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Journal Articles

CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy

Fraser Soares, Branson Chen, Jong Bok Lee, Musaddeque Ahmed, Dalam Ly, Enoch Tin, Hyeonjeong Kang, Yong Zeng, Nayeema Akhtar, Mark D. Minden, Housheng Hansen He, Li Zhang
Journal: Blood
Blood (2021) 137 (16): 2171–2181.
https://doi.org/10.1182/blood.2019004108
Published: 2021
Includes: Supplemental data
Journal Articles

TET1 Modulates DNA Replication in Leukemia Cells Via a Catalytic-Independent Mechanism through Cooperating with KAT8

Hengyou Weng, PhD, Huilin Huang, PhD, He Huang, Zhaojin Yu, Paulina Siejka-Zielinska, Zhenhua Chen, PhD, Emily Prince, Chao Shen, PhD, Zejuan Li, MD, Chunxiao Song, Yingming Zhao, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1249.
https://doi.org/10.1182/blood-2019-127321
Published: 2019
Journal Articles

Targeting Both BET and Crebbp/EP300 Proteins with the Novel Dual Inhibitor NEO2734 Leads to More Preclinical Anti-Tumor Activity in Diffuse Large B Cell Lymphomathan with Single BET or Crebbp/EP300 Inhibitors

Filippo Spriano, Eugenio Gaudio, PhD, Chiara Tarantelli, PhD, Gaetanina Golino, Luciano Cascione, PhD, Emanuele Zucca, Anastasios Stathis, MD, Francis J. Giles, MD FRCPI, FRCPath, Francesco Bertoni, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4174.
https://doi.org/10.1182/blood-2018-99-114900
Published: 2018
Journal Articles

Targeting Histone Acetyltransferase Gene Inactivation in Diffuse Large B Cell Lymphoma

Stefanie Meyer, PhD, Sofija Vlasevska, Laura Garcia Ibanez, PhD, Claudio Scuoppo, PhD, Riccardo Dalla-Favera, MD, Laura Pasqualucci, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 671.
https://doi.org/10.1182/blood-2018-99-117542
Published: 2018
Journal Articles

The Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance

Akihiko Numata, MD, Hui Si Kwok, PhD, Qi-Ling Zhou, Jia Li, PhD, Rebecca Hannah, Jihye Park, PhD, Vladimir Espinosa Angarcia, PhD, Berthold Gottgens, Henry Yang, PhD, John Lough, PhD, Deepak Bararia, PhD, Daniel G. Tenen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2554.
https://doi.org/10.1182/blood-2018-99-118316
Published: 2018
Journal Articles

Nucleosome Binding Protein HMGN1 Promotes HSPC Competitive Advantage with Decreased Quiescence and Cooperates with AML Oncogenes to Block Differentiation and Increase Clonogenicity

Lucia Cabal-Hierro, PhD, Katsuhiro Togami, MD PhD, Kelly Higby, Andrew A. Lane, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2606.
https://doi.org/10.1182/blood-2018-99-119348
Published: 2018
Journal Articles

Pan-HDAC Inhibitors May Restore PRDM1 Expression in Follicular Lymphoma

Thierry Fest, Fabienne Desmots-Loyer, Mikael Roussel, MD PhD, Celine Pangault, PhD, Cedric Pastoret, MD, Francisco Llamas-Gutierrez, Eric Guiheneuf, Valérie Camara-clayette, Thierry Lamy, Pr, MD PhD, Karin Tarte, PhD, Vincent Ribrag, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2848.
https://doi.org/10.1182/blood-2018-99-113269
Published: 2018
Journal Articles

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Johanna Melo-Cardenas, Yuanming Xu, Juncheng Wei, Can Tan, Sinyi Kong, Beixue Gao, Elena Montauti, Gina Kirsammer, Jonathan D. Licht, Jindan Yu, Peng Ji, John D. Crispino, Deyu Fang
Journal: Blood
Blood (2018) 132 (4): 423–434.
https://doi.org/10.1182/blood-2017-10-811760
Published: 2018
Includes: Supplemental data
Journal Articles

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Dilshad H. Khan, Michael Mullokandov, Yan Wu, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Neil MacLean, Danny V. Jeyaraju, PhD, G. Wei Xu, Rob C. Laister, PhD, Zachary Blatman, Troy Ketela, Mark D. Minden, MD PhD, Atan Gross, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 299.
https://doi.org/10.1182/blood.V130.Suppl_1.299.299
Published: 2017
Journal Articles

Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice

Daria G. Valerio, Haiming Xu, Meghan E. Eisold, Carolien M. Woolthuis, Tej K. Pandita, Scott A. Armstrong
Journal: Blood
Blood (2017) 129 (1): 48–59.
https://doi.org/10.1182/blood-2016-05-714568
Published: 2017
Includes: Supplemental data
Journal Articles

Histone-Modifying Gene Mutations Are Related to Tumor Progression and Response to Histone Deacetylase Inhibitors in Patients with Peripheral T-Cell Lymphoma Not Otherwise Specified

Mengmeng Ji, PhD
Journal: Blood
Blood (2016) 128 (22): 4110.
https://doi.org/10.1182/blood.V128.22.4110.4110
Published: 2016
Journal Articles

High PRMT1 Expression Promotes the Progression of Acute Megakaryocytic Leukemia Via Controlling Metabolic Pathways

Hairui Su, BS, Han Guo, PhD, Ngoc-Tung Tran, PhD, Minkui Luo, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2016) 128 (22): 1551.
https://doi.org/10.1182/blood.V128.22.1551.1551
Published: 2016
Journal Articles

