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Journal Articles

Development of KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the Treatment of Acute Myeloid Leukemia

Michele Mayo, Yogesh Chutake, Rahul Karnik, Alice McDonald, Patricia S. Cho, Jessica Filiatrault, Dapeng Chen, Vaishali Dixit, William Proctor, Susanne Breitkopf, Frank Qi, Kan-Nian Hu, Kirti Sharma, Reggie Ewesuedo, Matt Weiss, Joseph D. Growney, Juliet Williams, Stefanie S Schalm
Journal: Blood
Blood (2022) 140 (Supplement 1): 6239–6240.
https://doi.org/10.1182/blood-2022-169021
Published: 2022
Journal Articles

Precision Targeting of MYD88 Mutant DLBCL Using the Novel Combination of Irakimids and BCL2 Inhibition

Andre M. Grilo, Christine Klaus, Alice McDonald, Jared Gollob, Matt Weiss, Owen A. O'Connor, Gilles Salles, Jayanta Chaudhuri, Jennifer Kimberly Lue
Journal: Blood
Blood (2022) 140 (Supplement 1): 8862–8864.
https://doi.org/10.1182/blood-2022-159567
Published: 2022
Journal Articles

Ktx-120, a Novel Irakimid Degrader of IRAK4 and IMiD Substrates Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL CDX and PDX Models

Duncan Walker, PhD, Michele Mayo, Christine Klaus, BS, Dapeng Chen, PhD, Samyabrata Bhaduri, PhD, Kirti Sharma, Scott Rusin, Alice McDonald, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Matt Weiss, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41.
https://doi.org/10.1182/blood-2020-137750
Published: 2020
Journal Articles

Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma

Joseph Kelleher, PhD, Laurent Audoly, PhD, Veronica Campbell, Jesse Chen, PhD, Nan Ji, PhD, Hari Kamadurai, PhD, Henry Li, PhD, Christine Loh, PhD, Haojing Rong, PhD, Dominico Vigil, PhD, Matt Weiss, PhD, Karen Yuan, Yi Zhang, PhD, Nello Mainolfi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2018-99-120148
Published: 2018