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Journal Articles

Phase 1b/2 Study of Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Lenalidomide (ViPOR) in Relapsed/Refractory and Treatment-Naïve Mantle Cell Lymphoma: Preliminary Analysis of Safety, Efficacy, and Minimal Residual Disease

Christopher Melani, Rahul Lakhotia, Stefania Pittaluga, James D. Phelan, Jagan R. Muppidi, Max J Gordon, Yandan Yang, Weihong Xu, Theresa Davies-Hill, Da Wei Huang, Craig J. Thomas, Michele Ceribelli, Frances A Tosto, Anna M Juanitez, Amynah Pradhan, Candis Morrison, Atekelt Tadese, Colleen Ramsower, Lisa M. Rimsza, Allison P. Jacob, Heidi Simmons, Seth M. Steinberg, Elaine S. Jaffe, Mark Roschewski, Louis M. Staudt, Wyndham H Wilson
Journal: Blood
Blood (2024) 144 (Supplement 1): 750.
https://doi.org/10.1182/blood-2024-197956
Published: 2024
Journal Articles

Genetic Subclones Reveal Phenotypic Heterogeneity in Diffuse Large B-Cell Lymphoma

Boya Wang, George W. Wright, Julius C. Enssle, Yandan Yang, Da Wei Huang, Xin Yu, Arvin E Ruiz, James D. Phelan, Arthur L Shaffer, III, Thomas Oellerich, Giorgio Inghirami, Louis M. Staudt
Journal: Blood
Blood (2024) 144 (Supplement 1): 451.
https://doi.org/10.1182/blood-2024-204201
Published: 2024
Journal Articles

Phase 1/2 Study of Polatuzumab in Combination with Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Lenalidomide (ViPOR-P) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Preliminary Safety, Efficacy, and Molecular Analysis

Christopher Melani, Rahul Lakhotia, Stefania Pittaluga, James D. Phelan, Jagan R. Muppidi, Max J Gordon, Yandan Yang, Weihong Xu, Theresa Davies-Hill, Da Wei Huang, Craig J. Thomas, Michele Ceribelli, Frances A Tosto, Anna M Juanitez, Amynah Pradhan, Candis Morrison, Atekelt Tadese, Allison P. Jacob, Heidi Simmons, Seth M. Steinberg, Elaine S. Jaffe, Mark Roschewski, Louis M. Staudt, Wyndham H Wilson
Journal: Blood
Blood (2024) 144 (Supplement 1): 1722.
https://doi.org/10.1182/blood-2024-197987
Published: 2024
Journal Articles

Circulating Tumor DNA Predicts Time to First Treatment in Previously Untreated Follicular Lymphoma: Analysis from a Prospective Clonal Evolution Study

Rahul Lakhotia, Stefania Pittaluga, James D. Phelan, Allison Graeter, Christopher Melani, Max J Gordon, Jagan R. Muppidi, Sam Y. Ng, Sumaya Berg, Sarah Evans, Amynah Pradhan, Atekelt Tadese, Candis Morrison, Bonita Bryant, Yandan Yang, Theresa Davies-Hill, Liza Lindenberg, Mark Ahlman, Esther Mena, Ethan Bergvall, Nick Micheletti, Laura M Yee, Allison P. Jacob, Monica Gallucci, Heidi Simmons, Alexander Bagaev, Mark Meerson, Ekaterina Postovalova, Olga Kudryashova, Nikita Kotlov, Nathan H. Fowler, Elaine S. Jaffe, Louis M. Staudt, Wyndham H. Wilson, Mark Roschewski
Journal: Blood
Blood (2024) 144 (Supplement 1): 2958.
https://doi.org/10.1182/blood-2024-201711
Published: 2024
Journal Articles

Exceptional Response to BTK Inhibitors in Aggressive Lymphomas Linked to Chronic Selective Autophagy

James D Phelan, Sebastian Scheich, Jaewoo Choi, George Wright, Björn Häupl, Ryan M. Young, Sara Rieke, Martine Pape, Yanlong Ji, Henning Urlaub, Carmen Doebele, Alena Zindel, Tanja Wotapek, Monica Kasbekar, Da Wei Huang, Zana Coulibaly, Vivian M Morris, Xin Yu, Weihong Xu, Yandan Yang, Hong Zhao, Christopher J. Shoemaker, Zhuo Wang, Arthur Shaffer, Louis M. Staudt, Thomas Oellerich
Journal: Blood
Blood (2023) 142 (Supplement 1): 850.
https://doi.org/10.1182/blood-2023-190851
Published: 2023
Journal Articles

