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Journal Articles

Development of KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the Treatment of Acute Myeloid Leukemia

Michele Mayo, Yogesh Chutake, Rahul Karnik, Alice McDonald, Patricia S. Cho, Jessica Filiatrault, Dapeng Chen, Vaishali Dixit, William Proctor, Susanne Breitkopf, Frank Qi, Kan-Nian Hu, Kirti Sharma, Reggie Ewesuedo, Matt Weiss, Joseph D. Growney, Juliet Williams, Stefanie S Schalm
Journal: Blood
Blood (2022) 140 (Supplement 1): 6239–6240.
https://doi.org/10.1182/blood-2022-169021
Published: 2022
Journal Articles

A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers

Phillip CC Liu, Vaishali Dixit, Michele Mayo, Joyoti Dey, Karen Yuan, Rahul Karnik, Dirk Walther, Yatao Shi, Kirti Sharma, Haojing Rong, Bin Yang, Ashwin Gollerkeri, Jared Gollob, Chris DeSavi
Journal: Blood
Blood (2021) 138 (Supplement 1): 1865.
https://doi.org/10.1182/blood-2021-151125
Published: 2021
Journal Articles

Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens

Giuseppina Astone, Luca Vincenzo Cappelli, William Chiu, Clarisse Kayembe, Rui Wang, Bin Yang, Kirti Sharma, Joyoti Dey, Rahul Karnik, Lara Brambilla, David Levy, Liron Yoffe, Francesco Boccalatte, Javier Rodriguez Hernaez, Aristotelis Tsirigos, Paul Zumbo, Doron Betel, Akanksha Verma, Olivier Elemento, Michela Cumerlato, Roberto Piva, Steven M. Horwitz, Zachary D. Epstein-Peterson, Jared Gollob, Chris DeSavi, Phillip CC Liu, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 865.
https://doi.org/10.1182/blood-2021-153995
Published: 2021
Journal Articles

Ktx-120, a Novel Irakimid Degrader of IRAK4 and IMiD Substrates Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL CDX and PDX Models

Duncan Walker, PhD, Michele Mayo, Christine Klaus, BS, Dapeng Chen, PhD, Samyabrata Bhaduri, PhD, Kirti Sharma, Scott Rusin, Alice McDonald, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Matt Weiss, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41.
https://doi.org/10.1182/blood-2020-137750
Published: 2020
Journal Articles

Mechanisms of the Anti-Tumor Activity of STAT3 Degraders in Lymphoma

Haojing Rong, PhD, Kirti Sharma, Fred Csibi, Bin Yang, Scott Rusin, Yatao Shi, PhD, Joyoti Dey, PhD, Rahul Karnik, Michele Mayo, Karen Yuan, Yogesh Chutake, Alice McDonald, PhD, Sean Zhu, PhD, Nan Ji, PhD, Phillip Liu, PhD, Henry Li, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Chris Desavi
Journal: Blood
Blood (2020) 136 (Supplement 1): 42.
https://doi.org/10.1182/blood-2020-137778
Published: 2020
Journal Articles

Small Molecule-Induced, Selective STAT3 Degradation Leads to Anti-Tumor Activity in STAT3-Dependent Heme Malignancies

Fred Csibi, Nan Ji, PhD, Bin Yang, Karen Yuan, Michele Mayo, Haojing Rong, PhD, Scott Rusin, Kirti Sharma, Christine Loh, PhD, Henry Li, PhD, Sharon Townson, Jesse Chen, PhD, Hari Kamadurai, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3803.
https://doi.org/10.1182/blood-2019-128981
Published: 2019