 2019

Journal Articles

Active DNA Demethylation Mediated By GADD45β Is Essential during G-CSF Triggered Granulocytic Differentiation

Perihan Mir, Maksim Klimiankou, Narges Aghaallaei, Betuel Findik, Frederic Thalheimer, Susanne Wingert, Michael A. Rieger, Thomas Thumberger, Cornelia Zeidler, Baubak Bajoghli, Karl Welte, Julia Skokowa, MD PhD

Blood (2019) 134 (Supplement_1): 211.

https://doi.org/10.1182/blood-2019-128508

Published: 2019

Journal Articles

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Haiyang Yun, PhD, Shabana Vohra, PhD, Annalisa Mupo, PhD, George Giotopoulos, PhD, Daniel Sasca, MD, Sarah J. Horton, PhD, Shuchi Agrawal-Singh, PhD, Eshwar Meduri, PhD, Faisal Basheer, MBBChir, MA, PhD, Ludovica Marando, Malgorzata Gozdecka, PhD, Oliver M. Dovey, PhD, Xiaonan Wang, PhD, Paolo Gallipoli, PhD, Cameron Osborne, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath

Blood (2019) 134 (Supplement_1): 278.

https://doi.org/10.1182/blood-2019-122413

Published: 2019

Journal Articles

Coexistence and Prognostic Significance of EVI1 Expression and Driver Mutations in KMT2A -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, PhD, Kenichi Yoshida, MD PhD, Kana Nakatani, Yasuhiko Kamikubo, MD, PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Nobutaka Kiyokawa, MD PhD, Seishi Ogawa, MD PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Souichi Adachi, MD PhD

Blood (2019) 134 (Supplement_1): 1409.

https://doi.org/10.1182/blood-2019-124652

Published: 2019

Journal Articles

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

Tianyuan Hu, Kiyomi Morita, Matthew C. Hill, Yajian Jiang, Ayumi Kitano, Yusuke Saito, Feng Wang, Xizeng Mao, Kevin A. Hoegenauer, Kazuhiro Morishita, James F. Martin, P. Andrew Futreal, Koichi Takahashi, Daisuke Nakada

Blood (2019) 134 (7): 614–625.

https://doi.org/10.1182/blood.2018888255

Published: 2019

Includes: Supplemental data

Journal Articles

Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells

Malte U Ritter, Olga Klimenkova, Maksim Klimiankou, Amy E Schmidt, MDPhD, Carol Stocking, PhD, Lothar Kanz, Cornelia Zeidler, Daniel C. Link, MD, Karl Welte, Julia Skokowa, MDPhD

Blood (2018) 132 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2018-99-118644

Published: 2018

Journal Articles

Comprehensive Genomic Analysis of IDH Inhibitor-Treated AML Samples Delineates Molecular Mechanisms of Differentiation and Heterogeneous Patterns of Acquired Resistance

Blood (2018) 132 (Supplement 1): 441.

https://doi.org/10.1182/blood-2018-99-116383

Published: 2018

Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Blood (2018) 132 (Supplement 1): 4089.

https://doi.org/10.1182/blood-2018-99-111092

Published: 2018

Journal Articles

Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

Akinori Yuzuriha, Sou Nakamura, PhD, Toshie Kusunoki, Takuya Matsumoto, PhD, Naoshi Sugimoto, MD PhD, Kiyotoshi Sekiguchi, PhD, Koji Eto, MD PhD

Blood (2018) 132 (Supplement 1): 3845.

https://doi.org/10.1182/blood-2018-99-114505

Published: 2018

Journal Articles

Single-Cell Analysis Reveals Sequential Genetic Events from Hematopoietic Stem Cell Differentiation Hierarchy in Multiple Myeloma Patients with FGFR3/IGH Translocation

Wen Zhou, PhD, Fenghuang Zhan, MD PhD

Blood (2018) 132 (Supplement 1): 5598.