Molecular Mechanism of Action of Glucocorticoids in Lymphoma Therapy

Jaewoo Choi, Michele Ceribelli, James D Phelan, Björn Häupl, Da Wei Huang, George Wright, Tony Hsiao, Vivian M Morris, Francesco Ciccarese, Boya Wang, Sean R Corcoran, Sebastian Scheich, Xin Yu, Weihong Xu, Yandan Yang, Joyce Zhou, Grace Zhang, Jagan R. Muppidi, Giorgio Inghirami, Thomas Oellerich, Craig J. Thomas, Louis M. Staudt
Journal: Blood
Blood (2023) 142 (Supplement 1): 2986.
https://doi.org/10.1182/blood-2023-174325
Published: 2023
Journal Articles

Phase Ib/II Study of Multi-Targeted Therapy with Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Lenalidomide (ViPOR) in Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)

Christopher Melani, Rahul Lakhotia, Stefania Pittaluga, James D Phelan, Da Wei Huang, George Wright, Jillian Simard, Jagan R. Muppidi, Craig J. Thomas, Michele Ceribelli, Frances A Tosto, Yandan Yang, Weihong Xu, Theresa Davies-Hill, Svetlana Pack, Cody J Peer, Oluwatobi Arisa, Esther Mena, Maria L. Lindenberg, Ethan Bergvall, Craig A. Portell, Rafic J Farah, Seung Tae Lee, Amynah Pradhan, Candis Morrison, Atekelt Tadese, Anna M Juanitez, Crystal Lu, Allison P. Jacob, Heidi Simmons, William D Figg, Seth M. Steinberg, Elaine S Jaffe, Mark Roschewski, Louis M. Staudt, Wyndham H Wilson
Journal: Blood
Blood (2023) 142 (Supplement 1): 434.
https://doi.org/10.1182/blood-2023-180173
Published: 2023
Journal Articles

Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma

Takashi Ishio, Sarvesh Kumar, Joji Shimono, Anusara Daenthanasanmak, Sigrid Dubois, Yuquan Lin, Bonita Bryant, Michael N. Petrus, Emmanuel Bachy, Da Wei Huang, Yandan Yang, Patrick L. Green, Hiroo Hasegawa, Michiyuki Maeda, Hideki Goto, Tomoyuki Endo, Takashi Yokota, Kanako C. Hatanaka, Yutaka Hatanaka, Shinya Tanaka, Yoshihiro Matsuno, Yibin Yang, Satoshi Hashino, Takanori Teshima, Thomas A. Waldmann, Louis M. Staudt, Masao Nakagawa
Journal: Blood
Blood (2022) 139 (10): 1541–1556.
https://doi.org/10.1182/blood.2021012734
Published: 2022
Includes: Supplemental data
Journal Articles

Phase 2 Study of Acalabrutinib Window Prior to Frontline Therapy in Untreated Aggressive B-Cell Lymphoma: Preliminary Results and Correlatives of Response to Acalabrutinib

Mark Roschewski, James D. Phelan, Stefania Pittaluga, Christopher Melani, Rahul Lakhotia, Jacob J. Chabon, Jagan R. Muppidi, Kathryn A. Lurain, Jillian Simard, Amynah Pradhan, Amy Hillsman, Madeline Rilko, Seth M. Steinberg, George W. Wright, Da Wei Huang, Yandan Yang, Michail S. Lionakis, Alexander Bagaev, Ekaterina Postovalova, Mark Meerson, Olga Kudryashova, Nikita Kotlov, Nathan H. Fowler, David M. Kurtz, Ash A. Alizadeh, Elaine S. Jaffe, Louis M. Staudt, Wyndham H. Wilson
Journal: Blood
Blood (2021) 138 (Supplement 1): 524.
https://doi.org/10.1182/blood-2021-145228
Published: 2021
Journal Articles

A Prospective Study of Clonal Evolution in Follicular Lymphoma: Circulating Tumor DNA Correlates with Overall Tumor Burden and Fluctuates over Time without Therapy

Allison Distler, Rahul Lakhotia, James D. Phelan, Stefania Pittaluga, Christopher Melani, Jagan R. Muppidi, Jillian Simard, Amynah Pradhan, Amy Hillsman, Yandan Yang, Theresa Davies-Hill, Arthur L. Shaffer, III, Sarah Evans, Mark A. Ahlman, Allison P. Jacob, Alexander Bagaev, Mark Meerson, Ekaterina Postovalova, Olga Kudryashova, Nikita Kotlov, Nathan H. Fowler, Elaine S. Jaffe, Louis M. Staudt, Wyndham H. Wilson, Mark Roschewski
Journal: Blood
Blood (2021) 138 (Supplement 1): 1328.
https://doi.org/10.1182/blood-2021-151096
Published: 2021
Journal Articles

