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Janaki Purushe
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Journal Articles

Prediction of Therapeutic Potential of CD19 CAR-T Cells for LBCL By Histone Mark Analyses of Core Epigenetic Programming

Salvatore Fiorenza, Yue Cao, Ye Zheng, Janaki Purushe, Tamara Bock, Erik L Kimble, Derek Janssens, Delaney Kirchmeier, Alexandre V. Vinaud Hirayama, Jordan Gauthier, David G. Maloney, Stanley R. Riddell, Akira Nguyen-Shaw, Steven Henikoff, Jean Yang, Cameron J. Turtle
Journal: Blood
Blood (2024) 144 (Supplement 1): 2028.
https://doi.org/10.1182/blood-2024-200589
Published: 2024
Journal Articles

Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure

Clinical Trials & Observations
Jordan Gauthier, Alexandre V. Hirayama, Janaki Purushe, Kevin A. Hay, James Lymp, Daniel H. Li, Cecilia C. S. Yeung, Alyssa Sheih, Barbara S. Pender, Reed M. Hawkins, Aesha Vakil, Tinh-Doan Phi, Rachel N. Steinmetz, Mazyar Shadman, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle
Journal: Blood
Blood (2020) 135 (19): 1650–1660.
https://doi.org/10.1182/blood.2019002936
Published: 2020
Includes: Supplemental data
Journal Articles

Factors Impacting Progression-Free Survival after CD19-Specific CAR-T Cell Therapy for Relapsed/Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

Alexandre V. Hirayama, MD, Jordan Gauthier, MD, Kevin A. Hay, MDFRCPC,MSc, Jenna M. Voutsinas, MSc, Qian V. Wu, PhD, Ted Gooley, PhD, Daniel Li, PhD, Alyssa Sheih, PhD, Janaki Purushe, PhD, Sindhu Cherian, MD, Xueyan Chen, MD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Rachel N. Steinmetz, BS, Tinh-Doan Phi, BS, Ryan C. Lynch, MD, Aude G. Chapuis, MD, Brian G. Till, MD, Hans-Peter Kiem, MD PhD, Jorge Ramos, DO, Mazyar Shadman, MD MPH, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1681.
https://doi.org/10.1182/blood-2018-99-115126
Published: 2018
Journal Articles

Multivariable Modeling of Disease and Treatment Characteristics of Adults with B-ALL in MRD-Negative CR after CD19 CAR-T Cells Identifies Factors Impacting Disease-Free Survival

Kevin A. Hay, MDFRCPC,MSc, Jordan Gauthier, MD, Alexandre V. Hirayama, MD, Jenna M. Voutsinas, MSc, Qian V. Wu, PhD, Daniel Li, PhD, Ted Gooley, PhD, Alyssa Sheih, PhD, Janaki Purushe, PhD, Sindhu Cherian, MD, Xueyan Chen, MD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Rachel N. Steinmetz, BS, Tinh-Doan Phi, BS, Aude G. Chapuis, MD, Brian G. Till, MD, Hans-Peter Kiem, MD PhD, Jorge Ramos, DO, Mazyar Shadman, MD MPH, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 281.
https://doi.org/10.1182/blood-2018-99-110561
Published: 2018
Journal Articles

Comparison of Efficacy and Toxicity of CD19-Specific Chimeric Antigen Receptor T-Cells Alone or in Combination with Ibrutinib for Relapsed and/or Refractory CLL

Jordan Gauthier, MD, Alexandre V. Hirayama, MD, Kevin A. Hay, MDFRCPC,MSc, Daniel Li, PhD, James Lymp, PhD, Alyssa Sheih, PhD, Janaki Purushe, PhD, Barbara S. Pender, MSc, Reed M. Hawkins, BS, Aesha Vakil, MSc, Tinh-Doan Phi, BS, Rachel N. Steinmetz, BS, Aude G. Chapuis, MD, Brian G. Till, MD, Tejaswini Dhawale, MD, Paul C. Hendrie, MD PhD, Hans-Peter Kiem, MD PhD, Jorge Ramos, DO, Mazyar Shadman, Ryan D. Cassaday, MD, Utkarsh H. Acharya, DO, Stanley R. Riddell, MD, David G. Maloney, MD PhD, Cameron J. Turtle, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 299.
https://doi.org/10.1182/blood-2018-99-111061
Published: 2018
Journal Articles

The Phosphorylation State of Ezh2 Determines Its Capacity to Maintain CD8 + Memory T Cells for Antitumor Immunity

Shan He, PhD, Yongnian Liu, Lijun Meng, Hongxing SUN, Ying Wang, Yun Ji, Janaki Purushe, BS, Pan Chen, Changhong Li, Jozef Madzo, Jean-Pierre Issa, MD, Jonathan Soboloff, Ran Reshef, MD, Bethany Moore, Luca Gattinoni, Yi Zhang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4455.
https://doi.org/10.1182/blood.V130.Suppl_1.4455.4455
Published: 2017
Journal Articles

MLL Histone Methyltransferase Restrains Effector Differentiation and PD-1 Expression in Human CD8 + T Cells While Promoting Their Proliferation

Janaki Purushe, Hongxin Sun, PhD, Shan He, PhD, Yali Dou, PhD, Yi Zhang, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 863.
https://doi.org/10.1182/blood.V128.22.863.863
Published: 2016
Journal Articles

Programming of donor T cells using allogeneic δ-like ligand 4–positive dendritic cells to reduce GVHD in mice

Kazuhiro Mochizuki, Lijun Meng, Izumi Mochizuki, Qing Tong, Shan He, Yongnian Liu, Janaki Purushe, Henry Fung, M. Raza Zaidi, Yanyun Zhang, Ran Reshef, Bruce R. Blazar, Hideo Yagita, Shin Mineishi, Yi Zhang
Journal: Blood
Blood (2016) 127 (25): 3270–3280.
https://doi.org/10.1182/blood-2015-05-644476
Published: 2016
Includes: Supplemental data
Journal Articles

Programming of Donor T Cells Using Allogeneic Delta-like Ligand 4-Positive Dendritic Cells to Reduce Gvhd but Retain GVL Activity

Kazuhiro Mochizuki, MD PhD, Lijun Meng, Izumi Mochizuki, MD, Qing Tong, MD, Shan He, Yongnian Liu, Janaki Purushe, Hongxing Sun, Henry Fung, Raza Zaidi, Ran Reshef, MD, Bruce R. Blazar, MD, Hideo Yagita, PhD, Shin Mineishi, MD, Yi Zhang
Journal: Blood
Blood (2015) 126 (23): 233.
https://doi.org/10.1182/blood.V126.23.233.233
Published: 2015
Journal Articles

The Notch Ligand DLL4 Derived from Human Dendritic Cells Is Critical for Promoting T Helper (Th)1 and Th17 Cell Differentiation

Lijun Meng, Zhenjiang Bai, Shan He, Kazuhiro Mochizuki, MD PhD, Janaki Purushe, Hongxing Sun, Jian Wang, Hideo Yagita, PhD, Shin Mineishi, MD, Henry Fung, Gregory A. Yanik, MD, Roberto Caricchio, Xiaoxuan Fan, Lisa M Crisalli, Ran Reshef, MD, Yanyun Zhang, Yi Zhang
Journal: Blood
Blood (2015) 126 (23): 3431.
https://doi.org/10.1182/blood.V126.23.3431.3431
Published: 2015