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Journal Articles

Histone Methylation Mark Analyses Distinguish Carts Manufactured from Distinct Sources and Uncover Novel Transcription Factors Associated with In Vivo Function of Carts after Infusion into DLBCL Patients That Are Not Identified By RNA-Seq

Salvatore Fiorenza, Ye Zheng, Jay Sarthy, Alyssa Sheih, Erik L Kimble, Delaney Kirchmeier, Derek Janssens, Tinh-Doan Phi, Jordan Gauthier, Alexandre V Hirayama, Qian Wu, Raphael Gottardo, Stanley R. Riddell, David G Maloney, Steven Henikoff, Cameron J. Turtle
Journal: Blood
Blood (2023) 142 (Supplement 1): 3454.
https://doi.org/10.1182/blood-2023-188269
Published: 2023
Journal Articles

Targeting the Membrane-Proximal C2-Set Domain of CD33 for Improved CD33-Directed CAR T Cell Therapy

Salvatore Fiorenza, George S. Laszlo, Tinh-Doan Phi, Margaret C. Lunn, Delaney R. Kirchmeier, Colin D. Godwin, Erik L. Kimble, Cameron J. Turtle, Roland B. Walter
Journal: Blood
Blood (2021) 138 (Supplement 1): 2776.
https://doi.org/10.1182/blood-2021-149642
Published: 2021
Journal Articles

Long-Term Follow-up and Single-Cell Multiomics Characteristics of Infusion Products in Patients with Chronic Lymphocytic Leukemia Treated with CD19 CAR-T Cells

Alexandre V. Hirayama, Ye Zheng, Mark R. Dowling, Alyssa Sheih, Tinh-Doan Phi, Delaney R. Kirchmeier, Abby W. Chucka, Jordan Gauthier, David G. Maloney, Raphael Gottardo, Cameron J. Turtle
Journal: Blood
Blood (2021) 138 (Supplement 1): 1749.
https://doi.org/10.1182/blood-2021-151571
Published: 2021
Journal Articles

Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies

Clinical Trials & Observations
Jordan Gauthier, Evandro D. Bezerra, Alexandre V. Hirayama, Salvatore Fiorenza, Alyssa Sheih, Cassie K. Chou, Erik L. Kimble, Barbara S. Pender, Reed M. Hawkins, Aesha Vakil, Tinh-Doan Phi, Rachel N. Steinmetz, Abby W. Jamieson, Merav Bar, Ryan D. Cassaday, Aude G. Chapuis, Andrew J. Cowan, Damian J. Green, Hans-Peter Kiem, Filippo Milano, Mazyar Shadman, Brian G. Till, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle
Journal: Blood
Blood (2021) 137 (3): 323–335.
https://doi.org/10.1182/blood.2020006770
Published: 2021
Includes: Supplemental data
Journal Articles

High IL-15 Serum Concentrations Are Associated with Response to CD19 CAR T-Cell Therapy and Robust In Vivo CAR T-Cell Kinetics

Jordan Gauthier, MD MSc, Cassie Chou, MDPhD, Alexandre V. Hirayama, MD, Salvatore Fiorenza, MBBS, PhD, Alyssa Sheih, PhD, Barbara S. Pender, MSc, Tinh-Doan Phi, BSc, Rachel Steinmetz, BSc, Abby Jamieson, BSc, Delaney R Kirchmeier, BSc, Henna N Di, BSc, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-140120
Published: 2020
Journal Articles

Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure

Clinical Trials & Observations
Jordan Gauthier, Alexandre V. Hirayama, Janaki Purushe, Kevin A. Hay, James Lymp, Daniel H. Li, Cecilia C. S. Yeung, Alyssa Sheih, Barbara S. Pender, Reed M. Hawkins, Aesha Vakil, Tinh-Doan Phi, Rachel N. Steinmetz, Mazyar Shadman, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle
Journal: Blood
Blood (2020) 135 (19): 1650–1660.
https://doi.org/10.1182/blood.2019002936
Published: 2020
Includes: Supplemental data
Journal Articles

Combination of NKTR-255, a Polymer Conjugated Human IL-15, with CD19 CAR T Cell Immunotherapy in a Preclinical Lymphoma Model