Genome-Wide CRISPR Library Screening Identifies CDK6 As Genetic Vulnerability in Adult T-Cell Leukemia/Lymphoma

Takashi Ishio, Joji Shimono, Sarvesh Kumar, Yuquan Lin, Emmanuel Bachy, Michael N. Petrus, Yandan Yang, Michiyuki Maeda, Hideki Goto, Satoshi Hashino, Takanori Teshima, MD, Thomas A. Waldmann, MD, Louis Staudt, MD, Masao Nakagawa
Journal: Blood
Blood (2019) 134 (Supplement_1): 3781.
https://doi.org/10.1182/blood-2019-124670
Published: 2019
Journal Articles

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T-Cell Leukemia/Lymphoma

Masao Nakagawa, MD, Arthur L Shaffer, Michele Ceribelli, Meili Zhang, PhD, George Wright, Da Wei Huang, Wenming Xiao, John Powell, Michael N Petrus, Yibin Yang, James D Phelan, Holger Kohlhammer, Hee Min Yoo, Yandan Yang, Weihong Xu, Xin Yu, Hong Zhao, Bonita R Bryant, Michiyuki Maeda, Thomas A Waldmann, MD, Lou Staudt, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 731.
https://doi.org/10.1182/blood.V130.Suppl_1.731.731
Published: 2017
Journal Articles

Genetic and Pharmacologic Notch4 Inhibition Synergizes with FLT3 Tyrosine Kinase Inhibition in Vitro to More Effectively Eliminate FLT3/ITD-Positive Leukemia Cells

Courtney M. Shirley, PhD, S. Haihua Chu, PhD, Yandan Yang, PhD, George W. Wright, PhD, Louis M. Staudt, MD PhD, Donald Small, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3583.
https://doi.org/10.1182/blood.V124.21.3583.3583
Published: 2014
Journal Articles

A Gain-of-Function CCR4 Mutations in Adult T-Cell Leukemia/Lymphoma (ATLL) Enhance the Chemotactic Abilities and PI3K/AKT Activation

Masao Nakagawa, MD PhD, Roland Schmitz, PhD, Wenming Xiao, Carolyn K Goldman, Weihong Xu, Yandan Yang, PhD, Thomas A Waldmann, MD, Louis M. Staudt, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3566.
https://doi.org/10.1182/blood.V124.21.3566.3566
Published: 2014
Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Takaomi Sanda, MD, PhD, Jeffrey W Tyner, PhD, Alejandro Gutierrez, MD, Vu N Ngo, PhD, Jason M Glover, MD, Bill H Chang, MD, PhD, Arla J Yost, Andrew P Weng, MD, PhD, Wenxue Ma, M.D., Ph.D., Jessica Tatarek, Angela G. Fleischman, MD, PhD, Yebin Ahn, Yandan Yang, PhD, Wenjun Zhou, Donna S. Neuberg, ScD, Richard Moriggl, PhD, Mathias Müller, DVM, Michelle Kelliher, PhD, Catriona Jamieson, MD, PhD, Nathanael S Gray, PhD, Louis M. Staudt, MD, PhD, Brian J. Druker, Thomas Look, MD
Journal: Blood
Blood (2012) 120 (21): 1470.
https://doi.org/10.1182/blood.V120.21.1470.1470
Published: 2012
Journal Articles

The Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765), Has Preferential Activity in the ABC Subtype of Relapsed/Refractory De Novo Diffuse Large B-Cell Lymphoma (DLBCL): Interim Results of a Multicenter, Open-Label, Phase 2 Study

Wyndham H. Wilson, MD, PhD, John F. Gerecitano, MD, PhD, Andre Goy, MD, Sven de Vos, MD, PhD, Vaishalee P. Kenkre, MD, Paul M. Barr, MD, Kristie A. Blum, MD, Andrei R. Shustov, MD, Ranjana H. Advani, MD, Jason Lih, PhD, Mickey Williams, PhD, Roland Schmitz, PhD, Yandan Yang, PhD, Stefania Pittaluga, MD, PhD, George Wright, PhD, Lori A. Kunkel, MD, Jesse McGreivy, MD, Sriram Balasubramanian, PhD, Mei Cheng, PhD, Davina Moussa, Joseph J. Buggy, PhD, Louis M. Staudt, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 686.
https://doi.org/10.1182/blood.V120.21.686.686
Published: 2012