https://doi.org/10.1182/blood-2018-99-115606

Published: 2018

Journal Articles

A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia

Anna Cordeiro-Santanach, PhD, Sergey V Prykhozhij, PhD, Adam P Deveau, MSc, Kate L Del Bel, MSc, Stuart E Turvey, MBBS DPhil FRCPC, Jason Berman, MD

Blood (2018) 132 (Supplement 1): 3060.

https://doi.org/10.1182/blood-2018-99-112124

Published: 2018

Journal Articles

Loss-of-Function Mutation in tet2 in Zebrafish Leads to Early MDS like Phenotype

Vinothkumar Rajan, BS, Rachel Woodside, B.SC, Sergey V Prykhozhij, PhD, Jason Berman, MD

Blood (2018) 132 (Supplement 1): 2318.

https://doi.org/10.1182/blood-2018-99-118594

Published: 2018

Journal Articles

Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity

Allegra A Petti, PhD, Stephen R Williams, PhD, Christopher A Miller, PhD, Ian T Fiddes, PhD, David Chen, MD PhD, Sridhar Nonavinkere Srivatsan, MS, Catrina Fronick, BS, Robert Fulton, MS, Deanna M Church, PhD, Timothy J Ley, MD

Blood (2018) 132 (Supplement 1): 1314.

https://doi.org/10.1182/blood-2018-99-119075

Published: 2018

Journal Articles

Overexpression of BRD4 Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

Hima Bansal, Steven Kornblau, MD, Qiu Yihua, Kevin R Coombes, Subbarayalu Panneerdoss, Anand Karnad, MD, Steven Weitman, MD PhD, Gail Tomlinson, MD PhD, Sanjay Bansal, Swami P. Iyer, MD

Blood (2017) 130 (Supplement 1): 3794.

https://doi.org/10.1182/blood.V130.Suppl_1.3794.3794

Published: 2017

Journal Articles

Fetal Inactivation of the Nuclear Interacting SET Domain Protein 1 Impairs Terminal Erythroid Maturation and Results in Acute Erythroleukemia in Mice

Katharina Leonards, PhD, Marwa Almosailleakh, MSc, Samantha Tauchmann, Msc, Helene Mereau, PhD, Sabine Juge, Matheus Filgueira Bezerra, MSc, Susanne Kasper, PhD, Robert Ivanek, PhD, Alexandar Tzankov, Antoine HFM Peters, PhD, Juerg Schwaller, MD

Blood (2017) 130 (Supplement 1): 713.

https://doi.org/10.1182/blood.V130.Suppl_1.713.713

Published: 2017

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The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing By Self-Renewing Hematopoietic Stem and Progenitor Cells

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Glucocorticoids Regulate the Splicing Factor MBNL1, a Potential Control Point for B-Cell Specification

Untangling the Transcriptional Mis-Regulation Driven By Pml;rara

Inducible Expression of Mutant ELANE Correlates with Disruption of Differentiation Program, but Not the Unfolded Protein Response

Active DNA Demethylation Mediated By GADD45β Is Essential during G-CSF Triggered Granulocytic Differentiation

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Coexistence and Prognostic Significance of EVI1 Expression and Driver Mutations in KMT2A -Rearranged Acute Myeloid Leukemia

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells

Comprehensive Genomic Analysis of IDH Inhibitor-Treated AML Samples Delineates Molecular Mechanisms of Differentiation and Heterogeneous Patterns of Acquired Resistance

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

Single-Cell Analysis Reveals Sequential Genetic Events from Hematopoietic Stem Cell Differentiation Hierarchy in Multiple Myeloma Patients with FGFR3/IGH Translocation

A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia

Loss-of-Function Mutation in tet2 in Zebrafish Leads to Early MDS like Phenotype

Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity

Overexpression of BRD4 Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

Fetal Inactivation of the Nuclear Interacting SET Domain Protein 1 Impairs Terminal Erythroid Maturation and Results in Acute Erythroleukemia in Mice

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