Cassie Chou, MD PhD, Simon Fraessle, Rachel Steinmetz, BSc, Reed M. Hawkins, BS, Tinh-Doan Phi, BS, Dirk Busch, Takahiro Miyazaki, Mario Q. Marcondes, MD PhD, Stanley R. Riddell, MD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2866.
https://doi.org/10.1182/blood-2019-125960
Published: 2019
Journal Articles

Efficacy and Toxicity of JCAR014 in Combination with Durvalumab for the Treatment of Patients with Relapsed/Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

Alexandre V. Hirayama, MD, Jordan Gauthier, MD, Kevin A. Hay, MDFRCPC,MSc, Alyssa Sheih, PhD, Sindhu Cherian, MD, Xueyan Chen, MD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Rachel N. Steinmetz, BS, Tinh-Doan Phi, BS, Aude G. Chapuis, MD, Brian G. Till, MD, Hans-Peter Kiem, MD PhD, Mazyar Shadman, MD MPH, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1680.
https://doi.org/10.1182/blood-2018-99-116745
Published: 2018
Journal Articles

Factors Impacting Progression-Free Survival after CD19-Specific CAR-T Cell Therapy for Relapsed/Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

Alexandre V. Hirayama, MD, Jordan Gauthier, MD, Kevin A. Hay, MDFRCPC,MSc, Jenna M. Voutsinas, MSc, Qian V. Wu, PhD, Ted Gooley, PhD, Daniel Li, PhD, Alyssa Sheih, PhD, Janaki Purushe, PhD, Sindhu Cherian, MD, Xueyan Chen, MD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Rachel N. Steinmetz, BS, Tinh-Doan Phi, BS, Ryan C. Lynch, MD, Aude G. Chapuis, MD, Brian G. Till, MD, Hans-Peter Kiem, MD PhD, Jorge Ramos, DO, Mazyar Shadman, MD MPH, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1681.
https://doi.org/10.1182/blood-2018-99-115126
Published: 2018
Journal Articles

Multivariable Modeling of Disease and Treatment Characteristics of Adults with B-ALL in MRD-Negative CR after CD19 CAR-T Cells Identifies Factors Impacting Disease-Free Survival

Kevin A. Hay, MDFRCPC,MSc, Jordan Gauthier, MD, Alexandre V. Hirayama, MD, Jenna M. Voutsinas, MSc, Qian V. Wu, PhD, Daniel Li, PhD, Ted Gooley, PhD, Alyssa Sheih, PhD, Janaki Purushe, PhD, Sindhu Cherian, MD, Xueyan Chen, MD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Rachel N. Steinmetz, BS, Tinh-Doan Phi, BS, Aude G. Chapuis, MD, Brian G. Till, MD, Hans-Peter Kiem, MD PhD, Jorge Ramos, DO, Mazyar Shadman, MD MPH, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 281.
https://doi.org/10.1182/blood-2018-99-110561
Published: 2018
Journal Articles

Comparison of Efficacy and Toxicity of CD19-Specific Chimeric Antigen Receptor T-Cells Alone or in Combination with Ibrutinib for Relapsed and/or Refractory CLL

Jordan Gauthier, MD, Alexandre V. Hirayama, MD, Kevin A. Hay, MDFRCPC,MSc, Daniel Li, PhD, James Lymp, PhD, Alyssa Sheih, PhD, Janaki Purushe, PhD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Tinh-Doan Phi, BS, Rachel N. Steinmetz, BS, Aude G. Chapuis, MD, Brian G. Till, MD, Tejaswini Dhawale, MD, Paul C. Hendrie, MD PhD, Hans-Peter Kiem, MD PhD, Jorge Ramos, DO, Mazyar Shadman, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 299.
https://doi.org/10.1182/blood-2018-99-111061
Published: 2018
Journal Articles

Immunotherapy with T-Cells Engineered with a Chimeric Antigen Receptor Bearing a Human CD19-Binding Single Chain Variable Fragment for Relapsed or Refractory Acute Lymphoblastic Leukemia and B-Cell Non-Hodgkin Lymphoma

Jordan Gauthier, MD, Alexandre V. Hirayama, MD, Kevin A. Hay, MDFRCPC, MSc, Alyssa Sheih, PhD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Tinh-Doan Phi, BS, Rachel N. Steinmetz, BS, Aude G. Chapuis, MD, Brian G. Till, MD, Hans-Peter Kiem, MD PhD, Mazyar Shadman, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1415.
https://doi.org/10.1182/blood-2018-99-111528
Published: 2018