FANCA Fine-Tunes Chromosome Segregation By Controlling BUBR1 K250 Acetylation at the Kinetochores

Zahi Abdul Sater, Richa Sharma, MD, Elizabeth Sierra Potchanant, PhD, Ying He, Grzegorz Nalepa, MDPhD
Journal: Blood
Blood (2016) 128 (22): 1040.
https://doi.org/10.1182/blood.V128.22.1040.1040
Published: 2016
Journal Articles

Unravelling the Complexities of Hedgehog Mediated Signal Transduction in Acute Myeloid Leukaemia and Normal Haematopoiesis

Victoria Campbell, BSc hons, MBBS, MRCP, FRCPath, Anuradha Tarafdar, PhD, Edwina Dobbin, PhD, Gillian A. Horne, BSc hons, MBChB, MRCP, MRes, Laura Park, PhD, Colin Nixon, John R. Goodlad, MD FRCPath, Helen Wheadon, PhD, Mhairi Copland, PhD BSc, MB, ChB, MRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 2881.
https://doi.org/10.1182/blood.V128.22.2881.2881
Published: 2016
Journal Articles

CREBBP Loss Cooperates with BCL2 Over-Expression to Promote Lymphoma in Mice

García-Ramírez Idoia, Shashank Shrishrimal, Ines Gonzalez-Herrero, Alberto Martín-Lorenzo, Guillermo rodriguez-Hernandez, Romain Duval, Dalia Moore, Lucia Ruiz-Roca, Oscar Blanco, Diego Alonso-Lopez, Javier de Las Rivas, David Klinkibiel, Martin Bast, BS, Timothy C. Greiner, MD, Julie M Vose, MD, Matthew Lunning, DO, Fernando Rodrigues-Lima, PhD, Rafael Jiménez, Francisco Garcia-criado, Maria garcia Cenador, Paul Brindle, Carolina vicente-Duenas, Isidro Sánchez-García, MD, Michael R Green, PhD
Journal: Blood
Blood (2016) 128 (22): 458.
https://doi.org/10.1182/blood.V128.22.458.458
Published: 2016
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Qiao-Yang Sun, PhD, Ling-wen Ding, PhD, Kar-Tong Tan, Wenwen Chien, Anand Mayakonda, Allen Eng Juh Yeoh, MD, Norihiko Kawamata, Yasunobu Nagata, MD,PhD, Xiao Jin-Fen, Xin-Yi Loh, De-Chen Lin, Manoj Garg, PhD, Yan-Yi Jiang, Liang Xu, Su-Lin Lim, Li-Zhen Liu, Vikas Madan, PhD, Masashi Sanada, MD PhD, Lucia Torres Fernández, Hema Preethi S.S., Michael Lill, MD BS, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, Satoru Miyano, PhD, Der-Cherng Liang, MD, Seishi Ogawa, MD PhD, Lee-Yung Shih, Henry Yang, PhD, H. Phillip Koeffler, MD
Journal: Blood
Blood (2016) 128 (22): 452.
https://doi.org/10.1182/blood.V128.22.452.452
Published: 2016
Journal Articles

FOXO1-p300-Txn Circuit Regulates Oxidative Stress Responses in Diffuse Large B-Cell Lymphomas Characterized By Enhanced Oxidative Phosphorylation

Tomasz Sewastianik, MSc, Maciej Szydlowski, PhD, Emilia Bialopiotrowicz, PhD, Ewa Jablonska, PhD, Przemyslaw Kiliszek, MSc, Anna Polak, MSc, Monika Prochorec-Sobieszek, MD PhD, Anna Szumera-Cieckiewicz, MD PhD, Tomasz S. Kaminski, MSc, Patryk Gorniak, PhD, Sergiusz Markowicz, PhD, Eliza Nowak, MSc, Monika A. Grygorowicz, MSc, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD
Journal: Blood
Blood (2015) 126 (23): 466.
https://doi.org/10.1182/blood.V126.23.466.466
Published: 2015
Journal Articles

Benzene Induces Hematotoxicity Via Acetyltransferase p300 Inhibition-Mediated Autophagy

Shanhu Qian, Shenghui Zhang, Yifen Shi, Jiaqi Li, Junqing Wu, Gang Hu, Lan Sun, Yixiang Han, Kang Yu, MD
Journal: Blood
Blood (2015) 126 (23): 4759.
https://doi.org/10.1182/blood.V126.23.4759.4759
Published: 2015
Journal Articles

P300 Acetylates STAT3 and Increases Its Constitutive Transcriptional Activity in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Alessandra Ferrajoli, MD, Jan A Burger, MD PhD, Philip Thompson, MBBS, Nitin Jain, MD, William Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD
Journal: Blood
Blood (2015) 126 (23): 4143.
https://doi.org/10.1182/blood.V126.23.4143.4143
Published: 2015
Journal Articles

TAF10 Interacts with GATA1 Transcription Factor and Controls Mouse Erythropoiesis

Petros Papadopoulos, PhD, Laura Gutierrez, PhD, Jeroen Demmers, PhD, Dimitris Papageorgiou, PhD, Elena Karkoulia, PhD, John Strouboulis, PhD, Reinier van der Linden, Elisabeth Scheer, Farzin Pourfarzad, PhD, Dick Dekkers, Peter Vandenberghe, MD PhD, Sjaak Philipsen, PhD, Frank Grosveld, PhD, László Tora, PhD
Journal: Blood
Blood (2014) 124 (21): 2912.
https://doi.org/10.1182/blood.V124.21.2912.2912
Published: 2014