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Journal Articles

Targeting cereblon in AML

Steven Grant
Journal: Blood
Blood (2021) 137 (5): 584–586.
https://doi.org/10.1182/blood.2020009827
Published: 2021
Journal Articles

A master erythroid regulator gets its own GPS

Lily Jun-shen Huang, James J. Bieker
Journal: Blood
Blood (2020) 135 (25): 2209–2210.
https://doi.org/10.1182/blood.2020005882
Published: 2020
Journal Articles

Wdr26 regulates nuclear condensation in developing erythroblasts

Ru Zhen, Chingyee Moo, Zhenzhen Zhao, Mengying Chen, He Feng, Xiaojun Zheng, Liang Zhang, Jiahai Shi, Caiyong Chen
Journal: Blood
Blood (2020) 135 (3): 208–219.
https://doi.org/10.1182/blood.2019002165
Published: 2020
Includes: Supplemental data
Journal Articles

Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure

Yimeng Gao, PhD, Radovan Vasic, MD, Yuanbin Song, MD, Rhea Teng, B.Sc., Rana Gbyli, MS, Giulia Biancon, PhD, Raman Nelakanti, B.Sc., Eriko Kudo, B.Sc., Wei Liu, PhD, Anastasia Ardasheva, BS, Xiaoying Fu, MD, Xiaman Wang, MD PhD, Poorval Joshi, PhD, Burak Dura, PhD, Veronica Lee, Gabriella Viero, PhD, Akiko Iwasaki, PhD, Rong Fan, PhD, Andrew Xiao, PhD, Richard Flavell, PhD, Hua-Bing Li, PhD, Toma Tebaldi, PhD, Stephanie Halene, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 450.
https://doi.org/10.1182/blood-2019-130442
Published: 2019
Journal Articles

TNF-α Confers Resistance of Myeloma Cells to IMiDs through TRAF2 Degradation

Jiye Liu, PhD, Teru Hideshima, MD PhD, Lijie Xing, MD, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Yong Cang, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1809.
https://doi.org/10.1182/blood-2019-123141
Published: 2019
Journal Articles

Lenalidomide Induction and Maintenance Maximizes Outcome for Newly Diagnosed Transplant Eligible Myeloma Patients Irrespective of Risk Status: Long-Term Follow-up of the Myeloma XI Trial

Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, David Cairns, MSc, PhD, John R Jones, MD, Bhuvan Kishore, MB BS, MRCP, FRCPath, Mamta Garg, MD FRCP, FRCPath, Cathy Williams, MD MRCP, FRCPath, Kamaraj Karunanithi, MD FRCPath, Jindriska Lindsay, MD, MRCP, FRCPath, Nigel H. Russell, MD, Matthew Jenner, MBBS, MRCP, FRCPath, Gordon Cook, MB ChB, PhD FRCP(Glas), FRCPath, Mark T Drayson, MB ChB, PhD FRCPath, Roger G. Owen, MD, Walter M Gregory, PhD, Martin F. Kaiser, Faith E. Davies, MD, Gareth Morgan, MDPhDFRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 1910.
https://doi.org/10.1182/blood-2019-126160
Published: 2019
Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2073.
https://doi.org/10.1182/blood-2019-130666
Published: 2019
Journal Articles

SIX1 Transcription Factor Enhances Human Erythropoiesis Via GATA1

Michael Creed, MSc, Christian Eberly, Jevon Cutler, PhD, MinJung Kim, PhD, Akhilesh Pandey, MD PhD, Curt I Civin, MD, Tami J Kingsbury, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3503.
https://doi.org/10.1182/blood-2019-131203
Published: 2019
Journal Articles

Preliminary Lasso Regression Analysis Identifies DNA-Damage Gene Expression Signature Predictive of Clinical Outcomes in Patients Using Gemtuzumab Ozogamicin

Mohammed Gbadamosi, BS, Abdelrahman H. Elsayed, MSc, Rhonda E. Ries, MA, Soheil Meshinchi, MD PhD, Jatinder K Lamba, M.Sc., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1401.
https://doi.org/10.1182/blood-2019-131210
Published: 2019
Journal Articles

Pevonedistat, a Nedd-8 Activating Enzyme Inhibitor, Upregulates NOXA to Increase Effectiveness of Azacitidine and Venetoclax in Preclinical Models of Acute Myelogenous Leukemia

