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Journal Articles

SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing

Christoph Schürch, Thorsten Schaefer, Joëlle S. Müller, Pauline Hanns, Marlon Arnone, Alain Dumlin, Jonas Schärer, Irmgard Sinning, Klemens Wild, Julia Skokowa, Karl Welte, Raphael Carapito, Seiamak Bahram, Martina Konantz, Claudia Lengerke

Blood (2021) 137 (10): 1340–1352.

https://doi.org/10.1182/blood.2020008115

Published: 2021

Includes: Supplemental data

Journal Articles

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Timothy M Chlon, PhD, Emily Stepanchick, Kwangmin Choi, PhD, Yi Zheng, PhD, Kathleen Hueneman, Ashley Davis, Daniel T. Starczynowski, PhD

Blood (2019) 134 (Supplement_1): 773.

https://doi.org/10.1182/blood-2019-127471

Published: 2019

Journal Articles

Whole Genome Profiling of Adult B-Other Acute Lymphoblastic Leukaemia on the UKALL14 Trial

Daniel A. Leongamornlert, PhD, Emilio Barretta, Soo Lee, Thomas Creasey, MBBS, Rachel J. Mitchell, MSc, Amy A. Kirkwood, MSc, Laura Clifton-Hadley, PhDBSc, Pip Patrick, PhDMSc,MA, Peter J Campbell, Bela Wrench, MBBS, MD MRCP, FRCPath, Anthony V. Moorman, Adele K. Fielding, MBBS,PhDFRCP,FRCPath, Elli Papaemmanuil, PhD

Blood (2019) 134 (Supplement_1): 2743.

https://doi.org/10.1182/blood-2019-125723

Published: 2019

Journal Articles

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming"

Kamaleldin E Elagib, PhDMBBS, Ashton Brock, PhD, Goar Mosoyan, Cara Clementelli, Lorrie L Delehanty, BS, Alexandra Pacheco-Benichou, Corinne Fruit, Thierry Besson, PhD, Stephen Morris, MD, Koji Eto, MD, Camelia Iancu-Rubin, PhD, Adam N Goldfarb, MD

Blood (2019) 134 (Supplement_1): 3250.

https://doi.org/10.1182/blood-2019-129049

Published: 2019

Journal Articles

DNMT3A R882 Alters the Epigenome of Hematopoietic Cells

Amanda M Smith, PhD, Taylor LaValle, BS, Shamika Ketkar, PhD, Sai Mukund Ramakrishnan, MS, Christopher A Miller, PhD, Timothy J Ley, MD

Blood (2019) 134 (Supplement_1): 112.

https://doi.org/10.1182/blood-2019-129003

Published: 2019

Journal Articles

Mutation-Specific Dominant Negative Effects Determine the Phenotype in SRP54 D eficiency

Christoph Schuerch, MSc, Thorsten Schaefer, PhD, Joelle S. Müller, MSc, Pauline Hanns, MSc, Jonas Schärer, BSc, Julia Skokowa, MD PhD, Karl Welte, Raphael Carapito, PhD, Seiamak Bahram, MD, Martina Konantz, PhD, Claudia Lengerke, MD

Blood (2019) 134 (Supplement_1): 437.

https://doi.org/10.1182/blood-2019-127007

Published: 2019

Journal Articles

Epidermal Growth Factor Rejuvenates Aging Hematopoietic Stem Cells

Vivian Y. Chang, MD, M.S., Tiancheng Fang, Katherine A. Pohl, B.S., Evelyn Tran, B.A., Heather A Himburg, PhD, John P Chute, MD

Blood (2018) 132 (Supplement 1): 1284.

https://doi.org/10.1182/blood-2018-99-119929

Published: 2018

Journal Articles

Epigenetic Modifier Mutations in the LL-100 Panel

Hilmar Quentmeier, PhD, Claudia Pommerenke, PhD, Hans G. Drexler, MD PhD

Blood (2018) 132 (Supplement 1): 5271.

https://doi.org/10.1182/blood-2018-99-110060

Published: 2018

Journal Articles

Inactivation of Stage-Specific B-Cell Commitment Genes Generates Distinct Molecular Subtypes of BCR-ABL1 Lymphoblastic Leukemia

Jaeseung C. Kim, MSc, Michelle Chan-Seng-Yue, Gavin W. Wilson, PhD, Andrea Arruda, Karen Ng, Olga I. Gan, PhD, Stephanie M. Dobson, PhD, Paul M. Krzyzanowski, PhD, Johann K. Hitzler, MD, Anne Tierens, MD PhD, John E. Dick, PhD, Mark D. Minden, MD PhD, John D. McPherson, PhD, Faiyaz Notta, PhD

Blood (2018) 132 (Supplement 1): 569.

https://doi.org/10.1182/blood-2018-99-116981

Published: 2018

Journal Articles

Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration

Praveen K Suraneni, PhD, Seth J. Corey, MD, Michael Hession, BS, Rameez Ishaq, Arinola Awomolo, Shirin Hasan, PhD, Najet Debili, PhD, John D. Crispino, PhD MBA, Elizabeth A. Eklund, MD, Yolande Chen, MD

Blood (2018) 132 (Supplement 1): 2429.

https://doi.org/10.1182/blood-2018-99-118782

Published: 2018

Journal Articles

Systematic Analyses of Clinically Relevant Single Nucleotide Polymorphisms (SNPs) of NR3C1 in Patients from the Italian Registry of Diamond Blackfan Anemia

Jiawen Li, Mayte Suarez-Farinas, Stuart Scott, PhD, Lilian Varricchio, Carolyn F. Whitsett, MD, Ugo Ramenghi, MD, Irma Dianzani, Anna Rita Migliaccio, PhD

Blood (2017) 130 (Supplement 1): 2200.

https://doi.org/10.1182/blood.V130.Suppl_1.2200.2200

Published: 2017

Journal Articles

Characterization of the Pathogenicity of Novel Sequence Variants Identified in Type 1 VWD Subjects in the Zimmerman Program for the Molecular and Clinical Biology Study

Azza Abdelaal, MD, David Jakab, Pam A Christopherson, Sandra L Haberichter, PhD

Blood (2017) 130 (Supplement 1): 20.

https://doi.org/10.1182/blood.V130.Suppl_1.20.20

Published: 2017

Journal Articles

Necessity of Smc3 in Embryonic and Adult Hematopoiesis with an Emphasis on Myeloid Compartment

Tianjiao Wang, John S. Welch, MD PhD

Blood (2017) 130 (Supplement 1): 470.

https://doi.org/10.1182/blood.V130.Suppl_1.470.470

Published: 2017

Journal Articles

Reciprocal Regulation of BCL6 and MLL Expression As a Vulnerability in MLL -Rearranged Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Scott Armstrong, MD PhD, Thomas Arthur Milne, PhD BSc, MSc, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 1210.

https://doi.org/10.1182/blood.V130.Suppl_1.1210.1210

Published: 2017

Journal Articles

RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program

Mylène Gerritsen, MSc, Esther Tijchon, PhD, Guoqiang Yi, PhD, Jorren Kuster, BSc, Jan Jacob Schuringa, PhD, Joost H.A. Martens, Edo Vellenga, MD

Blood (2017) 130 (Supplement 1): 1229.

https://doi.org/10.1182/blood.V130.Suppl_1.1229.1229

Published: 2017

Journal Articles

A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells

Vania Baldan, PhD, Priyanka Ghongane, MSc, Evangelia Kokalaki, PhD, Wen Chean Lim, PhD, Shimobi Onuoha, PhD, Shaun Paul Cordoba, PhD, Simon Thomas, PhD, Martin Pule, MD PhD

Blood (2017) 130 (Supplement 1): 3190.

https://doi.org/10.1182/blood.V130.Suppl_1.3190.3190

Published: 2017

Journal Articles

Targeting the Mechanism of c-Mpl Exon-Inclusion through Antisense Oligonucleotides Yields a Dominant Negative Isoform

Sakiko Suzuki, MD, Ronny R Racine, PhD BS, Nathan A Manalo, MS, Neeraj Saini, MD, Cliff Odour, Michael Moazami, MS, Jeffrey A Bailey, MD PhD, Jonathan K Watts, PhD, Glen D. Raffel, MD PhD

Blood (2017) 130 (Supplement 1): 383.

https://doi.org/10.1182/blood.V130.Suppl_1.383.383

Published: 2017

Journal Articles

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Andrew Volk, PhD, Kaiwei Liang, PhD, Jianyun Zhao, Xinyu Li, Marinka Bulic, Stacy Marshall, Jeffrey W. Taub, MD, Yubin Ge, PhD, Sebastien Malinge, PhD, Elizabeth Bartom, PhD, Ali Shilatifard, PhD, John D. Crispino, PhD

Blood (2017) 130 (Supplement 1): 245.

https://doi.org/10.1182/blood.V130.Suppl_1.245.245

Published: 2017

Journal Articles

Smc3 Haploinsufficiency and Smc3 Deletion Alter Hematopoiesis In Vivo

Tianjiao Wang, John S. Welch

Blood (2016) 128 (22): 2903.

https://doi.org/10.1182/blood.V128.22.2903.2903

Published: 2016

Journal Articles

Dnmt3a Haploisufficiency Cooperates with Oncogenic Kras to Promote an Early-Onset T-Cell Leukemia

Yuan-I Chang, PhD, Guangyao Kong, PhD, Jing Zhang, PhD, Erik A. Ranheim, MD

Blood (2016) 128 (22): 2729.

https://doi.org/10.1182/blood.V128.22.2729.2729

Published: 2016

NARROW

SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Whole Genome Profiling of Adult B-Other Acute Lymphoblastic Leukaemia on the UKALL14 Trial

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming"

DNMT3A R882 Alters the Epigenome of Hematopoietic Cells

Mutation-Specific Dominant Negative Effects Determine the Phenotype in SRP54 D eficiency

Epidermal Growth Factor Rejuvenates Aging Hematopoietic Stem Cells

Epigenetic Modifier Mutations in the LL-100 Panel

Inactivation of Stage-Specific B-Cell Commitment Genes Generates Distinct Molecular Subtypes of BCR-ABL1 Lymphoblastic Leukemia

Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration

Systematic Analyses of Clinically Relevant Single Nucleotide Polymorphisms (SNPs) of NR3C1 in Patients from the Italian Registry of Diamond Blackfan Anemia

Characterization of the Pathogenicity of Novel Sequence Variants Identified in Type 1 VWD Subjects in the Zimmerman Program for the Molecular and Clinical Biology Study

Necessity of Smc3 in Embryonic and Adult Hematopoiesis with an Emphasis on Myeloid Compartment

Reciprocal Regulation of BCL6 and MLL Expression As a Vulnerability in MLL -Rearranged Acute Lymphoblastic Leukemia

RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program

A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells

Targeting the Mechanism of c-Mpl Exon-Inclusion through Antisense Oligonucleotides Yields a Dominant Negative Isoform

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Smc3 Haploinsufficiency and Smc3 Deletion Alter Hematopoiesis In Vivo

Dnmt3a Haploisufficiency Cooperates with Oncogenic Kras to Promote an Early-Onset T-Cell Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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