Brianna N Smith, MD MS, Dan Cojocari, PhD BSc, Julie J Purkal, MA, Maria Arrate, MSc, Haley E. Ramsey, PhDMSc, Joel D. Leverson, PhD, Erwin Boghaert, MS, MD, Darren C. Phillips, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1380.
https://doi.org/10.1182/blood-2019-123068
Published: 2019
Journal Articles

RFWD2 Induces Cellular Proliferation and Proteasome Inhibitor Resistance By Mediating p27 Ubiqutinaiton in Multiple Myeloma

Ye Yang, PhD, Mengjie Guo, Chunyan Gu
Journal: Blood
Blood (2019) 134 (Supplement_1): 3068.
https://doi.org/10.1182/blood-2019-127888
Published: 2019
Journal Articles

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Taishi Yonezawa, MSc, Hirotaka Takahasi, PhD, Tatsuya Sawasaki, PhD, Toshio Kitamura, MD PhD, Susumu Goyama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1252.
https://doi.org/10.1182/blood-2019-126264
Published: 2019
Journal Articles

Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors

Max Jan, MD PhD, Ana Castano, MD, Amanda Walker, BA, Andrew A Guirguis, MD PhD, Jessica A Gasser, PhD, Amanda A Bouffard, Mikolaj Slabicki, PhD, Alexander Tepper, Daniel E Grinshpun, Taeyoon Kyung, PhD, Quinlan Sievers, MD PhD, Michael E Birnbaum, PhD, Marcela V Maus, MD PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 866.
https://doi.org/10.1182/blood-2019-124210
Published: 2019
Journal Articles

Innate Immune Signaling Suppresses Acute Leukemia By Modifying MYC Oncogenic Activity

Tomoya Muto, MD PhD, Maria Guillamot, PhD, Jing Fang, MD PhD, Luna Zea Redondo, MS, Kwangmin Choi, PhD, Yixiao Gong, MSc, Callum S Walker, MSc, Kathleen Hueneman, Lyndsey C Bolanos, BSc, Laura Barreyro, PhD, Lynn Lee, MD, Kenneth D Greis, PhD, Alireza Khodadadi-Jamayran, M.Sc., Amaia Lujambio, PhD, Scott W. Lowe, PhD, Iannis Aifantis, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 727.
https://doi.org/10.1182/blood-2019-121423
Published: 2019
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL

Deyi Zhang, PhD, Hailey Harris, Aileen Kelly, PhD, Daniel W Robbins, May Tan, Timothy Ingallinera, Neil Bence, Arthur T Sands, Sivasubramanian Baskar, Sarah E. M. Herman, Adrian Wiestner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 174.
https://doi.org/10.1182/blood-2019-126921
Published: 2019
Journal Articles

ATRA Could Correct the Defective S1P-Mediated Cytoskeletal Reorganization in Proplatelet Formation of ITP

Qiu-Sha Huang, Jing Xue, Chen-Cong Wang, Ya-Zhen Qin, Lan-Ping Xu, Kaiyan Liu, Xiao-Jun Huang, MD, Xiao-Hui Zhang
Journal: Blood
Blood (2019) 134 (Supplement_1): 218.
https://doi.org/10.1182/blood-2019-126384
Published: 2019
Journal Articles

DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia

Yonghan He, MD, Raphael Koch, Vivekananda Budamagunta, Dongwen Lv, Sajid Khan, Xuan Zhang, Janet S Wiegand, Guangrong Zheng, David M. Weinstock, MD, Daohong Zhou
Journal: Blood
Blood (2019) 134 (Supplement_1): 303.
https://doi.org/10.1182/blood-2019-125820
Published: 2019
Journal Articles

Characterization of Monoclonal Gammopathy of Undetermined Significance Progression to Multiple Myeloma through Meta-Analysis of GEO Data

Jihad Aljabban, MMSc, BA, David Chen, BS, Francesca Cottini, MD, Saad Syed, BS, Nabeal Aljabban, BS, Sharjeel Syed, BS, Tiffany Hughes, PhD, David Feldman, BS, Dexter Hadley, MD PhD, Don M. Benson, Jr., MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4395.
https://doi.org/10.1182/blood-2019-129699
Published: 2019
Journal Articles

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Scott R Best, BS, Vi Lam, Nur Bruss, BS, Taylor Hashiguchi Rowland, BS, Adam S. Kittai, MD, Tingting Liu, Allison J Berger, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4313.
https://doi.org/10.1182/blood-2019-123600
Published: 2019